Work Package 4

Secondments to USA : Ukraine to US (2), Estonia (1)

Training:

• Mastering techniques of preparing unilamellar liposomes with given lipid composition for subsequent spectroscopic studies;
• Study of the influence of 2D nanoparticles on viability and cytotoxicity of the drugs, mastering corresponding techniques.

Results and knowledge transfer:

• Liposome preparation techniques transferred to Ukrainian team.
• Obtained liposomes with different composition and registered their VIS spectra.
• Cytotoxicity effect of 2D membranotropic nanoparticles is evaluated.

Dissemination:

• Lab seminar in US

Secondments to Ukraine: From Estonia (2), Latvia (1), France (3)

Training and knowledge transfer:

• Learning about possible ways of commercialization in MRCENTER

• Providing MRCENTER the current results of the project and its strategic goals

• Discussion about possible ways of using project results in the area of 2D materials covered by lipids and other biological molecules (area of expertise of MRCENTER and its US partners)

Lipid deposition on Graphene substrate: “Structures of single, double and triple layers of lipids adsorbed on graphene: Insights from all-atom molecular dynamics simulations”, Carbon 118 (2017) 358-369.

Publications:

1. Freiberg, A.; Chenchiliyan, M.; Rätsep, M.; Timpmann, K. (2016). Spectral and kinetic effects accompanying the assembly of core complexes of Rhodobacter sphaeroides. Biochimica et Biophysica Acta, 1857 (11), 1727−1733, 10.1016/j.bbabio.2016.08.001.
2. Chenchiliyan, M.; Timpmann, K.; Jalviste, E.; Adams, P.G.; Hunter, C.N.; Freiberg, A. (2016). Dimerization of core complexes as an efficient strategy for energy trapping in Rhodobacter sphaeroides. Biochimica et Biophysica Acta, 1857, 634−642, dx.doi.org/10.1016/j.bbabio.2016.03.020.
3. Timpmann, K.; Kangur, L.; Lõhmus, A.; Freiberg, A. (2017) High-pressure modulation of the structure of the bacterial photochemical reaction center at physiological and cryogenic temperatures J. Phys. B: At. Mol. Opt. Phys. 50 144006: https://doi.org/10.1088/1361-6455/aa77e4.
4. Kangur, L.; Jones, M.R.; Freiberg, A. (2017). Hydrogen bonds in the vicinity of the special pair of the bacterial reaction Enter probed by hydrostatic high-pressure absorption spectroscopy Biophysical Chemistry, in press: https://doi.org/10.1016/j.bpc.2017.04.003.