Lab members
Principle Investigator
Ph.D., Institute of Basic Medical Sciences, National Cheng-Kung University, Taiwan.
Research interests:
Bacterial pathogenesis & evolution
Antibiotic resistance & drug development
Bacterial community & Microbiota
Applications of microbiology (Phages & Probiotics)
Postdoctoral researcher
Ph.D. students
Jazon Harl Hidrosollo (2021 Oct ~)
Team A/D: Bacterial pathogenesis and gene regulation
Ms., Department of Medical Technology, University of San Agustin, Philippines.
Research topic:
The mechanism of compound 4e against S. lugdunensis
Investigating the mechanism of compound 4e derivatives against S. lugdunensis and the mechanism of drug resistance
The interaction between urinary stones and microbiota (side project)
Yen-Zheng Zhang (Jean) (2020 Aug ~ 2022 Aug, Master student; 2022 Sep ~)
Team B: Antibiotic resistance & bacterial evolution
Bs., Department of Biotechnology and Laboratory Science in medicine, National Yang-Ming University, Taiwan
Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan
Research topic:
Investigating the evolutionary mechanisms of strains in patients with recurrent urinary tract infections
Exploring the characteristics of bacteria causing systemic infections
Characteristics and diagnosis of carbapenemase-producing bacteria (side project)
Pei-Yun Kuo (Alice) (2020 Aug ~ 2022 Aug, Master student; 2022 Sep ~)
Team A/C: Bacterial pathogenesis and gene regulation
Bs., Department of Biotechnology and Laboratory Science in medicine, Chang-Gung University, Taiwan
Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan
Research topic:
Investigating the roles and interactions of Jhp0417 and Jhp0106
Exploring the regulatory mechanisms of CsrA
Investigating the influence of strain-specific regulation of CsrA variants on bacterial virulence
Developing novel probiotics for pets (side project)
Tran Thi Dieu Thuy (Andrea) (2020 Sep ~ 2022 Aug, Master student; 2022 Sep ~)
Team D: Drug development & microbial applications
Bs., Department of biotechnology, Ton Duc Thang University, Vietnam
Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan
Research topic:
Development and mechanism exploration of traditional probiotic products against pathogenic bacteri
Development of next-generation probiotics for anti-aging effects
Investigation of the correlation between microbiota and male reproductive tract diseases (side project)
Tran Thi Thuy Duong (Mira) (2020 Nov ~ 2022 Aug, Master student; 2022 Sep ~)
Team B/C: Antibiotic resistance & bacterial evolution
Bs., Department of biotechnology, Ton Duc Thang University, Vietnam
Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan
Research topic:
Investigating the characteristics of CRhvKP and developing a screening platform
Exploring the evolution and characteristics of CRhvKP, hvKP, and LAhvKP plasmids
Investigating the role of novel virulence factors in the pathogenesis of CRKP
Developing bacteriophages to inhibit CRhvKP
Studying the evolution of hvKP within the host
Developing antibacterial compounds and analyzing their mechanisms (side project)
Carl Jay Ballena Bregente (2022 Sep ~)
Team C: Bacterial community
Ms., Blizard Institute, London, United Kingdom
Research topic:
Exploring the characteristics of hypervirulent and carbapenem-resistant Pseudomonas aeruginosa (HvCRPA)
Investigating the characteristics of CAZ-AVI/cefiderocol-resistant Pseudomonas aeruginosa
Development of bacteriophages to combat HvCRPA
Development of bacteriophages to combat carbapenem-resistant Enterobacter cloacae (side project)
Investigation of the correlation between microbiota and male reproductive tract diseases (side project)
Pek Kee Chen (2021 Oct ~ 2023 Aug, Master student; 2023 Sep ~)
Team B: Antibiotic resistance & bacterial evolution
Bs., Universiti Tunku Abdul Rahman, Malaysia
Research topic:
Analysis of the characteristics and mechanisms of hypervirulent extensively drug-resistant Acinetobacter baumannii
Analysis of novel mechanisms of carbapenem resistance in Acinetobacter baumannii
Development of bacteriophages to combat hypervirulent XDR Acinetobacter baumannii
Analysis of the impact and mechanisms of induced resistance in Acinetobacter baumannii on pathogenicity
Development of probiotics with the potential to inhibit rUTI (side project)
Pei-Chun (Ella) (2022 Aug ~2024 Jul, Master student; 2024 Sep ~)
Team D: Drug development & microbial applications
Bs., Department of Food Science and Biotechnology, Chung Hsing University, Taiwan
Research topic:
Development and mechanistic study of Next-Generation Probiotics against metabolic syndrome
Zheng Ya-Yu (2022 Aug ~2024 Jul, Master student; 2024 Sep ~)
Team B: Antibiotic resistance & bacterial evolution
Bs., Department of Life Science, National Tsing Hua University, Taiwan.
