Seung Pil Yun

EDUCATION HISTORY

• 2009. 03-2012. 08 Ph.D, Veterinary Physiology (Stem Cell Biology), College of Veterinary Medicine, Chonnam National University, South Korea, Advisor: Soo Hyun Park, D.V.M, PhD.

• 2007. 03-2009. 02 M.S, Veterinary Physiology (Stem Cell Biology), College of Veterinary Medicine, Chonnam National University, South Korea, Advisor: Ho Jae Han, D.V.M, PhD.

• 1998. 03-2007. 02 B.S & D.V.M, Veterinary Medicine, College of Veterinary Medicine, Chonnam National University, South Korea, Advisor, Nam Yong Park, D.V.M, PhD.

PROFESSIONAL EXPERIENCE

• 2005.03-2006.02 Tuition Assistant, Veterinary Medicine (Pathology), College of Veterinary Medicine, Chonnam National University, South Korea

• 2012.09-2013.08 Post-doctoral fellow, Veterinary Medicine (Stem Cell Biology), College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, South Korea

• 2013.03-2013.08 Lecturer, Veterinary Medicine (Molecular & Cellular Biology), College of Veterinary Medicine, Seoul National University, South Korea

• 2014.05-2017.04 Post-doctoral fellow, Diana Helis Henry Medical Research Foundation, USA.

• 2013.10-2018.08 Post-doctoral fellow, Institute for Cell Engineering (Neurology/ Neuroregeneration/ Stem Cell Therapy), School of Medicine, Johns Hopkins University, USA.

• 2018.10-2019.02 Post-doctoral fellow, Department of Pathology, College of Medicine, Kyung Hee University.

• 2019.03-present Assistant professor, Department of Pharmacology, Gyeongsang National University School of Medicine.

RESEARCH INTERESTING

• 1. Parkinson’s disease

- 파킨슨병 병인 규명

- 파킨슨병 치료제 개발

- 파킨슨병 조기진단법 개발

• 2. InterDisease communication

- 신체 말단 장기(Kidney, Joint, intestine, immune organ)와 뇌 상호 관계 규명

- 신체 염증 반응과 뇌 상호 관계 규명

- 신체 반응 조절을 통한 뇌염증 반응 조절 기전 규명

- 공통 조절 약물의 reposition을 통한 신약 개발

• 3. Infectious disease and Brain

- SARS-CoV2와 신경계 상호 작용 분석

- SFTS에 의한 중추신경계 손상 기전 연구 및 치료법 개발

• 4. Metabolic disease and neuro-inflammation

- 당뇨/비만 모델을 활용한 말초신경 손상 기전 규명 연구

- 당뇨/비만 모델을 활용한 말초신경 손상 억제 약물 개발

• 기초연구실 외 공동연구팀

- 아주대학교 의과대학

- 경희대학교 의과대학

- 성균관대학교 의과대학

- 경북대학교 약학대학

- 전북대학교 인수공통전염병 센터

- 농림축산검역본부

- 경상국립대학교 병원

RESEARCH PROJECTS

• 기초연구연구실 지원사업

과제명: 자가면역 기반 파킨슨병 제어 연구실

지원기관: 한국연구재단

지원기간: 2021-2024 (5억/년)

연구목표: 본 연구는 자가면역반응이 파킨슨병 발병에 미치는 영향을 규명함으로써 파킨슨병 연구의 새로운 패러다임을 제공하고

이를 기반으로 파킨슨병 조기진단법 및 약물재생산을 통한 치료법 개발을 목표로 함.

• 기본연구

과제명: 중증열성혈소판감소증후군에서 의한 중추신경계 손상 기전 규명을 통한 중증환자 치료 방안 모색 지원기관: 한국연구재단

지원기간: 2021-2024 (0.5억/년)

연구목표: 열성혈소판감소증후군 바이러스 (severe fever with thrombocytopenia syndrome virus, SFTSV) 감염시 발생하는 중추신경계

손상의 원인 및 기전을 규명하고 이를 바탕으로 중증 신경계침범 환자의 치료 방법 개발을 목표로 함.

