Jang, J.Y., Kim, J.U., Yang, G. et al. Pharmacokinetics and Toxicity Study of a Single Intravenous Dose of Distilled Extract of Zanthoxylum piperitum in ICR Mice. Innov. Acupunct. Med. 18, 23 (2025). https://doi.org/10.1186/s44424-025-00024-0
Kim, Sung Wook et al. “Decoding Regnase-1's role in skin inflammation: potential therapeutic implication for dermatological disorders.” Journal of advanced research, S2090-1232(25)00851-3. 27 Oct. 2025, https://doi.org/10.1016/j.jare.2025.10.055 *한빛사 선정
Lee, H. J., Y. J.So, I.-J.Jo, et al. 2025. “Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy.” Phytotherapy Research1–33. https://doi.org/10.1002/ptr.70085.
Park, S.B., Lee, D.H., Kim, S.Y. et al. The Inflammasome-NETosis Axis: A Critical Pathway in Atherosclerosis Pathogenesis and Therapeutic Targeting. Innov. Acupunct. Med. 18, 12 (2025). https://doi.org/10.1186/s44424-025-00014-2
Nam, S.-B., et al. “Extracts from Allium pseudojaponicum Makino Target STAT3 Signaling Pathway to Overcome Cisplatin Resistance in Lung Cancer.” Marine Drugs, vol. 23, 2025, p. 167. https://doi.org/10.3390/md23040167.
Noh, Gyeong-Ran, et al. "Network pharmacology-based prediction of efficacy and mechanism of Pinellia ternata Breitenbach acting on psoriasis." The Korea Journal of Herbology 40.1 (2025): 13-26. https://doi.org/10.6116/kjh.2025.40.1.13
Kim, S.W.; Jeong, S.H.; Kim, J.U.; Kim, M.H.; Lee, W.; Lee, C.-J.; Yook, T.H.; Yang, G. Zanthoxylum piperitum Benn. Attenuates Monosodium Urate-Induced Gouty Arthritis: A Network Pharmacology Investigation of Its Anti-Inflammatory Mechanisms. Pharmaceuticals 2025, 18, 29. https://doi.org/10.3390/ph18010029
Lee, D. H., Lee, H. J., Yang, G., Kim, D. Y., Kim, J. U., Yook, T. H., Lee, J. H., & Kim, H. J. (2024). A novel treatment strategy targeting cellular pathways with natural products to alleviate sarcopenia. Phytotherapy Research, 38(11), 5033–5051. https://doi.org/10.1002/ptr.8301
Gyeong-Ran Noh, Kweon Bitna, 김동욱, Gabsik Yang, Jo Il Joo, Jin-Young Oh "Effect of Daehwangmokdanpitang on psoriasis-like skin inflammation" Journal of Convergence Korean Medicine 6.1 pp.29-36 (2024) : 29.
Kim, Hyeonjin et al. “Indigo Naturalis in Inflammatory Bowel Disease: mechanisms of action and insights from clinical trials.” Journal of pharmacopuncture vol. 27,2 (2024): 59-69. https://doi.org/10.3831/KPI.2024.27.2.59
Yang, K.E.; Nam, S.-B.; Lee, G.-E.; Yang, G.; Lee, M.-H.; Bang, G.; Choi, J.H.; Cho, Y.-Y.; Lee, C.-J. Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging. Mar. Drugs 2024, 22, 127. https://doi.org/10.3390/md22030127
So, Y.-J.; Lee, J.-U.; Yang, G.-S.; Yang, G.; Kim, S.-W.; Lee, J.-H.; Kim, J.-U. The Potentiality of Natural Products and Herbal Medicine as Novel Medications for Parkinson’s Disease: A Promising Therapeutic Approach. Int. J. Mol. Sci. 2024, 25, 1071. https://doi.org/10.3390/ijms25021071
Lim Y, Kong J, Lee J, Yang G, Yook T. The Evaluation of the Single-Dose Toxicity and Safety of 4-Carvomenthenol in ICR Mice. J Acupunct Res 2023;40:344-350. https://doi.org/10.13045/jar.2023.00164
Yang, Gabsik et al. “Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 162 (2023): 114558. https://doi.org/10.1016/j.biopha.2023.114558
Kim, S.W.; Lee, J.H.; Kim, B.; Yang, G.; Kim, J.U. Natural Products as the Potential to Improve Alzheimer’s and Parkinson’s Disease. Int. J. Mol. Sci. 2023, 24, 8827. https://doi.org/10.3390/ijms24108827
Kweon, Bitna, et al. "Prediction the efficacy and mechanism of action of Daehwangmokdanpitang to treat psoriasis based on network pharmacology." The Korea Journal of Herbology 38.6 (2023): 73-91.
