Nguyen Lab studies the integration of metabolism and T-cell biology. Specifically, Nguyen group tries to understand how metabolism regulates T-cell auto/allo-reactivity in autoimmune diseases, transplantation and cancers. It has now become apparent that metabolism is a key factor regulating T-cell response. Pathogenic T-cells possess distinct metabolic profiles in different immunological disorders. One line study of the Nguyen Lab will be translating knowledge of metabolism into therapeutic approaches for the treatment of autoimmune disease, transplant rejection, and graft-versus-host disease. T-cells and cancer cells are well known for competing for nutrients in tumor microenvironment. Nguyen Lab will be focusing on targeting nutrient sensing and metabolism to improve the efficacy of cancer immunotherapy. As metabolic comorbidity is a significant factor of COVID-19 mortality, his lab also investigates how immune cells eat and function during SARS-CoV-2 infection in patients.