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Seung Yeun Hyun, M.S.
Seung Yeun Hyun, M.S.
2023. 03. - Present Research Manager
2023. 03. - Present Research Manager
- Prestige Biopharma Ltd., Busan, Korea
2021. 03. - 2023. 02. M.S. in Health Sciences
2021. 03. - 2023. 02. M.S. in Health Sciences
- Department of Health Sciences, The Graduate School of Dong-A University, Busan, Korea
2016. 03. - 2021. 02. B.S. in Biological Sciences
2016. 03. - 2021. 02. B.S. in Biological Sciences
- Department of Biological Sciences, College of Natural Science, Dong-A University, Busan, Korea
Publications with Prof. Kim
3. Park, J.W.*, Kang, M.*, Kim, G.*, Hyun, S.Y., Shin, J., Kim, S.Y., Lee, J.H., Choi, W.S., Lee, J.H., Lee, K., Kim, S.H., Cho, W.S.*, Kim, H.S.* The impact of atmospheric ultrafine particulate matter on IgE-mediated type 1 hypersensitivity reaction. Journal of Hazardous Materials. 2025 Feb 15;484:136705. doi: 10.1016/j.jhazmat. 2024.136705. (IF 12.2 JCR 2023) Epub 2024 Nov 29.
2. Hyun, S.Y.*, Kim, E.Y.*, Kang, M.S., Park, J.W., Hong, K.S., Chung, H.M., Choi, W.S., Park, S.P.*, Noh, G.*, Kim, H.S.* Embryonic‑stem‑cell‑derived mesenchymal stem cells relieve experimental contact urticaria by regulating the functions of mast cells and T cells. Scientific Reports. 2023 Dec 20; 13:22694. doi: 10.1038/s41598-023-50258-2.
1. Min, K.Y.*, Koo, J.*, Noh, G., Lee, G., Jo, M.G., Lee, J., Kang, M., Hyun, S.Y., Choi,W.S.*, Kim, H.S.* CD1dhiPD-L1hiCD27+ regulatory natural killer subset suppresses atopic dermatitis. Frontiers in Immunology. 2022 Jan 5;12: 752888. doi: 10.3389/fimmu.2021.752888. (IF 8.786 JCR 2021)
Minseong Kang, M.S.
Minseong Kang, M.S.
2023. 03. - Present Research Manager
2023. 03. - Present Research Manager
- Asan medical center (AMC) Science, Seoul, Korea
2022. 09. - 2023. 02. Researcher
2022. 09. - 2023. 02. Researcher
- Department of Biomedical Sciences, College of Natural Science, Dong-A University, Busan, Korea
2020. 09. - 2022. 08. M.S. in Health Sciences
2020. 09. - 2022. 08. M.S. in Health Sciences
- Department of Health Sciences, The Graduate School of Dong-A University, Busan, Korea
2014. 03. - 2019. 02. B.S. in Medicinal Biotechnology
2014. 03. - 2019. 02. B.S. in Medicinal Biotechnology
- Department of Medicinal Biotechnology, College of Health Science, Dong-A University, Busan, Korea
Publications with Prof. Kim
3. Park, J.W.*, Kang, M.*, Kim, G.*, Hyun, S.Y., Shin, J., Kim, S.Y., Lee, J.H., Choi, W.S., Lee, J.H., Lee, K., Kim, S.H., Cho, W.S.*, Kim, H.S.* The impact of atmospheric ultrafine particulate matter on IgE-mediated type 1 hypersensitivity reaction. Journal of Hazardous Materials. 2025 Feb 15;484:136705. doi: 10.1016/j.jhazmat. 2024.136705. (IF 12.2 JCR 2023) Epub 2024 Nov 29.
2. Hyun, S.Y.*, Kim, E.Y.*, Kang, M., Park, J.W., Hong, K.S., Chung, H.M., Choi, W.S., Park, S.P.*, Noh, G.*, Kim, H.S.* Embryonic‑stem‑cell‑derived mesenchymal stem cells relieve experimental contact urticaria by regulating the functions of mast cells and T cells. Scientific Reports. 2023 Dec 20; 13:22694. doi: 10.1038/s41598-023-50258-2.
