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Extracellular vesicle-bound bacterial toxin pneumolysin triggers membrane engagement and damage beyond canonical pore formation
Aswathy C Sagilkumar, Avinashi Lal Kushwaha, Anuskha Shitut, Dheeraj Kumar Sarkar, Sruthika Sukumar, Jagannath Mondal, Karthik Subramanian
(under review- Journal of Extracellular vesicles)
biorxiv: https://www.biorxiv.org/content/10.64898/2026.03.09.710451v1
Sorafenib, a clinical kinase inhibitor attenuates Streptococcus pneumoniae pathogenesis and reduces disease progression in vivo
JOEL ABRAHAM, Aswathy SAGILKUMAR, Himani Dhyani, Charmi Panchal, Shaheena Aziz, Priyadatha K, Aan Ruth, Keerthana Bhaskaran, Sivakumar Chandrika, Shaima S, Rosemol Varghese, Ayyan Raj Neeravi, Balaji Veeraragavan, Nagarjun Narayanaswamy, Sandhya Ganesan, and Karthik Subramanian
in press - mBio
biorxiv: https://www.biorxiv.org/content/10.1101/2025.08.14.670243v1
Bacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
Saba Parveen, Chinmayi V. Bhat, Aswathy C. Sagilkumar, Shaheena Aziz, J. Arya, Asmita Dutta, Somit Dutta, Sautan Show, Kuldeep Sharma, Sumit Rakshit, John Bernet Johnson, Upendra Nongthomba, Anirban Banerjee, Karthik Subramanian
iScience, Volume 27, Issue No. 8, Aug. 2024, p. 110589, August 16, 2024
Deceiving the host: mechanisms of immune evasion and survival by pneumococcal bacteria
Karthik Subramanian and Anirban Banerjee
Frontiers in Cellular and Infection Microbiology, Volume 13, 19 June 2023
Emerging Roles of Extracellular Vesicles in Pneumococcal Infections: Immunomodulators to Potential Novel Vaccine Candidates
Saba Parveen and Karthik Subramanian
Frontiers in Cellular and Infection Microbiology, Volume 12, 14 February 2022
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