PROFESSIONAL CAREER

• Assistant Professor

Department of BioNano Technology, Gachon University, Seongnam-Si, Gyeonggi-do, Korea (2023-present)

• Research Professor

Department of Medicine, Sungkyunkwan University, Seoul, Korea (2021–2023)

• Postdoctoral Research Associates

Division of Hematology and Oncology, Samsung Medical Center, Seoul, Korea (2021–2023)

- Principal investigator: Jeeyun Lee, M.D., Ph.D.

• Research Associates

Institutes of Advanced Machines and Design, Seoul National University, Seoul, Korea (2018–2023)

EDUCATION

• Ph.D. in Mechanical Engineering, Seoul National University, Seoul, Republic of Korea (2021)

- Advisor: Prof. Noo Li Jeon

- Thesis: Engineering Vascularized Micro-tissue for Disease Modeling and Drug Screening

- Recipient of the Outstanding Doctoral Dissertation Award, Seoul National University 

• B.S. in Mechanical Engineering, Hanyang University, Seoul, Republic of Korea (2015)

HONORS AND AWARDS

• Microsystems & Nanoengineering, Young Academic Salon Awards, 2025

• Young Scientist Researchers, The Korean Society of Mechanical Engineers, 2024

• The 8th IBS Art in Science, Gold prize, Institute for Basic Science (IBS), 2022

• The Outstanding Doctoral Dissertation Award, Seoul National University, 2021

• The Best Paper Award, The Korean Society of Mechanical Engineers, 2021

• The 6th IBS Art in Science, Silver prize, Institute for Basic Science (IBS), 2020

• The Best Paper Award, The Korean BioChip Society, 2019

•  Young Researcher Session, The 13th IEEE International Conference on Nano/Molecular Medicine & Engineering, 2019

ACADEMIC ACTIVITIES

• Organizing Committee Member, 14th World Congress on Alternatives and Animal Use in the Life Sciences (WC14, 2027)

• Secretary, Organoid and 3D Model Division, Korean Society for Stem Cell Research

• Board Member, Korean Society for Cerebral Blood Flow and Metabolism

• Board Member, The Society of Micro and Nano Systems (Director, Bio Division)

• Board Member, The Korean Society for Precision Engineering (Director, Bio-Health Division)

• Board Member, The Korean Society of Mechanical Engineers (Director, Biomedical Engineering Division)

Publications

•  ORCID: https://orcid.org/0000-0002-6555-3728

•  H-index: 20 | i10-index: 29 | Total citations: 2,900 (as of Oct. 2025)

•  FWCI: 3.57 (Field-Weighted Citation Impact, Scopus via SciVal, 2022–2025)

†: co-first author | *: co-corresponding author

Manuscripts Currently Under Evaluation (as Corresponding Author)

1.  Lee, Y.†, Kim, S.†, Koh, H., Han, J.Y.*, Ko, J.* (2025). A Tumor Spheroid Array Chip for High-Fidelity Evaluation of Liposomal Drug Delivery Through the EPR Effect. Lab on a Chip – Under Revision (2nd Round).

2.  Lee, T., Kyung, S.Y., Kwon, M., Park, B.-J., Ko, J.* (2025). Innovations in Skin Microphysiological Systems for Nonclinical Testing and FDA Modernization. Microsystems & Nanoengineering. (IF: 9.9, JCR Top 0.6 %) – Under Revision (2nd Round).

3.  Lee, J.†, Min, J.†, Park, W.†, Hyung, S., Jung, S., Lee, K., Jeon, J., Jeon, N.L., Lee, J.*, Jang, H.R.*, Ko, J.* (2025). High-Throughput Digital Profiling of Tumor-Associated Vascular Networks in Patient-Derived Microphysiological Systems. Science Advances. (IF: 12.5, JCR Top 8.5 %) – Under Revision.

4.  Ahn, H.†, Min, J.†, Park, W., Park, S., Ko, J.*, Ahn, J.* (2025). A Perfusable Blood Vessel-on-a-Chip Enabling Simultaneous Measurement of Transendothelial Electrical Resistance and Vascular Permeability. Advanced Materials Technologies – Under Revision.