연구책임: 경상국립대학교 병원 홍경욱 교수

• 기본연구

과제명: 저산소 상태 매개 별아교세포 활성에 의한 파킨슨병 보호 효과 규명 연구

지원기관: 한국연구재단

지원기간: 2021-2024 (0.5억/년)

연구목표: 약한 저산소 상태에서 발생하는 뇌 별아교세포의 활성이 파킨슨병 발병 억제에 미치는 영향 및 별아교세포 유래 보호 인자를

규명함으로써 파킨슨병 치료를 위한 유효인자 발굴을 목표로 함.

연구책임: 경상국립대학교 병원 김민경 교수

• 학문균형 발전-지역우수과학자 지원사업

과제명: 사람의 도파민 뉴런 및 면역세포를 이용한 파킨슨병 예방/치료를 위한 신경면역 반응 조절 인자 발굴 및 발병 기전 연구

지원기관: 한국연구재단

지원기간: 2019-2022 (1억/년)

연구목표: 줄기세포에서 분화된 면역세포 및 신경세포를 이용하여 신체 과도한 면역반응과 신경퇴행성 질환 (파킨슨병)과의 상관관계를

규명하고 예방제 및 치료제 타겟을 선정한다. 이를 바탕으로 공동연구와 융합연구를 통하여 예방/치료 신약 후보 물질 개발을 목표로 함.

PUBLICATIONS

[2021]

• 74. Yongwun Cho, Seung Pil Yun, Mi-Hwa Park, Jin-Seok Seo, Gyu-Nam Kim, Woong-Sun Yoo, Rock-Bum Kim, Min-Chul Cho, Seong-Jae Kim. Reduced 25-Hydroxyvitamin D Concentration in the Aqueous Humor of Cataract Patients with Open Angle Glaucoma. under minor revision. (Co-First)

• 73. Gyu-Nam Kim, Young-Sool Hah, Woong-Sun Yoo, Hee-Young Cho, Seung-Pil Yun, Seong-Jae Kim. The Role of Nuclear Factor of Activated T Cells 5 in Hyperosmotic Stress-exposed Human Lens Epithelial Cells. International Journal of Molecular Sciences 2020. under major revision. (Corresponding Author)

• 72. Kwang-Soo Lyoo, Hyeon Myeong Kim, Bina Lee, Jeong Hee Kim, Young Hyun Che, Daesub Song, Minjoo Yeom, Hyemin Seong, Seong-Jae Kim, Min-Kyoung Shin, Woochang Hwang, Sun Lee, Jae-Hoon Park, Woonsung Na, Seung Pil Yun Yong Jun Kim,. Direct infection of SARS-CoV-2 induces neurologic pathogenesis 1 in hESC-derived peripheral neurons. Nature Communication. 2020. under major revision. (Corresponding Author)

• 71. Seong Jae Han, Hyemi Lee, Jimin Jeon, Chanmi Cho, Eunjeong Oh, Jiho Nam, Yu Su Shin, Joong Sun Kim, Seung Pil Yun, Li-Jung Kang. Safflower seed extract attenuates the development of arthritis by blocking IκB degradation. Pharmaceuticals 2021;14(3):258. (Corresponding Author) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999399/

• 70. Woong-Sun Yoo, Gyu-Nam Kim, Inyoung Chung, Min-Chul Cho, Yong Seop Han, Sang Soo Kang, Seung Pil Yun, Seong-Wook Seo, Seong-Jae Kim. Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reaction. Sci Rep 2021;11(1):8814. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065052/

• 69. Eun A Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee. Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice. Plants (Basel) 2021;10(5):837. (Corresponding Author) https://www.mdpi.com/2223-7747/10/5/837

• 68. Jihyun Je, Hwajin Kim, Eun Jung Park, So Ra Kim, Theodomir Dusabimana, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Kye Man Cho, Sang Won Park. Geniposide improves diabetic nephropathy by enhancing ULK1-mediated autophagy and reducing oxidative stress through AMPK activation. Int J Mol Sci. 2021;22(4):1651. https://pubmed.ncbi.nlm.nih.gov/33562139/

• 67. Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park. Safflower seed extract attenuates the development of arthritis by blocking IκB degradation. Int. J. Mol. Sci. 2021, 22(4), 1651. https://www.mdpi.com/1422-0067/22/4/1651

[2020]

