Model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation.
ALBERT GOLDBETER, GENEVIVE DUPONT, AND MICHAEL J. BERRIDGE , Proc. Natl. Acad. Sci. USA, Vol. 87, pp. 1461-1465, February 1990, Biophysics
Species Z: Concentration (uM) of cytosolic Ca2+
Species Y: Concentration (uM) of Ca2+ stored in the InsP3-insensitive pool.
Model parameters (select list):
v0: influx of Ca2+ into the cell, uM/s.
Vm2: maximum rate of Ca2+ pumping into the intracellular InsP3-insensitive store, uM/s.
K2: Threshold constant for Ca2+ pumping, uM.
n: Hill function cooperativity coefficient for Ca2+ pumping into the store.
m: Hill function cooperativity coefficient for Ca2+ pumping from the store.
Load the model below and then hit the 'Start' button to run the simulation. Adjust the parameter sliders below the plot to see how they affect CA2+ concentrations (Z, Y).