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Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase (MAPK) cascades. From Kholodenko 2000 paper.
Figure 1 of Kholodenko 2000 paper. Numbers correspond to reactions listed in table at the bottom.
Load the model below and then hit the 'Start' button to run the simulation. Adjust the parameter sliders below the plot to see how they affect the feedback in the reaction network and its ocillatory behavior.
J0 in model corresponds to reaction 1 in table below. J1 -> reaction 2, J7 -> reaction 8, etc.
Taken from Table 2 of Kholodenko 2000.
References:
Kholodenko BN. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur J Biochem. 2000 Mar;267(6):1583-8. doi: 10.1046/j.1432-1327.2000.01197.x. PMID: 10712587. Kholodenko 2000 (PubMed)
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