1. Min, K.Y.*, Koo, J.*, Noh, G., Lee, G., Jo, M.G., Lee, J., Kang, M., Hyun, S.Y., Choi,W.S.*, Kim, H.S.* CD1dhiPD-L1hiCD27+ regulatory natural killer subset suppresses atopic dermatitis. Frontiers in Immunology. 2022 Jan 5;12: 752888. doi: 10.3389/fimmu.2021.752888. (IF 8.786 JCR 2021)
Keun Young Min, Ph.D.
Keun Young Min, Ph.D.
(co-supervisor Prof. Wahn Soo Choi, School of Medicine, Konkuk Univ.)
(co-supervisor Prof. Wahn Soo Choi, School of Medicine, Konkuk Univ.)
2024. 10. - Present Postdoctoral Fellowship
2024. 10. - Present Postdoctoral Fellowship
- Department of Dermatology, Weill Cornell Medical College, Cornell University, New York, NY, USA
2022. 03. - 2024. 08. Postdoctoral Fellowship
2022. 03. - 2024. 08. Postdoctoral Fellowship
- Department of Immunology, School of Medicine, Konkuk University, Seoul, Korea
2016. 03. - 2022. 02. Integrated M.S./Ph.D. in Medicine
2016. 03. - 2022. 02. Integrated M.S./Ph.D. in Medicine
- Department of Immunology, School of Medicine, Konkuk University, Seoul, Korea
2010. 03. - 2016. 02. B.S. in Biotechnology
2010. 03. - 2016. 02. B.S. in Biotechnology
- Department of Biotechnology, College of Life Sciences, Sejong University, Seoul, Korea
Publications with Prof. Kim
18. Choi, M.Y.*, Jo, M.G.*, Min, K.Y., Kim, B., Kim, Y., Choi, W.S.* Antimicrobial Peptide Pro10-1D Exhibits Anti-Allergic Activity: A Promising Therapeutic Candidate. International Journal of Molecular Sciences. 2024 Nov 12;25(22):12138. doi: 10.3390/ijms252212138.
17. Lee, D.*, Jo, M.G.*, Min, K.Y., Choi, M.Y., Kim, Y.M., Kim, H.S.*, Choi, W.S.* IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation. Scientific Reports. 2024 Aug 6; 14(1):18164. doi:10.1038/s41598-024-68660-9.
16. Min, K.Y.*, Kim, D.K.*, Jo, M.G., Choi, M.Y., Lee, D., Park, J.W., Park, Y.J., Chung, Y., Kim, Y.M., Park, Y.M., Kim, H.S.*, Choi, W.S.* IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner. Experimental & Molecular Medicine. 2024 Mar 1; 56(3):616-629. doi: 10.1038/s12276-024-01187-1. (IF 12.8 JCR 2022)
15. Lee, S., Kim, M.J., Ahn, S.I., Choi, S.K., Min, K.Y., Choi, W.S., You, J.S. Epigenetic landscape analysis reveals the significance of early reduced chromatin accessibility in osteoclastogenesis. Bone. 2023 Dec;177:116918. doi: 10.1016/j.bone.2023.116918.
14. Lee, J.E., Choi, M.Y., Min, K.Y., Jo, M.G., Kim, Y.M., Kim, H.S., Choi, W.S. Drug repositioning of anti-microbial agent nifuratel to treat mast cell-mediated allergic responses. International Journal of Immunopathology and Pharmacology. 2023 Jan-Dec;37:3946320231202349. doi: 10.1177/03946320231202349.
13. Kim, S.J.*, Choi, M.Y.*, Min, K.Y., Jo, M.G., Kim, J.M., Kim, H.S., Kim, Y.M. AT9283, 1-Cyclopropyl-3-(3-(5-(Morpholinomethyl)-1H-Benzo[d]Imidazole-2-yl)-1H-Pyrazol-4-yl) Urea, Inhibits Syk to Suppress Mast Cell-Mediated Allergic Response. Biomolecules & Therapeutics. 2022 Nov 1; 30(6):520-528. doi: 10.4062/biomolther.2022.042.
