- Time: 2026. 03. 26. (Thu) 3:00 - 4:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: Dr. Tae-Hee Lee, LigaChem Biosciences, Senior researcher

- Topic: From DNA damage to cancer vulnerability 

- 2026.03~present : LigaChem Biosciences

- 2022.02~2026.03 : Postdoc fellow,  Johns Hopkins School of Medicine, USA

- 2019.02 : Ph.D., Deparment of Biological Science, Dong-A University, Korea

- 2012.02 : B.S., Deparment of Biological Science, Dong-A University, Korea

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

To evaluate the anti-allergic potential of pluviatolide, a lignan isolated from Podophyllum hexandrum, we examined its effects on mast cell degranulation, cytokine secretion, and intracellular signaling using BMMCs and RBL-2H3 cells. Pluviatolide suppressed IgE/antigen-induced β-hexosaminidase release concentration-dependently without cytotoxicity, and also inhibited degranulation triggered by ionomycin and thapsigargin, indicating its inhibitory mechanism extends to receptor-independent, Ca2+-mediated pathways. Immunoblot analysis revealed decreased phosphorylation of Lyn, Syk, LAT, PLCγ1, MAPKs, and NF-κB p65. In a passive cutaneous anaphylaxis mouse model, oral pluviatolide significantly reduced vascular leakage and mast cell degranulation in ear tissues, supporting its potential as a therapeutic candidate for mast cell-driven allergic disorders.

Kim, S.Y., Park, J.W., Shin, J., Lee, J.A., Leem, S.H., Jo, M.G., Choi, M.Y., Choi, W.S., Min, K.Y., Noh, G., Bae, S.J., Choi, Y.H., Kim, H.S. Pluviatolide attenuates type I hypersensitivity through regulation of mast cell activation. Biomolecules & Therapeutics. 2026 Mar 1; 34(2):413-422. doi: 10.4062/biomolther.2025.164. 

.- Time: 2026. 02. 25. (Wed) 3:00 - 4:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: Jeseok Jeon, Ph.D.c (Lab. of DNA Repair) 

- Topic: UV-Induced DNA Damage and Cellular Senescence in Skin Cells 

- Speaker: Ji-Ae Lee, M.S.c (Lab. of Immune Regulation) 

- Topic: Impact of polystyrene microplastics on the plasticity of macrophages

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

Our lab team enjoyed a refreshing picnic on February 10th to celebrate the end of the semester. we celebrated the graduation of Seon Young Kim (M.S.). We truly appreciate his work and contributions during his time with us. We wish him great success as he embarks on his new journey beyond the lab! 

- Time: 2025. 12. 11. (Thu) 1:00 - 8:00 pm

- Venue: Aquapalace, Busan, Korea

- Topic: Drug Repositioning-Based Immunomodulatory Complex: Local Delivery Formulation and Commercialization Strategy 

- International Scientific Acupuncture and Medicine Symposium (ISAMS 2025)

- Time: 2025. 10. 24. (Fri) - 2025. 10. 26. (Sun)

- Venue: Convention center, BPEX, Busan, Korea

- Session: Session 5. Translational and clinical strategies for managing medical condition

- Topic: Immunological rebalancing with IgG-histamine complex: From clinical outcomes to mechanistic evidence 

.- Time: 2025. 09. 25. (Thu) 3:00 - 4:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: Jae-Jun Kim, Ph.D.c (Lab. of Integrative Omics) 

- Topic: Identification of Agents Attenuating Cellular Senescence in Human Fibroblasts 

- Speaker: Eun Hee Ko, M.S.c (Lab. of Cancer Metabolism) 

- Topic: Mechanistic Study of RBM15-Mediated Regulation of PHGDH in the Serine Synthesis Pathway of TNBC

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2025. 06. 26. (Wed) 3:00 - 4:00 pm 

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: Hye Jin Yun, Ph.D.c (Lab. of Cancer Metabolism)

- Topic: Serine catabolism by HIF-1α-upregulated serine hydroxymethyltransferases maintains redox homeostasis and promotes glioblastoma growth  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2025. 03. 13. (Thu) 3:00 - 4:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: CEO Se-won Kim (DecodeCell)

