Publications
Submitted
Kosuke Mizuno, Tsuyoshi Hirashima*, Satoshi Toda*
Robust tissue pattern formation by coupling morphogen signal and cell adhesion.
Chaoyu Fu, Florian Dilasser, Zhao-Zhen Lin, Marc Karnat, Aditya Arora, Harini Rajendiran, Hui Ting Ong , Nai Mui Hoon Brenda, Sound Wai Phow , Tsuyoshi Hirashima, Michael P Sheetz, Jean-Francois Rupprecht, Sham Tlili, Virgile Viasnoff*
E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and collective migration modes
2024
Tsuyoshi Hirashima* and Michiyuki Matsuda
ERK-mediated Curvature Feedback Regulates Branching Morphogenesis in Lung Epithelial Tissue.
Current Biology, 34, 4, pp. 683-696, doi.org/10.1016/j.cub.2023.12.049, 2024.
[Preprint Highlight in MBoC] [KyotoU news (in Japanese)] [BPoD] [PNAS Front Matter] [EurekAlert!@AAAS]
2023
Ankita Nitin Nayak and Tsuyoshi Hirashima*
Tug-of-War via ERK Signaling Pathway for Tissue Organization – ERK Activation to Force Generation.
Current Opinion in Cell Biology, doi: 10.1016/j.ceb.2023.102249, 2023.
Veronica Lee Xi Min, Barry T. Hinton, Tsuyoshi Hirashima*
Collective Cell Dynamics and Luminal Fluid Flow in the Epididymis: A Mechanobiological Perspective.
Andrology, doi: 10.1111/andr.13490, 2023.
Daniel Boocock, Tsuyoshi Hirashima, Edouard Hannezo*
Interplay between mechanochemical patterning and glassy dynamics in cellular monolayers.
PRX Life, 1, 013001, doi: 10.1103/PRXLife.1.013001, 2023.
Akihito Kira, Ichiko Tatsutomi†, Keisuke Saito†, Machiko Murata†, Izumi Hattori, Haruna Kajita, Naoko Muraki, Yukako Oda, Saya Satoh, Yuta Tsukamoto, Seisuke Kimura, Kenta Onoue, Shigenobu Yonemura, Satoko Arakawa, Hiroki Kato, Tsuyoshi Hirashima*, and Kohki Kawane*
Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion.
Developmental Cell, 58, 14, pp.1282-1298, doi: 10.1016/j.devcel.2023.05.008, 2023.
Tsuyoshi Hirashima*, Naoya Hino, Kazuhiro Aoki*, Michiyuki Matsuda
Stretching the Limits of ERK Signaling – Cell Mechanosensing to ERK Activation.
Current Opinion in Cell Biology, doi: 10.1016/j.ceb.2023.102217, 2023.
Hiroaki Hirata*, Naotaka Nakazawa, Tsuyoshi Hirashima, Andrea Ravasio
Editorial: Multicellularity: Views from Cellular Signaling and Mechanics [Research Topic]
Frontiers in Cell and Developmental Biology, 11, doi: 10.3389/fcell.2023.1172921, 2023.
2022
Chii Jou Chan* and Tsuyoshi Hirashima*
Tissue hydraulics in reproduction (Review).
Seminars in Cell and Developmental Biology, doi: 10.1016/j.semcdb.2022.05.008, 2022.
Yuta Kanazawa, Takuya Omotehara*, Hiroki Nakata, Tsuyoshi Hirashima, Masahiro Itoh
Three-dimensional analysis and in vivo imaging for sperm release and transport in the murine seminiferous tubule.
Reproduction, 164, pp9-18, doi: 10.1530/REP-21-0400, 2022.
Tsuyoshi Hirashima*
Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development (Review) .
Biochemical Journal, 479, pp129-143, doi: 10.1042/BCJ20210557, 2022.
Tsuyoshi Hirashima*
Mechanical feedback control for multicellular tissue size maintenance: a minireview.
Frontiers in Cell and Developmental Biology, 9, doi: 10.3389/fcell.2021.820391, 2022.
