Dr. Cheng-Yen  (CY) Kao

Professional Experience:

• 2024/05 ~

Part-time Consultant, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. 林口長庚醫院兼任顧問

• 2024/02 ~ 

Associate Professor, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan.

• 2024/02 ~

Jointly Appointed Associate Professor, Biomedical Industry Ph.D program, National Yang Ming Chiao Tung University, Taiwan.

• 2024/02 ~ 

Jointly Appointed Associate Professor, Program in Molecular Medicine, National Yang Ming Chiao Tung University, Taiwan. 

• 2023/08 ~ 2025

Deputy Director, Microbiota Research Center, College of Medicine, National Yang Ming Chiao Tung University, Taiwan. 國立陽明交通大學醫學院微菌中心副主任

• 2021/02 ~ 2024/01

Jointly Appointed Assistant Professor, Biomedical Industry Ph.D program, National Yang Ming Chiao Tung University, Taiwan.

• 2020/08 ~ 2024/01

Jointly Appointed Assistant Professor, Program in Molecular Medicine, National Yang Ming Chiao Tung University, Taiwan. 

• 2019/08 ~ 2024/01

Assistant Professor, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan.

• 2017/10 ~ 2019/07

Postdoctoral fellow, Department of Medical Microbiology and Immunology, University of Wisconsin-Madison (Dr. John-Demian (JD) Sauer Lab).

• 2016/08 ~ 2017/10

Postdoctoral fellow, Department of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan (Prof. Jiunn-Jong Wu Lab).

• 2014/08 ~ 2016/07

Postdoctoral fellow, Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Prof. Jiunn-Jong Wu Lab).

• 2009/09 ~ 2014/07

Lecturer, Gole educational institution. 高元文教機構. Teaching courses: Microbiology and Immunology, Biotechnology, Molecular Biology.

Research Interest & Expertise:

• Antimicrobial resistance mechanisms; 

• Bacterial genomics and NGS;

• Virulence factors and bacterial pathogenesis;

• Gene regulation and transcriptome;

• Mouse model for bacterial infection; 

• Antimicrobial-drug and probiotic development.

Professional Service:

• 2023-2026. Director: Taiwan Testing and Quality Assurance Society (TTQAS), 社團法人台灣檢驗及品保學會第5屆理事.

• 2023-2025. Secretary-General: Taiwan Microbiota Consortium, 台灣微菌聯盟第二屆秘書長.

• 2023-2025. Secretary-General: Taiwan Society of Microbiology, 台灣微生物學會第24屆秘書長.

• 2020-2023. Deputy Secretary: Taiwan Testing and Quality Assurance Society (TTQAS), 社團法人台灣檢驗及品保學會第4屆副秘書長.

• 2019-2021. American Society for Microbiology (ASM) Young Ambassador to Taiwan. 2019 美國微生物學會駐台灣青年大使. 

• 2019-2022. Deputy Secretary: Taiwan Society of Microbiology, 台灣微生物學會第23屆副秘書長.

Memberships:

• Taiwan Microbiota Consortium (2023 ~) 

• Taiwan Testing and Quality Assurance Society (TTQAS) (2019 ~)

• European Society of Clinical Microbiology and Infectious Diseases (Member ID: 134433, 2017 ~).

• American Society for Microbiology (Member ID: 57016792/43426372, 2012 ~).

• Taiwan Society of Microbiology (Member ID: S93, 2010 ~).

Speaker and Moderator:

• 2023 Oct 14th. (Invited talk). Carbapenem-resistant hypervirulent Klebsiella pneumoniae. 25th Annual Meeting of Antimicrobial Resistance in Taiwan Artificial Intelligence and Innovative Technology. 第二十五屆台灣抗微生物製劑抗藥性現況研討會. 台北凱撒飯店4樓寶島廳.

• 2023 Aug 18th-20th. Urinary tract infections: From clinical observations to basic research. (Invited talk). 台灣泌尿科醫學會TUA 2023 年會. 台大醫院國際會議中心 2F 201 會議廳.

