This case report describes a 39-year-old woman with fibromyalgia accompanied by chronic urticaria and allergic rhinitis who experienced marked improvement in widespread pain, finger stiffness, insomnia, and daily functioning following immunoglobulin/histamine complex (Histobulin™) therapy. After six injections, symptoms of fibromyalgia, urticaria, and allergic rhinitis were substantially reduced, along with the need for rescue analgesics. These findings suggest that modulation of histamine-related or immune pathways may contribute to the improvement of fibromyalgia symptoms, although further controlled studies are required to confirm this association.

Kim, H.S., Nam, Y., Sohn, J.E., Noh, G. Improvement of Fibromyalgia by Immunoglobulin/Histamine Complex Therapy for Chronic Urticaria and Allergic Rhinitis: A Case Report. Clinical Case Reports. 2026 Aug 21; 14:e73248. doi: 10.1002/ccr3.73248.