5.  Lee, T., Kyung, S.Y., Park, W., Kwon, M., Park, B.-J., Ko, J.* (2025). Standardized Multi-Modal Microfluidic Skin-on-a-Plate for In Vitro Cosmetic Safety Evaluation. Microsystems & Nanoengineering (IF: 9.9, JCR Top 0.6 %) – Under Revision.

Publications as Lead/Corresponding Author

6.      Jung, S., Cheong, S., Lee, Y., Lee, J., Lee, J., Kwon, M.-S., Oh, Y.S., Kim, T., Ha, S., Kim, S.J., Jo, D.H., Ko, J.*, Jeon, N.L.* (2024). Integrating Vascular Phenotypic and Proteomic Analysis in Open Microfluidic Platforms. ACS Nano, 18(36), 24909–24928. (IF: 16.0, JCR Top 6 %)

7.      Ko, J.†, Hyung, S.†, An, M.†, Jung, S., Kim, S.T., Park, S.H., Park, J.O., Lim, H.Y., Kang, W.K., Kim, K.-M., Yoo, S., Jeon, N.L., Lee, J. (2024). Patient-derived tumor spheroid-induced angiogenesis preclinical platform for exploring therapeutic vulnerabilities in cancer. Biomaterials, 307, 122470. (IF: 12.9, JCR Top 3.6 %)

8.      Ko, J., Park, D., Lee, J., Jung, S., Baek, K., Sung, K.E., Lee, J., Jeon, N.L. (2024). Microfluidic high-throughput 3D cell culture. Nature Reviews Bioengineering, 2(6), 453–469. (Selected as Journal Cover, Cited by 47)

9.      Hyung, S.†, Ko, J.†, Heo, Y.J., Blum, S.M., Kim, S.T., Park, S.H., Park, J.O., Kang, W.K., Lim, H.Y., Klempner, S.J., Lee, J. (2023). Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric. Science Advances, 9(47), eadk1098. (IF: 12.5, JCR Top 8.5 %)

10.   Shin, J.†, Ko, J.†, Jeong, S., Won, P., Lee, Y., Kim, J., Hong, S., Jeon, N.L., Ko, S.H. (2021). Monolithic digital patterning of polydimethylsiloxane with successive laser pyrolysis. Nature Materials, 20(1), 100–107. (IF: 47.656, JCR Top 1.0%, Cited by 135, Selected as Journal Cover)

11.   Yi, H.†, Lee, G.†, Park, S., Ha, J., Choi, D., Ko, J.*, Ahn, J.* (2025). Reconstructing the Female Reproductive System Using 3D Bioprinting in Tissue Engineering. Materials Today Bio. (IF: 10.2, JCR Top 6.9%)

12.   Hyung, S.†, Ko, J.†, An, M., Kim, S.T., Park, S.H., Hong, J.Y., Lim, S.H., Kim, K.-M., Lee, J. (2025). Angiogenesis Gene Signatures in Patient-Derived Tumor Spheroids for Genetic and Tumor Angiogenesis Profiling. Journal of Materials Chemistry B. (Selected as Journal Cover)

13.   Park, W., Kim, C., Ko, J.* (2025). AI-Powered Image Standardization in Microphysiological System Platforms. JMST Advances.

14.   Lee, T., Min, J., Lee, Y., Ko, J.* (2025). Clinical Potential of Patient-Derived Microphysiological Systems. Journal of the Korean Medical Association.

15.   Lee, Y.†, Min, J.†, Kim, S.†, Ko, J.* (2025). AI-driven Microphysiological Systems for Advancing Nanoparticle Therapeutics. Advanced Intelligent Systems.

16.   Lee, Y.†, Min, J.†, Kim, S., Park, W., Ko, J.*, Jeon, N.L.* (2025). Recapitulating the Cancer-Immunity Cycle on a Chip. Advanced Healthcare Materials. (IF: 9.6, JCR Top 8.5%)

17.   Ko, J., Hyung, S., Cheong, S., Jeon, N.L.* (2024). Revealing the Clinical Potential of High-Resolution Organoids. Advanced Drug Delivery Reviews. (IF: 17.6, JCR Top 1.0%)

18.   Ko, J.*, Song, J., Lee, Y., Choi, N., Kim, H.* (2024). Understanding Organotropism in Cancer Metastasis Using Microphysiological Systems. Lab on a Chip.

