AON Biodistribution

We offer a specialized service for quantifying antisense oligonucleotide (AON) levels in animal tissues using a hybridization-based ELISA technique. This method provides high sensitivity and specificity for detecting AON in complex biological samples, delivering reliable data essential for preclinical and experimental research. Our expertise is grounded in first-hand experience applying this technique in our own research, successfully evaluating AON distribution and pharmacokinetics in various mouse tissues. This foundation enables us to offer not only technical proficiency but also tailored insights into experimental design and data interpretation to meet the unique requirements of each project. This service is available to researchers, institutions, and companies investigating therapeutic oligonucleotides and other nucleic acid-targeted treatments. Outsourcing these determinations ensures faster turnaround times while maintaining the highest standards of quality, reproducibility, and precision. We welcome collaborations and invite inquiries from those interested in leveraging this service to enhance the translational impact of their work. Please contact us for further details.