Hiroshi Ichise, Shoko Tsukamoto, Tsuyoshi Hirashima, Yoshinobu Konishi, Choji Oki, Shinya Tsukiji, Satoshi Iwano, Atsushi Miyawaki, Kenta Sumiyama, Kenta Terai, Michiyuki Matsuda*
Functional Visualization of NK Cell-mediated Killing of Metastatic Single Tumor Cells.
eLife, e76269, doi: 10.7554/eLife.76269, 2022.
Keisho Hirota*, Tsuyoshi Hirashima, Kazuki Horikawa, Akihiro Yasoda, Michiyuki Matsuda
C-type natriuretic peptide-induced PKA activation promotes endochondral bone formation in hypertrophic chondrocytes.
Endocrinology, vol. 163, bqac005, doi: 10.1210/endocr/bqac005, 2022.
Naoya Hino*, Kimiya Matsuda, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Kunio Matsumoto, Kazuhiro Aoki, Kenta Terai, Tsuyoshi Hirashima, Xavier Trepat, Michiyuki Matsuda*
A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.
Developmental Cell, doi: 10.1016/j.devcel.2022.09.003, 2022.
Kota Fujimoto, Daiki Hashimoto, Kenichi Kashimada, Shinji Kumegawa, Yuko Ueda, Taiju Hyuga, Tsuyoshi Hirashima, Norimitsu Inoue, Kentaro Suzuki, Isao Hara, Shinichi Asamura and Gen Yamada*
A visualization system for erectile vascular-dynamics.
Frontiers in Cell and Developmental Biology, doi: 10.3389/fcell.2022.1000342, 2022.
2021
Mamoru Ishii, Tomoko Tateya, Michiyuki Matsuda, Tsuyoshi Hirashima*
Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlear duct.
Royal Society Open Science, 8:211024, doi: 10.1098/rsos.211024, 2021.
Mamoru Ishii, Tomoko Tateya, Michiyuki Matsuda, Tsuyoshi Hirashima*
Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis.
eLife, 10:e61092, doi: 10.7554/eLife.61092, 2021.
Daiki Hashimoto, Tsuyoshi Hirashima*, Hisao Yamamura, Tomoya Kataoka, Kota Fujimoto, Taiju Hyuga, Atsushi Yoshiki, Kazunori Kimura, Shunsuke Kuroki, Makoto Tachibana, Kentaro Suzuki, Nobuhiko Yamamoto, Takehiko Sasaki, Gen Yamada*.
Dynamic erectile responses of a novel penile organ model utilizing two-photon excitation microscopy.
Biology of Reproduction, 104, 4, pp875-886, doi: 10.1093/biolre/ioab011, 2021.
Shinji Kumegawa, Gen Yamada*, Daiki Hashimoto, Tsuyoshi Hirashima, Mizuki Kajimoto, Kyoichi Isono, Kota Fujimoto, Kentaro Suzuki, Masatsugu Ema, Shinichi Asamura
Development of surgical and visualization procedures to analyze vasculatures by mouse tail edema model.
Biological Procedures Online, doi: 10.1186/s12575-021-00159-3, 2021.
Daniel Boocock#, Naoya Hino#, Natalia Ruzickova, Tsuyoshi Hirashima*, Edouard Hannezo*
Theory of mechano-chemical patterning and optimal migration in cell monolayers.
Nature Physics, 17, pp267–274, doi: 10.1038/s41567-020-01037-7, 2021.
#equally contributed
2020
Naoya Hino, Leone Rossetti, Ariadna Marín-Llauradó, Kazuhiro Aoki, Xavier Trepat, Michiyuki Matsuda*, Tsuyoshi Hirashima*
ERK-mediated mechanochemical waves direct collective cell polarization.
Developmental Cell, 53, 6, pp646-660, doi: 10.1016/j.devcel.2020.05.011, 2020.
[EurekAlert!][KyotoU News (in Japanese)][Faculty Opinions]
Takuya Yoshida, Michiyuki Matsuda, Tsuyoshi Hirashima*
Incoherent feedforward regulation via Sox9 and ERK underpins mouse tracheal cartilage development.
Frontiers in Cell and Developmental Biology, doi: 10.3389/fcell.2020.585640, 2020.
[Editor's Pick 2021: Highlights in Signaling]
Tsuyoshi Hirashima*
Mechanical tissue compression and whole-mount imaging at single cell resolution for developing murine epididymal tubules.
