Vitae
Jesse H. Goldberg
Robert R. Capranica Fellow
Associate Professor
Neurobiology and Behavior
Cornell University
EDUCATION
M.D, Ph.D. Columbia University, Medicine and Neurobiology, May 2005
B.S. Haverford College, Biology, May 1997
Oxford University, Visiting student in biochemistry, 1995-1996
APPOINTMENTS
2022 Jan-Jun Visiting Scientist, Mediterranean Institute for Neurobiology, INSERM, Marseille, FR
2019-present Associate Professor and Robert R. Capranica Fellow, Cornell University
2012-2019 Assistant Professor, Cornell University
2005-2012 Post-doctoral associate, Michale Fee Lab, M.I.T.
1997-2005 Medical Scientist Training Program, Rafael Yuste Lab, Columbia University
AWARDS AND HONORS (Selected)
2023-2026 Pew Innovation Scholar
2022-2023 New Frontiers Grant, College of Arts and Sciences, Cornell University
2017-2021 Scientific Advisory Board, Dystonia Medical Research Foundation
2016 Kavli Fellow
2015-2020 NIH New Innovator
2014-2018 Pew Biomedical Scholar
2014-2016 NSF BRAIN EAGER Award
2013-2016 Klingenstein Fellowship in the Neurosciences
2010-2015 K99/R00 Career Development Award, NIH, NINDS
2009-2020 Charles King Trust Fellowship
2006-2008 Damon Runyon Postdoctoral Fellowship
2003 Deans Award for best PhD thesis, Columbia University
1997 Phi Beta Kappa, Haverford College
GRANTS and SUPPORT
CURRENT SUPPORT
2020-2025 NIH R01 (PI) Neural Mechanisms of Performance Evaluation During Motor Sequence Learning
2023-2025 Pew Innovation Fund (PI) Neural Mechanisms of Parental Care
2023-2028 NIH R01 (Co-PI) Mechanisms and functions of cortical activity to restore behavior.
PREVIOUS SUPPORT
2023-2023 NIH R34 (PI). Neural mechanisms of social communication in parrots
2021-2022 Cornell Office of the Vice Provost for Academic Integration (PI)
2021-2022 New Frontier Grant, Cornell College of Arts and Sciences (PI)
2018-2021 NIH UF1 (Co-PI). Advanced MOTEs: Injectable Microscale Optoelectronically Transduced Electrodes
2016-2017 NIH R21 (Co-PI). MOTES: Micro-scale Opto-electronically Transduced Electrode Sites
2018-2020 Dystonia Medical Research Foundation (PI). Machine learning guided deep brain stimulation for neurological disease
2015-2021 NIH R01 (PI). Neural Mechanisms of Performance Evaluation During Motor Sequence Learning
2015-2021 NIH DP2 (PI). Identifying Pathways for Motor Variability in the Mammalian Brain
2014-2017 NSF BRAIN EAGER (Co-PI). Stretchable Graphene Transistors For High Signal, High Channel Count Neural Recording
2014-2016 Pew Biomedical Scholar (PI). Neural mechanisms of trial and error learning in songbirds
2013-2015 Klingenstein Fellowship (PI). Neural Circuits for Motor Exploration And Learning
PENDING APPLICATIONS
2024-2029 NIH R01 (PI). Neural Mechanisms of miss- and touch-guided sensorimotor corrections
2024-2034 Simons Collaboration on the Evolution of Social Cognition (Co-PI)
2024-2026 Brain Research Foundation (PI)
PUBLICATIONS
Goldberg Lab Member, Undergraduate#
SUBMITTED & IN REVISION
Tejapratap Bollu, Samuel C. Whitehead, Nikil Prasad#, Jackson Walker#, Nitin Shyamkumar#, Raghav Subramaniam#, Brian Kardon, Itai Cohen, Jesse Goldberg. Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task. In revision at Journal of Neurophysiology and available here.