- Topic: Latest Single-Cell Omics Technology Trends and Research Design 

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

To assess the impact of atmospheric ultrafine particulate matter (UPM) on respiratory allergic diseases, we purified black carbon, a core particle that closely mimics actual UPM, using simulated UPM (sUPM) generated through the spark discharge method. When dispersed sUPM was injected into the lungs of mice, it promoted infiltration and degranulation responses of pulmonary mast cells, and in an immunoglobulin E (IgE)-mediated passive anaphylaxis model, the degranulation response of peripheral mast cells was enhanced when exposed to sUPM. This was confirmed to amplify the downstream signaling mechanism of the high affinity IgE receptor (FcεRI) of IgE-mediated mast cells. These results demonstrated that airborne UPM can exacerbate type I hypersensitivity reactions by enhancing the IgE-mediated signaling pathway within mast cells, and provided mechanistic evidence for aggravated allergic lung disease induced by UPM inhalation. This research was conducted through collaborative research with Professor Cho Wan-seop of the Department of Medicinal Biotechnology. 

Park, J.W.*, Kang, M.*, Kim, G.*, Hyun, S.Y., Shin, J., Kim, S.Y., Lee, J.H., Choi, W.S., Lee, J.H., Lee, K., Kim, S.H., Cho, W.S.*, Kim. H.S.* The impact of atmospheric ultrafine particulate matter on IgE-mediated type 1 hypersensitivity reaction.  Journal of Hazardous Materials. 2025 Feb 15;484:136705. doi: 10.1016/j.jhazmat. 2024.136705.

Nanoplastics (NP) are emerging environmental pollutants present in atmospheric, freshwater, and aquatic environments. Nanoplastics can rapidly penetrate cell membranes and accumulate in human tissues and organs, potentially posing a threat to human health. In this study, we evaluated whether internalization of PS-NPs at near-lethal cytotoxic concentrations leads to increased senescence features such as increased β-galactosidase activity, increased expression of p16, p21, and senescence-associated secretory phenotype, and cell cycle arrest. Additionally, PS-NP treatment induced significant mitochondrial superoxide generation and damage, including mitochondrial membrane depolarization, content loss, fragmentation, and decreased ATP production. The results of this study confirmed the senescence effects of PS-NPs through mitochondrial superoxide generation and dysfunction in pre-differentiated myoblasts. This research was conducted as collaborative research with Professor Choi Young-hyun of Dong-eui University.

Bang, E, Hwangbo, H., Lee, H., Park, C., Hong, S.H., Kim, H.S., Jung, Y., Hyun, Y.M., Hyun, J.W., Kim, G.Y., Choi, Y.H. Exposure to polystyrene nanoplastics promotes premature cellular senescence through mitochondrial ROS production and dysfunction in pre-differentiated skeletal myoblasts. Toxicology. 2025 Jan 1; 510:154002. doi:10.1016/j.tox.2024.154002. 

Dong-A University announced on the 11th that a joint research team of Professor Kim Hyuk-soon (Department of Health Management) and Professor Cho Wan-seop (Department of Medicinal Biotechnology), affiliated with the 4th Stage BK21 Future Environmental Biodefense Convergence Research Group, recently elucidated the hazards of atmospheric ultrafine particulate matter on acute allergic diseases. Ultrafine particulate matter, a representative environment-derived harmful factor, is known to be harmful to the human body, including causing respiratory and allergic diseases. However, there have been difficulties in standardizing the association with diseases because the distribution of ultrafine particulate matter components varies according to region, season, temperature, etc., and the precise molecular mechanism is unclear. The Dong-A University research team purified 'carbon black,' the core particle of ultrafine particulate matter, using the 'spark discharge method' and evaluated its impact on acute respiratory allergic diseases.

The research results showed acute neutrophil inflammation in the lungs and peripheral immune cell inflammatory responses caused by ultrafine particulate matter. The severity of acute allergic diseases was aggravated by ultrafine particulate matter.