김현진 외. "류마티스 관절염에서 NLRP3 인플라마좀의 역할." 대한융합한의학회지, vol. 4, no. 1, Dec. 2022, pp. 5-11.
Shin, Hye Jeong et al. “Bacterial Reverse Mutation Test of Verbenalin.” Journal of pharmacopuncture vol. 25,4 (2022): 364-368. https://doi.org/10.3831/KPI.2022.25.4.364
Kim, Sung Wook et al. “Improvement Effect of Soyeom Pharmacopuncture on Gout via NLRP3 Inflammasome Regulation.” Journal of pharmacopuncture vol. 25,4 (2022): 396-403. https://doi.org/10.3831/KPI.2022.25.4.396
Lim, J.; Kim, S.; Lee, C.; Park, J.; Yang, G.; Yook, T. Verbenalin Reduces Amyloid-Beta Peptide Generation in Cellular and Animal Models of Alzheimer’s Disease. Molecules 2022, 27, 8678. https://doi.org/10.3390/molecules27248678
Shin H, Lim Y, Ha J, Yang G, Yook* T. The Evaluation of the Acute Toxicity and Safety of Verbenalin in ICR Mice. J Acupunct Res 2022;39:310-316. https://doi.org/10.13045/jar.2022.00248
Yang G, Kang HC, Cho Y-Y, Lee HS and Lee JY (2022) Inflammasomes and their roles in arthritic disease pathogenesis. Front. Mol. Biosci. 9:1027917. https://doi.org/10.3389/fmolb.2022.1027917
Jang, Joo Hyeon et al. “Loganin Prevents Hepatic Steatosis by Blocking NLRP3 Inflammasome Activation.” Biomolecules & therapeutics vol. 31,1 (2023): 40-47. https://doi.org/10.4062/biomolther.2022.077
Lee JH, Kim HS, Lee J-H, Yang G and Kim HJ (2022) Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout. Front. Pharmacol. 13:861399. https://doi.org/10.3389/fphar.2022.861399
Yang, G.; Lee, H.E.; Seok, J.K.; Kang, H.C.; Cho, Y.-Y.; Lee, H.S.; Lee, J.Y. RIG-I Deficiency Promotes Obesity-Induced Insulin Resistance. Pharmaceuticals 2021, 14, 1178. https://doi.org/10.3390/ph14111178
Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza & Daniela Morais Leme. (2022) Genetic variants affecting chemical mediated skin immunotoxicity. Journal of Toxicology and Environmental Health, Part B 25:2, pages 43-95.
