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Molecular Pathology of the Prions, edited by HF Baker (Humana Press Inc., Totowa, New Jersey).
Molecular Pathology of the Prions, edited by HF Baker (Humana Press Inc., Totowa, New Jersey).
In this book, published in July, 2001, internationally recognised investigators review their recent studies of prion protein and prion diseases at the molecular level. They seek to define the normal function of prion protein, to detect and measure early immune responses to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological techniques to elucidate the pathogenetic mechanisms involved in prion diseases. Other topics include the neuronal death that occurs in prion disease, the different strains of prion disease agents, and the accumulation of protein deposits within brain parenchyma.
In this book, published in July, 2001, internationally recognised investigators review their recent studies of prion protein and prion diseases at the molecular level. They seek to define the normal function of prion protein, to detect and measure early immune responses to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological techniques to elucidate the pathogenetic mechanisms involved in prion diseases. Other topics include the neuronal death that occurs in prion disease, the different strains of prion disease agents, and the accumulation of protein deposits within brain parenchyma.
Fatal Protein; the story of CJD, BSE and Other Prion Diseases, by RM Ridley and HF Baker (Oxford University Press)
Fatal Protein; the story of CJD, BSE and Other Prion Diseases, by RM Ridley and HF Baker (Oxford University Press)
Published in 1998, this book was written with the general reader in mind. It presents a historical account of research in the spongiform encephalopathies, including our own contribution to the discovery of the gene mutations which cause the inherited forms of spongiform encephalopathy in humans, Gerstmann-Sträussler syndrome and atypical prion disease. It covers the kuru epidemic in Papua New Guinea in the early to middle part of the 20th century, the arguments about the nature of the agent which causes scrapie in sheep and whether or not scrapie is a genetic disease, and BSE, the worst disaster ever to have befallen British farming.
Published in 1998, this book was written with the general reader in mind. It presents a historical account of research in the spongiform encephalopathies, including our own contribution to the discovery of the gene mutations which cause the inherited forms of spongiform encephalopathy in humans, Gerstmann-Sträussler syndrome and atypical prion disease. It covers the kuru epidemic in Papua New Guinea in the early to middle part of the 20th century, the arguments about the nature of the agent which causes scrapie in sheep and whether or not scrapie is a genetic disease, and BSE, the worst disaster ever to have befallen British farming.
Prion Diseases, edited by HF Baker and RM Ridley (Humana Press Inc., Totowa, New Jersey).
Prion Diseases, edited by HF Baker and RM Ridley (Humana Press Inc., Totowa, New Jersey).
Published in 1996, this volume contains chapters by leading researchers in the field of the spongiform encephalopathies, including members of the National CJD Surveillance Unit (Edinburgh, UK), members of the Neuropathogenesis Unit (Edinburgh, UK) and researchers in the United States and Europe. It covers the diagnosis and epidemiology of CJD and BSE, transgenic approaches to the 'species barrier', studies of amyloid formation, and the cell-free conversion of PrPc to PrPSc. There are comprehensive chapters on 'handling the BSE epidemic' and on the special problems of genetic counselling in adult onset disorders.
Published in 1996, this volume contains chapters by leading researchers in the field of the spongiform encephalopathies, including members of the National CJD Surveillance Unit (Edinburgh, UK), members of the Neuropathogenesis Unit (Edinburgh, UK) and researchers in the United States and Europe. It covers the diagnosis and epidemiology of CJD and BSE, transgenic approaches to the 'species barrier', studies of amyloid formation, and the cell-free conversion of PrPc to PrPSc. There are comprehensive chapters on 'handling the BSE epidemic' and on the special problems of genetic counselling in adult onset disorders.
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