The research results were published in the international academic journal 'Journal of Hazardous Materials' (top 5% in JCR, IF=12.2) in the field of environmental science and engineering under the title 'The impact of atmospheric ultrafine particulate matter on IgE-mediated type 1 hypersensitivity reaction.'

- Time: 2024. 10. 31. (Thu) 3:00 - 4:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: Seong Won Wang, M.S.c (Lab. of Regenerative Medicine)

- Topic: Cancer-derived Exosomes induce CSCs properties from normal fibroblast 

- Speaker: Seon Young Kim, M.S.c (Lab. of Immune Regulation)

- Topic: Effect of Pluviatolide on FcεRI mediated mast cell activation and Type I hypersensitivity    

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Organized by: Nanomaterials Immunotoxicity Research Team, Dong-A University

- Time: 2024. 08. 26. (Mon) 4:00 - 6:20 pm

- Venue: Conference Room, Ananti Cove Hotel, Busan, Korea

- Presentation Topic: Adaptive Immunotoxicity of Nanomaterials

- Organized by: Dong-eui University Anti-aging Research Institute / Basic Research Laboratory (BRL) supported by the National Research Foundation of Korea

- Time: 2024. 08. 26. (Mon) 4:00 ~ 06:20 pm 

- Venue: Seminar Room, College of Korean Medicine, Dong-eui University, Busan, Korea 

- Topic: Inducing Immune Tolerance in immune Diseases Using Regulatory Cells and Histamine-lgG Complex

It was published in Scientific Reports on August 26, 2024, that in vivo IL-10+ regulatory B cells suppress the expression of CCR3, a homing receptor of inflammatory eosinophils, in atopic dermatitis disease and have the function of suppressing IL-5 and EPO secretion. This research was conducted as collaborative research by Dr. Dajeong Lee and Dr. Min Geun Cho. 

Lee, D.*, Jo, M.G.*, Min, K.Y., Choi, M.Y., Kim, Y.M., Kim, H.S.*, Choi, W.S.* IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation. Scientific Reports. 2024 Aug 6; 14(1):18164. doi:10.1038/s41598-024-68660-9.

- Research Exchange for Promoting Busan-style Advanced Biohealth Open Innovation 

- Time: 2024. 07. 08. (Mon) 2:00 - 5:30 pm

- Venue: Grand Conference Room (12F), Prestige Biopharma IDC, Busan, Korea 

- Topic: Inducing Immune Tolerance in Immune Diseases Using Regulatory Cells and Histobulin 

- Time: 2024. 04. 30. (Thu) 3:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

Thesis Defense

- Speaker:Seong Hyun Choi, M.S.c (Lab. of Integrative Omics)

- Topic: Co-optimization of anti-CTHRC1 antibody for productivity and binding affinity using phage display library

Preliminary Defense

- Speaker: Min Hye Kim, Ph.D.c (Lab. of Cancer Genomics)

- Topic: Investigating the Impact of ZO1 Overexpression on Cancer Progression and Metastasis in Transgenic Mouse

- Speaker: Gi-Eun Yang, Ph.D.c (Lab. of Cancer Genomics)

- Topic: Study on the effects of CD73 expression on cancer progression and TME environment in bladder cancer

- Speaker: Jae-Jun Kim, M.S.c (Lab. of Cancer Genomics)

- Topic: Characterization of the secreted protein PAI-1 in Bladder Cancer Cells

- Speaker: Juwon Kim, M.S.c (Lab. of Integrative Omics)

- Topic: Development of nanoparticle-based COVID-19 Vaccine

- Speaker: Juhyun Shin, M.S.c (Lab. of Immune Regulation)

-Topic: Immunotoxic effect of zinc oxide nanoparticles through immune cell modulation in atopic dermatitis model

- Speaker: Jeseok Jeon, M.S.c (Lab. of DNA Repair)

- Topic: Study on the Mechanism of Nucleotide Excision Repair Activation by Phytochemicals

- Speaker: Sumin Choi, M.S.c (Lab. of Regenerative Medicine)

