Heinsbroek JA, Giannotti G, Bonilla J, Olson DE, Peters J (2023) Tabernanthalog reduces motivation for heroin and alcohol in a polydrug use model. Psychedelic Med 1(2):111-119. Pubmed
Soares-Cunha C, Heinsbroek JA (2023) Ventral pallidal regulation of motivated behaviors and reinforcement. Front Neural Circuits 17:1086053. Pubmed
Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM (2022) CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology 225:109400. Pubmed
Giannotti G*, Mottarlini F*, Heinsbroek JA, Mandel MR, James MH, Peters J (2022) Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias choice during relapse. Transl Psychiatry, 12(1):432. (* Equal contribution) Pubmed
Heinsbroek JA, Giannotti G, Mandel MR, Josey M, Aston-Jones G, James MH, and Peters J (2021) A common limiter circuit for opioid choice and relapse identified in a rodent addiction model. Nature Communications 12(1):4788. Pubmed
Gong S, Fayette N, Heinsbroek JA, Ford CP (2021) Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron 109(21):3421-3435. Pubmed
Giannotti G, Gong S, Fayette N, Heinsbroek JA, Orfila J, Herson PS, Ford CP, Peters J (2021) Extinction blunts paraventricular thalamic contributions to relapse. Cell Reports 36(8):109605. Pubmed
Nall RW, Heinsbroek JA, Nentwig TB, Kalivas PW, Bobadilla A-C (2020) Circuit Specificity in Drug versus Natural Reward Seeking Behaviors. Journal of Neurochemistry 157(5):1450-1472. Pubmed
Bobadilla A-C, Dereschewitz E, Vaccaro L, Heinsbroek JA, Scofield MD, Kalivas PW (2020) Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core. Molecular Psychiatry, 25(12):3150-3163. Pubmed
Heinsbroek JA, De Vries TJ, Peters J (2020) Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction. Cold Spring Harbor Perspectives in Medicine, 11(3):a039602. Pubmed
Heinsbroek JA, Bobadilla AC, Dereschewitz E, Assali A, Chalhoub RM, Cowan CW, Kalivas PW (2020) Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum. Cell Reports, 30(6):2018-2027. Pubmed
Pardo-Garcia TR, Garcia-Keller C, Penaloza T, Richie CT, Pickel J, Hope BT, Harvey BK, Kalivas PW*, Heinsbroek JA* (2019) Ventral pallidum is the primary target for accumbens D1 projections driving cocaine seeking. Journal of Neuroscience 39(11):2041-2051. (* Corresponding author). Pubmed
Giannotti G, Heinsbroek JA, Yue A, Deisseroth K, Peters J (2019) Prefrontal cortex neuronal ensembles encoding fear drive fear expression during long-term memory retrieval. Scientific Reports 9:10709. Pubmed
Roberts-Wolfe DJ, Heinsbroek JA, Spencer S, Bobadilla AC, Smith ACW, Kalivas PW (2019) Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking. Addiction Biology 25(3):e12759. Pubmed
Roberts-Wolfe DJ*, Bobadilla AC*, Heinsbroek JA, Neuhofer D, and Kalivas PW (2018) Drug refraining and seeking potentiate synapses on distinct populations of accumbens medium spiny neurons. Journal of Neuroscience, 38(32):7100-7107 Pubmed
Bobadilla AC, Garcia-Keller C, Chareunsouk V, Hyde J, Medina-Camacho D, Heinsbroek JA, Kalivas PW (2018) Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking. Addiction Biology 24(5):860-873 Pubmed
Heinsbroek JA, Furbish AB, Peters J (2018) A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse. Neuropsychopharmacology 43(7):1492-1497. Pubmed
Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes B, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Self DW, Kalivas PW, Lin Y, Cowan CW (2017) HDAC5 and its target gene, NPAS4, regulate cocaine-conditioned behavior in the nucleus accumbens. Neuron 96(1):130-144. Pubmed
Bobadilla AC, Heinsbroek JA, Gipson CD, Griffin WC, Fowler CD, Kenny PJ, Kalivas PW (2017) Corticostriatal plasticity, neuronal ensembles and regulation of drug-seeking behavior. Progress in Brain Research 234:93-112. Pubmed
Bobadilla AC, Garcia-Keller C, Heinsbroek JA, Scofield MD, Chareunsouk V, Monforton C, Kalivas PW (2017) Accumbens Mechanisms for Cued Sucrose Seeking. Neuropsychopharmacology 42(12):2377-2386. Pubmed
Spencer S, Garcia-Keller C, Roberts-Wolfe D, Heinsbroek JA, Mulvaney M, Sorrell A, Kalivas PW (2017) Cocaine use reverses striatal plasticity produced during cocaine seeking. Biological Psychiatry 81(7):616-624. Pubmed
Smith AC*, Scofield MD*, Heinsbroek JA*, Gipson CD*, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC 3rd, Boger HA, Kalivas PW (2017) Accumbens nNOS interneurons regulate cocaine relapse. Journal of Neuroscience 37(4):742-756 (* equal contribution). Pubmed
Heinsbroek JA*, Neuhofer DN*, Griffin WC 3rd, Siegel GS, Bobadilla AC, Kupchik YM, Kalivas PW (2017) Loss of plasticity in the D2-Accumbens pallidal pathway promotes cocaine seeking. Journal of Neuroscience 37(4):757-767. (* Equal contribution). Pubmed
Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW (2016) The nucleus accumbens: Mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacological Reviews 68(3):816-71. Pubmed
Garcia-Keller C, Kupchik YM, Gipson CD, Brown RM, Spencer S, Bollati F, Esparza MA, Roberts-Wolfe DJ, Heinsbroek JA, Bobadilla AC, Cancela LM and Kalivas PW (2016) Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Molecular Psychiatry 21(8):1063-9. Pubmed
Kupchik YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ and Kalivas PW (2015) Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nature Neuroscience 18(9):1230-1232. Pubmed
Peters J, Scofield MD, Ghee SM, Heinsbroek JA and Reichel CM (2015) Perirhinal cortex mGlu5 receptor activation reduces relapse to methamphetamine seeking by restoring novelty salience. Neuropsychopharmacology 41(6):1477-85. Pubmed
Van den Oever MC, Rotaru DC, Heinsbroek JA, Gouwenberg Y, Deisseroth K, Stuber GD, Mansvelder HD, Smit AB (2013) Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory. Journal of Neuroscience 33(46):18225-33. Pubmed