In 1910 the Augustinian Sisters took over the administration, incorporated the school, and on October 9, 1910, inaugurated it as the Colegio de la Sagrada Familia. Upon the request of the Archbishop of Manila, the administration of the school passed on into the hands of the Benedictine Sisters in 1922. Four German Sisters implemented all the requirements of the elementary course, changed the school’s name to Holy Family Academy and managed the school for the parish. 

In 1965, Sister Concepcion Pellosa, OSB, the first Filipino superior of Holy Family Academy, with the encouragement and support of Msgr. Serafin Ocampo, introduced series of constructions within the campus. In 1967 the four-story St. Mary Building rose as did the four-story St. Benedict with the auditorium. The fifth floor of St. Benedict Building and the two storey Home Economics Building were added during the time of Sister Winifrieda Bugayong, OSB (1971-1977). The arrival of Sister Simeona Ricalde, OSB on May 19, 1977 paved the way to the construction of the left wing of St. Mary’s while its right wing was built when Sister Mary Bernard Lansang, OSB (1980-1985) was the school directress. The construction of these buildings was financed by bank loans which the school amortized from year-end savings. 

In the year 2002, the school commemorated the 80th year of service and presence of the Benedictine Sisters at HFA. 

The anticipated 100th year of HFA foundation in 2006 was planned with memorable and laudable projects. With the pioneering efforts of S. Vicenta L. Anuran, OSB and the support of the Centennial Steering Committee, parents and alumni, the following projects were realized: the purchase of about 1.8 hectares of land which is now the site of HFA’s Centennial Housing benefited its employees and some parents of its clientele; the Centennial Peace Camp in January 2006; the Centennial Employees’ Day; the Catechism Teaching in Madapdap;l the Flores de Mayo; the Centennial Tree Planting; the week-long Grand Centennial Celebration which stated with a Motorcade and Calesa Ride, followed by a Grand Alumni Homecoming, Centennial Rides, Cultural Presentation, Lights and Sounds and Archives Viewing, Thanksgiving Mass, an Evening of Kampampangan Melodies; Blessing of the Centennial Housing Site and the ARTI STA. RITA Concert.