- Topic: The Pro-Angiogenic Effects of Lizard Tail-Derived Factor, Endoplasmin

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2024. 04. 24. (Wed) 3:00 - 4:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Su Hwan Park, Ph.D.c (Lab. of Cancer Metabolism)

- Topic: The adverse effect of environmental pollutants on metabolism essential in human bronchial epithelial cell survival  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2024. 03. 27. (Wed) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Hyung Rok Choi, Ph.D.c (Lab. of Regenerative Medicine)

- Topic: PLST contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway 

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2024. 02. 28. (Wed) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210 

- Speaker: Jeong Won Park, Intergrated MS/PhDc (Lab. of Immune Regulation)

- Topic: Effects of fine particulate matter on allergic inflammation  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

Dong-A University Team Identifies MMSC as Breakthrough Treatment for Chronic Urticaria

A research team led by Professor Hyuk-soon Kim (Dong-A University), in collaboration with MiraeCell Bio and Jeju National University, has demonstrated the superior therapeutic efficacy of Embryonic Stem Cell-derived MSCs (MMSC) for chronic urticaria. The study was published in Scientific Reports.

Key Findings:

• Enhanced Efficacy: MMSCs showed significantly higher skin lesion improvement, 1.5 times greater than conventional antihistamines and 2.6 times greater than bone marrow-derived MSCs.

• Core Mechanism: Professor Kim’s team verified that MMSC-derived TGF-beta suppresses the activation of inflammatory T-cells and histamine-releasing mast cells.

• Broad Application: Building on this success, the team aims to expand MMSC therapy to other refractory diseases, following its proven efficacy in both chronic urticaria and interstitial cystitis.

- Time: 2023. 12. 21. (Thu) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Prof. Tae Hyung Kim (University of New Mexico Health Science Center) 

- Topic: High extracellular glucose promotes cell motilty by modulating cell deformability and contractility via cAMP-RhoA-ROCK axis in human breast caner cells  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

Professor Hyuk-soon Kim’s research team at Dong-A University, in collaboration with MiraeCell Bio, successfully demonstrated the therapeutic potential of human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) for treating urticaria, with the findings published in Scientific Reports on December 20, 2023. By applying these hESC-MSCs to animal models of the disease, the study confirmed significant improvements in skin lesions alongside potent anti-inflammatory effects. The research further elucidated that the treatment functions through a TGF-beta-mediated mechanism, which effectively modulates the activation of inflammatory T cells and mast cells to alleviate the symptoms of urticaria. 

Hyun, S.Y.*, Kim, E.Y.*, Kang, M., Park, J.W., Hong, K.S., Chung, H.M., Choi, W.S., Park, S.P., Noh, G., Kim, H.S. Embryonic‑stem‑cell‑derived mesenchymal stem cells relieve experimental contact urticaria by regulating the functions of mast cells and T cells. Scientific Reports. 2023 Dec 20; 13:22694. doi: 10.1038/s41598-023-50258-2.

December 12, 2023,

Looking back on the year 2023 and looking forward to a new beginning in 2024, we held a year-end party.

- Time: 2023. 11. 23. (Thu) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Hye Jin Yun, M.S.c (Lab. of Cancer Metabolism ) 

- Topic: The Mechanistic Studies of Regulation of Serine Biosynthesis in the Brain Tumor  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2023. 10. 25. (Wed) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 5F room 0503

- Speaker: Prof. Ju-Seog Lee (MD Anderson Cancer Center) 

- Topic: Decoding Cancer Genomes and Its Clinical Implication  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Regenerative Medicine, Lab. of DNA Repair,

Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

To examine the drug repositioning effect of the antibacterial agent nifuratel, the degranulation control effect of mast cells, which are allergy-causing cells, was evaluated, and its mechanism was revealed; this was published in Int J Immunopathol Pharmacol. on September 14, 2023.

In the antigen-induced mast cell FceRI mechanism, it is a research result showing that the inhibition of the Src kinase family activity by nifuratel suppresses the mast cell degranulation reaction and inflammatory cytokine secretion, and has a disease suppression effect in an allergic anaphylaxis shock animal model.

