About the Project

Scientific goal of the project

We propose comprehensive interdisciplinary study of the influence of membrane asymmetry and curvature on the functioning of integral membrane proteins and the transmembrane transport of therapeutic compounds (such as cisplatin and its derivatives). The goal is to reveal major physical factors, which distinguish asymmetric and curved membrane environment and govern interactions, orientation and diffusion of the small molecules (drugs) and large integral proteins.
The combination of experimental methods (“wet” biochemistry and molecular biology, enhanced infrared and Raman spectroscopy) and computer simulations (coarse-grained and atomistic molecular dynamics, quantum chemistry) is used in the project in complementary manner.

Objectives of the project

1.To develop convergent methodology of studying curved and asymmetric lipid membranes by the combination of experimental techniques and computer simulations.

2.To study the influence of the membrane asymmetry and curvature on the translocation of metal-based anti-cancer drugs through the membranes.

3.To determine molecular determinants of the drug molecules, which maximize their cellular uptake and translocation through the membrane depending on the membrane lipid composition and curvature.

4.To study the influence of the membrane lipid charge asymmetry and curvature on the TM of integral membrane proteins, such as lactose permease and photosynthetic reaction centers.

5.To investigate the influence of the membrane environment on release of metalbased anti-cancer drugs from drug delivery carbon materials.

Financing

Full-time secondments to non-EU countries;
Research training;
Networking activities.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 690853

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