19.   Lee, J.†, Kim, S.†, Ko, J.†, Park, S., Lee, S.R., Kim, Y., Kim, W., Chung, Y., Kwon, O.H., Jeon, N.L.‡ (2024). Angio-Net: Deep Learning-based Label-free Detection and Morphometric Analysis of In Vitro Angiogenesis. Lab on a Chip.

20.   Ko, J.*, Song, J., Choi, N., Kim, H.N. (2023). Patient-Derived Microphysiological Systems for Precision Medicine. Advanced Healthcare Materials. (IF: 10.0, JCR Top 4.7%, Selected as Journal Cover)

21.   Lee, W., Yoon, B., Lee, J., Jung, S., Oh, Y.S., Ko, J.*, Jeon, N.L.* (2023). Machine Learning-Aided Three-Dimensional Morphological Quantification of Angiogenic Vasculature in the Multiculture Microfluidic Platform. BioChip Journal.

22.   Song, J.†, Ko, J.†, Choi, N., Jeon, N.L., Kim, H.N. (2023). Tumor Spheroid-Based and Microtumor-Based Vascularized Models for Replicating the Vascularized Tumor Microenvironment. Organoid.

23.   Ko, J.†, Jung, J.†, Kim, S.T., Hong, J.Y., Park, S., Park, J.O., Park, Y.S., Lim, H.Y., Ahn, S., Kim, K.-M., Kang, W.K., Lee, J. (2022). MET Gene Alterations Predict Poor Survival Following Chemotherapy in Patients with Metastatic Cancer. Pathology and Oncology Research.

24.   Ko, J., Park, D., Lee, S., Gumuscu, B., Jeon, N.L. (2022). Engineering Organ-on-a-Chip to Accelerate Translational Research. Micromachines.

25.   Kim, Y.†, Ko, J.†, Shin, N., Park, S., Lee, S.R., Kim, S., Song, J., Lee, S., Kang, K.-S., Lee, J., Jeon, N.L. (2022). All-in-One Microfluidic Design to Integrate Vascularized Tumor Spheroid into High-Throughput Platform. Biotechnology and Bioengineering.

26.   Lee, S.Y.†, Byeon, S.†, Ko, J.†, Hyung, S., Lee, I.K., Jeon, N.L., Hong, J.Y., Kim, S.T., Park, S.H., Lee, J. (2021). Reducing Tumor Invasiveness by Ramucirumab and TGF-β Receptor Kinase Inhibitor in a Diffuse-Type Gastric Cancer Patient-Derived Cell Model. Cancer Medicine.

27.   Kim, S.†, Ko, J.†, Lee, S.R., Park, D., Park, S., Jeon, N.L. (2021). Anchor-IMPACT: A Standardized Microfluidic Platform for High-Throughput Anti-Angiogenic Drug Screening. Biotechnology and Bioengineering.

28.   Jusoh, N.†, Ko, J.†, Jeon, N.L. (2019). Microfluidics-Based Skin Irritation Test Using In Vitro 3D Angiogenesis Platform. APL Bioengineering.

29.   Ko, J.†, Ahn, J.†, Kim, S., Lee, Y., Lee, J., Park, D., Jeon, N.L. (2019). Tumor Spheroid-on-a-Chip: A Standardized Microfluidic Culture Platform for Investigating Tumor Angiogenesis. Lab on a Chip.

30.   Ko, J., Lee, Y., Lee, S., Lee, S.R., Jeon, N.L. (2019). Human Ocular Angiogenesis-Inspired Vascular Models on an Injection-Molded Microfluidic Chip. Advanced Healthcare Materials. (IF: 7.4, JCR Top 7.5%, Selected as Journal Cover)

Publications as Contributing Author

31.   Kim, M., Yoon, J., Kim, D., Kim, J., Kim, J.S., Go, G., Song, J., Son, S., Park, K., Lee, J., Lee, D., Cho, S., Choi, W., Min, J., Cho, Y.S., Lee, S.J., Yi, H.G., Choi, A., Jeon, S., Lee, H., Choi, D., Han, S., Ko, J., Cho, D.W., Kim, D.S., Jang, J., Kang, H.W. (2025). Advanced Biomanufacturing Technologies for Micro-physiological Systems. International Journal of Precision Engineering and Manufacturing.