• 66. Hyojung Kim, Jeong-Yong Shin, Yun-Song Lee, Seung Pil Yun, Han-Joo Maeng, Yunjong Lee. Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson's Disease via a Vitamin D Receptor-Dependent Pathway. Int J Mol Sci. 2020;21(22):8538. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696047/

• 65. Hyojung Kim, Jisoo Park, Hojin Kang, Seung Pil Yun, Yun-Song Lee, Yun-Il Lee and Yunjong Lee. Activation of the Akt1-CREB pathway contributes to RNF146 expression and parthanatos inhibition. Science signaling. 2020;13(663):eaax7119. https://stke.sciencemag.org/content/13/663/eaax7119

• 64. Jihyun Je, Hwajin Kim, Eun Jung Park, So Ra Kim, Theodomir Dusabimana, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Kye Man Cho, Sang Won Park. Fermentation of Sprouted Ginseng ( Panax ginseng) Increases Flavonoid and Phenolic Contents to Attenuate Alcoholic Hangover and Acute Liver Injury in Mice. Am J Chin Med. 2020:26:1-16. https://pubmed.ncbi.nlm.nih.gov/33371811/

• 63. 류예리, 윤승필. 세계보건기구(WHO)의 대유행 인플루엔자 대비체계 (PIPF)와 나고야의정서의 관계. 강원대학교 환경법과 정책. 2020:25:171-192. (Corresponding Author) http://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE10477140

• 62. Mu Seog Choe, Joong Sun Kim, Han Cheol Yeo, Chang Min Bae, Ho Jae Han, Kyungmin Baek, Woochul Chang, Kyung Seob Lim, Seung Pil Yun, In-Sik Shin, Min Young Lee. A simple metastatic brain cancer model using human embryonic stem cell–derived cerebral organoids. The FASEB Journal. 2020:34(12):16464-16475. https://pubmed.ncbi.nlm.nih.gov/33099835/

• 61. Sangwoo Ham, Seung Pil Yun, Hyojung Kim, Donghoon Kim, Bo Am Seo, Heejeong Kim, Jeong-Yong Shin, Mohamad Aasif Dar, Gum Hwa Lee, Yun Il Lee, Doyeun Kim, Sunghoon Kim, Hee-Seok Kweon, Joo-Ho Shin, Han Seok Ko, and Yunjong Lee. Pathological AIMP2 aggregation leads to a-synuclein inclusion and dopaminergic toxicity in Parkinson’s disease contributes to a-synuclein interaction and Lewy-like inclusion. Science Translational Medicine. 2020:12(569):eaax0091. https://stm.sciencemag.org/content/12/569/eaax0091.short

• 60. Jean Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway. Biochem Pharmacol. 2020;182:114246. https://www.sciencedirect.com/science/article/abs/pii/S0006295220304822?via%3Dihub

• 59. Theodomir Dusabimana, So Ra Kim, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park. P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response. Mol Metab. 2020;25;101089. https://www.sciencedirect.com/science/article/pii/S2212877820301630?via%3Dihub

• 58. Eun Jung Park, Theodomir Dusabimana, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park. Honokiol protects the kidney from renal ischemia and reperfusion injury by upregulating the glutathione biosynthetic enzymes through activating Nrf2 via PI3K/Akt and PKC signaling. Biomedicines. 2020;15;8(9):E352. https://pubmed.ncbi.nlm.nih.gov/32942603/

• 57. So Ra Kim, Eun Jung Park, Theodomir Dusabimana, Jihyun Je, Kyuho, Seung Pil Yun, Hye Jung Kim , Kye Man Cho, Hwajin Kim, Sang Won Park. Platycodon grandiflorus fermented extracts attenuate endotoxin-induced acute liver injury in mice. Nutrients. 2020;12(9):E2802. https://pubmed.ncbi.nlm.nih.gov/32933130/

• 56. Hyojung Kim, Seok-Jae Kang, Young Mi Jo, Sanggyu Park, Seung Pil Yun, Yun-Song Lee, Hee-Tae Kim, Nae-Eung Lee, Yong-Sang Kim, Seok Hyun Cho, Yunjong Lee. Novel nasal epithelial cell markers of Parkinson’s disease identified using cells treated with a-synuclein preformed fibrils. J Clin Med. 2020;9(7):E2128. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408990/