• 2023 July 6th-8th. In Vivo Evolution of Escherichia coli and Recurrent Urinary Tract Infections. (Invited talk). 19th The Asia Pacific Congress of Clinical Microbiology & Infection (APCCMI). Seoul, Korea

• 2023 May 3rd. Characterization of the in vivo evolution of pathogens isolated from patients with recurrent urinary tract infections. (Invited talk). PROGRAMME 1ST INTERNATIONAL SCIENTIFIC CONFERENCE ON MICROBIOLOGY-2023. Ulaanbaatar city, Mongolia. 

• 2023 Apr 22nd. Microbiota: an alternative target for the treatment of patients with recurrent urinary tract infections? (Invited talk). 2023第六屆台灣微菌聯盟學術年會. Taipei Veterans General Hospital, Taipei, Taiwan.

• 2022 Dec 15th. Roles of Helicobacter pylori motility in pathogenesis and its regulatory mechanism: From clinical investigation to basic research. (Invited talk). Division of Gasteroenterology. Taipei Veterans General Hospital, Taipei, Taiwan. 

• 2022 Dec 3rd. Revisiting and revising the definition of hypervirulent K. pneumoniae by using a combination of phenotypic and genotypic assays. (Invited talk). 台灣微生物學會第二十四屆第一次會員大會及學術研討會. Taipei Nangang Exhibition Center, Taipei, Taiwan.

• 2022 Sep 26th. In vivo evolution of bacteria, focused on uropathogens and association with rUTI. (Invited talk). 高雄長庚紀念醫院 2022 年度震波研究中心教育訓練. Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

• 2022 Sep 25th. Unmet needs in uncomplicated urinary tract infection - Evolution of bacterial susceptibility pattern: Basic perspective. (Invited talk). Contemporary Urology Forum, 2022. Taipei Veterans General Hospital, Taipei, Taiwan. 

• 2022 Sep 6th. Defeating antibiotic-resistant bacteria: PASTA kinases as alternative drug targets for a coming post-antibiotic era. (Invited talk). Graduate Institute of Molecular and Comparative Pathobiology, National Taiwan University. National Taiwan University, Taipei, Taiwan.

• 2022 Aug 25th-27th. Committee Chair – 26th Bacteriology conference. 2022台灣第26屆細菌學研討會.National Yang Ming Chiao Tung University, HsinChu, Taiwan.

• 2021 Dec 4th. Conference committee-Taiwan Society of Microbiology 2021 Academic Seminars-Advances in clinical microbiology and antibiotic resistance during the SARS-CoV-2 pandemic (Co-hosted by ASM and TSM) 台灣微生物學會第二十三屆第二次會員大會及學術研討會. Taipei Nangang Exhibition Center, Taipei, Taiwan.

• 2021 Mar 19th. Defeating antibiotic-resistant bacteria: PASTA kinases as alternative drug targets for a coming post-antibiotic era. (Invited talk). Department of Microbiology, Immunology and Biopharmaceuticals, National Chia-Yi University, ChiaYi, Taiwan. 

• 2020 Dec 5th. PASTA kinases as alternative drug targets for a coming post-antibiotic era. Taiwan Society of Microbiology 2020 annual meeting and symposium. 台灣微生物學會第二十三屆第二次會員大會及學術研討會. Taipei Nangang Exhibition Center, Taipei, Taiwan.

• 2020 Sep 4th. Defeating antibiotic-resistant bacteria: exploring alternative drug targets for a post-antibiotic era. (Invited talk). 2020 YMCY symposium for Biological Technology and Therapeutic Development. 陽明交大生物科技與藥物發展研討會. National Chiao Tung University.

• 2020 Sep 3rd. Defeating antibiotic-resistant bacteria: PASTA kinases as alternative drug targets. (Invited talk). 2020 MMP and TIGP-Molecular Medicine Program joint retreat. The Great Roots Resort. 三峽大板根.