32.   Cho, G.-B., Lee, H.-J., Heo, Y.J., Ko, J., Lee, W.-S., Hyung, S. (2025). Tumor-Immune-On-Chip to Evaluate Pathophysiological Feature of T Lymphocytes Expanded from Patient Tumors and Lymph Node Tissues. Cancer Medicine.

33.   Park, S., Kim, Y., Lee, J., Jung, S., Hong, J., Kim, S., Lee, S.-R., Song, J., Park, S., Oh, Y.S., Ko, J., Jeon, N.L. (2024). Flow-IMPACT: A Pumpless, High-Throughput 3D Cell Culture Platform for Investigation of Synergistic Angiogenic Effects. Advanced Materials Technologies. (Selected as Journal Cover)

34.   Lee, J., Jung, S., Hong, H.K., Jo, H., Rhee, S., Jeong, Y.L., Ko, J., Cho, Y.B., Jeon, N.L. (2024). Vascularized Tissue Mesh-Assisted Platform (VT-MAP) for the Personalized Drug Screening of Colorectal Cancer Organoids. Lab on a Chip.

35.   Jung, J., Kim, S.T., Ko, J., Hong, J.Y., Park, J.O., Ha, S.Y., Lee, J. (2023). Clinical Implication of HER2 Aberration in Patients With Metastatic Cancer Using Next-Generation Sequencing: A Pan-Tumor Analysis. JCO Precision Oncology.

36.   Park, S., Kim, Y., Ko, J., Song, J., Lee, J., Hong, Y.K., Jeon, N.L. (2023). One-Step Achievement of Tumor Spheroid-Induced Angiogenesis in a High-Throughput Microfluidic Platform: One-Step Tumor Angiogenesis Platform. Organoid.

37.   Leung, C.M., Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H.S., Chen, Z., Habibovic, P., Jeon, N.L., Takayama, S., Shuler, M.L., Vunjak-Novakovic, G., Frey, O., Verpoorte, E., Toh, Y.-C. (2022). A Guide to the Organ-on-a-Chip. Nature Reviews Methods Primers. (IF: 56.0, JCR Top 0.4 %, Cited by 1,002)

38.   Ahn, J., Kim, D.H., Koo, D.J., Lim, J., Park, T.E., Lee, J., Ko, J., Kim, S., Kim, M., Kang, K.S., Kim, S.Y., Kim, Y., Jeon, N.L. (2022). 3D Microengineered Vascularized Tumor Spheroids for Drug Delivery and Efficacy Testing. Acta Biomaterialia.

39.   Shin, N., Kim, Y., Ko, J., Choi, S.W., Hyung, S., Lee, S.E., Park, S., Song, J., Jeon, N.L., Kang, K.S. (2022). Vascularization of iNSC Spheroid in a 3D Spheroid-on-a-Chip Platform Enhances Neural Maturation. Biotechnology and Bioengineering.

40.   Lee, B., Kim, S., Ko, J., Lee, S.R., Kim, Y., Park, S., Kim, J., Hyung, S., Kim, H.Y., Jeon, N.L. (2022). 3D Micromesh-Based Hybrid Bioprinting: Multidimensional Liquid Patterning for 3D Microtissue Engineering. NPG Asia Materials.

41.   Lee, S.R., Hyung, S., Bang, S., Lee, Y., Ko, J., Lee, S., Kim, H.J., Jeon, N.L. (2019). Modeling Neural Circuit, Blood–Brain Barrier, and Myelination on a Microfluidic 96-Well Plate. Biofabrication.

42.   Park, D., Son, K., Hwang, Y., Ko, J., Lee, Y., Doh, J., Jeon, N.L. (2019). High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy. Frontiers in Immunology.

43.   Ahn, J., Ko, J., Lee, S., Yu, J., Kim, Y.T., Jeon, N.L. (2018). Microfluidics in Nanoparticle Drug Delivery; From Synthesis to Pre-Clinical Screening. Advanced Drug Delivery Reviews. (IF: 15.5, JCR Top 0.9 %, Cited by 245)

44.   Lee, S., Ko, J., Park, D., Lee, S.R., Chung, M., Lee, Y., Jeon, N.L. (2018). Microfluidic-Based Vascularized Microphysiological Systems. Lab on a Chip.

