Job adv.

• https://www.esrf.fr/Jobs

• https://esrf.gestmax.eu/1570/1/postdoc-id16b/en_US

• PhD positions available for electron crystallography at Stockholm University.

• https://jobs.bnl.gov/job/upton/postdoctoral-research-associate-for-x-ray-pair-distribution-function-analysis/3437/11900994096

• Solid State Scientist, Research & Development

• PhD and Post doc positions at the University of Crete

• We are looking for an Industrial Service Scientist to join the macromolecular crystallography (MX) team at the Swiss Light Source.

Your new role

You share knowledge to help industrial customers make the most of our beamlines and crystallization facilities. You prepare samples for structural analysis, collect X-ray diffraction data, and handle data from processing to interpretation. Collaborating with facility staff, you contribute to ongoing projects, such as Fast Fragment and Compound Screening, and new automated solutions for MX beamlines. At conferences and workshops, you promote our MX industry services.

This job is for you if

• You are enthusiastic about supporting our Macromolecular Crystallography Group with your PhD knowledge and know-how in X-ray crystallography and structural biology.

• You have handled X-ray diffraction data collection at a Synchrotron facility in a past role.

• You love creating and handling service initiatives in an interdisciplinary environment.

• You feel comfortable presenting, explaining, and discussing MX services in English.

About Us

Join the largest research institute for natural and engineering sciences in Switzerland! At the Paul Scherrer Institute, people come together from across the globe to collaborate on ground-breaking research in different fields. Our mission: to find sustainable solutions to fundamental questions facing society, science, and the economy.

Company culture

People from multicultural backgrounds and as many as 60 nations work together at the PSI, enriching the local culture with a cosmopolitan way of life. One in four of our 2,100 staff are completing their vocational training, post-doctoral, or post-graduate studies. To foster professional and personal growth for all, we have created a diverse research environment that promotes inclusion and equal opportunities at all levels. These values inform our hiring process.

This is a 3-year project position with job sharing possibility. The closing date is 15^th May 2021. For further details, please contact Katherine McAuley (katherine.mcauley@psi.ch) or for more information and to apply, please visit https://www.psi.ch/en/pa/job-opportunities/44764-industrial-service-scientist-mx.

• The European Institute of Oncology IEO of Milan (Italy) invites applications for a Head of the Biochemistry and Structural Biology Unit. We are looking for a structural biologist to support researchers of the IEO Department of Experimental Oncology in the area of protein production, biochemical characterisation, and structure determination by X-ray crystallography and Cryo-EM. For more information about the job and the institute, please see https://www.research.ieo.it/careers-and-jobs/other-job-opportunities/head-of-the-biochemistry-and-structural-biology-unit/

and feel free to contact me directly. Applications should be sent to bsu-search@ieo.it

• Post-doctoral Fellow (m/f) in crystallography at SNBL’s BM01

Context & Job description The Swiss Norwegian Beam Lines at the European Synchrotron Radiation facility (SNBL at ESRF) provide scientists from both Norway and Switzerland with access to synchrotron radiation on two beamlines BM01 and BM31. SNBL operates around the clock state-of-the-art, custom-designed instrumentation for x-ray scattering and absorption experiments. The successful candidate will complement a group of scientists operating the beam lines. Within this team, the candidate will participate in the operation of SNBL’s crystallography and material science diffraction station BM01. The beamline performs a variety of diffraction experiments with single crystals, powders, and thin films, as a function of temperature, pressure, external fields, including in-situ and operando conditions. Your mission includes: Supporting visiting user teams as a local contact Develop his/her own research program Contribute to the continuous technical upgrades and development of the beamline in collaboration with other staff members Expected profile: PhD in chemistry, or physics, or materials science Experience in crystallography, powder diffraction. Experience with big data analytics and interest in application and development of big data tools for diffraction is a strong asset. Interest in instrumental (operando and in-situ) hardware development Experience with other experimental diffraction techniques, such as single crystal diffraction and diffuse scattering is an asset. Ability to interact with multi-disciplinary staff and facility users Good time management skills and ability to prioritize Proficiency in English (working language at the ESRF) Post-doctoral fellows will be employed for an eighteen-month period, renewable once and the contract should start soon as possible. The deadline for applications is 3 rd of May 2021. Contract type: Non-permanent contract (CDD). The working language of the ESRF is English. To apply for the position, send an application including curriculum vitae and publication list, and arrange for at least two letters of recommendation to be sent to Dr. Wouter van Beek SNBL / ESRF, 71, avenue des Martyrs CS 40220, 38043 Grenoble France (E-mail: wouter@esrf.fr. Website: www.snbl.eu).

• Dear colleagues, I would like to inform you that EMBL Hamburg Unit is currently advertising for a Beamline Scientist position in Small Angle Scattering. Detailed information can be obtained under the following link: https://s.embl.org/HH00196 Closing date is 2nd February 2021

• Στα πλαίσια εγκεκριμένου προγράμματος ΕΛ.ΙΔ.Ε.Κ. (για την ενίσχυση Μελών ΔΕΠ και Ερευνητών/τριών), δίνεται η δυνατότητα εκπόνησης μεταδιδακτορικής εργασίας στο πεδίο της Βιοχημείας και της Δομικής Βιολογίας.

ΘΕΜΑ: «Παραγωγή και Δομικός χαρακτηρισμός πρωτεϊνών φαρμακευτικού ενδιαφέροντος μέσω

νέο-αναπτυσσόμενων μεθοδολογιών.»

Οι ενδιαφερόμενοι καλούνται να υποβάλουν αίτηση έως τις 27/01/2021 στην διεύθυνση

• To start on February 1st 2021 as a permanent assignment, we are looking for an experienced small molecule crystallographer, with knowledge of X-ray devices, synchrotron facilities and with a passion for promoting the electron diffractometer in the fields of science and industry. Last year, Dr. Gustavo Santiso-Quinones, Dr. Gunther Steinfeld, Dr. Eric Hovestreydt and Nils Gebhardt founded the start-up company ELDICO Scientific. ELDICO stands for the Electron Diffraction Company.It emerged from a ground-breaking scientific publication on electron diffraction, which was nominated as Breakthrough of the Year by SCIENCE magazine in 2018. Electron diffraction and the electron diffractometer constitute a disruptive technology that will fundamentally change the way research is conducted at the nano-crystalline level. This will have a major impact in science as well as in the pharmaceutical, agrochemical, chemical and advanced materials industries.

Download job description

Dr. Eric Hovestreydt

Founder / CEO

Director of Sales

hovestreydt@eldico.ch

+49 (173) 7000 615

• Post available at start up company, details are provided.

• Στα πλαίσια εγκεκριμένου προγράμματος ΕΛ.ΙΔ.Ε.Κ. (για την ενίσχυση Μελών ΔΕΠ και Ερευνητών/τριών), δίνεται η δυνατότητα εκπόνησης Διδακτορικού στο πεδίο της Βιοχημείας και της Δομικής Βιολογίας με υποτροφία.

ΘΕΜΑ: «Παραγωγή και Δομικός χαρακτηρισμός πρωτεϊνών φαρμακευτικού ενδιαφέροντος μέσω νέο-αναπτυσσόμενων μεθοδολογιών.»

Οι ενδιαφερόμενοι καλούνται να υποβάλουν επιστολή εκδήλωσης ενδιαφέροντος στη διεύθυνση imargiola@upatras.gr. Οι αιτήσεις θα πρέπει να αποσταλούν με την ένδειξη: «Εκδήλωση ενδιαφέροντος στο πλαίσιο του προγράμματος CrystDRUG.».

• One postdoctoral and one PhD student position are available at the laboratory of Biological Chemistry, School of Medicine, University of Patras, Greece to work on a GSRT (General Secretariat for Research and Technology) funded project. We are looking for highly motivated, researchers to investigate molecular mechanisms regulating signal transduction responses of T lymphocytes. Applicants should have a strong background in lymphocyte biology (requirement for the postdoctoral position) and experience in molecular and cell biology laboratory techniques (requirement for both the PhD and postdoctoral positions). They must be independent thinkers with strong communication, team working and problemsolving skills and adaptability to changes in scientific directions. For informal inquiries please contact Konstantina Nika at knika@upatras.gr. To apply, please send a cover letter stating the candidate’s scientific background and expertise, a CV, and contact details of two referees to the above-mentioned email address.

• Please find below our entire list of vacancies.

For your information, you can find a full description of vacancies at the ESRF on our web site: http://www.esrf.fr/Jobs.

New vacancies at the ESRF are:

- Ref. 2152 - Beamline Scientist

- Ref. 2020-DASD - Director of the ESRF Accelerator and Source Division (ASD)

- Ref. PACR03 - Post-doctoral position in the Radio Frequency group

- Ref. PACR02 - Post-doctoral position in the Beam Dynamics group

- Ref. PACR01 - Post-doctoral position in the Diagnostics group

- Ref. 8199 - Optical Engineer

- Ref. 8523 - Mechanical/Instrumentation Technician

- Ref. 1516 - Radiation Protection Technician

- Ref. LINUX_ENG - LINUX Systems Administrator Engineer

- Ref. 9120 - IT Group Leader

- Ref. 8506 - Electronics Technician

- Ref. PDID/EBS/SoM - Postdoctoral Fellows in the Structure of Materials Group

- Ref. PDID/EBS/MEx - Postdoctoral Fellows in the Matter at Extremes Group

- Ref. PDID/EBS/SB - Postdoctoral Fellows in the Structural Biology Group

- Ref. PDID/EBS/CBS - Postdoctoral Fellows in the Complex Systems and Biomedical Sciences Group

- Ref. PDID/EBS/EMD - Postdoctoral Fellows in the Electronic Structure, Magnetism and Dynamics Group

- Ref. PDID/EBS/SPEC - Postdoctoral Researchers in the field of X-ray spectroscopy

- Ref. PDID/EBS/XNP - Post-doctoral Fellows in the X-Ray Nanoprobe Group

- Ref. 8188b - Mechanical Engineer

- Ref. 8565 - Detector Technician

- Ref. 1105 - Internal Auditor

- Ref. 9527 - Network Technician

- Ref. 8558 - Mechanical Draftsperson

- Ref. COD/PaNOSC-SYSADM - Linux System Administrator Engineer

Should you have any questions, please do not hesitate to contact the Recruitment Unit at recruitment@esrf.fr

• The European Synchrotron ESRF in Grenoble, France, will resume its activities this year after a complete machine upgrade, which will bring exciting new possibilities of experiments, in particular in time-resolved serial synchrotron crystallography (SSX). The Structural Biology Group is currently building a beamline dedicated to SSX planned to perform time-resolved experiments with a microsecond time resolution. In order to prepare these experiments, we are developing an offline setup to perform microsecond time-resolved UV-vis absorption spectroscopy experiments on protein crystals. This time-resolved setup is part of the in crystallo optical spectroscopy (icOS) Lab, (formerly known as the Cryobench , http://www.esrf.eu/home/UsersAndScience/Experiments/MX/icOS.html ), which provides various optical spectroscopic techniques (UV-vis absorption, fluorescence, Raman) that can be applied to proteins in the crystalline or solution state, before, during, or after an X-Ray diffraction experiment. We are looking for a postdoc interested in contributing to the development of the TR-icOS setup and to associated scientific projects coupling time-resolved optical spectroscopy and X-ray crystallography. The successful candidate should have strong expertise in at least one of the following topics: optical spectroscopy, instrumentation, X-ray crystallography. For further information, please email Antoine Royant, responsible of the icOS Lab (antoine.royant@esrf.fr) or Daniele de Sanctis, responsible of the SSX beamline ID29 (daniele.de_sanctis@esrf.fr).

