Publications - Full List

Publications 

* Co-first author;      # Senior author.

Contributions from members of the Hong lab are in bold. 

2025

#36. Yan L, Liu JJ, Hong L#.  Pharmacol Res. (2025) "Hv1 channel in immune cells and pharmacology."

#35. Cao X, Darbar F, Wu X, Zhang L, Darbar D#, Hong L#.  Am J Cardiovasc Dis. (2025) "A novel gain-of-function mutation SCN5A-N470K associated with an African American familial atrial fibrillation."

#34. Cao X, Yan L, Hong L#.  Biochem Biophys Rep. (2025) "Ion channel mutations and cancer."

2024

#33. Yan L,* Zhang L,* Ogunniyi K, Hong L#.  J Respir Biol Transl Med. (2024) "Ion channels in the immune response of asthma."

#32. Zhang L, Wu X, Hong L#.  Bioengineering. (2024) "Endothelial reprogramming in atherosclerosis."

#31. Zhang L, Wu X, Cao X, Rao K, Hong L#.  J Biol Chem. (2024) "Trp207 regulation of voltage dependent activation of human Hv1 proton channel."

2023

#30. Wu X, Singla S, Liu JJ, Hong L#.  Front Immunol. (2023) "The role of macrophage ion channels in the progression of atherosclerosis."

2022

#29. Wu X, Zhang L, Hong L#. iScience (2022) "The role of Phe150 in human voltage-gated proton channel." 

#28. Wu X, Li Y, Hong L#. Front Physiol. (2022) "Effects of mexiletine on a race-specific mutation in Nav1.5 associated with long QT syndrome." 

#27. Wu X, Li Y, Maienschein-Cline M, Feferman L, Wu L, Hong L#. Front Cell Dev Biol. (2022) "RNA-Seq analyses reveal roles of the HVCN1 proton channel in cardiac pH homeostasis." 

#26. Ly OT, Chen H, Brown G, Hong L, Wang X, Han Y, Pavel MA, Sridhar A, Maienschein-Cline M, Chalazan B, Ong SG, Abdelhady K, Massad M, Rizkallah LE, Rehman J, Khetani S, Darbar D. JCI Insight. (2022) "Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model." 

2021

#25. Wu X, Hong L#. Int J Mol Sci. (2021) "Calmodulin interactions with voltage-gated sodium channels." 

#24. Zhao C, Hong L, Riahi S, Lim VT, Tobias DJ, Tombola F. J Gen Physiol. (2021) "A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain."

#23. Zhao C*, Hong L*, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. J Gen Physiol. (2021) "HIFs: New arginine mimic inhibitors of Hv1 channel with improved VSD-ligand interactions."

#22. Hong L#*, Zhang M*, Ly OT, Chen H, Sridhar A, Lambers E, Chalazan B, Youn SW, Maienschein-Cline M, Feferman L, Ong SG, Wu JC, Rehman J, Darbar D#. Stem Cell Reports. (2021) "Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation." 

#21. Tang M, Hong L, Li H, Chen W, Tai L, Minshall R, Huang W, Chen J. Am J Transl Res. (2021) "Stiffness of aortic arch and carotid arteries increases in ApoE-knockout mice with high-fat diet: evidence from echocardiography." 

Before 2021

#20. Hong L#, Zhang M, Sridhar A, Darbar D#. "Pathogenic mutations perturb calmodulin regulation of Nav1.8 channel." Biochem Biophys Res Commun. (2020)

#19. McCauley MD*, Hong L*, Sridhar A*, Menon A, Perike S, Zhang M, Bezerra, Yan J, Bonini MG, Ai X, Rehman J, Darbar D. "Ion channel and structural remodeling in obesity-mediated atrial fibrillation." Circ Arrhythm Electrophysiol. (2020)

#18. Geragotelis AD, Wood ML, Göddeke H, Hong L, Webster PD, Wong EK, Freites JA, Tombola F, Tobias DJ. "Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations." PNAS (2020)

#17. Ornelas-Loredo A, Kany S, Abraham V, Alzahrani Z, Darbar FA, Sridhar A, Ahmed M, Alamar I, Menon A, Zhang M, Chen Y, Hong L, Konda S, Darbar D. "Association Between Obesity-Mediated Atrial Fibrillation and Therapy With Sodium Channel Blocker Antiarrhythmic Drugs." JAMA Cardiol. (2020)

#16. Menon A, Hong L, Savio-Galimberti E, Sridhar A, Youn SW, Zhang M, Kor K, Blair M, Kupershmidt S, Darbar D. "Electrophysiologic and molecular mechanisms of a frameshift NPPA mutation linked with familial atrial fibrillation." J Mol Cell Cardiol. (2019)

#15. Liu J, Liu D, Liu JJ, Zhao C, Yao S#, Hong L#. "Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells." Int J Oncol. (2018)

#14. Argenziano M, Lambers E, Hong L, Sridhar A, Zhang M, Chalazan B, Menon A, Savio-Galimberti E, Wu JC, Rehman J, Darbar D. "Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes." Stem Cell Reports. (2018)

#13. Hong L. "Modeling atrial fibrillation with human iPSCs." Open Access J Cardiol. (2018)

#12. Hong L. "Stem cell therapy: An emerging treatment approach for atrial fibrillation." Ann Cardiol Vasc Med. (2017)

#11. Pathak MM, Tran T, Hong L, Joós B, Morris CE, Tombola F. "The Hv1 proton channel responds to mechanical stimuli." J Gen Physiol. (2016)

#10. Hong L, Tombola F. "Allostery: A lipid two-step." Nat Chem Biol. (2016)

#9. Hong L, Singh V, Wulff H, Tombola F. "Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling." Sci Rep. (2015)

#8. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. "Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1." PLoS One. (2014)

#7. Hong L, Kim I, Tombola F. "Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives." PNAS (2014)

Highlighted in: "In pursuit of an inhibitory drug for the proton channel." PNAS (2014)

#6. Hong L, Pathak MM, Kim I, Ta D, and Tombola F. "Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains." Neuron (2013)

Highlighted in: "Common principles of voltage-dependent gating in Hv and Kv channels." Neuron (2013)

#5. Alkhalil A, Hong L, Nguitragool W, Desai SA. "Voltage-dependent inactivation of the plasmodial surface anion channel via a cleavable cytoplasmic component." Biochim Biophys Acta. (2012)

#4. Hong L*, Xie ZZ*, Du YH, Tang YB, Tao J, Lv XF, Zhou JG, Guan YY. "Alteration of volume-regulated chloride channel during macrophage-derived foam cell formation in atherosclerosis." Atherosclerosis (2011)

#3. Liu J, Hong L, Zhong X, Chen J, Chen Y. "Effect of serum from acute myocardial infarction rat on rat bone marrow mesenchymal stem cells differentiation into cardiomyocytes." J Clin Rehabil Tissue Eng Res. (2009)

#2. Hong L, Wang G, Guan Y. "Involvement of volume-regulated Cl- current in myocardial hypertrophy." Chin Pharmacol Bull. (2007)

#1. Guan YY, Zhou JG, Zhang Z, Wang GL, Cai BX, Hong L, Qiu QY, He H. "Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells." Eur J Pharmacol. (2006)