Publications

COVID-19: 

Gurshaney S, Alvarez A, Ezhakunnel K, Manalo A, Huynh TH, Abe J,  Le NT, Weiskopf D, Sette A, Lupu DS, Gardell SJ, Nguyen H. Metabolic dysregulation Impairs Lymphocyte Function during Severe SARS-CoV-2 infection. Communication Biology  (2023). doi: 10.1101/2021.12.06.471421. Link

• Allogeneic Bone Marrow Transplantation and GVHD

1. Schutt SD, Wu Y, Kharel A, Bastian D, Choi HJ, Hanief Sofi M, Mealer C, McDaniel Mims B, Nguyen H, Liu C, Helke K, Cui W, Zhang X, Ben-David Y, Yu XZ. The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease. J Clin Invest. 2022 Nov 1;132(21):e143950. doi:10.1172/JCI143950. PMID: 36074578; PMCID: PMC9621143. Link

2. Wu Y, Mealer C, Schutt SD, Wilson CL, Bastian D, Sofi MHH, Zhang M, Luo Z, Choi HJ, Yang K, Tian L, Nguyen H, Helke K, Schnapp LM, Wang H, Yu XZ. MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice. Blood Adv. 2022 Jan 24;. doi: 10.1182/bloodadvances.2021005103. [Epub ahead of print] PubMed PMID: 35073581. Link

3. Bastian D, Sui X, Nguyen HD, Wu Y, Schutt S, Tian L, Sofi MH, Liu Y, Martin P, Bartee E, Yu XZ. Interleukin-23 receptor signaling by interleukin-39 potentiates T cell pathogenicity in acute graft-versus-host disease. Am J Transplant. 2021 Nov;21(11):3538-3549. doi: 10.1111/ajt.16624. Epub 2021 Jun 1. PubMed PMID: 33934505. Link

4. Nguyen HD, Ticer T, Bastian D, Kuril S, Li H, Du H, Yan C, Yu XZ. Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease. Cell Rep. 2020 Oct 27;33(4):108316. doi: 10.1016/j.celrep.2020.108316. PMID: 33113360. Link Highlighted in GVHDHub Link

5. Nguyen HD, Huong PT, Hossack K, Gurshaney S, Ezhakunnel K, Huynh TH, Alvarez AM, Le NT, Luu HN. Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease. J Vis Exp. 2020 Mar 17;(157). doi: 10.3791/60083. PMID: 32250356. (Corresponding author). Link

6. Nguyen H*, Alawieh A, Bastian D, Kuril S, Daenthanasanmak A, Schutt S, Iamsawat S, Carl A, Tomlinson S, Yu XZ*. Targeting the Complement Alternative Pathway Permits Graft versus Leukemia Activity while Preventing Graft Versus Host Disease. Clin Cancer Res. 2020 Jul 1;26(13):3481-3490. doi: 10.1158/1078-0432.CCR-19-1717. Epub 2020 Jan 9. PMID: 31919135. (*, Corresponding author). Link

7. Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A, Heinrichs Voss J, Nguyen HD, Bastian D, Iamsawat S, Selvam SP, Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, Yu XZ. Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. Journal of Clinical Investigation 2019 May 2;129(8):2760-2774. doi: 10.1172/JCI122899. PMID: 31045571. Link

8. Iamsawat S, Daenthanasanmak A, Voss J-H, Nguyen HD, Bastian D, Liu C, and Yu X-Z. Targeting JAK2 Promotes Foxp3 Stability and Function of CD8 iTregs in Prevention of Murine Graft-versus-Host Disease. Journal of Immunology. 2018;201(9):2812-2823. PMID: 30242073. 

9. Bastian D, Liu Y, Wu Y, Schutt S, Nguyen HD, Daenthanasanmak A, Sofi H, Zhang M, Iamsuwat S and Yu X-Z. IL-27 Receptor Signaling on T cells Augments GVHD Severity through Enhancing Th1 Responses. Journal of Immunology Research and Therapy. 2018. 2(2): 151-157.

10. Zhang M, Wu Y, Iamsawat S, Chang J, Daenthanasanmak A, Bastian D, Nguyen HD, Steven Schutt S, Dai M, Chen F, Suh W-K, Yu XZ. Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells. Frontiers in immunology. 2018; 9:1461. PubMed [journal] PMID: 29988391, PMCID: PMC6023972 

11. Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen HD, Bastian D, Zhang M, Sofi MH, Chatterjee S, Hill EG, Mehrotra S, Kraft AS, Yu XZ. PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. The Journal of clinical investigation.2018; PubMed [journal] PMID: 29781812 

12. Wu Y, Schutt S, Paz K, Zhang M, Flynn RP, Bastian D, Sofi MH, Nguyen H, Dai M, Liu C, Chang YJ, Blazar BR, Yu XZ. MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice. Blood. 2018; 131(17):1974-1986. PubMed [journal] PMID: 29530952, PMCID: PMC5921962 

13. Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ. Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. Blood advances. 2018; 2(4):414-427. PubMed [journal] PMID: 29483082, PMCID: PMC5858472

14. Betts BC, Bastian D, Iamsawat S, Nguyen HD, Heinrichs JL, Wu Y, Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K, Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C, Pidala J, Anasetti C, Yu XZ. Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2018; 115(7):1582-1587. PubMed [journal] PMID: 29382747, PMCID: PMC5816153 