• ΥΠΟΤΡΟΦΙΑ ΓΙΑ ΕΚΠΟΝΗΣΗ ΔΙΔΑΚΤΟΡΙΚΗΣ ΔΙΑΤΡΙΒΗΣ Μία (1) θέση υποψηφίου διδάκτορα που θα απασχοληθεί στο ΙΗΔΛ-ΙΤΕ μέσω υποτροφίας ερευνητή-μεταπτυχιακού φοιτητή στο πλαίσιο υλοποίησης της Πράξης «Εθνική Υποδομή Νανοτεχνολογίας, Προηγμένων Υλικών και Μικρο-/ Νανοηλεκτρονικής (INNOVATION-EL)» (ΟΠΣ 5002772). Περαιτέρω λεπτομέρειες: https://www.iesl.forth.gr/en/about/job-positions/201916670. ΘΕΜΑ: «Ανάπτυξη και μελέτη δισδιάστατων υλικών μεταβατικών μετάλλων για ενεργειακές εφαρμογές» Δυνατότητα εκπόνησης Διδακτορικού στο πεδίο της Φυσικής Υλικών, με ενδιαφέρον σε τεχνολογίες για την εξοικονόμηση ενέργειας και τη βελτίωση της ενεργειακής αποδοτικότητας. Ο/Η υποψήφιος Διδάκτωρ θα μελετήσει χαμηλοδιάστατα υλικά με ισχυρές αλληλεπιδράσεις, οι οποίες εκφραζόμενες μέσω των διαφορετικών βαθμών ελευθερίας των ηλεκτρονίων (φορτίο και σπιν), σταθεροποιούν νέες καταστάσεις της συμπυκνωμένης ύλης (π.χ. κβαντικά υγρά σπιν). Θα εκπαιδευτείτε, αφενός σε μεθόδους παρασκευής υλικών (π.χ. καινοτόμα υβριδικά χαλκογονιδία μεταβατικών μετάλλων), και αφ’ ετέρου σε τεχνικές χαρακτηρισμού των περίπλοκων φυσικών ιδιοτήτων των φάσεων αυτών. Θα εφαρμόσετε προηγμένα διαγνωστικά εργαλεία για την ανίχνευση της δομής και δυναμικής των υλικών σε ευρεία περιοχή χωρο-χρονικών διαστάσεων. Ερμηνεύοντας τα πειραματικά σας αποτελέσματα, θα κατανοήσετε την επίδραση της τοπολογίας του κρυσταλλικού πλέγματος στην εκμετάλλευση ανταγωνιστικών φυσικών ιδιοτήτων (όπως ο μαγνητισμός και η υπεραγωγιμότητα), με σκοπό την αξιοποίηση αυτών σε τεχνολογίες αιχμής, π.χ. ηλεκτρικοί κινητήρες υψηλής απόδοσης, μνήμες μεγάλης πυκνότητας εγγραφής δεδομένων, τρένα μαγνητικής αιώρησης maglev, κ.α.). Ο/Η υποψήφιος θα έχει την ευκαιρία να διευρύνει την επιστημονική του/της γνώση μέσω υφιστάμενων συνεργασιών με Ακαδημαϊκά Ιδρύματα εντός και εκτός της Ελλάδας. Για περισσότερες πληροφορίες μπορείτε να απευθυνθείτε στον Δρ. Αλέξανδρο Λάππα. Ε-mail: lappas@iesl.forth.gr, Lab: http://funl.iesl.forth.gr, ΤΗΛ: 2810-391344 ή 391300. ΑΠΑΡΑΙΤΗΤΑ ΠΡΟΣΟΝΤΑ • Πτυχίο Σχολής Θετικών Επιστημών (π.χ. Φυσικής/ Χημείας/ Επιστήμης Υλικών κ.α.) ή συναφών ειδικοτήτων Πολυτεχνικής Σχολής. • Μεταπτυχιακός Τίτλος (MSc) σε σχετικό πεδίο. • Άριστη γνώση της Αγγλικής γλώσσας. ΑΙΤΗΣΗ Οι ενδιαφερόμενοι καλούνται να υποβάλουν τις αιτήσεις τους ηλεκτρονικά, μέχρι την 25 Νοεμβρίου 2019, στη διεύθυνση hr@iesl.forth.gr, και στον Επιστημονικό Υπεύθυνο (Ε.Υ.), Δρ. Α. Λάππα με τα εξής δικαιολογητικά: (α) βιογραφικό σημείωμα, (β) επιστολή που περιγράφει τα επιστημονικά τους ενδιαφέροντα, (γ) μεταπτυχιακό τίτλο σπουδών (MSc), (δ) αναλυτικές βαθμολογίες, (ε) δύο συστατικές επιστολές - θα σταλούν απευθείας από συνεργάτες σας στον Ε.Υ.. ΕΝΑΡΞΗ: 1 Ιανουαρίου 2020. ΔΙΑΡΚΕΙΑ: 12 μήνες. Η σύμβαση δύναται να ανανεώνεται. ΥΠΟΤΡΟΦΙΑ: 750 ΕΥΡΩ/ μήνα.

• New Job opening at Demokritos, https://drive.google.com/open?id=1b3kc_LVtyotS3AQ9JtESxaOVLZYdCIkX

• Just as a reminder, we recruiting a Beamline Scientist (permanent position) on PROXIMA 2A at Synchrotron SOLEIL, which would be an excellent opportunity for a suitably motivated scientist.

Please refer to the link below for more information:

https://www.synchrotron-soleil.fr/en/job-offers/scientist-proxima-2a-beamline-mf

William SHEPARD

PROXIMA 2A

Synchrotron SOLEIL

Gif-sur-Yvette

France

• https://job-search.astrazeneca.com/job/cambridge/3-year-phd-fellowship-innovative-training-network-bonepainii/7684/10739446?utm_source=jobalert&utm_medium=email&utm_campaign=GlobalTB_jobalert&utm_content=R-044100&ss=paid

• To EKEΦΕ «Δημόκριτος» προκηρύσσει τις εξής θέσεις 1)Μία θέση Μεταδιδακτορικού Επιστημονικού Συνεργάτη 2)Δύο θέσεις Επιστημονικών Συνεργατών για την εκπόνηση διδακτορικής διατριβής Οι υποψήφιοι θα εργαστούν για το Ευρωπαϊκό Πρόγραμμα Σύντηξης (https://www.eurofusion.org/) με σύμβαση εργασίας ορισμένου χρόνου. Η σύμβαση δύναται να έχει διάρκεια τουλάχιστον τριών (3) ετών. Το Ερευνητικό έργο που καλείται να εκτελέσει ο Επιστημονικός Συνεργάτης περιλαμβάνει πειραματική εργασία στο ΕΚΕΦΕ «Δ» και σε Ευρωπαϊκά Ερευνητικά Κέντρα η οποία αναφέρεται στη μελέτη της επίδρασης ακτινοβολίας ιόντων και νετρονίων στις ιδιότητες των υλικών με εφαρμογή στην παραγωγή ενέργειας μέσω σύντηξης. Προκήρυξη θέσης http://www.demokritos.gr/jobs/015-2019-570/ Προθεσμία υποβολής αιτήσεων: 28 Μαρτίου 2019 Πληροφορίες: Κ. Μεργιά, kmergia@ipta.demokritos.gr, τηλ.: 210-6503706

• Two doctoral student positions are available in the EU HORIZON 2020 MSC‐ITN project RNAct on:

Integrative structural biology and biophysics to analyze and design

RNA interactions of RNA‐Recognition Motif (RRM) proteins

Thesis supervisor: Prof. Dr. Michael Sattler, Helmholtz Zentrum München / Technical University of Munich

Starting date: Between March and December 2019

Duration: 36 months

ESR5 project: RRM structure and design for synthetic biology and bio‐analytics applications

This project will design RRM proteins with novel RNA binding properties and develop small molecules to

modulate RNA binding activity. The design will be confirmed using experimental structural biology. The

modulation of RNA binding by small molecules will be experimentally assessed by combining state‐of‐the‐

art solution NMR and biophysical techniques (ITC, FP, SPR). The project is in collaboration with

computational groups of the ITN for the design of RRM variants and for experimental validation in cellular

assays.

ESR6 project: Conformational dynamics and RNA binding specificity of RRMs using integrative structural

biology and biophysics

This project will characterize the dynamics and RNA recognition of RRMs using a combination of advanced

solution NMR (relaxation measurements to characterize internal dynamics from nanosecond to

millisecond timescales) and biophysical techniques (ITC, FP, SPR). These experiments will identify the role

of specific residues and dynamic features in RRM proteins for RNA binding specificity and identify key

residues and molecular features involved. In close collaboration with computational groups of the ITN,

RRM variants that modulate RNA recognition will be designed and experimentally verified.