• 55. Hyemi Lee, Dain Jang, Jimin Jeon, Chanmi Cho, Sangil Choi, Seong Jae Han, Eunjeong Oh, Jiho Nam, Chan Hum Park, Yu Su Shin, Seung Pil Yun, Siyoung Yang, Li-Jung Kang. Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice. J Cell Mol Med. 2020;24(14):8126-37. (Corresponding Author) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348148/

• 54. Hana Jin, Trojan Rugira, Young Shin Ko, Sang Won Park, Seung Pil Yun, Hye Jung Kim. ESM-1 overexpression is involved in increased tumorigenesis of radiotherapy-resistant breast cancer cells. Cancers. 2020;12(6):E1363. https://www.mdpi.com/2072-6694/12/6/1363

• 53. 박신욱, 윤승필. 합성생물학의 발전과 EU의 법적 대응방안에 대한 연구. 경상대학교 법학연구소. 2020;28(2):45-64. (Corresponding Author) http://ilaw.gnu.ac.kr/ilaw/sub.do?mode=view&idx=266740&mCode=MN0006

[2019]

• 52. Choe MS, Yeo HC, Bae CM, Han HJ, Baek KM, Kim JS, Lim KS, Shin IS, Chang WC, Yun SP, Lee HJ, Lee MY. Trolox-induced cardiac differentiation is mediated by the inhibition of Wnt/β-catenin signaling in human embryonic stem cells. Cell Biol Int. 2019 Jul: Online ahead of print. https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11200

• 51. Ham S, Kim H, Hwang S, Kang H, Yun SP, Kim S, Kim D, Kwon HS, Lee YS, Cho M, Shin HM, Choi H, Chung KY, Ko HS, Lee GH, Lee Y. Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 2019;42(6):480-494. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602149/

• 50. B rahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, Mao X, Lee Y, Swing DA, Tessarollo L, Ko HS, Dawson VL, Dawson TM. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain. 2019:142(8): 2380–2401. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658849/

[2018]

• 49. Tae-In Kam, Xiaobo Mao, Hyejin Park, Senthilkumar S. Karuppagounder, Shih-Ching Chou, George Essien Umanah, Saurav Brahmachari, Seung Pil Yun, Nikhil Panicker, Rong Chen, Shaida A. Andrabi, Chen Qi, Guy G. Poirier, Olga Pletnikova, Juan C. Troncoso, James B. Leverenz, Alexander Pantelyat, Han Seok Ko, Liana S. Rosenthal, Ted M. Dawson and Valina L. Dawson. Poly (ADP-ribose) Drives Pathologic a-Synuclein Neurodegeneration. Science 2018: 362(6414). pii: eaat8407. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=30385548

• 48. Goun Je, Subhrangshu Guhathakurta, Seung Pil Yun, Han Seok Ko, Yoon-Seong Kim. A novel extended form of alpha-synuclein 3′UTR in the human brain. Molecular brain 2018: 11(1):29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970512/

• 47. Seung Pil Yun*, Tae-In Kam*, Nikhil Panicker, SangMin Kim, Yumin Oh, Jong-Sung Park, Seung-Hwan Kwon, Yong Joo Park, Senthilkumar S. Karuppagounder, Hyejin Park, Sangjune Kim, Nayeon Oh, Nayoung Alice Kim, Saebom Lee, Saurav Brahmachari, Xiaobo Mao, Jun Hee Lee, Manoj Kumar, Daniel An, Sung-Ung Kang, Yunjong Lee, Kang Choon Lee, Dong Hee Na, Donghoon Kim, Sang Hun Lee, Shane A. Liddelow, Zoltan Mari, Ben. A. Barres, Valina L. Dawson, Seulki Lee, Ted M. Dawson, Han Seok Ko. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease. Nature Medicine 2018: 24(7):931-938. https://www.nature.com/articles/s41591-018-0051-5

• 46. Seung Pil Yun*, Donghoon Kim*, Sangjune Kim*, Sangmin Kim, Senthilkumar S. Karuppagounder, Suhyun Lee, Valina L. Dawson, Ted M. Dawson, Han Seok Ko. Accumulation of α-synuclein and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced Parkinsonism. Molecular Neurodegeneration 2018:13(1):1. https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-017-0233-5