Research topic:
The bacterial interactions in polymicrobial infections and their impact on bacterial pathogenesis.
Master students
I-Yuan Hsu (Eva) (2022 Aug ~)
Team A: Bacterial pathogenesis and gene regulation
Bs., Department of Laboratory Medicine and Biotechnology, College of Medicine, TCU, Taiwan.
Research topic:
Characterization of novel virulence factors in H. pylori pathogenesis
Jason Torres (2022 Aug ~)
Team B: Antibiotic resistance & bacterial evolution
Bs., Bachelors of Science in Biology. University of Belize, Belize
Research topic:
Exploring the characteristics of K. pneumoniae causing systemic infections
Tong Dang Khoa (2023 Feb ~)
Team A: H. pylori pathogenesis
Bs., Ho Chi Minh City International University, Vietnam.
Research topic:
Investigating the characteristics of siderophore-carbapenemase carrying plasmids and their impact on bacterial pathogenesis.
Bui Thi Linh (2023 Sep ~)
Team D: Drug development & microbial applications
Bs., Department of biotechnology and food technology, Thai Nguyen University of Agriculture and Forestry, Vietnam
Research topic:
Characterizing probiotics with antimicrobial and bile salt hydrolase (BSH) activity for product development.
Alonso Enrique Africa (2024 Feb ~)
Team D:
Bs., College of Science of the University of Santo Tomas, Philippines.
Research topic:
Development and mechanism studies of antimicrobial active compounds
Development of compounds that inhibit PASTA kinase activity (side project)
Undergraduate students
Chiao-Yu Kao (Claudia) (2023 Feb ~)
Team B: Antibiotic resistance & bacterial evolution
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Klebsiella pneumoniae complex (Supervised by Jean)
Yi-Chien Kao (Tina) (2023 Mar ~)
Team B: Antibiotic resistance & bacterial evolution
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Acinetobacter baumannii evolution (Supervised by Pekkee)
芊芊 (Chien-Chien) (2023 Apr ~)
Team D: Drug development & microbial applications
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Acinetobacter baumannii phages (Supervised by Pekkee)
采倪 (NiNi) (2023 Jun ~)
Team D: Drug development & microbial applications
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Probiotic characterization (Supervised by Andrea)
聖翔 (Shawn) (2023 Jul ~)
Team D: Drug development & microbial applications
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Phage therapy (Supervised by Carl)
李佳芮 Rachel (2024 Mar ~)
Team B:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Antimicrobial resistance mechanisms of P. aeruginosa (Supervised by Carl)
呂忠洲 Mark (2024 Mar ~)
Team D:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Enterococcus characteristics (Supervised by Andrea)
施進華 Cookie (2024 Mar ~)
Team D:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Phages characteristics (Supervised by Pekkee)
劉逸菲 Yvonne (2024 Mar ~)
Team B:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Characteristics of Klebsiella oxytoca complex (Supervised by Carl)
戴爾賢 (Tai, Erh Hsien) Mori (2024 Mar ~)
Team D:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Enterococcus characteristics (Supervised by Andrea)
卓佳威 Sam (2024 Mar ~)
Team D:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Phages characteristics (Supervised by Pekkee)
孫于然 Kimberly（Kim）(2024 Mar ~)
Team D:
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Probiotic applications (Supervised by Andrea)
王天淇 Tian-Qi (2024 May ~)
Team B:
Department of Medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Antibiotic resistance (Supervised by Carl)
Interns/Research assistant
Rong-Xuan Wu (Michelle) (2024 Feb~)
Team D:
Bs., Department of Food Science and Biotechnology, Chung Hsing University, Taiwan
Topic: Probiotic product development
Aditi (2024 May ~)
Team D:
Department of Biotechnology (major) & Department of computer science engineering (minor), National Institute of Technology, Warangal, India
Topic: Probiotic product development
Lab Alumni
Pek Kee Chen (2019 Sep ~ 2020 Jan, Malaysia exchange undergraduate student)
BS., Universiti Tunku Abdul Rahman, Malaysia
Shang-Rong Zhuang (2019 Aug ~ 2020 Feb, Master student )
BS., Department of Biotechnology, Ming-Chuan University, Taiwan
Hsin-Tung Yeo (2019 Nov ~ 2020 Jul, Undergraduate student)
Bs., Department of Biotechnology and Laboratory Science in medicine, National Yang-Ming University, Taiwan
Po-Shun Chen (Anthony) (2020 Dec ~ 2021 Aug, Undergraduate student)
Team B: Antibiotic resistance & bacterial evolution
Bs. Biochemistry and Biomedical Engineering, Department of Chemistry and Department of Biomedical Engineering, Dornsife School of Science and Viterbi School of Engineering, University of Southern California, USA
Topic: Characteristics of pathogens cause urinary tract infection.
