Research

Research Themes

• Understanding the mechanisms that drive aging in the hematopoietic and autonomic nervous systems

• Investigating age-associated remodeling of cell–cell and organ–organ networks using organoid models

• Developing organoid-based approaches to modulate aging-related biological changes

1. Elucidating the mechanisms of hematopoietic stem cell functional restoration through regulation of the niche microenvironment

The hematopoietic system is maintained and regulated by hematopoietic stem cells. With aging, hematopoietic stem cell function undergoes substantial changes, which are known to contribute to impaired immune function and the onset or progression of age-associated diseases. Our laboratory focuses on the niche microenvironment surrounding hematopoietic stem cells and aims to elucidate how regulation of this niche can restore the function of aged hematopoietic stem cells, thereby contributing to the maintenance of tissue homeostasis and the suppression of age-associated pathological conditions. In addition, we are working to reconstruct such niche environments using organoid technologies, with the goal of establishing new research platforms for understanding the regulation of aged hematopoiesis.

2. Elucidating how age-associated remodeling of the autonomic nervous system regulates organ function

The autonomic nervous system projects to various organs throughout the body and plays an essential role in maintaining homeostasis. Our laboratory focuses particularly on the sympathetic nervous system and aims to clarify how the autonomic nervous system changes with aging, what drives these changes, and how they affect organ function. We investigate these questions across multiple organs at the molecular and cellular levels.

3. Elucidating cell–cell and interorgan network mechanisms of aging using organoid-based models

Using human iPS cells and primary cells, we develop organoid-based models of aging to investigate the mechanisms of human aging from the perspective of cell–cell and interorgan networks. By leveraging these organoid models, we aim to visualize the progression of aging-related changes, perform drug screening, identify therapeutic targets and biomarkers, and ultimately contribute to the development of regenerative medicine and personalized medicine.