12. Min, K.Y.*, Koo, J.*, Noh, G., Lee, G., Jo, M.G., Lee, J., Kang, M., Hyun, S.Y., Choi,W.S.*, Kim, H.S.* CD1dhiPD-L1hiCD27+ regulatory natural killer subset suppresses atopic dermatitis. Frontiers in Immunology. 2022 Jan 5;12: 752888. (IF 8.786 JCR 2021)
11. Min, K.Y., Lee, M.B., Hong, S.H., Lee, D., Jo, M.G., Lee, J., Choi, M.Y., You, J.S., Kim, Y.M., Park, Y.M., Kim, H.S.*, Choi, W.S.* Entinostat, a histone deacetylase inhibitor, increases the population of IL-10+ regulatory B cells to suppress contact hypersensitivity. BMB Reports. 2021 Oct 31;54(10): 534-539. (IF 5.041 JCR 2021)
10. Kim, M.J.*, Kim, H.S.*, Lee, S. Min, K.Y., Choi, W.S., You, J.S. Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation. International Journal of Molecular Sciences. 2021 Aug 18; 22(16): 8888.
9. Lee, S.Y.*, Kim, H.S.*, Kim, M.J., Min, K.Y., Choi, W.S., You, J.S. Glutamin metabolite a-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation. Bone. 2021 Jan 13;145:115836.
8. Lee, D., Park, Y.H., Lee, J.E., Kim, H.S., Min, K.Y., Jo, M.G., Kim, H.S., Choi, W.S., Kim, Y.M. Dasatinib Inhibits Lyn and Fyn Src-Family Kinases in Mast Cells to Suppress Type I Hypersensitivity in Mice. Biomolecules & Therapeutics. 2020 Sep 1;28(5):456-464.
7. Park, Y.H.*, Kim, D.K.*, Kim, H.S.*, Lee, D., Lee, M.B., Min, K.Y., Jo, M.G., Lee, J.E., Kim, Y.M., Choi, W.S. WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo. Toxicology and Applied Pharmacology. 2019 Nov 15;383: 114763.
6. Kim, H.S.*, Lee, M.B.*, Lee, D., Min, K.Y., Koo, J., Kim, H.W., Park, Y.H., Kim, S.J., Ikutani, M., Takaki, S., Park, Y.M., Choi, W.S. The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses contact hypersensitivity. Science Advances. 2019 Jul 17;5(7):aav8152. (IF 14.972 JCR 2021)
5. Park, Y.H., Kim, H.W., Kim, H.S., Nam S.T., Lee, D., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Kim, Y.M., Kim, H.S., Choi, W.S. An Anti-Cancer Drug Candidate CYC116 Suppresses Type I Hypersensitive Immune Responses through the Inhibition of Fyn Kinase in Mast Cells. Biomolecules & Therapeutics. 2019 May 1;27(3):311-317.
4. Park, Y.H., Kim, D.K., Kim, H.W., Kim, H.S., Lee, D., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Kang, C., Kim, Y.M., Kim, H.S., Choi, W.S. Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn. Biochemical Pharmacology. 2018 Aug;154:270-277.
3. Nam, S.T., Kim, H.W., Kim, H.S., Park, Y.H., Lee, D., Lee, M.B., Min, K.Y., Kim, Y.M., Choi, W.S. Furaltadone suppresses IgE-mediated allergic response through the inhibition of Lyn/Syk pathway in mast cells. European Journal of Pharmacology. 2018 Jun 5; 828:119-125.
2. Lee, D.*, Kim, H.S.*, Shin, E., Do, S.G., Lee, C.K., Kim, Y.M., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Nam, S.T., Kim, H.W., Park, Y.H., Choi, W.S. Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice. Biomedicine & Pharmacotherapy. 2018 May;101:201-210. (IF 7.419 JCR 2021)
1. Lee, M.B.*, Lee, J.H.*, Hong, S.H., You, J.S., Nam, S.T., Kim, H.W., Park, Y.H., Lee, D., Min, K.Y., Kim, Y.M., Kim, H.S.*, Choi, W.S.* JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis. BMB Reports. 2017 Dec;50(12):640-646.