45.   Park, D., Kang, M., Choi, J.W., Paik, S.M., Ko, J., Lee, S., Lee, Y., Son, K., Ha, J., Choi, M., Park, W., Kim, H.Y., Jeon, N.L. (2018). Microstructure Guided Multi-Scale Liquid Patterning on an Open Surface. Lab on a Chip.

46.   Bang, S., Lee, S.R., Ko, J., Son, K., Tahk, D., Ahn, J., Im, C., Jeon, N.L. (2017). A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact Between Perfusable Vascular Network and Astrocytes. Scientific Reports.

47.   Oh, S., Ryu, H., Tahk, D., Ko, J., Chung, Y., Lee, H.K., Lee, T.R., Jeon, N.L. (2017). Open-Top Microfluidic Device for In Vitro Three-Dimensional Capillary Beds. Lab on a Chip.

Patents

1.      고지훈 이희수, “다세포 공배양 가능한 오픈형 오가노이드 칩”, 2025 (10-2025-0124608)

2.      고지훈, 경상윤, “생체 장벽 투과성 평가용 미세유체칩”, 2025 (10-2025-0124609)

3.      이지연 형수진 임성희 고지훈, “환자 맞춤형 종양 혈관신생 평가 모델 및 이의 용도” 2025 (10-2025-0106749)

4.      J. Lee, J. Ko, S. Hyung, “라무시루맙 및 HER2 억제제를 포함하는 항-혈관 신생 및/또는 암의 예방 또는 치료용 약학물 조성물”, 2022 (10-2022-0130775)

5.      J. Lee, J. Ko, S. Hyung, “라무시루맙 및 MET 억제제를 포함하는 항-혈관 신생 및/또는 암의 예방 또는 치료용 약학물 조성물”, 2022 (10-2022-0130791)

6.      J. Lee, J. Ko, S. Hyung, “라무시루맙 및 FGFR2 억제제를 포함하는 항-혈관 신생 및/또는 암의 예방 또는 치료용 약학물 조성물”, 2022 (10-2022-0130796)

7.      N.L. Jeon, B. Lee, J. Yu, J. Ko, “Microfluidic device having partially enclosed microfluidic channel and use thereof” 2019

8.      N.L. Jeon, J. Ko, S. Lee, J. Ahn, D. Park, S.R. Lee, S. Kim, B. Lee, “Microfluidic device having partially enclosed microfluidic channel and use thereof”, 2018

9.      N.L. Jeon, J. Ko, Y. Lee, S. Kim, “Fluid guiding structure mediated 3D co-culture device” 2018

Grants

1.      “Intestinal Organoid-on-a-Chip for Immune–Vascular Interaction in Bowel Diseases”

-       NRF, Young Investigator Program | PI | 2025.09–2026.08

2.      “3D MPS for Peripheral Neuropathy in Chronic Pain”

-       NRF, Future Medical Innovation Program | Co-I | 2024.07–2028.12

3.      “3D Biofabrication Materials & Monitoring Devices for Drug Safety”

-       KEIT, Materials & Components Program | Co-I | 2024.07–2028.12

4.      “MPS for Immunotherapeutic Safety Assessment”

-       KHIDI, Korea ARPA Project | Contracted PI | 2024.11–2029.02

5.      “Microfluidic Safety Assessment Platform (Co-development)”

-       Kolmar Korea | PI | 2024.07–2025.06

6.      “Retinal Therapeutic Evaluation Using Angiogenesis Chip”

-       Neotes Bio | PI | 2025.05–2025.07

7.      “AAV-Based AMD Drug Evaluation Using Angiogenesis Chip”

-       Eyegene Co. | PI | 2024.01–2025.05

8.      “3D Printing System for Tumor–Vessel–Immune Mapping”

-       NRF, Basic Research / RS-2023-00253722 | PI | 2023.06–2026.02 (Completed)

