Drug Development & Repurposing

Streptococcus pneumoniae has several virulence factors that contribute to the severity of the disease it causes. This project aims to develop drugs targeting multiple virulence factors as an antimicrobial treatment for pneumococcal infections. Unlike conventional antibiotics, which typically target a single pathway and are often susceptible to resistance, our approach focuses on inhibiting various bacterial virulence factors by repurposing drugs that are already approved for other infectious agents. We use computational methods to screen large chemical libraries and identify lead compounds for further validation through virulence inhibition assays.