研究室業績
２０２５年
原著論文
Sunagawa Y, Iwashimizu S, Ono M, Mochizuki S, Iwashita K, Sato R, Shimizu S, Funamoto M, Shimizu K, Hamabe-Horiike T, Katanasaka Y, Murakami A, Asakawa T, Inai M, Kan T, Komiyama M, Hawke P, Mori K, Arakawa Y, Hasegawa K, Sakamoto K, Kurokawa J, Morimoto T*. The citrus flavonoid nobiletin prevents the development of doxorubicin-induced heart failure by inhibiting apoptosis.
J Pharmacol Sci, 2025, 158, 84-94.
Tsujii K, Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H*. Comparative analysis of the single-molecule transport kinetics of OATP1B1 genetic variants.
J Pharmacol Sci, 2025, 158, 166-171
２０２４年
原著論文
Nagasawa §, Kodama M§ (§ : contributed equally), Hagiwara R, Sakamoto K, Nishiyama K, Arima Y, Kurihara H, Kurokawa J*. Sex differences in the functional morphology of coronary arteries in embryonic mice.
Am J Physiol Heart Circ Physiol, 327, H1390-H1399 (2024)
Satsuka A, Ribeiro AJS, Kawagishi H, Yanagida S, Hirata N, Yoshinaga T, Kurokawa J, Sugiyama A, Strauss DG., Kanda Y. Contractility assessment using aligned human iPSC-derived cardiomyocytes.
J Pharmacol Toxicol Methods, 128, 107530 (2024)
総説
児玉昌美、清水聡史、坂本多穗、黒川洵子*. 検査値・薬物動態での性差 第5章 女性の健康と性差医療．
「ウィメンズヘルスケアのための薬の使い方」月刊薬事, 2024, 66-2, 461-465
坂本多穗*、黒川洵子．骨格筋に着目した敗血症病態生理学の解明と創薬への応用．
日本薬理学雑誌、2024, 159, 112-117
黒川洵子*、清水聡史、坂本多穗．ヒトiPS細胞由来心筋細胞を用いた収縮機能評価について
YAKUGAKUZASSHI, 2024, 144, 251-255
諫田泰成*、黒川洵子．抗がん剤心毒性の統合的な理解～基礎から臨床まで～
YAKUGAKUZASSHI, 2024, 144, 249-250.
清水聡史、若林聖士、黒川洵子*. 薬物動態の性差、医学のあゆみ、2024, 290;10; 904-908.
２０２３年
原著論文
K Yajima, T Akiyoshi, K Sakamoto, Y Suzuki, T Oka, A Imaoka, H Yamamura, J Kurokawa, H Ohtani*. Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.
J Pharmacol Sci, 153, 153-160 (2023)
総説
清水聡史、児玉昌美、坂本多穗、黒川洵子. 薬物動態と薬力学における性差. 日本臨床, 2023, 81, 961-966.
２０２１年
原著論文
Iseki Y, Ono Y, Hibi C, Tanaka S, Takeshita S, Maejima Y, Kurokawa J, Murakawa M, Shimomura K, Sakamoto K: Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway.
J Pharmacol Exp Ther. 376, 454-462 (2021)
Aghasafari P, Yang PC, Kernik DC, Sakamoto K, Kanda Y, Kurokawa J, Vorobyov I, Clancy CE.: A deep learning algorithm to translate and classify cardiac electrophysiology.
eLife, 10, e68335 (2021)
Tamura F, Sugimoto S, Sugimoto M, Sakamoto K, Yamaguchi M, Suzuki T, Fukuda K, Ieda M, Kurokawa J.: The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031.
Biomolecules, 11, 1385 (2021)
総説・その他
山口賢彦、坂本多穗、黒川洵子： 抗がん薬の心毒性評価を指向したヒトiPS細胞由来心筋細胞の力学的機能解析.
日薬理誌, 156, 214-219 (2021)
諫田泰成、黒川洵子： 序文、特集：ヒトiPS細胞技術を活用した創薬研究の新たな展開、
日本薬理学雑誌, 156: 207 (2021)
２０２０年
原著論文
KernikDC, Yang PC, Kurokawa J, Wu JC, Clancy CE.:A computational model of induced pluripotent stem-cellderivedcardiomyocytes for high throughput risk stratification of KCNQ1 geneticvariants.PLoS Comput Biol,16,e1008109(2020)
Ono Y,Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J.:TAK-242, a specific inhibitorof Toll-likereceptor 4 signalling, prevents endotoxemia-induced skeletalmuscle wasting in mice.
Sci Rep,10,694(2020)
総説・その他
黒川洵子.性差医学に基づく薬の研究と安全性の追求ヘルシスト, 262, 6-9(2020)
Kurokawa J.Involvementof sex hormonal regulation of K+channels in electrophysiologicaland contractile functions ofmuscle tissues electrophysiological andcontractile functions of muscle tissues.
Healthist,Special Issue, 30-33 (2020)
２０１９年
原著論文
SakamotoK, Sakatoku K, Sugimoto S, Iwasaki N, Sano Y, Yamaguchi M, Kurokawa J.:Continued exposure ofanti-cancerdrugs to human iPS cell-derived cardiomyocytes can unmask theircardiotoxic effects.
J Pharmacol Sci,140,345-349(2019)
KodamaM, Furutani K, Kimura R, Ando T, Sakamoto K, Nagamori S, Ashihara T, Kurachi Y,Sekino Y, Furukawa T, Kanda Y,Kurokawa J.:Systematic expression analysis of genes related togeneration of action potentials in human iPS cell-derivedcardiomyocytes.
J Pharmacol Sci,140,325-330(2019)
KernikDC, Morotti S, Wu HD, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E,Clancy CE.:A computational modelofinduced pluripotent stem-cell derived cardiomyocytes incorporating experimentalvariability from multiple data sources.
J Physiol (Lond.),597,4533-4564(2019)
総説・その他
黒川洵子.ヒトiPS細胞由来心筋細胞を用いた薬物作用評価法の現状
BIO Clinica, 34, 80-87(2019)
SakamotoK, Kurokawa J.Involvementof sex hormonal regulation of K+channels in electrophysiologicaland contractilefunctions of muscle tissues electrophysiological andcontractile functions of muscle tissues.
J Pharmacol Sci,139, 259-265 (2019)
２０１８年
原著論文
Okada J,Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T.:Arrhythmic hazard map for a 3Dwhole-ventricles model under multiple ion channel block.
Br J Pharmacol,175, 3435-3452 (2018)
総説・その他
坂本多穂.エストラジオールによる骨格筋ミトコンドリア呼吸代謝の活性化機構
ファルマシア, 54, 1084 (2018)
坂本多穂..筋委縮治療薬の開発を目指した細胞薬理学的アプローチ
薬学雑誌, 138, 1271-1275 (2018
２０１７年
原著論文
Okada J,Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T.:Arrhythmic hazard map for a 3Dwhole-ventricles model under multiple ion channel block.
Br J Pharmacol,175, 3435-3452 (2018)
総説・その他
坂本多穂.エストラジオールによる骨格筋ミトコンドリア呼吸代謝の活性化機構
ファルマシア, 54, 1084 (2018)
坂本多穂..筋萎縮治療薬の開発を目指した細胞薬理学的アプローチ
薬学雑誌, 138, 1271-1275 (2018