• ΥΠΟΤΡΟΦΙΑ ΓΙΑ ΕΚΠΟΝΗΣΗ ΔΙΔΑΚΤΟΡΙΚΗΣ ΔΙΑΤΡΙΒΗΣ ΣΤΙΣ ΦΥΣΙΚΕΣ ΕΠΙΣΤΗΜΕΣ Μία (1) θέση έκτακτου προσωπικού που θα απασχοληθεί στο ΙΗΔΛ-ΙΤΕ μέσω υποτροφίας ερευνητή/μεταπτυχιακού φοιτητή στο πλαίσιο του προγράμματος ΚΡΗΠΙΣ, με τίτλο «Υλικά και Διεργασίες για Ενεργειακές και Περιβαλλοντικές Εφαρμογές (ΑΕΝΑΟ)» (ΟΠΣ 5002556). Λεπτομέρειες στην ιστοσελίδα: http://www.iesl.forth.gr/downloads/projects/pdf/1182.pdf. ΘΕΜΑ Δισδιάστατα υλικά ενώσεων μεταβατικών μετάλλων για εξοικονόμηση ενέργειας. ΠΕΡΙΓΡΑΦΗ ΘΕΣΗΣ Η εξοικονόμηση ενέργειας και βελτίωση της ενεργειακής αποδοτικότητας, όπως για παράδειγμα στα δίκτυα μεταφοράς ρεύματος, βασίζεται στην ανάπτυξη νέων τεχνολογιών (π.χ. ηλιακές κυψελίδες, υπεραγώγιμα καλώδια, κινητήρες υψηλής απόδοσης κ.α.). Αυτές απαιτούν την κατανόηση εξωτικών καταστάσεων της ύλης, στις οποίες αναδύονται και γίνονται εμφανείς οι κβαντικές ιδιότητες των ατόμων. Τέτοια ασυνήθιστη συμπεριφορά εκδηλώνεται στους υπεραγωγούς, υλικά τα οποία αφήνουν το ηλεκτρικό ρεύμα να περνά με πρακτικά μηδενική αντίσταση. Το ερευνητικό πεδίο της διδακτορικής διατριβής αφορά στην κατανόηση της φυσικής νέων δισδιάστατων κρυσταλλικών ενώσεων (π.χ. αλογονίδια ή χαλκογονίδια) μεταβατικών μετάλλων για εφαρμογές χαμηλής ή μηδενικής κατανάλωσης ενέργειας. Για το σκοπό αυτό ο υποψήφιος διδάκτωρ θα εστιάσει στη δημιουργία καινοτόμων φυσικών υβριδικών υλικών που εκμεταλλεύονται τις «διεπαφές» μεταξύ μαγνητικών/ μεταλλικών / μοριακών νανομετρικών στρωμάτων. Θα εκπαιδευτείτε σε καινοτόμες πειραματικές μεθόδους (π.χ. σκέδαση ακτίνων-Χ και νετρονίων, μαγνητομετρία SQUID κλπ) ώστε να διευρύνετε την επιστημονική σας γνώση μέσω της μελέτης της δομής και δυναμικής των υλικών αυτών. Τα πειραματικά στοιχεία θα οδηγήσουν στην κατανόηση θεμελιωδών αρχών που απορρέουν από τη σύζευξη σπιν-φορτίου-πλέγματος, ρυθμίζουν το μυστήριο της υπεραγωγιμότητας, και μπορούν να οδηγήσουν σε αξιοποιήσιμες τεχνολογίες. Για περισσότερες πληροφορίες μπορείτε να απευθύνεστε στον Δρ. Αλέξανδρο Λάππα, «Εργαστήριο Λειτουργικών Νανοκρυστάλλων & Κβαντικού Μαγνητισμού», ΙΗΔΛ-ΙΤΕ. Ε-mail: lappas@iesl.forth.gr, Lab: http://funl.iesl.forth.gr, ΤΗΛ: 2810-391344 ή 391300. ΑΠΑΡΑΙΤΗΤΑ ΠΡΟΣΟΝΤΑ • Πτυχίο Σχολής Θετικών (π.χ. Φυσικής/ Χημείας/ Επιστήμης Υλικών κ.α.) ή Τεχνολογικών Επιστημών/ Εφαρμογών (π.χ. Μηχανολογίας / Ηλεκτρολογίας κ.α.) ή συναφών ειδικοτήτων Πολυτεχνικής Σχολής. • Μεταπτυχιακός Τίτλος (MSc) σε σχετικό πεδίο. • Εμπειρία σε διασύνδεση ηλεκτρονικών συσκευών, διατάξεων και επιστημονικών οργάνων με Η/Υ σε πειραματικούς σταθμούς. • Άριστη γνώση της Αγγλικής γλώσσας. ΑΙΤΗΣΗ Οι ενδιαφερόμενοι καλούνται να υποβάλουν τις αιτήσεις τους ηλεκτρονικά, το αργότερο μέχρι την 7 Απριλίου 2019, στη διεύθυνση hr@iesl.forth.gr, και στον Επιστημονικό Υπεύθυνο (Ε.Υ.), Δρ. Αλ. Λάππα με τα εξής δικαιολογητικά: (α) βιογραφικό σημείωμα, (β) επιστολή που περιγράφει τα επιστημονικά σας ενδιαφέροντα, (γ) μεταπτυχιακό τίτλο σπουδών (MSc), (δ) αναλυτικές βαθμολογίες, (ε) δύο συστατικές επιστολές, οι οποίες θα σταλούν απευθείας από συνεργάτες σας στον Ε.Υ.. ΕΝΑΡΞΗ: 1 Μαϊου 2019 ΔΙΑΡΚΕΙΑ: 12 μήνες. Η σύμβαση δύνανται να ανανεωθεί.

• Πρόσκληση εκδήλωσης ενδιαφέροντος για 3 θέσεις Υποψηφίων Διδακτόρων

στo πλαίσιo χρηματοδοτούμενων ερευνητικών προγραμμάτων με ανταποδοτικές υποτροφίες

στο Πανεπιστήμιο Πατρών, Τμήμα Ιατρικής, Εργαστήριο Υγιεινής

Για τις θέσεις των υποψηφίων Διδακτόρων οι υποψήφιοι θα πρέπει να έχουν πτυχίο από τμήμα Βιολογίας, Μοριακής Βιολογίας, Γεωπονίας, ή άλλο συναφές και μεταπτυχιακό δίπλωμα ειδίκευσης, και πολύ καλή γνώση Αγγλικών.

Οι θέσεις είναι άμεσα διαθέσιμες και αφορούν ερευνητικά προγράμματα σε θέματα

1.Μοριακή Μικροβιολογία τροφίμων και νερών (2 θέσεις)

2. Αισθητήρες μικροβιολογικής ποιότητας νερών (1 θέση)

Παρακαλούνται οι ενδιαφερόμενοι να επικοινωνήσουν με τον κο Απόστολο Βανταράκη, Καθηγητή, avanta@upatras.gr

Απόστολος Βανταράκης

Καθηγητής

Εργ. Υγιεινής, Τμ. Ιατρικής

Παν/μιο Πατρών

e-mail: avanta@upatras.gr

Τηλ/Fax: 2610969875

Κιν. 6945336243

• PhD position at the Institute for Structural Biology, Grenoble, France

Development of ultrastable fluorescent proteins for quantitative super resolution microscopy at cryogenic temperature.

The recruited student will work in the Pixel team: http://www.ibs.fr/…/dynamics-and-kinetics-of-molecul…/pixel/

He/she will investigate the structural photophysics of fluorescent proteins used as markers in super-resolution microscopy in conditions of cryogenic temperature.

The ultimate goal will be to engineer a variant that efficiently photoactivates at such low temperature.

Candidates should have a strong background in biophysics and/or biochemistry. Preliminary experience in protein crystallography, molecular biology and/or advanced optical microscopy will be key advantages.

The project will start in September/October 2019 and is financed by the French "CEA" ("Thèse Phare"):

see http://www-instn.cea.fr/…/developpement-de-marqueurs-fluore…

Applications are now open. Please send a CV, a motivation letter and 2 reference letters to Dominique Bourgeois (dominique.bourgeois@ibs.fr).

--

Dominique BOURGEOIS

**************************************************************

Equipe PIXEL

Groupe DYNAMOP

Institut de Biologie Structurale J-P. Ebel

IBS

71 AVENUE DES MARTYRS

CS 10090

38044 GRENOBLE CEDEX 9

FRANCE

Tel: 33-(0)4 57 42 86 44 Fax: 33-(0)4 76 50 18 90

http://www.ibs.fr/…/dynamics-and-kinetics-of-molecul…/pixel/

• Postdoc: Layered Metal Chalcogenides (magnets and superconductors)

The Institute of Electronic Structure and Laser (IESL) of the Foundation for Research and Technology - Hellas (FORTH), in the frame of the project "Deciphering the workings of molecule intercalated iron chalcogenides" (DOMINION), funded under the Office of Naval Research (ONR) Global (ONR Announcement #N00014-17-S-B001), is seeking to recruit one (1) post-doctoral researcher.

Job Description

DOMINION provides an intimate engagement of syntheses and characterisation for a wide range of layered iron-based chalcogenide compounds. The successful post-doctoral candidate will focus on the fundamental physics and chemistry of inter-atomic interactions of solid-state iron-chalcogenide magnets and superconductors, made up of functional molecular components with nanoscale dimensions. For this, user-facility photon and neutron science US DOE labs, with their advanced analytical instrumentation, optimized for high -flux/ -resolution/ -data throughput, unavailable anywhere else in the world, will be utilized to generate key insights on how (structural and electronic / magnetic) correlations at the atomic level of matter are built and influence the superconducting electrons to pair-up. Knowledge of physical crystallography, including diffraction experiments and data analysis strategies, will be highly valuable for the proposed research endeavors.

Required Qualifications & Application Submission

In order to be considered for the post, the application must include the particulars defined in the original announcement at the links shown below:

IESL-FORTH website

http://www.iesl.forth.gr/downloads/projects/pdf/1165.pdf

or

EURAXESS website

https://euraxess.ec.europa.eu/jobs/369638

Applications received before 1st March 2019 will receive immediate attention. However, applications will be reviewed thereafter until the position is filled.

• Dear all, I have an opening for a postdoctoral researcher in my group at the Department of Cell and Molecular Biology, Uppsala University. The project aims to study the structure and function of metal-responsive transcription factors. The successful candidate should have an excellent track record and experience in X-ray crystallography as well as protein expression and purification. Experience of complementary techniques in biochemistry and biophysics would be a benefit. For more information about the position and how to apply please see:

http://uu.se/en/about-uu/join-us/details/?positionId=199363

You are welcome to contact me for more information, but please note that you have to apply through the university system. Applications sent directly to me cannot be processed.

Dr. Julia Griese, Assistant Professor

Department of Cell and Molecular Biology

Uppsala University, Sweden

email: julia.griese@icm.uu.se

phone: +46-(0)18-471 4043

• Παρακαλώ όπως προωθήσετε την προκήρυξη στα ανάλογα Τμήματα & Γραμματείες προς ενημέρωση των ενδιαφερομένων.

Δέκα (10) υποτροφίες για εκπόνηση διδακτορικής διατριβής από κοινού στο ΕΚΕΦΕ "Δημόκριτος" και σε Πανεπιστήμια των ΗΠΑ και του Καναδά.

Έρευνα στους τομείς της Τεχνητής Νοημοσύνης, της Ρομποτικής, της Μηχανικής Μάθησης, των Big Data και της Βιοπληροφορικής.

Το Ινστιτούτο Πληροφορικής και Τηλεπικοινωνιών (ΙΠ&Τ) του ΕΚΕΦΕ «Δημόκριτος», προσκαλεί τους ενδιαφερόμενους να υποβάλλουν αίτηση για τη χορήγηση υποτροφίας με στόχο την εκπόνηση Διδακτορικής διατριβής, στο πλαίσιο του προγράμματος εκπαιδευτικής και ερευνητικής συνεργασίας του ΙΠ&Τ με τα ακόλουθα Πανεπιστήμια:

• Rice University

• University of Texas at Arlington

• Houston University

• Dalhousie University

Περισσότερες πληροφορίες για τις θέσεις μπορείτε να βρείτε εδώ: https://www.iit.demokritos.gr/el/news/scholarships2019

Καταληκτική ημερομηνία υποβολής αιτήσεων: 3/12/2018

Πληροφορίες

Γραμματεία SKEL: Δ. Κατσαμώρη (gram_skel@iit.demokritos.gr)

Τηλ.: 210 6503204

• We would like to inform you that there is an official opening for a faculty position in Biochemistry at the rank of Assistant Professor (it is announced by the Greek Appela system, and in the official government news post, FEK, underlined in yellow colour; see attached documents). Some of you may remember receiving email message of mine (at the end of December 2017), preannouncing this event.

Expressing the strong desire of the faculty members of the Biology Department for the selection of the best candidate for this position, we would very much appreciate your help to pass on this info to prospective candidates (having Greek citizenship), who possess high academic credentials for this position.

