Our laboratory is interested in studying the various aspects of nuclear cell biology. Our goal is to understand how the nucleus evolved, what regulates nuclear shape, how the nucleus interacts with other organelles, and finally, how all of these influence genome organization and function. Our primary model of choice is the budding yeast, Saccharomyces cerevisiae.  Our genetic and visual screens have unravelled unanticipated regulators of nuclear architecture and gene expression. 

Our genetic screen in S. cerevisiae to understand the molecular basis of compartmentalization within the nucleus identified protein SUMOylation as a key regulator of inter-compartmental mobility for Sir2, a conserved NAD-dependent histone deacetylase. In a visual genome-wide screen for components that regulate nuclear shape, we have identified several key processes that influence nuclear shape and nuclear envelope (NE) organization. This includes the nucleolus, chromatin remodelers and components of the endoplasmic reticulum and vacuoles.  

To understand the origin of the NE, we have taken a comparative genomics approach to identify components of the NE that are conserved across supergroups. Interestingly, this study shows the ancient origin of several components of the NE proteome. 

For more details, please take a look at our Research and Publications pages. 

Over the years, our lab has produced stellar students who are pursuing a variety of careers. We aim to create a collaborative environment and strive to nurture every student's scientific interest regardless of their regionality and creed. 

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