Min Bum Lee, Ph.D.
Min Bum Lee, Ph.D.
(co-supervisor Prof. Wahn Soo Choi, School of Medicine, Konkuk Univ.)
(co-supervisor Prof. Wahn Soo Choi, School of Medicine, Konkuk Univ.)
2020. 01. - Present Section Chief
2020. 01. - Present Section Chief
- FROMBIO Corp., Suwon, Korea
2015. 03. - 2020. 02. Integrated M.S./Ph.D. in Medicine
2015. 03. - 2020. 02. Integrated M.S./Ph.D. in Medicine
- Department of Immunology, School of Medicine, Konkuk University, Seoul, Korea
2007. 03. - 2013. 02. B.S. in Biological Sciences
2007. 03. - 2013. 02. B.S. in Biological Sciences
- Department of Biological Sciences, College of Natural Science, Daejin University, Pocheon, Korea
Publications with Prof. Kim
12. Min, K.Y., Lee, M.B., Hong, S.H., Lee, D., Jo, M.G., Lee, J., Choi, M.Y., You, J.S., Kim, Y.M., Park, Y.M., Kim, H.S.*, Choi, W.S.* Entinostat, a histone deacetylase inhibitor, increases the population of IL-10+ regulatory B cells to suppress contact hypersensitivity. BMB Reports. 2021 Oct 31;54(10): 534-539. (IF 5.041 JCR 2021)
11. Park, Y.H.*, Kim, D.K.*, Kim, H.S.*, Lee, D., Lee, M.B., Min, K.Y., Jo, M.G., Lee, J.E., Kim, Y.M., Choi, W.S. WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo. Toxicology and Applied Pharmacology. 2019 Nov 15;383: 114763.
10. Kim, H.S.*, Lee, M.B.*, Lee, D., Min, K.Y., Koo, J., Kim, H.W., Park, Y.H., Kim, S.J., Ikutani, M., Takaki, S., Park, Y.M., Choi, W.S. The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses contact hypersensitivity. Science Advances. 2019 Jul 17;5(7):aav8152. (IF 14.972 JCR 2021)
9. Park, Y.H., Kim, H.W., Kim, H.S., Nam S.T., Lee, D., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Kim, Y.M., Kim, H.S., Choi, W.S. An Anti-Cancer Drug Candidate CYC116 Suppresses Type I Hypersensitive Immune Responses through the Inhibition of Fyn Kinase in Mast Cells. Biomolecules & Therapeutics. 2019 May 1;27(3):311-317.
8. Park, Y.H., Kim, D.K., Kim, H.W., Kim, H.S., Lee, D., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Kang, C., Kim, Y.M., Kim, H.S., Choi, W.S. Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn. Biochemical Pharmacology. 2018 Aug;154:270-277.
7. Nam, S.T., Kim, H.W., Kim, H.S., Park, Y.H., Lee, D., Lee, M.B., Min, K.Y., Kim, Y.M., Choi, W.S. Furaltadone suppresses IgE-mediated allergic response through the inhibition of Lyn/Syk pathway in mast cells. European Journal of Pharmacology. 2018 Jun 5; 828:119-125.
6. Lee, D.*, Kim, H.S.*, Shin, E., Do, S.G., Lee, C.K., Kim, Y.M., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Nam, S.T., Kim, H.W., Park, Y.H., Choi, W.S. Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice. Biomedicine & Pharmacotherapy. 2018 May;101:201-210. (IF 7.419 JCR 2021)
5. Lee, M.B., Lee, J.H., Hong, S.H., You, J.S., Nam, S.T., Kim, H.W., Park, Y.H., Lee, D., Min, K.Y., Kim, Y.M., Kim, H.S.*, Choi, W.S.* JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis. BMB Reports. 2017 Dec;50(12):640-646. (IF 5.041 JCR 2021)
4. Nam, S.T., Park, Y.H., Kim, H.W., Kim, H.S., Lee, D., Lee, M.B., Kim, Y.M., Choi, W.S. Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C. Toxicology and Applied Pharmacology. 2017 Oct 1;332:25-31.