Most preferred would be those candidates with strong background in biochemistry (e.g. graduate studies leading to master, doctorate, and postdoc experience), and with training in the specified biochemistry subject areas, and for assuming teaching responsibilities, both officially described in the attached Appela document.

As the Appela document also points out, interested candidates can officially apply for this position (dead line July 1, 2018) through the Department of Biology (for more info: https://www.upatras.gr/en/node/22).

Best regards

Christos Georgiou & Irene Margiolaki

Department of Biology, Section of Genetics, Cell Biology and Development, University of Patras, GR-26500, Patras, Greece

• We have an opening for a highly motivated scientist in the Synchrotron Crystallography team at the EMBL Grenoble Outstation.

This team works in close collaboration with the ESRF Structural Biology Group in the operation and development of high performance structural biology beamlines with the aim of impacting on challenging structural biological problems. Towards this goal, as well as providing world leading experimental facilities, the EMBL-ESRF Joint Structural Biology Group also develops advanced instrumentation and data collection methods.

The successful candidate will contribute to the operation and development of methods for biological micro-crystallography on the ESRF beamlines ID23-2 and/or ID29. The recent upgrade of ID23-2 to a high intensity microfocus beam (~2 um in diameter), and installation of a high performance MD3-Up diffracometer represents an excellent opportunity to further develop techniques in biological micro-

crystallography. This position also allows the opportunity to contribute in the complete upgrade of ID29 to provide an extremely high intensity, tunable, and microfocus beamline for serial crystallography data collection. He/She is expected to actively participate in local and international initiatives aimed at the further development of synchrotron serial and micro-crystallography techniques required to maximise the scientific potential of ID23-2 and ID29 post ESRF Extremely Brilliant Source upgrade.

The successful candidate should have a PhD degree in Structural Biology or a related discipline and a minimum three years of post-doctoral experience in MX data collection and analyses. A practical knowledge, or an interest, in synchrotron beamline instrumentation and developing new methods for micro-crystallography at advanced light sources is essential. The candidate should be familiar with the latest MX software developments. Experience in computer programming would be advantageous.

The closing date for applications is the 31st of March and interviews are currently planned for the 15th of May.

For more information please see: https://www.embl.fr/jobs/searchjobs/index.php?ref=GR_00116

• International PhD Program in Integrative Structural Biology (ISB) www.phd-structural-biology.at invites applications for PhD studentships

The ISB Program offers a unique training and research network to study the structure and mechanism of complex macro-molecular systems involved in fundamental biological processes, including muscle development, lipid activated signal transduction, and protein-nucleic acids interactions.

The ISB Program integrates state-of-the-art structural, functional and computational biology approaches with an emphasis on the implementation of hybrid structural biology methods. We offer challenging, interdisciplinary PhD projects, an innovative research-based training and mentoring program and a supportive, collaborative research environment. The working language for research and teaching is English.

Highly motivated students with a strong interest in Structural and/or Computational Biology are welcome to apply. PhD applicants should have an academic degree equivalent to a Diploma or a Masters in Biochemistry, Biophysics, Chemistry, Computational Biology or related disciplines and should be able to communicate in English at an advanced level.

Interested candidates are invited to visit the home pages of the teams of the International PhD program in Integrative Structural Biology at: www.mfpl.ac.at/training/phd-opportunities/doctoral-program-structural-biology.html

Students will receive a monthly salary according to the scales of the Austrian Science Fund FWF. At present, this is 2000 € per month before deductions for tax, health insurance and pension contributions.

Apply at: http://www.mfpl.ac.at/training/phd-opportunities/how-to-apply.html (Deadline: 8^th March 2018).

--

Department of Structural and Computational Biology

Max F. Perutz Laboratories

University of Vienna

Vienna Biocenter (VBC), Campus Vienna Biocenter 5

A-1030 Vienna

Austria

e-mail: kristina.djinovic@univie.ac.at

• The Müller group at EMBL Heidelberg in collaboration with GlaxoSmithKline (GSK) seeks to recruit an outstanding postdoctoral fellow to explore the use of cryo-EM to study small-molecule ligand-bound structures of chromatin complexes. The successful candidate will apply recent cryo-EM methodological developments to study epigenetic targets; develop protocols that increase throughput and support lead optimization in drug discovery projects; acquire high resolution data sets of ligand-bound chromatin complexes and other epigenetic targets.

The successful candidate holds a Ph.D. in structural biology or biochemistry. The project is particularly suitable for a postdoctoral fellow with solid previous experience in cryo-EM who is interested in utilizing and further developing cryo-EM methodology for studying epigenetic targets and visualizing small molecule ligands in the drug discovery process. The position requires exceptional motivation and commitment, the ability to work independently as well as in a team and excellent technical, organizational and management skills. A contract of 2 years, with an optional 3rd year, will be offered to the successful candidate.

Closing date for applications is 20 January 2018. Please apply online through www.embl.org/jobs

Best wishes,

Christoph Müller

• We are looking for an enthusiastic methods developer to join the team here at Diamond developing integration methods for small molecule X-ray diffraction data:

http://www.diamond.ac.uk/Careers/Vacancies/All/132_17_CH.html

The focus of this work is the analysis of more challenging samples brought to our dedicated small molecule X-ray diffraction beamline I19. You will work closely with the DIALS team, and the post offers an opportunity to work on methods development at the boundary between academic research and a major scientific facility, where modern open source software development techniques are used.

For informal enquiries about this post please feel free to contact me on this email address.

For people interested in moving into data analysis but outside of X-ray crystallography, I also draw your attention to other data analysis and acquisition posts:

http://www.diamond.ac.uk/Careers/Vacancies.html

In particular:

http://www.diamond.ac.uk/Careers/Vacancies/All/136_17_CH.html

http://www.diamond.ac.uk/Careers/Vacancies/All/130_17_CH.html

http://www.diamond.ac.uk/Careers/Vacancies/All/129_17_CH.html

http://www.diamond.ac.uk/Careers/Vacancies/All/128_17_CH.html

http://www.diamond.ac.uk/Careers/Vacancies/All/048_17_CH.html

In all cases the application process is via http://www.diamond.ac.uk/Careers/Applicant-Information.html

• There is a vacancy for an X-Ray Laboratory Manager at the Institute for Structural and Molecular Biology at Birkbeck/UCL based at Birkbeck, University of London.

see https://tinyurl.com/y7jgfmr5

This is a permanent University Funded post. A brief description of the role is below and informal enquiries can be made to me (n.keep@mail.cryst.bbk.ac.uk). Closing date is the end of the 10th December 2017.

The Laboratory Manager role will ensure efficient day-to-day running of the X-ray Laboratory (including X-ray generators, detectors and crystallisation robots) for research staff and students in Biological Sciences, the ISMB and for external collaborators and hirers of the equipment; ensure that all safety procedures in the laboratory are implemented; provide training in use of equipment and to give general assistance in crystallography to students and research staff; keep abreast of new technologies and methodologies and assess and advise on the purchase of new equipment, software, and reagents.

The role holder will coordinate trips to synchrotrons and organise Beamline applications. The role holder will also contribute to teaching in the department through design, deliver and supervision of practicals, tutorials and projects in the general area of molecular biology and crystallography

--

Prof Nicholas H. Keep

Executive Dean of School of Science

Professor of Biomolecular Science

Crystallography, Institute for Structural and Molecular Biology,

Department of Biological Sciences

Birkbeck, University of London,

email n.keep@mail.cryst.bbk.ac.uk

• Υποτροφίες για την εκπόνηση διδακτορικής διατριβής στο ΙΠ&Τ του ΕΚΕΦΕ "Δημόκριτος" σε συνεργασία με Πανεπιστήμια των ΗΠΑ και του Καναδά

https://www.iit.demokritos.gr/news/2018_scholarships

Καταληκτική ημερομηνία υποβολής των αιτήσεων: 22/12/2017

Το Ινστιτούτο Πληροφορικής και Τηλεπικοινωνιών (ΙΠ&Τ) του ΕΚΕΦΕ «Δημόκριτος» (https://www.iit.demokritos.gr/), προσκαλεί τους ενδιαφερόμενους να υποβάλλουν αίτηση για τη χορήγηση υποτροφίας με στόχο την εκπόνηση διδακτορικής διατριβής, στο πλαίσιο του προγράμματος εκπαιδευτικής και ερευνητικής συνεργασίας του ΙΠ&Τ με τα ακόλουθα Πανεπιστήμια:

- Department of Computer Science at the Rice University (RICE), ΗΠΑ (http://compsci.rice.edu/)

- Department of Computer Science and Engineering at the University of Texas at Arlington (UTA), ΗΠΑ (http://cse.uta.edu/)

- Department of Computer Science at the University of Houston (UH), ΗΠΑ(http://www.cs.uh.edu/)

- Faculty of Computer Science at the Dalhousie University (DAL), Καναδάς (http://www.cs.dal.ca/)

Η εκδήλωση ενδιαφέροντος αφορά τη χορήγηση υποτροφιών στις ακόλουθες ερευνητικές περιοχές (σε παρένθεση το αντίστοιχο Πανεπιστήμιο):

- Robot motion planning (RICE)

- Biological interaction modelling and analysis (RICE)

- Robot motion signalling in joint action (UTA)

- Identification of argument elements and argument relations in natural language texts (UH)

- Content-based analysis of multimedia (UH)

- Translating latent features to actionable knowledge (UH)

- Multimodal analysis of biomedical texts (UH)

- Computationally-Driven Contact-Free Physiological Measurements (UH)

- Big data analysis for precision medicine (DAL)

Περιγραφές για το αντικείμενο των θέσεων μπορείτε να βρείτε στο

https://www.iit.demokritos.gr/news/9_phd_abroad_2018_descriptions

Κάθε υποτροφία είναι πλήρης, καλύπτοντας τα δίδακτρα για τα Πανεπιστήμια που αναφέρονται, καθώς και τα έξοδα διαβίωσης για την παραμονή των φοιτητών τόσο στο εξωτερικό όσο και την Ελλάδα. Η μέση διάρκεια σπουδών είναι 4-5 χρόνια, από τα οποία τουλάχιστον 1,5 έτος είναι στο ΕΚΕΦΕ Δημόκριτος.

Πληροφορίες για τα απαιτούμενα δικαιολογητικά και τη διαδικασία επιλογής, μπορείτε να βρείτε στο

https://www.iit.demokritos.gr/news/2018_scholarships

Εκεί θα βρείτε και το έντυπο αίτησης

https://www.iit.demokritos.gr/sites/default/files/aitese_prokeruxes_upotrophies_2017_2018.doc

Καταληκτική ημερομηνία υποβολής των αιτήσεων: 22/12/2017

• Πρόσκληση εκδήλωσης ενδιαφέροντος για θέσεις Υποψηφίων Διδακτόρων Υ/Δ και Μεταδιδακτορικών Ερευνητών (ΜΕ)

στα πλαίσια χρηματοδοτούμενων ερευνητικών προγραμμάτων.