Seok, J.K.; Hong, E.-H.; Yang, G.; Lee, H.E.; Kim, S.-E.; Liu, K.-H.; Kang, H.C.; Cho, Y.-Y.; Lee, H.S.; Lee, J.Y. Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy. Cells 2021, 10, 558. https://doi.org/10.3390/cells10030558
Choi, N.; Yang, G.; Jang, J.H.; Kang, H.C.; Cho, Y.-Y.; Lee, H.S.; Lee, J.Y. Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage. Molecules 2021, 26, 1071. https://doi.org/10.3390/molecules26041071
Lee, J.H.; Kim, H.J.; Kim, J.U.; Yook, T.H.; Kim, K.H.; Lee, J.Y.; Yang, G. A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease. Int. J. Mol. Sci. 2021, 22, 1324. https://doi.org/10.3390/ijms22031324
Lee, J.K., Lee, H.E., Yang, G. et al. Para-phenylenediamine, an oxidative hair dye ingredient, increases thymic stromal lymphopoietin and proinflammatory cytokines causing acute dermatitis. Toxicol Res. 36, 329–336 (2020). https://doi.org/10.1007/s43188-020-00041-6
Yang, G., Lee, H.E., Moon, S.-J., Ko, K.M., Koh, J.H., Seok, J.K., Min, J.-K., Heo, T.-H., Kang, H.C., Cho, Y.-Y., Lee, H.S., Fitzgerald, K.A. and Lee, J.Y. (2020), Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis. Arthritis Rheumatol, 72: 1192-1202. https://doi.org/10.1002/art.41245
Yang, Gabsik et al. “Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome.” Biomolecules & therapeutics vol. 28,5 (2020): 437-442. https://doi.org/10.4062/biomolther.2020.004
Yang, G.; Seok, J.K.; Kang, H.C.; Cho, Y.-Y.; Lee, H.S.; Lee, J.Y. Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis. Int. J. Mol. Sci. 2020, 21, 2867. https://doi.org/10.3390/ijms21082867 *한빛사 선정
Yang, G.; Jang, J.H.; Kim, S.W.; Han, S.-H.; Ma, K.-H.; Jang, J.-K.; Kang, H.C.; Cho, Y.-Y.; Lee, H.S.; Lee, J.Y. Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome. Int. J. Mol. Sci. 2020, 21, 2790. https://doi.org/10.3390/ijms21082790
Lee, H.E., Lee, J.Y., Yang, G. et al. Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells. Sci Rep 9, 12277 (2019). https://doi.org/10.1038/s41598-019-48794-x
Lee, H.E.; Yang, G.; Park, Y.B.; Kang, H.C.; Cho, Y.-Y.; Lee, H.S.; Lee, J.Y. Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis. Molecules 2019, 24, 2138. https://doi.org/10.3390/molecules24112138
Yang, Gabsik et al. “Immunostimulatory activity of Y-shaped DNA nanostructures mediated through the activation of TLR9.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 112 (2019): 108657. https://doi.org/10.1016/j.biopha.2019.108657
Yang G, Lee HE, Yeon SH, et al. Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome. Phytotherapy Research. 2018;32:2551–2559. https://doi.org/10.1002/ptr.6195
G.Yang, H. E.Lee, S. W.Shin, S. H.Um, J. D.Lee, K.-B.Kim, H. C.Kang, Y.-Y.Cho, H. S.Lee, J. Y.Lee, Adv. Funct. Mater.2018, 28, 1801918. https://doi.org/10.1002/adfm.201801918 *한빛사 선정
Lee, Hye Eun et al. “Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning.” Biochemical and biophysical research communications vol. 503,3 (2018): 2117-2123. https://doi.org/10.1016/j.bbrc.2018.07.168
Gabsik Yang, Sang Hyeon Yeon, Hye Eun Lee, Han Chang Kang, Yong Yeon Cho, Hye Suk Lee, Joo Young Lee, Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation, Rheumatology, Volume 57, Issue 4, April 2018, Pages 727–736, https://doi.org/10.1093/rheumatology/kex499
Yang, Gabsik et al. “Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms.” Chemico-biological interactions vol. 284 (2018): 41-47. https://doi.org/10.1016/j.cbi.2018.02.020
Lee, Hye Eun et al. “Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice.” Biomolecules & therapeutics vol. 26,5 (2018): 481-486. https://doi.org/10.4062/biomolther.2017.130