Embedded Files
37.
37.
Liu, S.-K.; Alotaibi, S.; Kuan, J.-Y.; Gonçalves, T. P.; Huang*, K.-W.; Han*, J.-L.
“Solvent-controlled Regiodivergent Friedel-Crafts Reactions of 1-Naphthol with
in situ Generated Aza-o-quinone Methides” J. Org. Chem. 2025, accepted.
36.
36.
Huang, B.-W.; Tsou, Y.-J.; Han*, J.-L. “Substrate-Dependent Asymmetric Allylic
Alkylation of MBH Carbonates with 3-Alkylidene Oxindoles” Adv. Synth. Catal.
2025, accepted. Link
35.
35.
Ou, C.-Y.; Huang, B.-W.; Chu, T.-H.; Lin, P.-H.; Han*, J.-L. “Asymmetric
Organocatalytic Synthesis of Chiral Polycyclic 1,4-Dihydropyridines and Axially
Chiral 4-Arylpyridines Using 2,3-Dioxopyrrolidines and 1,3-Diketones” Eur. J.
Org. Chem. 2025, 28, e202500205. Link
34.
34.
Kuan, J.-Y.; Chen, J.-H.; Han*, J.-L. “Switchable Synthesis of Tritylone Alcohols and 2-Benzoylbenzoate Esters from Spiroindane-1,3-diones ” J. Org. Chem. 2024, 89, 12360-12369.
33.
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Wu, Y.-D.; Huang, B.-W.;Chen, Y.-C.; Han*, J.-L. “Asymmetric Organocatalytic Benzylation of Morita−Baylis−Hillman Carbonates with 2,4-Dinitrotoluene Derivatives” Synthesis, 2024, 56, 3181-3190.
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Huang, S.-H.; Chen, I.-T. Han*, J.-L. “Asymmetric (3 + 3) and (4 + 2) Annulation Reactions of 2,3-Dioxopyrrolidines with 3‑Alkylidene Oxindoles to Construct Diverse Chiral Heterocyclic Frameworks” s” J. Org. Chem. 2024, 89, 8970−8984.
31.
31.
Huang, B.-W.; Han*, J.-L. “ Regioselectivity Switch between Enantioselective 1,2- and 1,4-Addition of Allyl Aryl Ketones with 2,3-Dioxopyrrolidines” J. Org. Chem. 2023, 88, 16376−16390. Link
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Kuan, J.-Y.; Chen, I.-T.; Lin, H. Han*, J.-L. “Organocatalytic Vinylogous Michael Addition/Cyclization Cascade of 2-Alkylidene Indane-1,3-diones with Enals: A Regioand Stereocontrolled Diversity-Oriented Route to Indane-1,3- dione Derivatives” Adv. Synth. Catal. 2023, 365, 3496-3504. Link
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29.
Liu, S.-K.; Chien, P.-H.; Huang, B.-W.; Han*, J.-L. “Catalyst-controlled regiodivergent Friedel-Crafts reactions of 1-naphthols with 2,3-dioxopyrrolidines: synthesis of polycyclic 2-pyrrolidinones” Org. Biomol. Chem. 2023, 21, 4999-5013. Link
28.
28.
Lu, T.-Y.; Hsu, W.-Y; Huang, B.-W. Han*, J.-L. “Reagent Controlled Regiodivergent Annulations of Achmatowicz Products with Vinylogous Nucleophiles: Synthesis of Bicyclic Cyclopenta[b]pyrans and 8‑Oxabicyclo[3.2.1]octane Derivatives” Org. Lett. 2022, 24, 7806-7811. Link
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27.
Chen, I.-T.; Guan, R.-Y.; Han*, J.-L. “Asymmetric Sequential Vinylogous Mannich/Annulation/Acylation Process of 2-Ethylidene 1,3- Indandiones and Isatin N-Boc Ketimines: Access to Chiral Spiro- Oxindole Piperidine Derivatives” Adv. Synth. Catal. 2022, 364, 2613-2619. Link
26.
26.