Οι Υ/Δ θα πρέπει να έχουν πτυχίο από τμήμα Φαρμακευτικής, Χημικών Μηχανικών, Χημείας, Βιολογίας ή άλλο συναφές, και πολύ καλή γνώση Αγγλικών.

Οι υποψήφιοι ΜΕ θα πρέπει να έχουν διδακτορικό δίπλωμα από τμήμα Φαρμακευτικής, Χημικών Μηχανικών, Χημείας, Βιολογίας ή άλλο συναφές και πολύ καλή γνώση Αγγλικών, ενώ είναι επιθυμητή η εμπειρία σε αναλυτικές τεχνικές, τεχνικές παρασκευής και χαρακτηρισμού νανοσωματιδίων, τεχνικές μικροσκοπίας και καλλιέργειας κυττάρων.

Σχετικά με τα προγράμματα:

1] Στα πλαίδια του Εργου: Καινοτόμα ΣΥστήματα για ΣΤΟχευμένη και ελεγχόμενη χορήγηση ΦΑΡμάκων ή/και απεικονιστικών ουσιών θα γίνει ανάπτυξη καινοτόμων θεραπευτικών συστημάτων για θεραπεία ή/και διάγνωση ασθενειών, με την εφαρμογή της νανοτεχνολογίας και της συνδυαστικήςχρήσης προηγμένων βιοϋλικών και απεικονιστικών μεθόδων. Συνδυάζοντας δομικά συστατικά με αντικαρκινική δράση, με άλλα που αυξάνουν την διάρκεια κυκλοφορίας νανοσωματιδών στο αίμα, ΘΑ ΑΝΑΠΤΥΧΤΟΎΝ ΠΡΟΗΓΜΈΝΕΣ (ΝΑΝΟ)ΜΟΡΦΈΣ ΧΟΡΉΓΗΣΗΣ χημειοθεραπευτικών φαρμάκων. Στην επιφάνεια των ΝΣ, θα ακινητοποιηθούν μόρια-προσδέτες που θα επιλεγούν βάσει πρόσφατων δεδομένων σχετικά με τις οργανοτροπικές ιδιότητες εξωκυτταρικών κυστιδίων.

2] Στα πλαίσια του Έργου ΠΡΟΚΛΙΝΙΚΗ ΑΝΑΠΤΥΞΗ ΚΑΙΝΟΤΟΜΩΝ ΝΕΥΡΟΠΡΟΣΤΑΤΕΥΤΙΚΩΝ ΚΑΙ ΝΕΥΡΟΑΝΑΓΕΝΝΗΤΙΚΏΝ ΣΥΝΘΕΤΙΚΩΝ ΜΙΚΡΟΝΕΥΡΟΤΡΟΦΙΝΩΝ (ΜΝΤ) ΚΑΤΑ ΤΗΣ ΝΟΣΟΥ ALZHEIMER (ΑD), για την αποτελεσματικότερη στόχευση της νέας θεραπείας της AD, θα μελετηθεί η χρήση νανοσωματιδίων ως όχημα μεταφοράς τους στον εγκέφαλο, μέσω εγκλεισμού τους σε λιπιδικά νανοσφαιρίδια φέροντα προσδέτες με χημική συγγένεια για το β-αμυλοειδές. Θα μελετηθεί η φαρμακοκινητική /εντοπισμός στον εγκέφαλο μετά από χορήγηση των νανοσωματιδίων-ΜΝΤ (σε σύγκριση με τα ελευθερα μόρια), σε ζωικό μοντέλο 5xFAD της AD που θα προσδιορισθεί με χρωματογραφικές μεθόδους αιχμής.

Παρακαλούνται οι ενδιαφερόμενοι να επικοινωνήσουν με την Καθ. κ. Σοφία Αντιμησιάρη (santimis@hotmail.com; 2610-962332).

• Postdoctoral research position: molecular biologist/⁠bioinformatician

A 2-year Post-Doctoral position is available immediately in the Laboratory of Molecular Biology and Genomics in the Department of Biochemistry and Biotechnology of the University of Thessaly, located in the city of Larissa. The selected candidate will work in the framework of a national Research Infrastructure program on Synthetic Biology.

Research in the Laboratory of Molecular Biology and Genomics focuses on various aspects of insect olfaction, reproduction and evolution, aiming at the development of new approaches for control of insects of agricultural or medical importance. We are seeking a highly motivated and creative scientist with a track record of successful research. A good bioinformatics background is strongly desired. The ideal candidate should be able to analyze raw sequencing data, perform genome assembly and annotation and have a good understanding of comparative and functional genomics. At the same time, he/she should be able to design and perform experiments in support of the bioinformatics analyses.

Candidates should have a PhD and should have training in one or more of the following disciplines: bioinformatics, molecular biology, biochemistry, cell biology, and genome-wide technologies. Familiarity with insect rearing is desirable but not essential. Curriculum Vitae, a brief letter describing interests and prior experience and names of three references should be sent to: kmathiop@bio.uth.gr.

Research position: MSc Bioinformatician

A 2-year position for an MSc Bioinformatician is available immediately in the Laboratory of Molecular Biology and Genomics in the Department of Biochemistry and Biotechnology of the University of Thessaly, located in the city of Larissa. The selected candidate will work in the framework of a national Research Infrastructure program on Synthetic Biology.

Research in the Laboratory of Molecular Biology and Genomics focuses on various aspects of insect olfaction, reproduction and evolution, aiming at the development of new approaches for control of insects of agricultural or medical importance. We are seeking a highly motivated individual with a BSc in Biology or related science and an MSc in Bioinformatics. The successful candidate will be involved in raw sequencing data analysis, genome assembly and annotation and comparative and functional genomics studies. His/her research could also lead to a PhD. Curriculum Vitae, a brief letter describing interests and prior experience and names of three references should be sent to: kmathiop@bio.uth.gr.

• ASSISTANT OR ASSOCIATE PROFESSOR CRYO-ELECTRON MICROSCOPY The Department of Molecular and Cellular Biochemistry (MCB) at Indiana University (http://www.indiana.edu/~mcbdept) invites applications for a position beginning August 2018 at the rank the Assistant or Associate Professor. The search is for candidates in all areas of biochemistry who use cryo-electron microscopy as a primary tool. Indiana UniversityBloomington has immediate plans to purchase a Talos Arctica electron microscope with a Gatan K3 camera that will be part of our EM core which already includes a JEOL 3200 equipped with a DE64 direct electron detection camera. The successful candidate will be an affiliate with Indiana University’s emerging Center for Chemical Biology and Biotherapeutics (C2B2) organized under the Precision Health Initiative (PHI; https://grandchallenges.iu.edu/precisionhealth/index.html) in collaboration with the Indiana University School of Medicine. They will also be a trainer in our NIH funded Chemistry-Biology Interface (CBI) training program in Quantitative and Chemical Biology (http://www.chem.indiana.edu/qcb/). Successful candidates will be expected to develop or already have a visible, externally funded research program. Primary teaching assignments will involve undergraduate and graduate level biochemistry or related courses in the molecular life sciences. Interested candidates with a Ph.D. in biochemistry, chemistry or a related field with relevant postdoctoral experience should submit their application at: (https://indiana.peopleadmin.com/postings/4940). A completed application includes a curriculum vitae, a summary of future research plans. The applicant should also arrange the submission of four letters of recommendations addressed to Chair, Faculty Search Committee. Questions regarding the position or application process can be directed to: Suzanne Schwartz (mcbdept@indiana.edu). Applications received by December 15, 2017 will receive full consideration; later applicants will also be considered until the position is filled. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. All qualified applicants will receive consideration for employment without regard to age, ethnicity, color, race, religion, sex, sexual orientation or identity, national origin, disability status or protected veteran status. The College of Arts and Sciences is committed to building and supporting a diverse, inclusive, and equitable community of students and scholars.

• The Helmholtz Zentrum Berlin für Materialien und Energie, the Max-Delbrück-Center for Molecular Medicine, the Freie Universität Berlin and the Humboldt Universität zu Berlin jointly operate three experimental stations for bio-macromolecular crystallography at BESSY II, one of the world's most modern synchrotron radiation sources for VUV and soft X-rays.

(http://www.helmholtz-berlin.de/forschung/oe/em/soft-matter/forschung/bessy-mx/index_en.html)

The Max-Delbrück-Center is seeking a

Post Doctoral Research Assistant

to support a structure-based drug discovery project on various GTPase families (headed by Dr. Oliver Daumke). The successful candidate will also be involved in the operation of the BESSY II bio-macromolecular crystallography beamlines (headed by Dr. Manfred S. Weiss) and will take part in graduate student education.

Initially, a three-year contract will be offered to the successful candidate with the possibility for an extension. The salary will be based on German Federal TVöD. The position is available from March, 2018.

Applicants should hold a Ph.D. in the biological, chemical or physical sciences and have a background in bio-macromolecular crystallography, biochemistry or computational chemistry. The position also requires the documented ability to conduct independent research as well as excellent communication and interpersonal skills.

The MDC is an equal opportunity employer and supports gender equality.

Please send applications (CV, list of publications, .pdf-file format) in electronic form until 30.11.2017 to:

Dr. Manfred Weiss (msweiss@helmholtz-berlin.de) and

Dr. Oliver Daumke (oliver.daumke@mdc-berlin.de)

• We are currently recruiting students for a new Marie Sklodowska-Curie Joint Doctorate Program in simulation and data science.

Students either having a Master's degree or in their final year of a Master's degree program are eligible to apply.

We will greatly appreciate it if you could bring to the attention of postgraduate students or other of your colleagues these fellowships. You may use the suggested text below and the link directing to the flyer:

http://www.stimulate-ejd.eu/sites/default/files/stimulate_poster.png

With my best regards,

Constantia Alexandrou

The Cyprus Institute

The European Joint Doctorate Program in Simulation in multiscale physical and biological systems (STIMULATE) is accepting applications for the academic year 2018-2019.

STIMULATE offers 15 PhD Marie-Sklodwska Curie fellowships for cross-disciplinary research in Lattice QCD, Computational Biology, Computational Fluid Dynamics and Mathematical Modelling and Algorithms.

Applications are welcome from candidates worldwide with relevant scientific background and a keen interest in simulation and data science. A Master's degree or being in the final year of a Master's degree program is compulsory for applying. The selected fellows will be admitted at three European institutions of the STIMULATE consortium receiving a joint triple PhD degree upon successful completion of their program of studies.

The fellowships include an attractive remuneration package (about 4000 euro/month), including salary, mobility and family allowances.

Deadline for applications: 15th of December 2017

Expected starting date: September 2018

For further information on admissions, requirements and eligibility criteria please visit the STIMULATE website: www.stimulate-ejd.eu

or contact the STIMULATE Graduate office.

http://www.stimulate-ejd.eu/sites/default/files/stimulate_poster.png

Graduate office

STIMULATE EJD programme

20 Konstantinou Kavafi Street

2121 Aglantzia, Nicosia, Cyprus

Tel: +357 22 208 742

www.stimulate-ejd.eu

Email: graduate.office@stimulate-ejd.eu

• Dear colleagues,

My group is looking for a postdoc interested in doing subtomogram averaging on membrane proteins.