• 2019 Nov 23rd. Uncovering the secrets of bacterial pathogenesis. (Invited talk). Taiwan Society of Microbiology 2019 annual meeting and symposium. 台灣微生物學會第二十三屆第一次會員大會及學術研討會. National Taiwan University, Taipei, Taiwan.

• 2019 Nov 13th. Fighting antibiotic resistant bugs: exploring alternative drug targets for post-antibiotic era. (Invited talk).  En Chu Kong Hospital, New Taipei City, Taiwan.

• 2019 Nov 6th. Uncovering the secrets of bacterial pathogenesis. (Invited talk). School of Life Sciences, National Yang-Ming University, Taipei, Taiwan.

• 2019 Sep 26th. Uncovering the secrets of bacterial pathogenesis. (Invited talk). Department of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang Ming University, Taipei,  Taiwan.

• 2019 Aug 31st. Committee Chair - Hot topics in the 119th ASM General Meeting-細菌診斷與抗藥性新知研討會 (Co-hosted by ASM, TSM, and NYMU) National Yang-Ming University.

• 2019 Aug 31st. New pipeline drugs for post-antibiotic era. (Conference invited talk). Hot topics in the 119th ASM General Meeting-2019細菌診斷與抗藥性新知研討會. National Yang-Ming University, Taipei, Taiwan.

• 2019 Feb 24th. Uncovering the secrets of Listeria monocytogenes pathogenesis: ‘Live' in the cytosol. (Job talk, Faculty application). Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.

• 2019. Feb 18th. Uncovering the secrets of bacterial pathogenesis. (Invited talk). College of medicine, National Cheng-Kung University​, Tainan, Taiwan.

• 2019. Feb 13th. TrfA, a novel transcriptional regulator of fermentation, regulates cytosolic survival of 1,4-dihydroxy-2-naphthoate (DHNA) deficient Listeria monocytogenes.  (Job talk, Faculty application). Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan.

• 2019. Feb 14th. Uncovering the secrets of bacterial pathogenesis. (Job talk, Faculty application). Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan.

• 2019 Jan 24th. TrfA, a novel transcriptional regulator of fermentation, regulates cytosolic survival of 1,4-dihydroxy-2-naphthoate (DHNA) deficient Listeria monocytogenes.  (Job talk, Faculty application). Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

• 2018 Nov 5th. A novel screen suggests that regulation of fermentation is critical for cytosolic survival and virulence of Listeria monocytogenes (Job talk, Faculty application). Department of Microbiology and Immunology, School of Medicine, Taipei Medical University, Taipei, Taiwan.

• 2018. Oct 31st. What makes a successful pathogen ? (Job talk, Faculty application). Department of Life Sciences, Tunghai University​, Taichung, Taiwan.

• 2018. Sep 30th. A novel screen suggests that regulation of fermentation is critical for cytosolic survival and virulence of Listeria monocytogenes. (Conference invited talk). 25th Annual Midwest Microbial Pathogenesis Conference, University of Iowa, Iowa, IA (MMPC).

• 2018 Mar 7th. Motility and metabolism, two crucial factors in bacterial pathogenesis. (Job talk, Faculty application). Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan.

• 2018 Mar 5th. Motility and metabolism, two crucial factors in bacterial pathogenesis. (Invited talk). Department of Biochemical Science and Technology, National Chiayi University, Chiayi 60004, Taiwan.

• 2016 May 19th. Roles of Helicobacter pylori motility in pathogenesis and its regulatory mechanism: from clinical investigation to basic research. (Job talk, Postdoctoral fellow application). Institut Pasteur, Biology of Infection Unit, Paris, France.

• 2015 Oct 6th. Past, Present, and Future of Research in Helicobacter pylori Pathogenesis. (Job talk, Faculty application). Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan. 