Tsou, Y.-J.; Sathishkumar, N.; Chen, I-T.; Lee, T.-A.; Chen, H.-T.; Han*, J.-L. “Hydrogen-Bond-Donor-Directed Switching of Enantioselectivity in the Vinylogous Aldol–Cyclization Cascade Reaction of Prostereogenic 3-Alkylidene Oxindoles with Isatins and o-Quinones” J. Org. Chem. 2022, 87, 2520-2531. Link
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Xu, J.-X.; Jiang, Y.-S.; Chen, C.-H.; Sathishkumar, N.; Chu, K.-T.; Chiang, M.-H.; Chen, H.-T.; Han*, J.-L. “Enantioselective Organocatalytic Three-Component Vinylogous Michael/Aldol Tandem Reaction among 3-Alkylidene oxindoles,Methyleneindolinones, and Aldehyde” J. Org. Chem. 2022, 87, 197-210. Link
24.
24.
Jin, P.-R.; Ta, N. Y.-N.; Chen, I.-T.; Yu, Y.-N.; Hsieh, H.T.; Nguyen, T.V.-A.; Hsieh, S.-Y.; Hsia, T.; Liu, H.; Hsu, C.-W.; Han*, J.-L.; Chen*, Y. “Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy” J. Med. Chem. 2021, 64, 14513–14525. Link
23.
23.
Tsou, Y.-J.; Guan, R.-Y.; *Han, J.-L. “Enantioselective organocatalytic vinylogous aldolcyclization cascade reaction of 3-alkylidene oxindoles with o-quinones” Org. Biomol. Chem. 2021, 19, 5836–5843. Link
22.
22.
Xu, J.-X.; Chu, K.-D.; Chiang, M.-H.; *Han, J.-L. “Organocatalytic asymmetric allylic alkylation of 2-methyl-3-nitroindoles: a route to direct enantioselective functionalization of indole C(sp3)-H bonds” Org. Biomol. Chem. 2021, 19, 1503-1507.
21.
21.
Guan, R.-Y.; Hsu, C.-W.; *Han, J.-L “Trifluoroethanol-mediated Decarboxylative Addition Reactions of β-Ketoacids with Diverse Electrophiles” Asian. J. Org. Chem. 2021, 10, 273-284.
20.
20.
Chang, C.-H.; Sathishkumar, N.; Liao, Y.-T.; *Chen, H.-T.; *Han, J.-L. “Solvent-Dependent Enantiodivergent Friedel-Crafts Reaction of Arylsulfonyl Indoles with 1-Naphthols” Adv. Synth. Catal. 2020, 362, 903-912.
19.
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*Han, J.-L.; Liao, Y.-T.; Chang, C.-H. “Asymmetric Organocatalytic Conjugate Addition of Electron-Rich Phenols and 1,3-Dicarbonyls to Arylsulfonyl Indoles in an Oil-Water Biphasic System” Eur. J. Org. Chem. 2019, 5815-5823.
18.
18.
*Han, J.-L.; Tsai, Y.-D.; Chang, C.-H. “Asymmetric Synthesis of Spirooxindole δ-Lactones with Vicinal Tertiary and Quaternary Stereocenters via Regio-, Diastereo-, and Enantioselective Organocatalytic Vinylogous Aldol−cyclization Cascade Reaction” Adv. Synth. Catal. 2017, 359, 4043-4049.
17.
17.
Vinu, M.; Lin, W.-C.; D. Raja, S.; *Han, J.-L.; *Lin, C.-H. “Microwave-Assisted Synthesis of Nanoporous Aluminum-Based Coordination Polymers as Catalysts for Selective Sulfoxidation Reaction” Polymers. 2017, 9, 498.
16.
16.
Chang, H.-H.; Chu, K.-D.; Chiang, M.-H.; *Han, J.-L. “Organocatalytic Enantioselective Michael Reaction of 1,3-Dicarbonyls with α-Substituted β-Nitroacrylates” Tetrahedron, 2017, 73, 727-734.
15.
15.
Chang, C.-H.; *Han, J.-L. “Organocatalytic Enantioselective Friedel-Crafts Reaction of Sesamol and Electron–rich Phenols with Alkylideneindolenine Intermediates Generated from Arylsulfonyl Indoles” ChemistrySelect, 2016, 1, 5628-5632.
14.
14.
Guo, Y.-L.; Li, Y.-H.; Chang, H.-H.; Kuo, T.-S.; *Han, J.-L. “Molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael addition reaction: efficient and mild conditions for the synthesis of 3,3-disubstituted oxindoles with an all carbon quaternary center” RSC Advances 2016, 6, 74683-74690.
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13.
*Han, J.-L.; Chang, C.–H. “Asymmetric assembly of spirooxindole dihydropyranones through direct enantioselective organocatalytic vinylogous aldol/cyclization cascade reaction of 3-alkylidene oxindoles with isatins” Chem. Communs 2016, 52, 2322-2325.