Malavika Ramarao#, Andrea Roeser, Caleb Jones, Jesse H. Goldberg. Songbird mesostriatal dopamine pathways are spatially segregated before the onset of vocal learning. In revision at PLOS One and posted at biorxiv.
Zhilei Zhao, Han Kheng Teoh, Julie Carpenter, Frieda Nemon#, Brian Kardon, Itai Cohen, Jesse H. Goldberg. An anterior forebrain pathway in parrots is necessary for individual signatures of learned vocalizations. In revision at Current Biology and posted at biorxiv.
Caleb Jones and Jesse Goldberg. Auditory cortical error signals retune during songbird courtship. In revision at eLife and posted at biorxiv.
PUBLISHED & IN PRESS
38. Andrea Roeser*, Vikram3 Gadagkar*, Anindita Das, Pavel A. Puzerey, Brian Kardon and Jesse H. Goldberg. Dopaminergic signals for reward, performance and social outcomes are dynamically gated during courtship. Nature (cover article), 2023 Sep 27.
37. Zhao Z, Goldberg JH. Dopaminergic signals for improved parental behavior. Neuron. 2023 Feb 15;111(4):452-453
36. Jesse Goldberg. Book Chapter: Motor Thalamic Interactions with Brainstem and Basal Ganglia. Chapter 14, pages 269-283.In: The Thalamus, Michael M. Halassa, Editor. Cambridge University Press. 2022
35. Anindita Das and Jesse H. Goldberg. Songbird subthalamic neurons project to dopaminergic midbrain and exhibit singing-related activity. Journal of Neurophysiology. 2022 Feb 1;127(2):373-383.
34. Alison Duffy, Kenneth W. Latimer, Jesse H. Goldberg, Adrienne L. Fairhall, Vikram Gadagkar. Dopamine neurons evaluate natural fluctuations in performance quality. Cell Reports. 2022 Mar 29;38(13):110574.
33. Bollu T*, Ito B*, Whitehead SC, Kardon B, Liu MH#, Goldberg JH. Cortex-dependent corrections as the tongue reaches for and misses targets. Nature. 2021 Jun;594(7861):82-87.
32. Chen R, Gadagkar V, Roeser A, Puzerey P, Goldberg JH. Movement signaling in ventral pallidum and dopaminergic midbrain is gated by behavioral state in singing birds. J Neurophysiol. 2021 Jun 1;125(6):2219-2227. doi: 10.1152/jn.00110.2021.
31. Chen R and Goldberg JH. Actor-critic reinforcement learning in the songbird. Chen R, Goldberg JH. Current Opinion in Neurobiology. 2020 Sep 5;65:1-9. doi: 10.1016/j.conb.2020.08.005.
30. Sheehan MJ, Goldberg JH. Animal Behavior: Socially Distanced Wasps Learn About Rivals. Current Biology. 2020 Aug 3;30(15):
29. Chen R, Puzerey P, Roeser A, Riccelli T#, Podury A#, Maher K#, Farhang A#, Goldberg JH. Songbird ventral pallidum sends diverse performance error signals to dopaminergic midbrain. Neuron. 2019 May 11. 6273(19)30395-2.
28. Bollu T, Whitehead SC, Prasad N#, Walker JR#, Shyamkumar N#, Subramaniam R#, Kardon BM, Cohen I, Goldberg JH. Automated homecage training of mice in a hold-still center-out reach task. J Neurophysiol. 2019 Feb 1;121(2):500-512.
27. Chen R, Bollu T, Goldberg JH. A stable neural code for birdsong. Neuron (Preview). 2018 Jun 27;98(6):1057-1059
26. Puzerey P, Maher K#, Chen R, Prasad N#, Goldberg JH. Vocal learning in songbirds requires cholinergic signaling in a motor cortex-like nucleus. J Neurophysiol. 2018 Oct 1;120(4):1796-1806.