Editorial Board Member:

• Frontiers in Medical Technology (2021 ~, Guest associated editor) https://www.frontiersin.org/research-topics/18898/drugs-for-a-coming-post-antibiotic-era

• Journal of Visualized Experiments (JoVE) (SCI, Impact factor: 1.424, 2021 ~, Guest editor) https://www.jove.com/methods-collections/867

• Life (SCI, Impact factor: 3.251, 2021 ~, Topic editor) https://www.mdpi.com/journal/life/special_issues/Bacterial_Metabolism 

• Biomolecules (SCI, Impact factor: 6.064, 2022 ~, Guest editor)  https://www.mdpi.com/journal/biomolecules/special_issues/9VFT8Y75RW 

Peer Reviewer for Academic Journals:

• Acta Biomaterialia (SCI, Impact factor: 9.7, 2018)

• BBA Gene Regulatory Mechanisms (SCI, Impact factor: 4.7, 2018)

• Microbial Pathogenesis (SCI, Impact factor: 3.8, 2019)

• Heliyon (SCI, Impact factor: 4.0, 2019)

• Practical Laboratory Medicine (SCI, Impact factor: 1.9. 2019)

• Frontiers in Cellular and Infection Microbiology (SCI, Impact factor: 5.7, 2020)

• Infectious Disorders-Drug Targets (2020)

• Molecules (SCI, Impact factor: 4.6, 2020)

• Microorganisms (SCI, Impact factor: 4.5, 2020)

• Antibiotics (SCI, Impact factor: 4.8, 2020)

• Infection and Drug Resistance (SCI, Impact factor: 3.9, 2020)

• Journal of Microbiology, Immunology and Infection (SCI, Impact factor: 7.4, 2021)

• Microbiology research (SCI, Impact factor: 1.5, 2021)

• Journal of Traditional and Complementary Medicine (SCI, Impact factor: 4.5, 2021)

• Frontiers in Microbiology (SCI, Impact factor: 5.2, 2021)

• Pharmaceuticals (SCI, Impact factor: 4.6, 2021 )

• Frontiers in Medicine (SCI, Impact factor: 3.9, 2021)

• Microbial Cell Factories (SCI, Impact factor: 6.4, 2021)

• Open Veterinary Journal (SCI, Impact factor: 1.2, 2021)

• International Journal of Molecular Sciences (SCI, Impact factor: 5.6, 2021)

• Gene Reports (SCI, Impact factor: 1.3, 2021)

• Life (SCI, Impact factor: 3.2, 2021)

• SAGE Open Medicine (SCI, Impact factor: 2.3, 2021)

• International Journal of Environmental Research and Public Health (SCI, Impact factor: 4.614, 2021)

• Scientific reports (SCI, Impact factor: 4.6, 2021)

• International Microbiology (SCI, Impact factor: 3.1, 2021)

• Germs (SCI, Impact factor: 2.0, 2021)

• Diagnostics (SCI, Impact factor: 3.6, 2021)

• Biology (SCI, Impact factor: 4.2, 2021)

• Show Chwan Medical Journal" 秀傳醫學雜誌 (2022)

• Lancet Microbe (SCI, Impact factor: 38.2, 2022)

• Frontiers in Bioscience-Elite (SCI, Impact factor: 3.308, 2022)

• International Journal of Nanomedicine (SCI, Impact factor: 8.0, 2022)

• Applied Microbiology and Biotechnology (SCI, Impact factor: 5.0, 2022)

• Open Forum Infectious Diseases (SCI, Impact factor: 4.2, 2022)

• Food Bioscience (SCI, Impact factor: 5.2, 2022)

• Frontiers in Immunology (SCI, Impact factor: 7.3, 2022)

• eBioMedicine (SCI, Impact factor: 11.1, 2022)

• World Journal of Microbiology and Biotechnology (SCI, Impact factor: 4.1, 2022)

• Journal of Fungi (SCI, Impact factor: 4.7, 2022)

• Life Sciences (SCI, Impact factor: 6.1, 2023, 2024)

• Food & Function (SCI, Impact factor: 6.1, 2023, 2024)

• Computational and Structural Biotechnology Journal (SCI, Impact factor: 6.0, 2023)

• AIMS Microbiology (SCI, Impact factor: 4.8, 2023)