Lee, J.E.*, Choi, M.Y.*, Min, K.Y., Jo, M.G., Kim, Y.M., Kim, H.S., Choi, W.S. Drug repositioning of anti-microbial agent nifuratel to treat mast cell-mediated allergic responses. International Journal of Immunopathology and Pharmacology. 2023 Jan-Dec;37:3946320231202349. doi:10.1177/ 03946320231202349. 2023 Sep 14 online published.

- Time: 2023.08. 30. (Wed) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Jae-Jun Kim, M.S.c (Lab. of Cancer Genomics) 

- Topic:  Development of Liquid Biopsy Markers in Bladder Cancer 

- Speaker: Juhyun Shin, M.S.c (Lab. of Immune Regulation) 

- Topic: Effects of tumor cell-derived factors for inducing immune evasion on IL-10-producing B cells  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Tumor Complex System, Lab. of Regenerative Medicine, Lab. of DNA Repair, Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2023. 06. 28. (Wed) 5:00 - 6:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Dr. Jin-hyuk Jung 

(Department of Biomedical Sciences, Dong-A University)

(Formerly Class of '10, Department of Biological Sciences) 

- (Current) Researcher, Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) 

- Published as the first author of a paper listed in "People Who Made Korea Shine" (A.K.A. Hanbitsa) in 2023 

- Topic:  A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

- Hosted by:

Lab. of Cancer Genomics, Lab. of Tumor Complex System, Lab. of Regenerative Medicine, Lab. of DNA Repair, Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- The research team of the Department of Biomedical Sciences Consortium (Professors Sun-hee Leem, Sang-seok Koh, Jong-ho Lee, Hyuk-soon Kim, and Tae-hwan Shin) signed a Memorandum of Understanding (MOU) with 'Prestige Biopharma IDC' located in Busan for multi-omics-based liquid biopsy diagnostic biomarker technology. 

The extraction and pharmacological efficacy of plant-derived exosomes are fields of recent interest; we confirmed that plant exosomes promote the differentiation of bone-forming osteoblasts and are effective in treating osteoporosis when administered orally, and reported this to the academic community. This study was conducted as a joint research project with Prof. Young-eun Cho from the Department of Food and Nutrition at Andong National University and Prof. Do-kyun Kim from the Zoonosis Research Institute at Jeonbuk National University.

The journal 'Journal of Controlled Release' has a Journal Impact Factor (JIF) of 11.467 according to the Journal Citation Reports (JCR), achieving the feat of being published in a world-class journal that ranks in the top 4% among academic journals in the field of pharmacology and pharmacy.

Hwang, J.H.*, Park, Y.S.*, Kim, H.S.*, Kim, D.H., Lee, S.H., Lee, C.H., Lee, S.H., Kim, J.E., Lee, S.K., Kim, H.M., Kim, H.W., Lim, J.H., Song, B.J., Kim, D.K.*, Baek, M.C.*, Cho, Y.E.* Yam-Derived Exosome-Like Nanovesicles Stimulate Osteoblast Formation and Prevent Osteoporosis in Mice. Journal of Controlled Release. 2023 Mar 31;355:184-198. 

Prof. Hyuk Soon Kim of the Department of Biomedical Sciences at Dong-A University announced on February 14 that his paper was recently selected for the "People Who Shine in Korea (Hanbitsa)" by the Biological Research Information Center (BRIC). The joint research team of Professor Hyuk-soon Kim (Department of Biomedical Sciences) and Chonbuk, Kyungpook, and Andong National Universities was published in the February online edition of the 'Journal of Controlled Release', a world-renowned journal in the field of pharmacology and pharmacy.

The 'Journal of Controlled Release' has a Journal Impact Factor (JIF) of 11.467 according to the Journal Citation Reports (JCR), making it a world-class academic journal ranking in the top 4% of the pharmacology and pharmacy field. The title of the selected paper is ‘Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice’.