Po-Yao Liu (Eric) (2020 Jun ~ 2021 Aug, Undergraduate student)
Team B: Antibiotic resistance & bacterial evolution
Department of Biotechnology and Laboratory Science in medicine, National Yang-Ming University, Taiwan
Topic: Characteristics of pathogens cause urinary tract infection.
Shining Wang (2020 Feb ~ 2022 May, Master student)
Team B: Antibiotic resistance & bacterial evolution
Bs., Department of Biotechnology and Laboratory Science in medicine, National Cheng-Kung University, Taiwan
Research topic: Characterization of patients infected with carbapenem-resistant Enterobacteriaceae.
David Wong (2021 Dec ~ 2023 Jan, PhD student)
PhD Candidate, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan.
Team D: Drug development & microbial applications
Research interests:
Microbiota and their metabolites, uremic toxin, in chronic kidney disease.
Oral microbiota and related disease.
Microbiota related detection technologies, PCR / LC method validation
Chao-An Chen (Fiorina) (2021 Aug ~ 2022 Aug, Undergraduate student)
Team B: Antibiotic resistance & bacterial evolution
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Characterization of E. coli in different phylogenetic groups.
Hung-Sheng Huang (Alan) (2020 Aug ~ 2022 Sep, Master student)
Team A: Bacterial pathogenesis and gene regulation
Bs., Department of Biotechnology and Laboratory Science in medicine, Chang-Gung University, Taiwan
Research topic: Characterization of novel virulence factors in H. pylori pathogenesis
Yi-Hong Lee (Red) (2021 Apr ~ 2022 Sep, Master student)
Team B: Antibiotic resistance & bacterial evolution
Bs., Department of biotechnology, National Chia-Yi University, Taiwan
Research topic: Patients with recurrent E. coli infections
Liza Gonzales (2022 Jan ~ 2022 Jul, Intern)
Team D: Drug development & microbial applications
Ms., International Health Program, National Yang Ming Chiao Tung University, Taiwan.
Research topic: Phage therapy for MDR-pathogens.
Kieu Anh (Annie) (2020 Nov ~ 2023 Mar, Master student)
Team B: Antibiotic resistance & bacterial evolution
Bs., Department of biotechnology, Ton Duc Thang University, Vietnam
Research topic: Characterization of carbapenem-nonsusceptible Acinetobacter.
Yu-Jing Chiou (FiFi) (2021 Aug ~ 2023 Aug, Master student)
Team D: Drug development & microbial applications
Bs., Department of Biotechnology and Laboratory Science in medicine, Chang-Gung University, Taiwan
Research topic: Probiotics
Yu-Ting Lo (Daphne) (2021 Aug ~ 2023 Aug, Master student)
Team D: Drug development & microbial applications
Bs., Department of Fragrance and Cosmetics Science, Kaoshiung Medical University, Taiwan
Research topic: Drug screening
Shao-Kai Chen (Vincent) (2021 Sep ~ 2023 Jul, Undergraduate student)
Team B: Antibiotic resistance & bacterial evolution
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: Recurrent infections
Shu-Fei Tang (Sophie) (2022 Mar ~ 2023 Jul, Undergraduate student )
Team A: Bacterial pathogenesis and gene regulation
Department of Biotechnology and Laboratory Science in medicine, National Yang Ming Chiao Tung University, Taiwan
Topic: H. pylori pathogenesis
Chris How-Ming Tan (2023 Jul ~ 2023 Dec, international exchange intern)
Team A: H. pylori pathogenesis
Bs., Malaysia.
Research topic: Oil against H. pylori