Naturejob post: https://www.nature.com/naturejobs/science/jobs/626553-postdoc-in-cryo-em-of-membrane-proteins-in-situ

Informal Inquiries are welcome.

Misha Kudryashev

Group Leader

Phone +49 (0) 69 6303 1700

Email: misha.kudryashev@biophys.mpg.de

http://www.biophys.mpg.de/en/kudryashev.html

• Σας ενημερώνουμε ότι, σύμφωνα με σχετική ανακοίνωση, στο πλαίσιο της υλοποίησης της Πράξης «ΛΟΙΜΩΔΗ, ΑΥΤΟΑΝΟΣΑ ΚΑΙ ΝΕΥΡΟΕΚΦΥΛΙΣΤΙΚΑ ΝΟΣΗΜΑΤΑ: ΜΕΛΕΤΗ ΠΑΘΟΓΕΝΕΤΙΚΩΝ ΜΗΧΑΝΙΣΜΩΝ ΚΑΙ ΑΝΑΠΤΥΞΗ ΔΙΑΓΝΩΣΤΙΚΩΝ, ΠΡΟΓΝΩΣΤΙΚΩΝ ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΩΝ ΠΡΟΣΕΓΓΙΣΕΩΝ» με κωδικό ΟΠΣ MIS 5002486, η οποία έχει ενταχθεί στη Δράση «Στρατηγική Ανάπτυξης Ερευνητικών και Τεχνολογικών Φορέων» του Ε.Π "Επιχειρηματικότητα Ανταγωνιστικότητα και Καινοτομία (ΕΠΑνΕΚ)", το Ελληνικό Ινστιτούτο Παστέρ προτίθεται να απασχολήσει έκτακτο προσωπικό και προσκαλεί φυσικά πρόσωπα να εκδηλώσουν το ενδιαφέρον τους για την ανάληψη των σχετικών έργων, σύμφωνα με τους όρους που αναφέρονται στη παρούσα πρόσκληση.

Συνεπώς, στο πλαίσιο της παρούσας Πρόσκλησης προκηρύσσονται Δέκα Οκτώ (18) θέσεις έκτακτου προσωπικού και ειδικότερα: εννέα (9) θέσεις Μεταδιδακτορικών Συνεργατών, τρείς (3) θέσεις Επιστημονικών Συνεργατών και έξι (6) θέσεις Υποψηφίων Διδακτόρων, που θα απασχοληθεί στο Ελληνικό Ινστιτούτο Παστέρ, μέσω σύναψης σύμβασης εργασίας ορισμένου χρόνου ή χορηγίας (υποτροφίας) στην οποία θα προσδιορίζεται η αποκλειστική απασχόληση στην Πράξη.

Οι ενδιαφερόμενοι καλούνται να υποβάλουν τις αιτήσεις τους και όλα τα απαραίτητα δικαιολογητικά εντός δεκαπέντε (15) ημερολογιακών ημερών από τη δημοσίευση της παρούσας πρόσκλησης, δηλαδή το αργότερο μέχρι την Τετάρτη, 25 Οκτωβρίου 2017 και ώρα 16:00, μέσω της ηλεκτρονικής διεύθυνσης: prosopiko@pasteur.gr και prosopiko.pasteur@gmail.com.

Οι αιτήσεις θα πρέπει να αποσταλούν με την ένδειξη: «Αίτηση στο πλαίσιο της Πρόσκλησης Εκδήλωσης Ενδιαφέροντος για την Πράξη με τίτλο «ΛΟΙΜΩΛΗ, ΑΥΤΟΑΝΟΣΑ ΚΑΙ ΝΕΥΡΟΕΚΦΥΛΙΣΤΙΚΑ ΝΟΣΗΜΑΤΑ: ΜΕΛΕΤΗ ΠΑΘΟΓΕΝΕΤΙΚΩΝ ΜΗΧΑΝΙΣΜΩΝ ΚΑΙ ΑΝΑΠΤΥΞΗ ΛΙΑΓΝΩΣΤΙΚΩΝ, ΠΡΟΓΝΩΣΤΙΚΩΝ ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΩΝ ΠΡΟΣΕΓΓΙΣΕΩΝ» και κωδικό ΜΙ8 5002486 για τη θέση με Αύξοντα Αριθμό (Α/Α) ... » (όπως αυτός αναφέρεται στον πίνακα του Παραρτήματος, αντιστοίχως).

• One post-doc position in the project DOMINION "Deciphering the workings of molecule intercalated iron chalcogenides" (Call: Long Range Broad Agency Announcement (BAA) for Navy and Marine Corps Science and Technology, ONR BAA Announcement #N00014-17-S-B001, Award No N62909-17-1-2126) http://www.iesl.forth.gr/downloads/projects/pdf/997.pdf

• The Duerfeldt Lab (http://www.duerfeldtlabs.com) in the Department of Chemistry & Biochemistry at the University of Oklahoma has an immediate opening for a highly-motivated postdoc trained in microbiology, molecular biology, and/or structural biology. The major research interest of the lab is to exploit bacterial enzyme/pathway activation as a strategy to diminish microbial fitness and/or pathogenicity. The ideal applicant should have an interest in determining the structure and function of specified proteins within pathogenic organisms to uncover the therapeutic potential of these targets. We are located on the same floor as the University of Oklahoma’s Structural Biology Center of Biomedical Research Excellence (COBRE) and as a COBRE affiliated lab, the Duerfeldt Group has prioritized access to all equipment, facilities, and expertise in the COBRE cores. More information about the cores can be found at the structuralbiology.ou.edu/. This represents a great opportunity for a postdoc trained in the aforementioned areas to contribute complementary expertise to the major research initiatives of the group, all while being immersed in a medicinal chemistry focused environment.To apply, please send a CV, research summary, and contact information for 3 references to adam.duerfeldt@ou.edu. Only complete applications will be reviewed.

• Προκήρυξη μιας (1) θέσης Ερευνητή Γ΄βαθμίδας

Το Ίδρυμα Τεχνολογίας και Έρευνας (ΙΤΕ) / Ινστιτούτο Επιστημών Χημικής Μηχανικής προκηρύσσει μία (1) θέση Ερευνητή Γ΄ βαθμίδας με γνωστικό αντικείμενο:

«Προηγμένες τεχνικές μελέτης και βελτίωσης περιβαλλοντικών συστημάτων».

Για περισσότερες πληροφορίες επισκεφθείτε το σύνδεσμο http://www.iceht.forth.gr/jobs/PROKIRIKSI%202_WEB.pdf

• Faculty of Science and Engineering at Abo Akademi University (Turku,

Finland) has currently 16 open PhD student positions for the period

1.1.2018-⁠31.12.2021:

https://abo.rekrytointi.com/paikat/?o=A_RJ&jgid=1&jid=22

I am looking for a PhD student candidate who would be eligible to

apply for a position at the Structural Bioinformatics Laboratory, Abo

Akademi University, Turku, Finland

(http://www.abo.fi/fakultet/biokemipersonal#document3;

http://www.abo.fi/fakultet/biokemisbl)

under my supervision in a structural biology and bioinformatics

project concerning development of anti-⁠inflammatory agents and

diagnostics tool for detecting inflammation.

The project is drafted in a research plan and includes

well-⁠established collaboration. The dead line for the application is

29.9.2017 and the candidate must receive MSc degree (or equivalent)

latest 29.9.2017. Therefore, the interested applicants should contact

me with a free format email and CV as soon as possible.

I would be grateful if you could bring this possibility to the

attention of any suitable candidates you may know.

Best regards, Tiina Salminen, PhD, Adjunct professor in structural biochemistry

Senior lecturer in structural biochemistry and bioinformatics

Structural Bioinformatics Laboratory

Biochemistry, Faculty of Science and Engineering

Abo Akademi University

Tykistökatu 6A

FIN-⁠20520 Turku

Finland +358-⁠405151201

• Dear Friends and Colleagues,

In the framework of recently obtained ERC grant, we are looking for 2 postdocs and 1 PhD student to investigate the lanthanide/actinide oxides nanomaterials by X-ray absorption/emission spectroscopy and electronic structure calculations. Each contract is for 3 years. I will very much appreciate if you can share that information with anyone who might be interested. Thank you in advance! With best wishes, Kristina

More information is here http://www.esrf.fr/Jobs/CRGJobs

http://www.esrf.fr/files/live/sites/www/files/Jobs/giant/ROBL_phd_student_a.pdf

http://www.esrf.fr/files/live/sites/www/files/Jobs/giant/ROBL_Postdoc1.pdf

http://www.esrf.fr/files/live/sites/www/files/Jobs/giant/ROBL_Postdoc2.pdf

=================================================================

BOUCHENOIRE Laurence

XMaS, The UK-CRG

ESRF - The European Synchrotron

• Αγαπητοί Συνάδελφοι,

Παρακαλώ ενημερώστε πιθανούς ενδιαφερόμενους για την προκήρυξη θέσης επιστημονικού συνεργάτη με σύμβαση εργασίας ορισμένου χρόνου όπως περιγράφεται στο συνημμένο αρχείο.

Dr Konstantina (Dina) Mergia

Research Director, National Centre for Scientific Research “Demokritos”

Institute for Nuclear and Radiological Science and Technology, Safety and Energy

Athens, Greece

Tel: +30 210 6503706

Email: kmergia@ipta.demokritos.gr

• Group Leader in Structural Biology at EMBL Grenoble, France

Application closing date: 8 October 2017.

Interviews are planned for December 2017.

A pdf of the advert is attached. Feel free to display it in your Institute.

The appointed Group Leader will be an ambitious structural or structural-cell biologist with an original research programme on structure-function relationships of macromolecular complexes in eukaryotic systems. He/she will benefit from the world-class environment offered by the inter-institutional Partnership for Structural Biology (EMBL, ESRF, ILL, IBS, http://www.psb-grenoble.fr) which provides access to state-of-the-art instrumentation including the recently upgraded ESRF synchrotron X-ray beamlines for MX and SAXS, cryo-EM (Polara/K2, Titan Krios/K2), high-field NMR (600-950 MHz spectrometers), the ILL neutron scattering beamlines and a biophysics platform. He/she will also have direct access to in-house bacterial, insect and mammalian cell expression facilities, confocal microscopy and high-throughput crystallization platforms for soluble and membrane proteins. We are particularly interested in candidates who will make use of local opportunities in advanced X-ray crystallography and cryo-EM and/or are interested in structural-cell biology e.g. cryo-electron tomography, super-resolution microscopy and correlative light and electron microscopy. Existing groups at EMBL Grenoble focus their research on protein-nucleic acid complexes involved in transcription, epigenetics, RNA metabolism, RNA virus replication and host-pathogen interactions.

Applicants should have a PhD, at least 3 years post-doctoral experience and a strong record of achievement in structural, molecular or cell biology. An initial contract of 5 years will be offered to the successful candidate. This is

foreseen to be extended to a maximum of 9 years, subject to an external review

Further information about this position can be obtained from the Head of EMBL Grenoble, Stephen Cusack (cusack@embl.fr).

Further information about research at EMBL Grenoble can be found at www.embl.org.