The joint research team, including Professor Hyuk-soon Kim, reported to the academic community that 'plant-derived exosome-like nanovesicles (PENs) containing miRNAs, bioactive lipids, mRNA, and proteins exhibit antioxidant, anti-inflammatory, and regenerative activities' and that 'plant-derived exosome-like nanovesicle substances extracted from Chinese yam promote osteoblast growth in bone regeneration to alleviate and prevent osteoporosis'. It was also confirmed that orally administered plant-derived exosomes are transported to the gastrointestinal tract and absorbed through the small intestine.

The research team explained that these results, 'with excellent systemic biosafety determined by histological analysis and liver/kidney toxicity tests, can act as a safer and orally effective agent for the treatment of osteoporosis'. Prof. Hyuk-soon Kim stated, “The great achievement of this study is that we not only confirmed the induction of osteoblast activity and the treatment effect on osteoporosis by plant-derived exosomes but also verified the pharmaceutical ease through oral administration.” He added, “It could be utilized to create new research fields that can be applied as oral drug delivery systems for new inflammatory immune disease treatments or vaccines.”

January 02, 2023, the Year of the Black Rabbit (Gyemyonyun),

Looking back on the year 2022 and with new goals and mindsets for 2023, we held the Immune regulation Laboratory's annual meeting and kick-off ceremony.

- Time: 2022. 12. 28. (Wed) 4:00 - 5:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Hyung Rok Choi, Ph.D.c (Lab. of Regenerative Medicine) 

- Topic:  Isolation of lizard-derived bioactive materials and confirmation of biological effects 

- Speaker: Su Bin Lee, M.S.c (Lab. of Cancer Metabolism) 

- Topic: The functional studies of PFKP dimethylation in brain tumor metabolism 

- Hosted by:

Lab. of Cancer Genomics, Lab. of Tumor Complex System, Lab. of Regenerative Medicine, Lab. of DNA Repair, Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2022. 12. 02. (Fri) 10:40 - 3:00 pm

- Venue: On-line ZOOM meeting

- Speaker: Prof. Song Young Park (University of Nebraska omaha)

- Topic:  Attenuated vascular mitochondrial function and microcirculation in aging and disease

- Speaker: Prof. Dong Ryeol Ryu (Sunkyunkwan University)

- Topic: L-threonine promotes healthsapn by expediting ferritin-dependent ferroptosis inhibition in C. elegans

- Speaker: Prof. Min-hyuk Kwon (California state polytechnic University)

- Topic:  Inability to produce fast contraction with aging

- Speaker: Prof. Chang Hong Youm (Dong-A University)

- Topic: Classification of parkinson's disease with freezing of gait based on 360 turning analysis using 36 kinematic features

- Speaker: Bo Hyeon Kim (Dong-A University)

- Topic: Association of muscle mass, muscle strength, and muscle function with gait ability assessed using inertial measurement unit sensors in older women

- Speaker: Thapa Ngeemasara (Dong-A University)

- Topic: The relationship between objectively measured physical activity, sleep behaviour, and cognitive and brain health in older adults

- Time: 2022. 11. 09. (Wed) 3:30 - 5:30 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Yeon Jung Kim, Ph.D.c (Lab. of Tumor Complex System)

- Topic:  Identification of the mechanisms of PAUF-mediated monocyte activation and development of a therapeutic antibody

- Speaker: So Eun Yoon, Ph.D.c (Lab. of Tumor Complex System)

- Topic: PAUF induces the migration of human pancreatic cancer cells exclusively through the TLR4/MyD88/NF-κB signaling pathway 

- Speaker: Da Eun Hong, M.S.c (Lab. of Tumor Complex System)

- Topic:  Identification of PAUF's role in pancreatic stellate cell activation and consequent PDAC migration

- Speaker: Hyerim Ryu, M.S.c (Lab. of Tumor Complex System)

- Topic: Development of PAUF detection method using sandwich ELISA experimental technique for diagnosis of pancreatic cancer

- Speaker: Seung Yeun Hyun, M.S.c (Lab. of Immune Regulation)