Bio-protocol, doi: 10.21769/BioProtoc.3694, 2020.
Ryo Okabe, Toyofumi F Chen-Yoshikawa, Akihiko Yoshizawa, Tsuyoshi Hirashima, Masao Saito, Hiroshi Date, Takanori Takebe*
Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice.
Eur J Cardiothorac Surg, 58, 3, pp638-645, doi: 10.1093/ejcts/ezaa091, 2020.
2019
Tsuyoshi Hirashima* and Taiji Adachi
Polarized Cellular Mechanoresponse System for Maintaining Radial Size in Developing Epithelial Tubes.
Development, 146:dev181206, doi: 10.1242/dev.181206, 2019.
Tomoko Tateya*, Susumu Sakamoto, Fumiyoshi Ishidate, Tsuyoshi Hirashima, Itaru Imayoshi, and Ryoichiro Kageyama*
Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea.
Development, 146:dev.177881, doi: 10.1242/dev.177881, 2019.
-2018
Anneliis Ihermann-Hella, Tsuyoshi Hirashima, Jussi Kupari, Kristen Kurtzeborn, Hao Li, Hyuk Nam Kwon, Cristina Cebrian, Abdul Soofi, Arvydas Dapkunas, Ilkka Miinalainen, Gregory R. Dressler, Michiyuki Matsuda, and Satu Kuure*
Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation.
Stem Cell Reports, 11, pp912-928, 2018.
Tsuyoshi Hirashima*, Miho Hoshuyama, and Taiji Adachi
In vitro tubulogenesis of Madin-Darby canine kidney (MDCK) spheroids occurs depending on constituent cell number and scaffold gel concentration.
Journal of Theoretical Biology, 435, pp110-115, 2017.
Tsuyoshi Hirashima*, Elisabeth G. Rens, and Roeland M.H. Merks
Cellular Potts Modeling of Complex Multicellular Behaviors in Tissue Morphogenesis (Review).
Development, Growth & Differentiation, 59, pp329-339, 2017.
Tsuyoshi Hirashima*
Mathematical Study on Robust Tissue Pattern Formation in Growing Epididymal Tubule.
Journal of Theoretical Biology, 407, pp71-80, 2016.
Tsuyoshi Hirashima* and Taiji Adachi
Procedures for the Quantification of Whole-Tissue Immunofluorescence Images Obtained at Single-Cell Resolution During Murine Tubular Organ Development.
PLOS ONE, 10(8): e0135343, 2015.
Tsuyoshi Hirashima*
Pattern Formation of an Epithelial Tubule by Mechanical Instability during Epididymal Development.
Cell Reports, 9, pp866-873, 2014.
Tsuyoshi Hirashima*, Yoichiroh Hosokawa, Takanori Iino, Masaharu Nagayama*
On Fundamental Cellular Processes for Emergence of Collective Epithelial Movement.
Biology Open, 2, pp660-666, 2013.
Tsuyoshi Hirashima*
Cellular Potts Model on Collective Cell Movement.
RIMS Kôkyûroku, 1853, pp49-55, 2013.
Yoshiki Koizumi, Yoh Iwasa, Tsuyoshi Hirashima*
Mathematical Study of the Role of Delta/Notch Lateral Inhibition during Primary Branching of Drosophila Trachea Development.
Biophysical Journal, 103, pp2549-2559, 2012.
Tsuyoshi Hirashima*
A Kinetic Model of ERK Cyclic Pathway on Substrate Control.
Mathematical Biosciences, 239, pp207-212, 2012.
Tsuyoshi Hirashima*, Yoh Iwasa, Yoshihiro Morishita
Mechanisms for Split Localization of Fgf10 Expression in Early Lung Development.
Developmental Dynamics, 238, pp2813-2822, 2009.
Tsuyoshi Hirashima*, Yoh Iwasa, Yoshihiro Morishita
Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development.
Journal of Theoretical Biology, 259, pp58-66, 2009.
Tsuyoshi Hirashima, Yoh Iwasa, Yoshihiro Morishita*
Distance between AER and ZPA is defined by feed-forward loop and is stabilized by their feedback loop in vertebrate limb bud.
Bulletin of Mathematical Biology, 70, pp438-459, 2008.