This case report demonstrates for the first time that nonallergen-specific immunotherapy using an immunoglobulin/histamine complex (IHC) can successfully induce tolerance in food allergy. The study presents two Korean patients a 5-year-old male with anaphylactic wheat allergy and a 40-year-old female with crab and shrimp allergy both presenting with comorbid allergic conditions like allergic rhinitis, atopic dermatitis, or chronic spontaneous urticaria (CSU). Following a regimen of subcutaneous Histobulin™ (IHC) injections, both patients achieved complete tolerance, consuming the offending foods during post-treatment open food challenges without any adverse reactions, while simultaneously resolving their comorbid allergic diseases.

The authors propose a "histamine-nourishing theory," positing that persistent reduction of systemic histamine levels via IHC-induced histaminopexy "withers" preexisting allergen-specific allergies. By avoiding direct allergenic desensitization, this approach offers a safer alternative to traditional oral immunotherapy (OIT) without the risk of therapy-induced anaphylaxis. These findings position IHC as a promising, safe therapeutic candidate capable of simultaneously tolerating multiple allergens and managing complex allergic disorders.

Kim, H.S., Noh, G. Tolerance Induction for Food Allergy using Immunoglobulin/Histamine Complex: A Case Report. Allergologia et immunopathologia. 2026 Jul 1; 54(4): 135-143. doi: 10.15586/aei.v54i4.1541.