Publications

2026

Functional trihydroxyl germanium moiety in THGP confers novel enzyme activity inhibition abilities while also attenuating intracellular effects against multidrug-resistant Acinetobacter baumannii.

Yamabe K, Arakawa Y, Shoji M, Miyamoto K, Tsuchiya T, Fujii S, Minoura K, Akeda Y, Tomono K, Fukunaga R, Onda M.

Metallomics 2026;18(1): mfg008.

2025

Dissecting stress-activated protein kinase (SAPK)-signaling pathways using multiplex gene knockout HeLa cells.

Ito C, Yamamoto M, Yokota N, Nakamura N, Shiomi M, Kizu M, Ichinose M, Fujii S, Fujii T, Fukunaga R.

J. Biol. Chem. 2025;301(12):110901.

2024

Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice.

Hernandez-Benitez R, Wang C, Shi L, Ouchi Y, Zhong C, Hishida T, Liao HK, Magill EA, Memczak S, Soligalla RD, Fresia C, Hatanaka F, Lamas V, Guillen I, Sahu S, Yamamoto M, Shao Y, Aguirre-Vazquez A, Nuñez Delicado E, Guillen P, Rodriguez Esteban C, Qu J, Reddy P, Horvath S, Liu GH, Magistretti P, Izpisua Belmonte JC.

Cell Rep. Med. 2024;5(3):101449.

One-Step Affinity Purification of Leucine-Rich α2-Glycoproteins from Snake Sera and Characterization of Their Phospholipase A2-Inhibitory Activities as β-Type Phospholipase A2 Inhibitors.

Shirai R, Shibata K, Fujii S, Fukunaga R, Inoue S.

Toxins 2024;16(3):126.

2023

Overlapping role of c-Jun N-terminal kinase (JNK) 1 and 2 in imidazole ketone erastin-induced ferroptosis.

Odongoo R, Gunarta IK, Erdenebaatar P, Suzuki R, Meguro-Horike M, Horike S, Endo Y, Fujii T, Fukunaga R, Yoshioka K

Gene Rep. 2023;33:101813.

The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming.

Sato S*, Hishida T*, Kinouchi K*, Hatanaka F, Li Y, Nguyen Q, Chen Y, Wang PH, Kessenbrock H, Li W, Izpisua Belmonte JC, Sassone-Corsi P. *Contributed eqally

Cell Rep. 2023;42(6):112590.

A simple, rapid, and efficient method for generating multigene-knockout culture cells by the CRISPR/Cas9 system.

Fujii T,  Inoue N, Nobeyama T, Inoue J, Ogasawara S, Otani Y, Fujii S, Ito C, Fukunaga R.

Genes Cells 2023;28(5):390-397.

Redundant roles of extra-cellular signal-regulated kinase (ERK) 1 and 2 in the G1-S transition and etoposide-induced G2/M checkpoint in HCT116 cells.

Erdenebaatar P, Gunarta IK, Suzuki R, Odongoo R, Fujii T, Fukunaga R, Kanemaki MT, Yoshioka K.

Drug Discov. Ther. 2023;17(1):10-17.

Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice.

Takahashi Y, Morales Valencia M, Yu Y, Ouchi Y, Takahashi K, Shokhirev MN, Lande K, Williams AE, Fresia C, Kurita M, Hishida T, Shojima K, Hatanaka F, Nuñez-Delicado E, Esteban CR, Izpisua Belmonte JC.

Cell 2023;186(4):715-731.

2022

Functional Analysis of a Juvenile Hormone Inducible Transcription Factor, Krüppel homolog 1, in the Bean Bug, Riptortus pedestris.

Dong L, Muramatsu N, Numata H, Ito C.

Zoolog. Sci. 2022;39(6):562-569. 

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing.

Yuan B, Zhou X, Suzuki K, Ramos-Mandujano G, Wang M, Tehseen M, Cortés-Medina LV, Moresco JJ, Dunn S, Hernandez-Benitez R, Hishida T, Kim NY, Andijani MM, Bi C, Ku M, Takahashi Y, Xu J, Qiu J, Huang L, Benner C, Aizawa E, Qu J, Liu GH, Li Z, Yi F, Ghosheh Y, Shao C, Shokhirev M, Comoli P, Frassoni F, Yates JR 3rd, Fu XD, Esteban CR, Hamdan S, Izpisua Belmonte JC, Li M.

Nat. Commun. 2022;13(1):3646. 

In vivo partial cellular reprogramming enhances liver plasticity and regeneration.

Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC.

Cell Rep. 2022;39(4):110730.

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium.

Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Takemoto Y, Hatanaka F, Yoshida K, Prieto J, Sahu SK, Takahashi Y, Reddy P, O'Keefe DD, Rodriguez Esteban C, Knoepfler PS, Nuñez Delicado E, Castells A, Campistol JM, Kato R, Nakagawa H, Izpisua Belmonte JC.

Front. Cell Dev. Biol. 2022;10:786031.

2021

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche.

Wang C, Rabadan Ros R, Martinez-Redondo P, Ma Z, Shi L, Xue Y, Guillen-Guillen I, Huang L, Hishida T, Liao HK, Nuñez Delicado E, Rodriguez Esteban C, Guillen-Garcia P, Reddy P, Izpisua Belmonte JC.

Nat. Commun. 2021;12(1):3094. 

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration.

Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Belmonte JCI, Guillen P, Chan P, Zhou Q, Zhang W, Qu J, Liu GH.

Cell Res. 2021;31(2):187-205. 

Regulation of Krüppel homolog 1 expression by photoperiod in the bean bug, Riptortus pedestris.

Dong L, Udaka H, Numata H, Ito C.

Physiol. Entomol, 2021;46: 82-93.

Presentations

2026

タバコ抽出液による細胞老化誘導効果の解析

山本健心, 柴田歩夢, 菱田友里子, 長田茂宏, 菱田友昭

日本薬学会第146年会(大阪), 2026年3月29日

ヒト肝がん由来細胞におけるヒストン脱アセチル化酵素HDAC9機能制御機構の解明

菊池宏佑, 菱田友昭, 長田茂宏

日本薬学会第146年会(大阪), 2026年3月29日

ES細胞におけるDNAトポイソメラーゼⅡの機能解析

西中悠希, 菱田友里子, 長田茂宏, 菱田友昭

日本薬学会第146年会(大阪), 2026年3月29日

デグロンシステムを用いたEMT誘導因子Snailの細胞増殖に及ぼす影響の検討

柴田歩夢, 山本健心, 菱田友里子, 長田茂宏, 菱田友昭

日本薬学会第146年会(大阪), 2026年3月28日

Nanogはp16陽性細胞のiPSCリプログラミングを促進する

服部 妃莉, 木村 文乃, 菱田 友里子, 中野 泰博, 長田 茂宏, 城村 由和, 菱田 友昭

日本薬学会第146年会(大阪), 2026年3月27日