25. Murdoch D, Chen R, Goldberg JH. Place preference and vocal learning rely on distinct reinforcers in songbirds. Scientific Reports. 2018 Apr 30;8(1):6766.
24. Gadagkar V, Puzerey P, Chen R, Baird-Daniel E#, Farhang A#, Goldberg JH. Dopamine neurons encode performance error in singing birds. Science. 2016 Dec 9;354(6317):1278-1282.
23. Pidoux M, Bollu T, Riccelli T#, Goldberg JH. Origins of basal ganglia output signals in singing juvenile birds. Journal of Neurophysiology. 2015 Feb 1;113(3):843-5.
22. Gadagkar V and Goldberg JH. A Variability-Generating Circuit Goes Awry in a Songbird Model of the FOXP2 Speech Disorder. Neuron. 2013 Dec 18;80(6):1341-44.
21. Goldberg JH, Farries MA and Fee MS. Basal ganglia output to the thalamus: still a paradox.
Trends Neurosci. 2013 Dec;36(12):695-705.
20. Goldberg JH, Farries MA and Fee MS. Integration of cortical and pallidal inputs in the basal ganglia-recipient thalamus of singing birds. Journal of Neurophysiology 2012 Sep;108(5):1403-29.
19. Goldberg JH and Fee MS. A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds. Nature Neuroscience. 2012 Feb 12;15(4):620-7.
18. Fee MS and Goldberg JH. A hypothesis for basal ganglia dependent reinforcement learning in the songbird. Neuroscience. 2011 Dec 15;198:152-70.
17. Aronov D, Veit L, Goldberg JH, Fee MS. Two distinct modes of forebrain circuit dynamics underlie temporal patterning in the vocalizations of young songbirds. Journal of Neuroscience. 2011 Nov 9;31(45): 16353-68
16. Goldberg JH and Fee MS. Vocal babbling in songbirds requires the basal ganglia-recipient motor thalamus. Journal of Neurophysiology. 2011 Jun;105(6):2729-39.
15. Ölveczky BP, Otchy T, Goldberg JH, Aronov D, Fee MS. Changes in the neural control of a complex motor sequence during learning. Journal of Neurophysiology. 2011 Jul;106(1):386-97.
14. Goldberg JH, Adler A, Bergman H, and Fee MS. Singing related neural activity distinguishes two classes of putative pallidal neuron in the songbird basal ganglia: Comparison to the primate internal and external pallidal segments. Journal of Neuroscience. 2010 May 19;30(20):7088-98
13. Goldberg JH and Fee MS. Singing related neural activity distinguishes four classes of putative striatal neuron in the songbird basal ganglia. Journal of Neurophysiology. 2010 Apr;103(4):2002-14.
12. Petilla Cortical Interneuron Nomenclature Group. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nature Reviews Neuroscience. 2008 Jul;9(7):557-68.
11. Skeberdis V, Chevaleyre V, Suadicani SO, Goldberg JH, Bennett MVL, Yuste R, Castillo PE and Zukin RS. Protein kinase A promotes LTP induction by increasing calcium permeability of NMDA receptors in dendritic spines. Nature Neuroscience, 2006 Apr 9(4) 501-510.
10. Goldberg JH and Yuste R. Space Matters: Local and global dendritic calcium comparmentalization in cortical interneurons. Trends in Neurosciences. 2005 28: 158-167.
9. Goldberg JH, Lacefield CO, Yuste R. Global dendritic calcium spikes in mouse layer 5 low-threshold spiking (LTS) interneurones: implications for control of pyramidal bursting. Journal of Physiology. 2004 Jul 15;558(Pt 2):465-78.
8. Goldberg JH, Tamas G, Aronov D, Yuste R. Calcium microdomains in aspiny dendrites. Neuron (Cover article). 2003 Nov 13;40(4):807-21.
7. Goldberg JH, Tamas G, Yuste R. Ca2+ imaging of mouse neocortical interneuron dendrites: Ia-type K+ channels control action potential backpropagation. Journal of Physiology (Previewed article). 2003 Aug 15;551:49-65.
