Publications

Endoplasmic reticulum stress responses in anticancer immunity

Hwang SM*, Chang S*, Rodriguez PC, Cubillos-Ruiz JR. Nat Rev Cancer. 2025 Jun 24. doi: 10.1038/s41568-025-00836-5. Epub ahead of print. PMID: 40555746  (*Co-first authors)

Transgelin 2 guards T cell lipid metabolism and anti-tumor function

Hwang SM, Awasthi D, Jeong J, Sandoval TA, Chae CS, Ramos Y, Tan C, Falco MM, Salvagno C, Emmanuelli A, McBain IT, Mishra B, Ivashkiv LB, Zamarin D, Cantillo E, Chapman-Davis E, Holcomb K, Morales DK, Yu X, Rodriguez PC, Conejo-Garcia JR, Kaczocha M, Vähärautio A, Song M, Cubillos-Ruiz JR. Nature. 2024 Nov;635(8040):1010-1018. doi: 10.1038/s41586-024-08071-y. Epub 2024 Oct 23. PMID: 39443795

[Research Highlight in Signal Transduct Target Ther. 2025 Feb 14;10(1):53. doi: 10.1038/s41392-025-02151-9. PMID: 39948077] [Research Highlight in MedComm. 2025 March 30 doi.org/10.1002/mco2.70164. PMID: 40166645] [Highlighted in Forbes, a prestigious international media outlet covering science and innovation]

High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils

Emmanuelli A, Salvagno C, Hwang SM, Awasthi D, Sandoval TA, Chae CS, Cheong JG, Tan C, Iwawaki T, Cubillos-Ruiz JR. OncoImmunology. 2024 Oct 02 doi: 10.1080/2162402X.2024.2411070.

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer

Sandoval TA, Salvagno C, Chae CS, Awasthi D, Giovanelli P, Marin Falco M, Hwang SM, Teran-Cabanillas E, Suominen L, Yamazaki T, Kuo HH, Moyer JE, Martin ML, Manohar J, Kim K, Sierra MA, Ramos Y, Tan C, Emmanuelli A, Song M, Morales DK, Zamarin D, Frey MK, Cantillo E, Chapman-Davis E, Holcomb K, Mason CE, Galluzzi L, Zhou ZN, Vaharautio A, Cloonan SM, Cubillos-Ruiz JR. Cancer Discov. 2024 Jul 29. doi: 10.1158/2159-8290. CD-23-1451. Epub ahead of print. PMID: 39073085.

Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis

Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR. J Clin Invest. 2023 Jul 11:e167359. doi: 10.1172/JCI167359. Epub ahead of print. PMID: 37432737.

Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses

Chaudhary V, Ah Kioon MD, Hwang SM, Mishra B, Lakin K, Kirou KA, Zhang-Sun J, Wiseman RL, Spiera RF, Crow MK, Gordon JK, Cubillos-Ruiz JR, Barrat FJ. J Exp Med. 2022 Nov 7;219(11):e20221085. doi: 10.1084/jem.20221085. Epub 2022 Sep 2. PMID: 36053251.

Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress

Ramos Y, Sansone S, Hwang SM, Sandoval TA, Zhu M, Zhang G, Cubillos-Ruiz JR, Morales DK. mBio. 2022 Nov 10;13(6):e0229422. doi: 10.1128/mbio.02294-22. Epub ahead of print. PMID: 36354750; PMCID: PMC9765498.

LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis

Hwang SM*, Ha YJ*, Koo GB, Noh HJ, Lee AY, Kim BJ, Hong SM, Morgan MJ, Eyun SI, Lee D, Roe JS, Lee Y, Kim YS. Adv Sci. 2022 Nov;9(32): e2204522. doi: 10.1002/advs.202204522. Epub 2022 Sep 25. PubMed PMID: 36161785 (*Co-first authors)

Signaling networks controlling ID and E protein activity in T cell differentiation and function

Hwang SM, Im SH, Rudra D. Front Immunol. 2022 Aug 2; 13:964581. doi: 10.3389/fimmu. 2022.964581. eCollection 2022. PMID: 35983065

Tumor-derived Lysophosphatidic Acid Blunts Protective Type-I Interferon Responses in Ovarian Cancer

Chae CS, Sandoval TA, Hwang SM, Park ES, Giovanelli P, Awasthi D, Salvagno C, Emmanuelli A, Tan C, Chaudhary V, Casado J, Kossenkov AV, Song M, Barrat FJ, Holcomb K, Romero-Sandoval EA, Zamarin D, Pepin D, D'Andrea AD, Farkkila A, Cubillos-Ruiz JR. Cancer Discov. 2022 May 12:candisc.1181.2021. doi: 10.1158/2159-8290. CD-21-1181. Epub ahead of print. PMID: 35552618

NAMPT mitigates colitis susceptibility by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

Hong SM, Lee AY, Hwang SM, Ha YJ, Kim MJ, Min S, Hwang W, Yoon G, Kwon SM, Woo HG, Kim HH, Jeong WI, Shen HM, Im SH, Lee D, Kim YS. Redox Biol. 2022 Apr;50:102237. doi: 10.1016/j.redox.2022.102237. Epub 2022 Jan 15. PMID: 35063804

RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment

Park HH, Kim HR, Park SY, Hwang SM, Hong SM, Park S, Kang HC, Morgan MJ, Cha JH, Lee D, Roe JS, Kim YS. Mol Cancer. 2021 Aug 21;20(1):107. doi: 10.1186/s12943-021-01399-3. PMID: 34419074

HnRNP K supports the maintenance of RORγ circadian rhythm through ERK signaling

Kwon PK, Kim HM, Kang B, Kim SW, Hwang SM, Im SH, Roh TY, Kim KT. FASEB J. 2021 Apr;35(4):e21507. doi:10.1096/fj.202002076R. PMID: 33724572

Harnessing the bioresponsive adhesion of immuno-bioglue for enhanced local immune checkpoint blockade therapy

Joo KI*, Jeong Y*, Hwang SM*, Shin M, Lee J, Sharma G, Lee H, Im SH, Cha HJ. Biomaterials. 2020 Dec; 263:120380. doi: 10.1016/j.biomaterials.2020.120380. Epub 2020 Sep 11. PMID: 32942128 (*Co-first authors)

The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus

Kim CJ, Lee CG, Jung JY, Ghosh A, Hasan SN, Hwang SM, Kang H, Lee C, Kim GC, Rudra D, Suh CH, Im SH. Immunity. 2018 Dec 18;49(6):1034-1048.e8. doi: 10.1016/j.immuni.2018.10.012. PMID: 30566881

Inflammation-induced Id2 promotes plasticity in regulatory T cells

Hwang SM, Sharma G, Verma R, Byun S, Rudra D, Im SH. Nat Commun. 2018 Nov 9;9(1):4736. doi: 10.1038/s41467-018-07254-2. PMID: 30413714

Targeted Inhibition of the NCOA1/STAT6 Protein–Protein Interaction

Lee Y, Yoon H, Hwang SM, Shin MK, Lee JH, Oh M, Im SH, Song J, Lim HS. J Am Chem Soc. 2017 Nov 15;139(45):16056-16059. doi: 10.1021/jacs.7b08972. Epub 2017 Nov 1. PMID: 29090910

NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease

Hwang JS, Kim GC, Park E, Kim JE, Chae CS, Hwang W, Lee C, Hwang SM, Wang HS, Jun CD, Rudra D, Im SH. J Immunol. 2015 Feb 15;194(4):1963-74. doi: 10.4049/jimmunol.1401862. Epub 2015 Jan 16. PMID: 25595785 

Link to the Complete List of Peer-reviewed Publications:

https://scholar.google.com/citations?user=ZPY9PQ0AAAAJ&hl=ko

PATENTS