- Topic: Embryonic stem cell-derived mesenchymal stem cells relieve experimental urticaria by regulating the functions of mast cells and T cells 

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2022. 10. 27. (Thu) 4:00 - 6:00 pm

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker : Kyoung Jin Ryu, M.S.c (Lab. of Tumor Complex System)

- Topic:  A blocking of CTHRC1 attenuates liver fibrosis by inhibiting the activation of Hepatic stellate cells 

- Speaker : Seung Yeon Pyo, M.S.c (Lab. of Tumor Complex System)

- Topic: Optimization of immunogenicity assay in vitro for therapeutic antibody 

- Speaker : Hyang Eun Im, M.S.c (Lab. of Tumor Complex System)

- Topic: Improving humanized antibody production by human framework grafting  

- Hosted by:

Lab. of Cancer Genomics, Lab. of Tumor Complex System, Lab. of Regenerative Medicine, Lab. of DNA Repair, Lab. of Cancer Metabolism, Lab. of Immune Regulation, Lab. of Integrative Omics

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

- Time: 2022. 10. 06. (Thu) 4:30 - 5:30 pm

- Venue: Bldg s11 (College of Natural Science), 5F room 0510

- Speaker: Jun-ho Lee, CEO of Dacapo Co., Ltd. / Professor, College of Korean Medicine, Woosuk University

- Topic:  Bench-to-market in the Bio Fields

As part of the Leaders in Industry-University Cooperation (LINC 3.0) project, an industry-academia linked employment capability enhancement education program was conducted. In this event, as part of the "Bio-health Advanced Technology-based Regulatory Science Talent Cultivation Program," CEO Jun-ho Lee of Dacapo Co., Ltd., a health functional food company, was invited to give a special lecture on research processes and market entry in the bio fields. 

- Time: 2022. 09. 21. 수요일 오후 4:00 - 6:00

- Venue: Bldg s11 (College of Natural Science), 2F room 0210

- Speaker: Min Kyung Kang, Ph.D.c (Lab. of Tumor Complex System)

- Topic: Identification of the role of metastatic factor CTHRC1 in desmoplasia and development of anti-CTHRC1 therapeutic antibody

- Speaker: So Eun Yoon, Ph.D.c (Lab. of Tumor Complex System)

- Topic: PAUF induces the migration of human pancreatic cancer cells exclusively through the TLR4/MyD88 signaling pathway

- Speaker: Da Eun Hong, M.S.c (Lab. of Tumor Complex System)

- Topic:  Functional verification in activated pancreatic stellate cell induced by PAUF

- Speaker: Hyerim Ryu, M.S.c (Lab. of Tumor Complex System)

- Topic: Detection of PAUF with sandwich ELISA for pancreatic cancer diagnosis

- Speaker: Seung Yeun Hyun, M.S.c (Lab. of Immune Regulation)

- Topic: Effect of Mesenchymal stem cell in Contact Urticaria mouse model

*Graduate and undergraduate researchers in the Department of Biomedical Sciences are highly encouraged to participate.

Under the research topic "Effects of the Immunoglobulin/Histamine Complex in Chronic Spontaneous Urticaria Focusing on Remission Induction". We reported to the academic community the confirmation of a sustained and stable disease remission (virtual cure) effect in 71.4% of chronic urticaria patients who visited the hospital and received 'immunoglobulin/histamine complex' treatment. This study was conducted as a joint research project with Dr. Geunwoong Noh, Director of the Allergy and Clinical Immunology Center at Jeju Halla General Hospital (President Sung Soo Kim).

The journal 'Allergy' has a Journal Impact Factor (JIF) of 14.710 according to the Journal Citation Reports (JCR), achieving the feat of being published in 'Allergy', a world-class journal that ranks 1st (top 1%) among academic journals in the field of allergy and 9th (top 5%) among academic journals in the field of immunology.

Kim, H.S., Noh, G. Effects of the immunoglobulin/histamine complex in chronic spontaneous urticaria focusing on remission induction. Allergy. 2022 Sep 01;77(9):2846-2848. doi: 10.1111/all.15381.