Publications

2020-2025

Yang H, Zingaro VA, Lincoff J, Tom H, Oikawa S, Oses-Prieto JA, Edmondson Q, Seiple I, Shah H, Kajimura S, Burlingame AL, Grabe M, Ruggero D. Remodelling of the translatome controls diet and its impact on tumorigenesis. Nature. 2024; 633(8028):189–197. PMID: 39143206 

Yang H#, Kabin E, Dong Y, Zhang X, Ralle M, Lutsenko S#. ATP7A-dependent copper sequestration contributes to termination of β-CATENIN signaling during early adipogenesis. Molecular Metabolism. 2024; 80:101872. PMID: 38185452  # - Co-corresponding

Kabin E, Dong Y, Roy S, Smirnova J, Smith JW, Ralle M, Summers K, Yang H, Dev S, Wang Y, Devenney B, Cole RN, Palumaa P, Lutsenko S. α-Lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance. Proc Natl Acad Sci. 2023; 120(40):e2305961120. PMID: 37751556

Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JFF, Blanchard SC, Ruggero D, Taunton J. Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3. Nat Chem. 2022; 14(12):1443–1450. PMID: 36123449

Muchenditsi A, Talbot CC Jr, Gottlieb A, Yang H, Kang B, Boronina T, Cole R, Wang L, Dev S, Hamilton JP, Lutsenko S. Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease. Sci Rep. 2021; 11:5659.

Conn CS*, Yang H*#, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D.s-Prieto JA, Vu H, Oguri Y, Nair S, Lee JH, Gray NS, #Ruggero D. The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity. Nat Metab. 2021; 3(2):244–257. PMID: 33619378 * - Co-first # - Co-corresponding

2014-2019

Pierson H, Yang H, Lutsenko S. Copper transport and disease: what can we learn from organoids? Annu Rev Nutr. 2019; 39:75–94  PMID: 31150593

Yang H#, Liu CN, Wolf RM, Ralle M, Dev S, Pierson H, Askin F, Steele KE, Magnuson TH, Schweitzer MA, Wong GW, Lutsenko S#. Obesity is associated with copper elevation in serum and tissues. Metallomics. 2019; 11(8):1363–1371. PMID: 31249997   # - Co-corresponding 

Yang H#, Ralle M, Wolfgang MJ, Dhawan N, Burkhead JL, Rodriguez S, Kaplan JH, Wong GW, Haughey N, Lutsenko S#. Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. PLoS Biol. 2018; 16(9):e2006519. PMID: 30199530   #- Co-corresponding

Muchenditsi A., Talbot C.C., Gottlieb A. Yang H., et al. Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease. Sci Rep 11, 5659 (2021). PMID: 33707579 

Muchenditsi A, Yang H, Hamilton JP, Koganti L, Housseau F, Aronov L, Bhattacharjee A, Cooper CJ, Jin Y, Lutsenko S. Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. Am J Physiol Gastrointest Liver Physiol. 2017; 313(1):G39–G49. PMID: 28428350

Bhattacharjee A*, Yang H*, Duffy M, Robinson E, Conrad-Antoville A, Lu YW, Capps T, Braiterman L, Wolfgang M, Murphy MP, Yi L, Kaler SG, Lutsenko S, Ralle M. The activity of Menkes disease protein ATP7A is essential for redox balance in mitochondria. J Biol Chem. 2016; 291(32):16644–16658. PMID: 27226607 * - Co-first

Huang Y, Nokhrin S, Hassanzadeh-Ghassabeh G, Yu CH, Yang H, Barry AN, Tonelli M, Markley JL, Muyldermans S, Dmitriev OY, Lutsenko S. Interactions between metal-binding domains modulate intracellular targeting of Cu(I)-ATPase ATP7B, as revealed by nanobody binding. J Biol Chem. 2014; 289(47):32682–32693. PMID: 25253690