6. Goldberg JH, Yuste R, Tamas G. Ca2+ imaging of mouse neocortical interneuron dendrites: Contribution of Ca2+-permeable AMPA and NMDA receptors to subthreshold Ca2+dynamics. Journal of Physiology (Previewed article). 2003 Aug 15;551:67-78.
5. Goldberg J, Holthoff K, Yuste R. A Problem with Hebb and local spikes. Trends in Neurosciences. 2002 Sep; 25(9): 433-5.
4. Hirase H, Nikolenko V, Goldberg JH, Yuste R. Multiphoton stimulation of neurons. Journal of Neurobiology. 2002 Jun 5; 51(3):237-47.
3. Tashiro A, Goldberg J, Yuste R. Calcium oscillations in neocortical astrocytes under epileptiform conditions. Journal of Neurobiology. 2002 Jan;50(1):45-55
2. Badea T, Tashiro A, Goldberg J, Mao B, Yuste R. Imaging epileptiform events in juvenile neocortical slices with single cell resolution. Journal of Neurobiology. 2001 Sep 5;48(3):215-27.
1. Cavallaro S, Meiri N, Yi C, Musco S, Ma W, Goldberg JH, Alkon DL. Late memory-related genes in the hippocampus revealed by RNA fingerprinting, PNAS 94 (1999): 9669-9673.
STUDENT AND POSTDOC MENTORING
POSTDOCTORAL MENTEES
Zhilei Zhao 2021-present, Klarman Fellow
Anindita Das 2017-2020
Vikram Gadagkar 2013-2019, Simons Fellow, K99/R00 Awardee, Gruber Prize
Pavel Puzerey 2014-2018, NIH F32 Fellow
Morgane Pidoux 2013-2015
PhD STUDENTS MAJOR ADVISOR
Teja Bollu NBB, Cornell 2013-2020
Ruidong Chen NBB, Cornell 2015-2021
Andrea Roeser NBB, Cornell 2017-2023
Brendan Ito NBB, Cornell 2018-expected 2024
Xu (Heidi) Huang NBB, Cornell 2019-expected 2024
Yongui (Jason) Gao NBB, Cornell 2020-expected 2025
Caleb Jones BME, Cornell 2020-expected 2024
Lizemarie Cirone NBB, Cornell 2022-
Mira Vanchiswar NBB, Cornell 2023-
PhD STUDENT MINOR COMMITTEE MEMBER
Anna Gruzdeva (Yapici Lab, Cornell NBB), Edward Szoka (Molnar lab, Cornell ECE), Shahab Ghajari (Molnar lab, Cornell ECE), Alynda Wood (Emory, Sober lab), Zena Casteel (NBB, Webster), Akash Guru (NBB, Warden lab), Sam Whitehead (Cornell Physics, Cohen lab), Han Keng Teoh (Cornell Physics, Cohen lab), Chunyan Wu (Cornell Engineering Physics, Xu lab), Artem Bolshakov (Cornell ECE, Sabuncu lab), Changwoo Seo (NBB, Warden); Ryan Post (NBB, Warden), Jaeeon Lee (Harvard, Sabatini lab), Uisub Shin (Cornell ECE, Molnar Lab), Alynda Wood (Emory, Sober Lab).