15. Sofi MH, Heinrichs J, Dany M, Nguyen HD, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ. Ceramide synthesis regulates T cell activity and GVHD development. JCI insight. 2017; 2(10). PubMed [journal] PMID: 28515365, PMCID: PMC5436544 

16. Heinrichs J, Li J, Nguyen HD, Wu Y, Bastian D, Daethanasanmak A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ. CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice. Oncoimmunology. 2016; 5(6):e1146842. PubMed [journal] PMID: 27471614, PMCID: PMC4938369 

17. Fu J, Wu Y, Nguyen HD, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ. T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. Journal of immunology (Baltimore, Md.: 1950).2016; 196(7):3168-79. NIHMSID: NIHMS754865 PubMed [journal] PMID: 26903480, PMCID: PMC4799777 

18. Wu Y, Heinrichs J, Bastian D, Fu J, Nguyen HD, Schutt S, Liu Y, Jin J, Liu C, Li QJ, Xia C, Yu XZ. MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. Blood. 2015; 126(11):1314-23. PubMed [journal] PMID: 26138686, PMCID: PMC4566810 

19. Schutt SD, Fu J, Nguyen HD, Bastian D, Heinrichs J, Wu Y, Liu C, McDonald DG, Pidala J, Yu XZ. Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice. PloS one. 2015; 10(9):e0137641. PubMed [journal] PMID: 26348529, PMCID: PMC4562702

20. Wu Y, Bastian D, Schutt S, Nguyen HD, Fu J, Heinrichs J, Xia C, Yu XZ. Essential Role of Interleukin 12/23p40 in the Development of Graft-versus-Host Disease in Mice. Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation. 2015; 21(7):1195-204. NIHMSID: NIHMS678063 PubMed [journal] PMID: 25846718, PMCID: PMC4466028 

Immunometabolism in Cancer Immunotherapy

1. Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metabolism 2018 Jan 9;27(1):85-100.e8. doi: 10.1016/j.cmet.2017.10.006. Epub 2017 Nov 9.

2. Chakraborty P, Vaena SG, Thyagarajan K, Chatterjee S, Al-Khami A, Selvam SP, Nguyen HD, Kang I, Wyatt MW, Baliga U, Hedley Z, Ngang RN, Guo B, Beeson GC, Husain S, Paulos CM, Beeson CC, Zilliox MJ, Hill EG, Mehrotra M, Yu XZ, Ogretmen B, Mehrotra S. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. Cell Report 2019 Aug 13;28(7):1879-1893.e7. doi: 10.1016/j.celrep.2019.07.044. PMID: 31412253. Link

3. Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen HD, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball LE, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S. Thioredoxin-1 improves the immuno-metabolic phenotype of anti-tumor T cells. Journal of Biological Chemistry 2019 Jun 7;294(23):9198-9212. doi: 10.1074/jbc.RA118.006753. PMID: 31045571. Link

4. Thanh Huong P, Gurshaney S, Thanh Binh N, Gia Pham A, Hoang Nguyen H, Thanh Nguyen X, Pham-The H, Tran PT, Truong Vu K, Xuan Duong N, Pelucchi C, La Vecchia C, Boffetta P, Nguyen HD*, Luu HN*. Emerging Role of Circulating Tumor Cells in Gastric Cancer (*, Corresponding author). Cancers (Basel) 2020 Mar 15;12(3):695. doi: 10.3390/cancers12030695. Link

5. Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, Peterson YK, Marangoni E, Saatci O, Sahin O, Lilly M, Atkinson C, Tomlinson S, Mehrotra S, Ogretmen B. Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome- mediated tumor metastasis. Cell Report 2022 Dec 6;41(10):111742. doi: 10.1016/j.celrep.2022.111742. PMID: 36476873; PMCID: PMC9791981.Link

Anti-inflammatory Activity of Lysolipids

1. Nguyen MD, Nguyen HD, Yoo JM, Myung PK, Kim MR, Sok DE: Effect of endocannabinoids on soybean lipoxygenase-1 activity. Bioorg Chem. 49:24-32, 2013.

2. Hung ND, Sok DE, Kim MR: Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine. Inflamm Res. 61(5): 473-481, 2012.

3. Hung ND, Kim MR, Sok DE: 2-Polyunsaturated acyl lysophosphatidylethanolamine attenuates inflammatory response in zymosan A-induced peritonitis in mice. Lipids 46(10):893-906, 2011.

4. Hung ND, Kim MR, Sok DE: Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis. Br J Pharmacol. 162(5):1119-35, 2011.

5. Hung ND, Kim MR, Sok DE: Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. Inflammation 34(3):147-60, 2011.

6. Huang LS*, Hung ND*, Sok DE, Kim MR: Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory. Lipids 45(3):225-36, 2010 (* co-first authors).

7. Hung ND, Kim MR, Sok DE: Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis. Prostaglandins Other Lipid Mediat. 90(3-4):105-11, 2009.

• Oxidative Stress

1. Ha do T, Kim H, Thuong PT, Ngoc TM, Lee I, Hung ND, Bae K: Antioxidant and lipoxygenase inhibitory activity of oligostilbenes from the leaf and stem of Vitis amurensis. J Ethnopharmacol. 125(2):304-9, 2009.

2. Nguyen SD, Hung ND, Cheon-Ho P, Ree KM, Dai-Eun S: Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1). Biochim Biophys Acta. 1790(3):155-60, 2009.

• Novel Enzyme Lysophospholipase C

Hung ND, Kim MR, Sok DE: Purification and characterization of lysophospholipase C from pig brain. Neurochem Res. 35(1):50-9, 2010.