2025
Daiki Hayashi*, Charikleia S Batsika, Asimina Bourboula, Masakazu Shinohara, Kengo Kanamaru, George Kokotos, Edward A Dennis*, Specificity mechanism of Group VIA calcium-independent phospholipase A2 toward truncated-oxidized phospholipids and its application for specific inhibitor design, Biochimica et biophysica acta. Molecular and cell biology of lipids 1870(6) 159655 (2025).
Felicity J Ashcroft, Asimina Bourboula, Nur Mahammad, Efrosini Barbayianni, Astrid J Feuerherm, Thanh Thuy Nguyen, Daiki Hayashi, Maroula G Kokotou, Konstantinos Alevizopoulos, Edward A Dennis, George Kokotos, Berit Johansen, Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2α for targeted cancer therapy, Nature Communications 16, 164 (2025). https://doi.org/10.1038/s41467-024-55536-9
Tomoka Namba, Daiki Hayashi, Itsuko Fukuda, Shuji Ueda and Yasuhito Shirai, Tocotrienols activate diacylglycerol kinase a via 67 KDa laminin receptor, Functional Food Science 5(5): 160-169 (2025). https://doi.org/10.31989/ffs.v5i5.1638
2024
Daiki Hayashi and Edward A. Dennis, Differentiating human phospholipase A2's activity toward phosphatidylinositol, phosphatidylinositol phosphate and phosphatidylinositol bisphosphate, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1869(7), 159527 (2024). https://doi.org/10.1016/j.bbalip.2024.159527
Varnavas D Mouchlis, Yuan-Hao Hsu, Daiki Hayashi, Jian Cao, Sheng Li, J Andrew McCammon, Edward A Dennis, The mechanism of allosteric regulation of calcium-independent phospholipase A2 by ATP and calmodulin binding to the ankyrin domain, Proceedings of the National Academy of Sciences 121(48) e2411539121 (2024). https://doi.org/10.1073/pnas.2411539121
2023
Daiki Hayashi and Edward A. Dennis, Molecular basis of unique specificity and regulation of group VIA calcium-independent phospholipase A2 (PNPLA9) and its role in neurodegenerative diseases, Pharmacology & Therapeutics 245,108395 (2023). https://doi.org/10.1016/j.pharmthera.2023.108395
2022
Daiki Hayashi, Varnavas D. Mouchlis, Seika Okamoto, Namba Tomoka, Liuqing Wang, Sheng Li, Tomoka Namba, Shuji Ueda, Minoru Yamanoue, Hirofumi Tachibana, Hiroyuki Arai, Hitoshi Ashida, Edward A. Dennis, and Yasuhito Shirai, Vitamin E Functions by Association with a Novel Binding Site on the 67 kDa Laminin Receptor Activating Diacylglycerol Kinase, The Journal of Nutritional Biochemistry 110, 109129 (2022). https://doi.org/10.1016/j.jnutbio.2022.109129
Daiki Hayashi and Yasuhito Shirai, The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy, Molecules 27 (20), 6784 (2022). https://doi.org/10.3390/molecules27206784
Varnavas D. Mouchlis, Daiki Hayashi, Alexis M. Vasquez, Jian Cao, J. Andrew McCammon, and Edward A. Dennis, Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes, PNAS 119(2): e2102953118 (2022). https://doi.org/10.1073/pnas.2102953118
Daiki Hayashi, Varnavas D. Mouchlis, and Edward A. Dennis, Each phospholipase A2 type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids, Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1867: 159067 (2022). https://doi.org/10.1016/j.bbalip.2021.159067
Maria A Theodoropoulou, Anastasia Psarra, Martin Erhardt, Aikaterini Nikolaou, Anna-Dimitra D Gerogiannopoulou, Dimitra Hadjipavlou-Litina, Daiki Hayashi, Edward A Dennis, Andrea Huwiler, and George Kokotos, N-Acylated and N-Alkylated 2-Aminobenzothiazoles Are Novel Agents That Suppress the Generation of Prostaglandin E2, Biomolecules 12: 267 (2022). https://doi.org/10.3390/biom12020267
~2021
Daiki Hayashi, Varnavas D. Mouchlis, and Edward A. Dennis, Omega-3 Versus Omega-6 Fatty Acid Availability is Controlled by Hydrophobic Site Geometries of Phospholipase A2s, Journal of Lipid Research 62: 100113 (2021). https://doi.org/10.1016/j.jlr.2021.100113
Daiki Hyashi, Liuqing Wang, Shuji Ueda, Minoru Yamanoue, Hitoshi Ashida, and Yasuhito Shirai, The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase a, Scientific Reports 10: 11790 (2020). https://doi.org/10.1038/s41598-020-68716-6
Giorgos S. Koutoulogenis, Maroula G. Kokotou, Daiki Hayashi, Varnavas D. Mouchlis, Edward A. Dennis, and George Kokotos, 2-Oxoester Phospholipase A2 Inhibitors with Enhanced Metabolic Stability, Biomolecules 10: 491 (2020). https://doi.org/10.3390/biom10030491
Daiki Hayashi, Ryosuke Tsumagari, Ke Liu, Shuji Ueda, Minoru Yamanoue, Fumio Sakane, and Yasuhito Shirai, Screening of subtype-specific activators and inhibitors for diacylglycerol kinase, J. Biochem. 165(6): 517–522 (2019). https://doi.org/10.1093/jb/mvz008
Daiki Hayashi, Shuji Ueda, Minoru Yamanoue, Hitoshi Ashida, and Yasuhito Shirai, Amelioration of diabetic nephropathy by oral administration of d-a-tocopherol and its mechanisms, Biosci. Biotechnol. Biochem. 82(1): 65-73 (2018). https://doi.org/10.1080/09168451.2017.1411184
Daiki Hayashi, Keiko Yagi, Chihong Song, Shuji Ueda, Minoru Yamanoue, Matthew Topham, Toshinobu Suzaki, Naoaki Saito, Noriaki Emoto, and Yasuhito Shirai, Diacylglycerol Kinase alpha is involved in the Vitamin E-induced amelioration of diabetic nephropathy in mice, Scientific Reports 7(1): 2597 (2017). https://doi.org/10.1038/s41598-017-02354-3
Daiki Hayashi, Shuji Ueda, Minoru Yamanoue, Naoaki Saito, Hitoshi Ashida, and Yasuhito Shirai, Epigallocatechin-3-gallate activates diacylglycerol kinase alpha via a 67 kDa laminin receptor: a possibility of galloylated catechins as functional food to prevent and/or improve diabetic renal dysfunctions, Journal of Functional Foods, 15: 561-569 (2015). https://doi.org/10.1016/j.jff.2015.04.005
Yukiko Kurohane Kaneko, Yosuke Kobayashi, Keisuke Motoki, Kunihito Nakata, Shoko Miyagawa, Mao Yamamoto, Daiki Hayashi, Yasuhito Shirai, Fumio Sakane, and Tomohisa Ishikawa, Depression of type I diacylglycerol kinases in pancreatic b-cells from male mice results in impaired insulin secretion, Endocrinology 154 (11): 4089-4098 (2013). https://doi.org/10.1210/en.2013-1356