UNDERGRADUATE HONORS THESES AND MENTORSHIP
(*Honors Thesis in my lab; # co-author on published paper)
Class of 2025 Frieda Nemon#,*
Class of 2024: Ash Ashok*
Class of 2023: Malavika Ramarao#,*
Class of 2021: Treasure Nwokoleme#,*, Haashim Shah, Eugene Kim*;
Class of 2020: Mei Hong Lui#,*, Katerina Sadov;
Class of 2019: Archana Podury#,*, Nigel Kravatz;
Class of 2018: Kamal Maher#,*, Vidya Ramesh;
Class of 2017: Nitin Shyamkumar#, Nikil Prasad#,*;
Class of 2016: Tori Riccelli#,*, Alexander Farhang#,*, Jieying Wu*;
Class of 2015: Eliza Baird-Daniel#,*, Eric Gao, Raghav Subramaniam#
INVITED SEMINARS AND CONFERENCE PRESENTATIONS (Selected)
2023 Rockefeller University, Price Family Center for the Social Brain, NY, NY
2023 Case Western Reserve, Dept Biology, Cleveland, OH
2023 European Birdsong Meeting, Sardinia, Italy
2023 NYU, Department of Neuroscience, NY, NY
2022 CSHL Seminar Series, Cold Spring Harbor, NY
2022 Jackson Labs, Machine Learning quantification of animal behavior Workshop, Bar Harbor, ME
2022 Paris Saclay Institute of Neurosience, Paris, FR
2022 Université Paris Nanterre, Paris, FR
2022 European Birdsong Meeting, Sardinia, Italy
2022 Southern Denmark University, Dept.of Biology, Odense, Denmark
2022 Mediterranean Institute of Neuroscience, Marseille, FR
2022 CSHL Neural Circuits Meeting, Cold Spring Harbor, NY
2020 Brandeis University, Neuroscience Seminar Series (Zoom)
2020 VIDA Virtual Dopamine, Zoom talk
2020 Harvard Medical School, Boston, MA
2020 Google DeepMind, London, UK
2020 University College London, Sainsbury Wellcome Center for Neural Circuits, UK
2019 James S. McDonnell Foundation, Neuromodulation Workshop, Tarrytown, NY
2019 University of Pennsylvania, MindCORE Seminar Series, Philadelphia, PA
2019 Gordon Conference on Catecholamines, Sunday River, ME
2019 University of Tokyo, Dept Biology, Hongyo Campus, Tokyo, Japan
2019 University of Tokyo Medical School, Tokyo, Japan
2019 Okinawa Institute of Technology, Okinawa, Japan
2019 Gordon Conference on Neural Circuits and Behavior, Les Diablerets, SZ
2019 NIH BRAIN Initiative meeting, Rockville, MD
2019 Champalimaud Institute for the Unknown, Lisbon, PT
2019 DMRF Annual meeting, Houston, TX
2019 Boston University, Dept Neuroscience, Boston, MA
2018 Baylor School of Medicine, Dept Neuroscience, Houston, TX
2018 Annual Birdsong and Animal Communication Meeting, Millbrook, NY
2018 University of Toronto Medical School, Keynote Speaker, Dept Psychiatry
2018 HHMI Janelia Farm, Dexterous Control of Movement
2018 Duke University, Dept of Neurobiology, Durham, NC
2018 Dystonia Medical Research Foundation Annual Meeting, San Antonio, TX
2017 University of California San Francisco (UCSF), San Francisco, CA
2017 UCSD, Computational Biology, San Diego, CA
2017 MIT, Brain and Cognitive Sciences, Cambridge, MA
2017 Pennsylvania State University, State College, PA
2017 Harvard Medical School Dept. Neurobiology, Boston, MA
2017 Emory University, Atlanta, GA
2017 Rockefeller University, New York, NY
2017 HHMI Janelia Farm, Mushroom Body Meeting, Ashburn, VA
2017 Computational and Systems Neuroscience Meeting, Snowbird, UT
2017 Dystonia Medical Research Foundation Meeting (Keynote), Phoenix, AZ
2017 Wesleyan University, Middletown, CT
2016 Arab American Frontiers of Science, Abu Dhabi, UAE
2016 Society for Neuroscience, Minisymposium on Vocal learning, San Diego, CA