APPLICATION INSTRUCTIONS

Please apply online through www.embl.org/jobs and include a cover letter, CV and a concise description of research interests and future research plans. Please also arrange for 3 letters of recommendation to be emailed to: references@embl.de at the latest by 1 October 2017.

ADDITIONAL INFORMATION

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment.

The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family.

EMBL is committed to achieving gender balance and strongly encourages applications from all under-represented groups. Appointment will be based on merit alone. Further details on Group Leader appointments can be found under www.embl.org/gl_faq.

• Postdoctoral Fellowships in Structural Biology and Drug Development

Two postdoctoral positions (three years) are available in the Group of Structural Biology and Drug Development (Luecke group, hudel@ncmm.uio.no) at the Nordic Centre for Molecular Medicine (NCMM), the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine.

The Group for Structural Biology and Drug Development investigates medically relevant proteins and protein complexes using biophysical, biochemical and structural approaches. The projects aim at understanding structure-function relationships with an emphasis on drug discovery. We employ a variety of biochemical and biophysical techniques (x-ray crystallography, single particle cryo electron microscopy, SAXS, ITC, SPR, molecular dynamics simulations etc.). Specific projects include the Helicobacter pylori pH acclimation system of a pH-gated urea channel and a cytoplasmic urease and discovery of compounds that reactivate p53 cancer mutants in vitro and in vivo.

Strugatsky, D., McNulty, R.M., Munson, K., Chen, C.-K., Soltis, S.M., Sachs, G., Luecke H. "Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori" (2013) Nature 493, 255–258.

Luecke, H. & Sachs, G. "Helicobacter pylori's Achilles' Heel" (2013) Immuno-Gastroenterology 2, 76.

McNulty, R., Ulmschneider, J.P., Luecke, H., Ulmschneider, M.B. "Mechanisms of molecular transport through the urea channel of Helicobacter pylori" (2013) Nature Communications 4, article number 2900.

Postdoctoral fellow

The positions are available starting January 2018. We seek highly motivated individuals with an excellent track record and experience in protein purification and biophysical and biochemical characterization of proteins and protein complexes, preferably including membrane proteins. Knowledge of structural biology techniques (x-ray crystallography and/or cryo electron microscopy) is required. Postdoctoral fellows are expected to develop their own research area on their path to independence. We offer a stimulating environment with excellent working and social benefits in the happiest country on Earth.

The ideal candidate will have:

• A Ph.D. degree in biochemistry, chemistry, molecular biology or a related area

• Hands-on experience with extraction and purification of proteins and assembly of protein complexes (membrane protein experience preferred)

• Ability to independently perform experiments, analyze and interpret results

• Documented ability to write scientific manuscripts (one or more first author papers from Ph.D. and postdoctoral studies will be highly valued)

• Excellent interpersonal/communication skills

• Excellent written and oral English

• Ability to operate as a team player in a multi-disciplinary environment

The online application (deadline 15 September 2017) must include:

• A cover letter stating motivation and research interests

• A C.V.

• A complete list of scientific publications

• List of references (name, relation to candidate, e-mail and telephone number)

• https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development

Salary:

The postdoctoral position will be placed as Postdoctoral Research Fellow (SKO 1352) with a salary level of NOK486,100–569,000 (app. €51,800-€60,900) per year, depending on qualifications.

Inquiries:

About the position: Prof. Hartmut "Hudel" Luecke (hudel@ncmm.uio.no).

About administrative aspects of the application: Nina Modahl (ninam@ncmm.uio.no).

https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development

• Σας ενημερώνουμε ότι Το Ελληνικό Ίδρυμα Έρευνας και Καινοτομίας (ΕΛΙΔΕΚ) πρόκειται να προκηρύξει τον Οκτώβριο του 2017 Υποτροφίες για τη στήριξη Υποψηφίων Διδακτόρων.

Αίτηση για χρηματοδότηση μπορεί να υποβάλουν και υποψήφιοι διδάκτορες οι οποίοι/ες εκπονούν ήδη τη διδακτορική διατριβή τους σε ΑΕΙ της ημεδαπής ή της αλλοδαπής με την προϋπόθεση στην τελευταία περίπτωση, να έχουν γίνει δεκτοί από ελληνικό ΑΕΙ για να την ολοκληρώσουν στην Ελλάδα, εφόσον πληρούν τις προϋποθέσεις του Κεφαλαίου 3 της παρούσας προκήρυξης.

Η διάρκεια της χρηματοδότησης (υπό μορφή υποτροφίας) είναι έως 3 έτη.

Το μηνιαίο ύψος της υποτροφίας του Υποψήφιου Διδάκτορα ανέρχεται σε εννιακόσια ευρώ (900€).

Αναλυτικές οδηγίες για την ηλεκτρονική υποβολή των προτάσεων θα αναρτηθούν στην ιστοσελίδα του ΕΛΙΔΕΚ (www.elidek.gr).

Η υποβολή γίνεται από τον Υποψήφιο Διδάκτορα ηλεκτρονικά. Οι υποψήφιοι μπορούν να υποβάλουν μόνο μία αίτηση στο πλαίσιο της παρούσας πρόσκλησης στην ελληνική ή την Αγγλική γλώσσα. http://www.gsrt.gr/News/Files/New91551/%CE%A0%CE%A1%CE%9F%CE%94%CE%97%CE%9C%CE%9F%CE%A3%CE%99%CE%95%CE%A5%CE%A3%CE%97-%CE%93%CE%99%CE%91-%CE%A0%CE%A1%CE%9F%CE%9A%CE%97%CE%A1%CE%A5%CE%9E%CE%97-PhD.pdf

• Postdoctoral Researcher (Synchrotron X-ray characterization: XPS,

XAFS etc) (Fixed Term)

Affiliation: Synchrotron X-ray Station at SPring-8

Work Place: National Institute for Materials Science, Harima-site

(Hyogo, Japan)

Deadline: Until the position is filled

More information:

http://www.nims.go.jp/eng/research/station/beam/employment/hdfqf1000008zh4y.html

• https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=77114

• A grant for a year renewable for a further year is available in the "Bioorganic Chemistry and Bio-Crystallography laboratory" of the Free University of Bolzano, to work on the structural and functional characterization of enzymes (e.g., double bond reductases, UDP-glucosyltransferases) from Malus. domestica

The call is available at the following URL:

https://www.unibz.it/en/home/position-calls/positions-for-academic-staff/3158-organic-chemistry-prof-benini?group=18

The project ExPoApple2 (EUREGIO IPN) - Exploring the potential of applied hydro-chalcones is in collaboration with Dr Stefan Martens (Edmund Mach Foundation) and Professor Hermann Stuppner (University of Innsbruck)

Informal enquiries could be sent to: Benini Stefano Stefano.Benini@unibz.it<mailto:Stefano.Benini@unibz.it>

• Dear all, The Oxford Interdisciplinary Bioscience (http://www.biodtp.ox.ac.uk) is funding a joint PhD studentship between Diamond and the Division of Structural Biology (STRUBI, Oxford). The aim of the project is to unravel the mechanism of viral fusion of pestiviruses using crystallographic and/or electron microscopy techniques. For further details see: http://www.biodtp.ox.ac.uk/…/iCASE-Advert_ElOmari-Stuart.pdf

This project is funded for four years by the Biotechnology and Biological Sciences Research Council BBSRC and Diamond Light Source. BBSRC eligibility criteria for studentship funding applies (http://www.bbsrc.ac.uk/documen…/studentship-eligibility-pdf/).

Further particulars, including details on how to apply can be accessed online: http://www.biodtp.ox.ac.uk/diamond-light-source-…/index.html

• Dear All, Job Title: Structural Biologist (Ref: SB/0617) Location: Cambridge, UK

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery (FBDD) platform to generate multiple new drug candidates that are progressing in clinical development.

The Molecular Sciences Team is responsible for supporting all activities from 'gene to structure' and for prosecuting fragment based screening campaigns. Astex's Molecular Sciences Team is currently seeking to recruit a talented structural biologist.

The role is laboratory based and the successful candidate will be responsible for supporting projects during all phases of the drug discovery process.

Please find the full advert for the position in the attachment.

To apply, please send your CV and a cover letter quoting the job reference: SB/0617 to HR.UK@astx.com<mailto:HR.UK@astx.com

Closing Date - 22nd July, 2017

Regards,

Judith Reeks Astex Pharmaceuticals 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, UK

• Position: Postdoctoral Fellow in Integrated Structural Biology in the Viral Infection and Cancer (VIC) Group at the Institut de Biologie Structurale (IBS) under the supervision of Dr. Joanna Timmins

Title: Study of the hNTH1/YB1 Complex: a new anti-cancer drug target

Project summary: The most prevalent non-surgical cancer treatments function by generating DNA damage. Such therapies generate dose-limiting toxicities in normal tissues, but are often efficacious since cancer cells often display impaired DNA repair systems and proliferate more rapidly than most normal cells. Nonetheless, in such cells, functional DNA repair pathways provide a common mechanism for cancer-therapy resistance. The development of resistance to cytotoxic therapy that was initially effective is extremely common and is a major clinical issue. Drugs targeting repair pathways thus exhibit a promising potential as new anti-cancer agents. This project aims at characterising a complex formed between a human DNA repair enzyme (the DNA glycosylase hNTH1) and a transcription factor (Y-box binding protein, YB1) that is implicated in resistance of tumour cells to the chemotherapeutic drug, cisplatin. More specifically, our objectives are to: (i) determine the structures of hNTH1 alone and in complex with either lesion-containing DNA or YB1, (ii) characterise the N-terminal extension of hNTH1 and its role in regulating DNA repair activity and interaction with YB1 and (iii) gain further structural information regarding YB1. Structural information will be obtained using a combination of X-ray crystallography, small-angle X-ray scattering and NMR.

The project is funded by the French Labex GRAL and involves the collaboration between three partners: the teams of J. Timmins and M. Blackledge at IBS and the CMBA screening platform at CEA/BIG Grenoble.

Laboratory: The IBS is located on the European Photon Campus (alongside EMBL, ILL and ESRF) in Grenoble, France. The IBS performs interdisciplinary research at the interface of biology, physics and chemistry and benefits of a privileged access to the EMBL High Throughput Crystallization (HTX) platform to explore crystallization conditions and to the Synchrotron Radiation source, ESRF, to collect diffraction data.

Qualification requirements: The applicant should hold a PhD degree in Structural Biology or in Biophysics obtained in 2015, 2016 or 2017. Prior experience with X-ray crystallography and/or NMR would be a strong asset.

Terms of employment: 18 months contract with the Université Grenoble Alpes. Gross salary ~2500€/month.

Applications: Please send a detailed CV (including degrees, grades, ranks and other completed courses, work experience and a list of publications), a cover letter and two recommendation letters (one of which should be from your PhD supervisor) to: Joanna.timmins@ibs.fr.

Deadline for sending applications: 31^st July 2017.