Invited Talks & Conference Presentations

2025

1.      KTERMS 2025 Symposium – Education, Early Career Researcher, and Industry Collaboration Program, Nov 21, 2025

2.      Microsystems & Nanoengineering 2025 Young Academic Salon (invited), Oct 16, 2025

3.      Korean Human Proteome Organization (KHUPO) Annual Conference, Drug Discovery Session, Busan, Oct 15–17, 2025

4.      Japan Society of Mechanical Engineers (JMSE) Conference, Hokkaido University, Japan, Sep 7–10, 2025

5.      Ajou University Mechanical Engineering Graduate Seminar (Organizer: Prof. 최정일), Aug 6, 2025

6.      Inha University Multi-Organ Chip Research Group Seminar (Organizer: Prof. 김선민), Jul 23, 2025

7.      Korea University College of Pharmacy Graduate Seminar (Organizer: Prof. 김한준), May 1, 2025

8.      Seoul National University School of Dentistry Graduate Seminar (Organizer: Prof. 오석배), Apr 28, 2025

9.      KSME Precision Engineering Division Biohealth Spring Workshop (Organizer: Prof. 김동성 & Prof. 신현정), Catholic University, Mar 7, 2025

10.   MicroNanoSystem Society Convergence Devices Division Workshop, Sogang University, Feb 19, 2025

2024

11.   BrainLink X-Lab Day, Grand Josun Busan, Dec 8–11, 2024

12.   MicroNanoSystem Society Fall Meeting, Asti Hotel, Busan, Nov 22, 2024

13.   Korean Society of Medical and Biological Engineering (KOSOMBE), Swiss Grand Hotel, Seoul, Nov 8, 2024

14.   KVBM 2024 Annual Meeting (Korean Vascular Biology Meeting), The-K Hotel, Gyeongju, Nov 1, 2024

15.   Sungkyunkwan University Mechanical Engineering Graduate Seminar (Organizer: Prof. 박성수), Oct 17, 2024

16.   MicroNanoSystem Society Gyeongin-Gangwon-Jeju Regional Symposium, Hallym University, Sep 6, 2024

17.   World Biomaterials Congress (WBC 2024), “Engineering patient-derived microphysiological systems to reconstruct the tumor microenvironments”, May 27, 2024

18.   KTERMS 2024 Annual Meeting, “Patient-derived Microphysiological Systems to Reconstruct Tumor Microenvironments”, May 4, 2024

19.   KSME Spring Bioengineering Division Meeting, “Development of patient-derived microphysiological systems using microfluidic fabrication approaches”, Apr 25, 2024

20.   Korean Society for Alternatives to Animal Experiments (KSAAE) Annual Meeting, “Development of high-throughput microfluidic cell culture platforms for vascularized organ systems”, Jun 23, 2024

21.   KIST Biomaterials Research Center Seminar (Organizer: Dr. 정영미), Aug 14, 2024

22.   CHA University Department of Microbiology Seminar (Organizer: Prof. 안중호), “Microfluidic High-throughput 3D Cell Culture”, May 17, 2024

23.   Seoul National University College of Medicine Anatomy Seminar (Organizer: Prof. 조동현), “Engineering Microfluidic 3D Cell Culture Devices for Patient-specific Vascularized Microphysiological Systems”, Apr 9, 2024

24.   Sejong University Biomedical Engineering Seminar (Organizer: Prof. 이길용), “Patient-derived Microphysiological Systems to Reconstruct Tumor Microenvironments”, Mar 19, 2024

25.   POSTECH Biomedical Materials and Devices Workshop (Organizer: Prof. 이준민), “High-throughput Microfluidic Vascularized Organ Systems”, Jan 12, 2024

2023

26.   Korean Physical Society Fall Meeting, Biophysics Division, “Engineering Microfluidic Vascularized Organ Systems for Clinical Utility”, Oct 26, 2023

27.   Korean BioChip Society Fall Meeting, “High-throughput Vascularized Microfluidic Scaffolds for Clinical Utility”, Nov 16, 2023

28.   Hanyang University Department of Biotechnology Seminar (Organizer: Prof. 신흥수), Oct 6, 2023

29.   Dongguk University Biomedical Engineering Seminar (Organizer: Prof. 방석영), Oct 4, 2023

30.   Osstem Implant Co. Ltd. R&D Seminar, “Engineering High-throughput Microfluidic Vascularized Organ Systems”, Sep 14, 2023