2016 Cornell University, Mong Neurotech Symposium, Ithaca NY
2016 CSHL Neuroscience Seminar Series, Cold Spring Harbor, NY
2016 Klingenstein Annual Meeting, NY, NY
2016 German-American Kavli Frontiers of Science Symposium, Berlin, Germany
2016 HHMI Janelia Farm, Central Complex IV, Ashburn, VA
2015 Collaborative Computational Neuroscience Meeting, Plenary Speaker, Seattle, WA
2015 Meinig Sympoisum, Dept of biomedical engineering (Cornell)
2015 Electron Devices Society talk, Dept ECE, Cornell
2015 HHMI Janelia Farm, Thalamus and corticothalamic interactions (Meeting organizer)
2015 Klingenstein Annual Meeting, New York, NY
2015 Pew Scholars Annual Meeting, Vieques, Puerto Rico
2015 Computational and Systems Neuroscience Meeting, Salt Lake City, UT
2014 Computational Neurosciences Meeting, Quebec City
2014 University of Pittsburgh Dept of Neuroscience, Pittsburgh, PA
2013 Conference on Neurobiology of Action, Stresa, Italy
2013 Janelia Farm Workshop on Motor Efference Copy, Ashburn, VA
2013 Dept of Neurobiology, Weizman Institute of Science, Rehovot, Israel
PROFESSIONAL ACTIVITY and REVIEWING
PROFESSIONAL MEMBERSHIPS
Society for Neuroscience (SFN)
International Basal Ganglia Society
Committee on Animal Research (CAR), SFN
Dystonia Medical Research Foundation
GRANT REVIEWING (ad hoc)
NSF, Israel Science Foundation, NIH, NIH Brain Initiative, Wellcome Trust DBT India Alliance Fellowship, Dystonia Medical Research Foundation, Human Frontiers Science Program
JOURNAL EDITORIAL DUTIES
Board of reviewing editors, eLife
REVIEWING ACTIVITY
Science, Nature, Cell, Neuron, Nature Neuroscience, Cell Reports, Journal of Neurophysiology, Journal of Neuroscience, Journal of Physiology, eLife, Royal Proceedings B, Brain and Behavioral Sciences, PLOS Biology, Nature Communications, Scientific Reports, Current Biology
UNIVERSITY SERVICE (Selected)
2023-ongoing Co-Director, Cornell Radical Collaboration for Artificial Intelligence
2023 Speaker, Founders’ Circle Recognition Dinner
2023 Chair, NBB Faculty Search committee for new Chair
2023 Co-Chair, Computational Biology Faculty Search committee
2023 Co-director, Cornell AI Initiative
2023 Faculty affiliate, T32 Program in AI and Precision Nutrition
2023 Associate Director, Cornell University AI for Science Institute
2022 Mitzi Sutton Russekoff Lecturer, Cornell Club, NYC
2022 Steering Committee, Cornell AI initiative
2021 Organizer, Cornell symposium bridging AI and Neuroscience
2021-2022 Chair, Neuro/AI faculty search committee
2021-ongoing Member, Cornell Initiative on Artificial Intelligence
2020-ongoing, Director of Graduate Studies
2012-2022 Graduate Executive Committee, Dept Neurobiology and Behavior
2013-ongoing Faculty search committee, Dept Neurobiology and Behavior
2015-ongoing Member, Cornell Neurotech advisory board
2018-ongoing College of Arts & Sciences Ad Hoc Committee on a Cognitive Science Major
2018-2020, AS1102 Freshman Advising
2017 Member, Provost's Internal Review of the Social Sciences
2016-ongoing Faculty Advisor, Men’s lightweight rowing team
2015, Lab sponsor Leadership Program for Veterinary Scholars
2013-ongoing, Faculty Fellow, Hans Bethe House
TEACHING
BIONB 7210 Introductory Graduate Survey in Neurobiology and Behavior
BIONB 2220 Introduction to Neurobiology
BIONB 4320 Neural Circuits for Motor Control
BIONB 4200 Microcircuits of the Neocortex
BIONB 4200 Neuroethology