Expected start date: October/November 2017

For further enquiries: Joanna.timmins@ibs.fr; Phone: +33 (0)4 57 42 86 78

• http://www.afc.asso.fr/82-recrutement/1285-phd-in-structural-biology

• The Institute of Pharmacology and Structural Biology (IPBS) in Toulouse is seeking new group leaders. Details of the call are available at http://www.ipbs.fr/call2017. Please note that the application deadline is July 15, 2017. Any questions about the call should be addressed directly to recruit@ipbs.fr. In order to reinforce its research endeavors in an inspiring, collaborative and cutting-edge environment, the IPBS is seeking new talented junior group leaders addressing fundamental questions within the spectrum of its research fields. Young scientists of any nationality, at junior or midcareer level, and with an excellent track record of publications in internationally recognized journals, are encouraged to apply. International experience as well as capacity to interact with other research groups within the institute are highly recommended. Successful candidate(s) will be provided laboratory and office space for 5-8 people, a technical personnel and free access to the institute's core facilities for a period of 2 years, together with a starting package for basic equipment and consumables. In addition, strong support will be provided from the IPBS to obtain tenured positions at CNRS, INSERM or the University of Toulouse. Outstanding candidates are expected to establish independent and vigorous national and international extramurally-funded research programs (ANR, ERC, etc.) that fit at least with one of the priority topics listed below. Researchers already holding a permanent position are also welcome to apply. IPBS Priority topics

See full details for each topic at: http://www.ipbs.fr/call2017

• Tumor microenvironment – Cancer immunology - Interactions of immune cells with stromal cells, the extracellular matrix and/or other immune cells; immune response to cancer.

• DNA repair/chromatin remodeling in cancer - DNA damage response (DDR) in connection with cancer through epigenetics, transcriptional regulation, DNA repair pathologies, chromosomal translocations, DDR- based drug discovery, or tumor resistance to clastogenic agents.

• Pulmonary infections - Biology of bacterial respiratory pathogens, with a strong focus on mechanisms underlying pathogen's persistence, drug resistance or tolerance within the host.

• Drug discovery & structural biology - Development of biological and chemical drugs of the future, with the aim of strengthening the pharmacological aspects of the IPBS research framework; characterization of drug-target interactions and mechanism of action; "hit to lead" strategies and new approaches for drug target deconvolution or vectorization will be favored. A particular attention will be given to candidates willing to create a group in biological NMR.

Application (about 5 pages in English) should include a cover letter describing previous research experience, an outline of the future research project, motivation for joining the institute and names and e-mail address of 3 referees, together with an updated CV (including a complete list of publications). Application should be sent to recruit@ipbs.fr in a single PDF file named LASTNAME_FIRSTNAME_IPBS2017.pdf. Other formats will not be considered.

Jean-Denis PEDELACQ jean-denis.pedelacq AT ipbs DOT fr

Research Scientist (CR-CNRS)

Institut de Pharmacologie et de Biologie Structurale (IPBS)

UMR 5089 - BP 64182 / Structural Biology and Biophysics Dpt

205 route de Narbonne / 31077 TOULOUSE Cedex 04 / FRANCE

Tél: +33 (0)561 175 496 Fax : +33 (0)561 175 994

• Cher(e)s collègues, Bruker Biospin recherche un ingénieur commercial en diffraction RX Trouvez toutes les informations sur ce poste dans cette annonce.

http://www.afc.asso.fr/…/1286-ingenieur-commercial-en-diffr…

Arie van der Lee, Européen des Membranes, Université de Montpellier - Case Courrier 047

Place E. Bataillon, 34095 Montpellier CEDEX 5, France

Tél.: 0033-467149135

• Chers collègues, un poste d'ingénieur(e) de recherche pour la synthèse de cristaux pour la physique du solide est ouvert au concours CNRS 2017 (poste n.15) . L'affectation sera à l'institut Néel, Grenoble. Le profil recherché est un chimiste du solide, cf. fiche jointe. Un savoir faire en synthèse de monocristaux sera un plus. La date limite de candidature est au 28 juin (cf. https://www.dgdr.cnrs.fr/drhita/concoursita/ )

Pourriez vous diffuser très largement cette annonce dans vos laboratoires respectifs et les laboratoires de chimie du solide vous environnant ou à des candidats potentiels.

• Research engineer permanent position in Macromolecular Crystallography Application deadline: June 30th, 2017 The Institut Pasteur in Paris is one of the leading institutes worldwide in fundamental biology and biomedical research. It is home to more than 130 research groups with scientists from over 70 countries. The recently created Center for Innovation and Technological Research (Citech) includes all Core Facilities of the Institut Pasteur, including the X-Ray Crystallography Platform (PFX). The PFX has two major missions: (1) to provide research teams working in the field of macromolecular crystallography with the expertise and technology for high-throughput crystallization, X-ray diffraction measurements and crystallographic computing, and (2) to offer expertise in bio-crystallography and structural analysis to research groups in biology at Institut Pasteur and outside organisations. The PFX is looking for a research engineer in Macromolecular Crystallography, who should fulfill the missions and tasks described thereafter under the supervision of the head of the facility. This is a full-time tenured position funded by the Institut Pasteur. We offer a dynamic working environment in an international and multidisciplinary world renowned institute. Scientific language is English. We are an equal opportunity employer. Salary and benefits will be commensurate with experience. Application must include a cover letter, curriculum vitae with publications, summary of service and research accomplishments (maximum 3 pages) and at least 2 letters of recommendation. The cover letter and summary should clearly indicate how you meet the required and preferred qualifications. Missions/Tasks: • Design and perform experiments in protein crystallography (sample preparation, crystallization, data collection, structure determination, crystallographic refinement and structure analysis). • Document and communicate scientific results clearly and promptly to our collaborators, take in charge the deposition of atomic coordinates and structure factors in the PDB. • Write structure description reports and peer-reviewed publications. • Build capabilities and infrastructure through interactions with the internal and external scientific community. • Work effectively and efficiently in multiple projects, and collaborate with team members and lab users. • Maintain and operate our home X-ray diffraction system. • Supervise students and research laboratory technicians and participate in structural biology courses organized in the Institut Pasteur. Qualifications & Experience: The candidate must hold a University Ph.D. (Physics or Biochemistry) and at least four years of postdoctoral experience in Structural Biology. He/she must have a proven track record in protein crystallography, with a strong background in protein biochemistry of soluble and membrane proteins, and solid experience in computational crystallography (with up-to-date knowledge of relevant software packages such as CCP4 or Phenix). Experience in cryo-electron microscopy is not essential, but highly desirable. Preference will be given to candidates with a strong publication record and experience in writing grant proposals. The ideal candidate should be highly motivated, show initiative and willingness to acquire new skills and function well within a highly collaborative environment. Excellent attention to detail, command of the English language (both written and oral) and organizational skills are considered essential for success in this position. Applications are to be submitted by June 30th, 2017 to Dr. Ahmed HAOUZ (ahmed.haouz@pasteur.fr)

• PhD (CIFRE) position – SANOFI & ESRF on cryoEM methods applied to antibodies

PhD thesis title: High resolution Cryo- Electron Microscopy of Antibody / Antigen complexes

More and more research focus is being put on biologics and their development as drugs. These molecules are usually large and flexible and they can interact with various targets located on the surface of cells; Bi-specific antibodies are an example that can potentially bind to two different antigens and which have gained attention due to their potential application in cancer immunotherapy and drug delivery. To fully understand their mechanism, structural knowledge at an atomic level is needed.

While low resolution studies can be obtained using traditional microscopy, high resolution studies of these interactions are usually performed by protein crystallography (or by Hydrogen Deuterium Exchange studies) using fragments of both antibody and antigen. The ESRF is in progress of installing a Krios microscope which, coupled with a direct electron detector and a Volta phase plate will enable us to determine the full structure of the complexes.

The successful candidate will characterise Ag/Biologics complexes from Sanofi, using state-of-the-art microscopes at the cryo-EM platform of the Partnership for Structural Biology (PSB) and will determine the high-resolution structure of one or more of these complexes.

The PhD thesis will last 3 years starting in late autumn 2017, in a collaboration between Sanofi (Vitry sur Seine, France) and the ESRF (Grenoble, France) under the co-supervision of Dr. Magali Mathieu (Sanofi) and Dr. Gordon Leonard (ESRF). This thesis will be CIFRE (Conventions Industrielles de Formation par la REcherche) and the student will be a Sanofi employee (CDD) for the whole duration of the thesis. Most of his/her work will be performed at the ESRF.

The applicant must have a Master Degree (Master2 or MSc) in integrated structural biology or biophysics, some knowledge in cryo-electron microscopy and in molecular and cell biology. He/she should be a team player and have good communication skills.

CV and accompanying letter should be sent to magali.mathieu@sanofi.com AND christoph.mueller_dieckmann@esrf.fr before July 7, 2017.

Magali Mathieu Sanofi, Bio Structure and Biophysics / iDD France, Centre de Recherche de Vitry/Alfortville

TÉL. : +33 (0) 1.58.93.39.90 - FAX : +33 (0) 1.58.93.80.63, 13, quai Jules Guesde – BP 14 – 94403 Vitry-sur-Seine Cedex France

• A position is available for a Professor of Structural Biology at the University of St Andrews.

Structural biology in St Andrews is based in a large shared purpose-built laboratory, capable of hosting ~40 researchers. This space is currently shared with the Gloster, Schwarz-Linek, Taylor and Pliotas groups. The laboratory has great facilities for protein biochemistry (incubators, floor centrifuges), crystallisation (Gryphon crystallisation robot for dispensing nano-drops and Scorpion robot for mixing crystallisation screens), crystal visualisation (two crystallisation incubators and Minstrel robot for automated crystal imaging), and in-house crystal testing (Rigaku generator with two CCD detectors; one robotically controlled).

Crystallographers have regular access to BAG synchrotron time, both at Diamond and ESRF, which is shared with users in Dundee. St Andrews provides an excellent mass spectrometry/proteomics facility for protein identification and more complex analyses. Solution state biomolecular NMR is supported by a dedicated 700 MHz instrument (Bruker Ascend, Prodigy TCI cryoprobe). Structural biology is also supported by a uniquely powerful EPR setup (X, Q, W band); St Andrews hosts the two most sensitive pulse EPR spectrometers in the UK. A new biophysics suite provides ITC (Microcal PEAQ and VP), SPR (Biacore T200), CD, and stopped-flow machines.

There are also dedicated rooms for insect and mammalian cell culture, with hoods and large incubators containing shaking platforms for protein expression. For more information and to apply, please follow this link https://www.structuralbiology.eu/jobs/professorreader-in-structural-biologychemical-biology---ac7037ml/

• On behalf of Prof. Scardi

In the attachment: an advertisement for PhD positions which are available here at University of Trento, Call will open from mid June to August, selection will be early September. Participation is open to people with a Master level university degree (minimum 5 years) obtained before the beginning of the course (Nov. 1st). We also accept candidates who wish to take a second PhD. Grant is not rich, but enough to stay here for studying; it includes a contribution for lodging, usually enough to cover all expenses and a little more.

Prof. Paolo Scardi , University of Trento

38123 via Mesiano 77, Trento - Italy

Tel: +39 0461 282417 / 282477 / 282467 / 282426 281919 (switchboard)

Fax: +39 0461 281999 / 282672

E-mail: Paolo.Scardi@unitn.it

WWW: http://www.unitn.it/en/dicam