• European Journal of Clinical Microbiology & Infectious Diseases (SCI, Impact factor: 4.5, 2023)

• Future Microbiology (SCI, Impact factor: 3.1, 2023)

• Nature Microbiology (SCI, Impact factor: 28.3, 2023)

• Journal of Global Antimicrobial Resistance (SCI, Impact factor: 4.6, 2023)

• Current Microbiology (SCI, Impact factor: 2.6, 2023, 2024)

• Communications Medicine (SCI, 2023)

• American Journal of Infection Control (SCI, Impact factor: 4.9, 2023)

• BMC Genomics (SCI, Impact factor: 4.4, 2023)

• Virulence (SCI, Impact factor: 5.2, 2024)

• The Microbe (SCI, 2024)

• Microbiological Research (SCI, Impact factor: 6.7, 2024)

• Journal of Biomedical Science (SCI, Impact factor: 11.0, 2024)

• Journal of Ovarian Research (SCI, Impact factor: 4.7, 2024)

• Gut pathogens (SCI, Impact factor: 4.3, 2024)

Honors and Awards:

• 2021. Phylogenetic Distribution of CRISPR-Cas Systems in Staphylococcus lugdunensis，刊登於Microbiology Spectrum，獲選陽明交通大學110年第4季(10-12月)重要論文

• 2020. Outstanding alumni, Department of Biochemical Science and Technology, National Chia-Yi University. 嘉義大學生化科技學系108年度傑出系友.

• 2019. ASM Young Ambassador/Travel Award.第119屆 美國微生物學會年會 American Society for Microbiology 2019 119th General Meeting, SF, USA.

• 2019-2021. American Society for Microbiology (ASM) Young Ambassador to Taiwan. 2019美國微生物學會駐台灣青年大使.

• 2018. MMPC Fellowship/Travel Award. 25th Annual Midwest Microbial Pathogenesis Conference (MMPC), University of Iowa, Iowa, IA.

• 2017. 科技部補助國內專家學者出席國際學術會議. MOST Travel Grant Award (The 27th European Congress of Clinical Microbiology and Infectious  Diseases, ECCMID). Ministry of Science and Technology, Taiwan.

• 2016. Taiwan Society of Microbiology. 2nd prize for oral presentation at the 2016 annual meeting and symposium. (Basic microbiology research). 台灣微生物學會第二十二屆第一次會員大會及學術研討會口頭論文基礎微生物學組第二名. Helicobacter pylori J99 jhp0106 Gene, Under the Control of CsrA/RpoN Regulatory System, Modulates Flagella Formation and Motility.

• 2016. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2016 annual meeting and symposium. (Clinical microbiology research). 台灣微生物學會第二十二屆第一次會員大會及學術研討會口頭論文臨床微生物學組第一名. Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015. 

• 2015. 科技部補助國內專家學者出席國際學術會議. MOST Travel Grant Award (American Society for Microbiology 2015 115th General Meeting). Ministry of Science and  Technology, Taiwan.

• 2014. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2014 annual meeting and symposium. (Basic microbiology research). 台灣微生物學會第二十一屆第二次年會口頭論文基礎微生物學組第一名. Roles of Helicobacter pylori motility in pathogenesis and its regulatory mechanism: From clinical investigation to basic research.

• 2013. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2013 annual meeting and symposium. (Clinical microbiology research). 台灣微生物學會第二十一屆第一次年會口頭論文臨床微生物學組第一名. Heteroresistance of Helicobacter pylori within the same patient prior to antibiotic treatment

• 2013. 科技部補助國內研究生出席國際學術會議. MOST Travel Grant Award (American Society for Microbiology 2013 113th General Meeting). Ministry of Science and  Technology, Taiwan.

• 2012. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2012 annual meeting and symposium. (Basic microbiology research). 台灣微生物學會第二十屆第三次年會口頭論文基礎微生物學組第一名. CsrA regulates H. pylori motility and adhesion ability through controlling alternative sigma factor rpoN expression and flagella formation.