Ph.D and Postdoc work
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Penas, C.; Govek, E.; Fang, Y.; Ramachandran, V.; Daniel, M.; Wang, W.; Maloof, M. E.; Rahaim, R. J.; Bibian, M.; Kawauchi, D.; Finkelstein, D.; Han, J. -L.; Long, J.; Li, B.; Robbins, D. J.; Malumbres, M.; Roussel, M. F.; Roush, W. R.; Hatten, M. E.; Ayad, N. G. “Casein Kinase 1d Is an APC/CCdh1 Substrate that Regulates Cerebellar Granule Cell Neurogenesis” Cell Reports 2015, 11, 249-260.
11.
11.
Han, J.-L.; Chen, M.; Roush, W. R. “Diastereo- and Enantioselective Synthesis of (E)-2-Methyl-1,2-syn- and (E)-2-Methyl-1,2-anti-3-pentenediols via Allenyl -boronate Kinetic Resolution with (dIpc)2BH and Aldehyde Allylboration” Org. Lett. 2012, 14, 3028-3031.
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Tsai, B.-L.; Han, J.-L.; Ren, C.-T.; Wu, C.-Y.; Wong, C.-H. “Programmable one-pot synthesis of tumor-associated carbohydrate antigens Lewis X dimer and KH-1 epitopes” Tetrahedron Lett. 2011, 52, 2132-2135.
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Chu, K.-C.; Ren, C.-T.; Lu, C.-P.; Hsu, C.-H.; Sun, T.-H.; Han, J.-L.; Pal, B.; Chao, T.-A.; Lin, Y.-F.; Wu, S.-H.; Wong, C.-H.; Wu, C.-Y. “Efficient and Stereoselective Synthesis of alpha(2 -> 9) Oligosialic Acids: From Monomers to Dodecamers” Angew. Chem. Int. Ed. 2011, 50, 9391 – 9395.
8.
8.
Chang, S.-H.; Han, J.-L.; Tseng, Susan Y.; Lee, H.-Y.; Lin, C.-W.; Lin, Y.-C.; Jeng, W.-Y.; Wang, Andrew H.-J.; Wu, C.-Y.; Wong, C.-H. “Glycan Array on Aluminum Oxide-Coated Glass Slides through Phosphonate Chemistry” J. Am. Chem. Soc. 2010, 132, 13371-13380.
7.
7.
Han, J.-L.; Liu, M. C.; Ong, C. W. “Diastereoselective Synthesis of a Highly Functionalized Angularly Substituted cis-Perhydroisoquinoline-3,6-dione via Organoiron” J. Org. Chem. 2010, 75, 1637-1642.
6.
6.
Hsu, C. -H.; Chu, K. -C.; Lin, Y. -S.; Han, J.-L.; Peng, Y. -S.; Ren, C. -T.; Wu, C. -Y.; Wong, C. -H. “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides” Chem. Eur. J. 2010, 16, 1754 – 1760.
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Han, J.-L.; Ong, C. W. “Construction of Spiro-oxaquinolizidinone Framework of Upenamide via Organoiron complexes” Tetrahedron, 2007, 63, 609-614.
4.
4.
Han, J.-L.; Ong, C. W. “(4+2) Cycloaddition to tricarbonyl[(1-4-η)-2-methoxy-5-methylene-cyclohexa-1,3-diene]iron for the rapid construction of a spiro[5.5]-undecane system”. Tetrahedron, 2006, 62, 8169-8172.
3.
3.
Juang, S. S.; Chang, Michael.; Wang, L. F.; Han, J. -L.; Ong, C. W. “One pot synthesis of fused [1,2-a]pyrrole from 1,6-dioxo-2,4-diene and haloalkyl primary amine”. Tetrahedron, 2005, 61, 1693-1697.
2.
2.
Han, J.-L.; Ong, C. W. “Reaction of tricarbonyl[(1-4-η)-2-methoxy-5-vinylidene-cyclohexa-1,3-diene]iron derivatives with carbene: (2+1) cycloaddition for the rapid synthesis of spiro[2,5]octane”. Tetrahedron, 2005, 61, 1501-1507.
1.
1.
Ong, C. W.; Han, J.-L. “Some Aspects of Anticancer Drug Activation”. Chin. Pharm. J. (review) 2002, 54, 313-329.
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