• 45. Sangjune Kim*, Seung Pil Yun*, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Peter Rhee, Senthilkumar S. Karuppagounder, Xiling Yin, Donghoon Kim, Valina L. Dawsona, Ted M. Dawson, Han Seok Ko. GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A. 2018:115(4):798-803. *Equally contributed. http://www.pnas.org/content/115/4/798.long

• 44. Seung Pil Yun, Yeo Min Yoon, Jun Hee Lee, Minjee Kook, Yong-Seok Han, Seo Kyung Jung, Sang Hun Lee. Tauroursodeoxycholic Acid Protects Against the Effects of P-Cresol-induced Reactive Oxygen Species via the Expression of Cellular Prion Protein. International Journal of Molecular Sciences 2018:25;19(2) http://www.mdpi.com/1422-0067/19/2/352

• 43. Yong-Seok Han*, Seung Pil Yun*, Jun Hee Lee, Seung-Hwan Kwon, SangMin Kim, Sang Hun Lee (2018) c-Met-activated mesenchymal stem cells rescue ischemic damage via interaction with cellular prion protein. Cellular Physiology and Biochemistry 2018:11(1):29. *Equally contributed. https://www.karger.com/Article/FullText/489368

• 42. Seung Pil Yun, Chul Won Yun, Jun Hee Lee, SangMin Kim, Sang Hun Lee. (2018) Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner. Biomolecules & Therapeutic 2018:26(5):464-473. http://www.biomolther.org/journal/view.html?uid=850&vmd=Full

• 41. Seung Pil Yun, Yong-Seok Han, Jun Hee Lee, SangMin Kim, Sang Hun Lee (2018) Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy. Biomolecules & Therapeutic 2018: 26(4):389-398. http://www.biomolther.org/journal/view.html?uid=829&vmd=Full

• 40. Donghoon Kim, Je Min Yoo, Heehong Hwang, Junghee Lee, Su Hyun Lee, Seung Pil Yun, Myungjin Park, MinJun Lee, Seulah Choi, Sang Ho Kwon, Saebom Lee, Seung-Hwan Kwon, Sangjune Kim, Young Joo Park, Misaki Kinoshita, Young-Ho Lee, Seokmin Shin, Seung R. Paik, Sung Joong Lee, Seulki Lee, Byung Hee Hong, Han Seok Ko (2018) Graphene quantum dots prevent α-synuclein transmission in Parkinson’s disease. Nature Nanotechnology 2018 https://www.ncbi.nlm.nih.gov/pubmed/29988049

• 39. Saebom Lee, Sangjune Kim, Yong Joo Park, Seung Pil Yun, Seung-Hwan Kwon, Donghoon Kim, Dong Yeon Kim, Jae Soo Shin, Dae Jin Cho, Gong Yeal Lee, Hyun Soo Ju, Hyo Jung Yun, Jae Hong Park, Wonjoong Kim, Eun Ah Jung, Seulki Lee, Han Seok Ko. The c-Abl inhibitor, Radotinib HCl is neuroprotective in a preclinical Parkinson’s disease mouse model. Human Molecular Genetics 27(13):2344-2356. https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddy143/4980307

• 38. So Mi Park, Mu SeoG Choi, Han Cheol yeo, Ho Jae Han, Joong Sun Kim, Woo Chul Chang, Seung Pil Yun, Ho Jin Lee, Min Young Lee. Yes-Associated Protein Mediates Human Embryonic Stem Cell-Derived Cardiomyocyte Proliferation: Involvement of Epidermal Growth Factor Receptor Signaling. Journal of Cellular Physiology 2018:233(10):7016-7025 https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.26625

[2017]

• 37. Sang Min Kim, Yong Joo Park, Myung-Sook Shin, Ha-Ryong Kim, Sang Hun Lee^#, Seung Pil Yun^#, Seung-Hwan Kwon^#. Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson's disease model. Bioorganic & Medicinal Chemistry Letters 2017:27(23):5207-5212. ^#Co-corresponding authors. https://www.sciencedirect.com/science/article/pii/S0960894X17310405?via%3Dihub

• 36. Seung Pil Yun*, Hyojung Kim*, Sangwoo Ham, Seung-Hwan Kwon, Gum Hwa Lee, Joo-Ho Shin, Sang Hun Lee, Han Seok Ko, Yunjong Lee. VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2. Cell death & Disease 2017:8(4):e2741 *Equally contributed. https://www.nature.com/articles/cddis2017157