3. Kim, A.R., Kim, H.S., Kim, D.K., Lee, J.H., Yoo, Y.H., Kim, J.Y., Park, S.K., Nam, S.T., Kim, H.W., Park, Y.H., Lee, D., Lee, M.B., Kim, Y.M., Choi, W.S. The Extract of Chrysanthemum zawadskii var. latilobum Ameliorates Collagen-Induced Arthritis in Mice. Evidence based complementary and alternative medicine. 2016 Oct;2016:3915013.
2. Kim, H.S., Jang, J.H., Lee, M.B., Jung, I.D., Kim, Y.M., Park, Y.M., Choi, W.S. A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model. BMB Reports. 2016 May;49(5):293-6.
1. Kim, A.R.*, Kim, H.S.*, Kim, D.K., Nam, S.T., Kim, H.W., Park, Y.H., Lee, D., Lee, M.B., Lee, J.H., Kim, B., Beaven, M.A., Kim, H.S., Kim, Y.M., Choi, W.S. Mesenteric IL-10-producing CD5+ B cells suppress cow’s milk casein-induced allergic responses in mice. Scientific Reports. 2016 Jan 20;6:19685.
Jimo Koo, M.S.
Jimo Koo, M.S.
(co-supervisor Prof. Wahn Soo Choi, School of Medicine, Konkuk Univ.)
(co-supervisor Prof. Wahn Soo Choi, School of Medicine, Konkuk Univ.)
2021. 09. - Present Research Associate
2021. 09. - Present Research Associate
- CHA BIOTECH Corp., Seongnam, Korea
2019. 02. - 2021. 08. Research Manager
2019. 02. - 2021. 08. Research Manager
- CELLID Corp. Seoul, Korea
2017. 03. - 2019. 02. M.S. in Medicine
2017. 03. - 2019. 02. M.S. in Medicine
- Department of Immunology, School of Medicine, Konkuk University, Seoul, Korea
2009. 03. - 2016. 02. B.S. in Biotechnology
2009. 03. - 2016. 02. B.S. in Biotechnology
- Department of Intergrative Bioscience and Biotechnology, Konkuk University, Seoul, Korea
Publications with Prof. Kim
5. Min, K.Y.*, Koo, J.*, Noh, G., Lee, G., Jo, M.G., Lee, J., Kang, M., Hyun, S.Y., Choi,W.S.*, Kim, H.S.* CD1dhiPD-L1hiCD27+ regulatory natural killer subset suppresses atopic dermatitis. Frontiers in Immunology. 2022 Jan 5;12: 752888. doi: 10.3389/fimmu.2021.752888. (IF 8.786 JCR 2021)
4. Kim, H.S.*, Lee, M.B.*, Lee, D., Min, K.Y., Koo, J., Kim, H.W., Park, Y.H., Kim, S.J., Ikutani, M., Takaki, S., Park, Y.M., Choi, W.S. The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses contact hypersensitivity. Science Advances. 2019 Jul 17;5(7):aav8152. (IF 14.972 JCR 2021)
3. Park, Y.H., Kim, H.W., Kim, H.S., Nam S.T., Lee, D., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Kim, Y.M., Kim, H.S., Choi, W.S. An Anti-Cancer Drug Candidate CYC116 Suppresses Type I Hypersensitive Immune Responses through the Inhibition of Fyn Kinase in Mast Cells. Biomolecules & Therapeutics. 2019 May 1;27(3):311-317.
2. Park, Y.H., Kim, D.K., Kim, H.W., Kim, H.S., Lee, D., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Kang, C., Kim, Y.M., Kim, H.S., Choi, W.S. Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn. Biochemical Pharmacology. 2018 Aug;154:270-277.
1. Lee, D.*, Kim, H.S.*, Shin, E., Do, S.G., Lee, C.K., Kim, Y.M., Lee, M.B., Min, K.Y., Koo, J., Kim, S.J., Nam, S.T., Kim, H.W., Park, Y.H., Choi, W.S. Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice. Biomedicine & Pharmacotherapy. 2018 May;101:201-210. (IF 7.419 JCR 2021)
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