Our laboratory is dedicated to developing single-molecule and single-cell detection platforms. Leveraging the experience accumulated over the years in single-molecule experiments, we aim to design corresponding systems to investigate the dynamic interactions between these functional proteins. By developing and constructing suitable DNA substrates and fluorescent modifications, and utilizing single-molecule detection techniques (including FRET, protein-induced fluorescence enhancement, and exonuclease-induced fluorescence quenching), we aim to obtain sufficiently clear information to explain the DNA repair process and deduce the corresponding reaction mechanisms. This will help us understand the cellular DNA protection mechanisms and provide an alternative detection method for studying the reaction characteristics of related proteins in future research. Additionally, our lab is focused on developing single-cell detection methods and investigating measurement techniques and pathological mechanisms related to neurodegenerative diseases.
Welcome to all interested colleagues!
Postdoctoral researchers, PhD students, and Master's students are all very welcome to join!
Contact information: bendyfan@imst.nsysu.edu.tw