• 35. Seung Pil Yun, Yong-Seok Han, Jun Hee Lee, SangMin Kim, Sang Hun Lee. Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. Anticancer Research 2017:37(6):2975-2984. http://ar.iiarjournals.org/content/37/6/2975.long

• 34. Yunjong Lee, Daniel A. Stevens, Sung-Ung Kang, Haisong Jiang, Yun-Il Lee, Han Seok Ko, Leslie A. Scarff, George E. Umanah, Hojin Kang, Sangwoo Ham, Tae-In Ka, Kathleen Allen, Saurav Brahmachari, Jungwoo Wren Kim, Stewart Neifert, Seung Pil Yun, Fabienne C. Fiesel, Wolfdieter Springer, Valina L. Dawson, Joo-Ho Shin, and Ted M. Dawson. PINK1 primes parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival. Cell Reports 2017:18(4):918-932. http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31812-5? _ returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124716318125%3Fshowall%3Dtrue

• 33. Geun Hye Hwang, So Mi Park, Ho Jae Han, Joong Sun Kim, Seung Pil Yun, Jung Min Ryu, Ho Jin Lee, Woochul Chang, Su-Jin Lee, Jeong-Hee Choi, Jin-Sung Choi, Min Young Lee. Purification of Small Molecule-induced Cardiomyocytes from Human Induced Pluripotent Stem Cells Using a Reporter System. Journal of Cellular Physiology 2017:232(12):3384-3395. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.25783

• 32. Geun Hye Hwang, So Mi Park, Ho Jae Han, Kyoung Min Baek, Joong Sun Kim, Woochul Chang, Ho Jin Lee, Seung Pil Yun, Jung Min Ryu, and Min Young Lee. Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells. Oncology Letters 2017:14(5): 5484–5490. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652246/pdf/ol-14-05-5484.pdf

• 31. Jun Hee Lee, Yong-Seok Han, Yeo Min Yoon, Chul Won Yun, Seung Pil Yun, Hyog Young Kwon, Dongjun Jeong, Moo Jun Baek, Hyun Jik Lee, Sei-Jung Lee, Ho Jae Han, Sang Hun Lee. Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis. Oncogene 2017:36(47):6555-6567. https://www.nature.com/articles/onc2017263

[2016]

• 31. Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, Ted M. Dawson. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science 2016:30;353(6307). http://science.sciencemag.org/content/353/6307/aah3374.long

• 30. Chul Won Yun*, Seung Pil Yun*, Jun Hee Lee, Yong-seok Han, Yeo Min Yoon, Daniel An, Sang Hun Lee. Silencing Prion Protein in HT29 Human Colorectal Cancer Cells Enhances Anticancer Response to Fucoidan. Anticancer Research 2016:36(9):4449-4458. *Equally contributed. http://ar.iiarjournals.org/content/36/9/4449.long

• 29. Yeo Min Yoon*, Jun Hee Lee*, Seung Pil Yun*, Yong-Seok Han, Chul Won Yun, Hyun Jik Lee, Hyunjin Noh, Sei-Jung Lee, Ho Jae Han, San Hun Lee. Tauroursodeoxycholic acid reduces ER stress through the regulation of Akt-dependent cellular prion protein. Scientific Reports 2016:6:39838. *Equally contributed. https://www.nature.com/articles/srep39838

[2015]

• 28. Seulah Choi, Donghoon Kim, Tae-In Kam, Seung Pil Yun, Hyejin Park, Olga Pletnikova, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, Han Seok Ko. Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS One 2015:10(12):e0143854. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143854

[2014]

• 27. Se-Jung Lee, Sang Yub Oh, Young Hyun Jung, Seung Pil Yun, Ho Jae Han. Melatonin enhances the human mesenchymal stem cells motility via melatonin receptor 2 coupling with Gαq in skin wound healing. Journal of Pineal Research 2014:57(4):393-407. https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12179

• 26. Yong-seok Han, Seung Pil Yun, Han Seok Ko, Sang Hun Lee. Therapeutic effect of genistein-stimulated human mesenchymal stem cells in myocardial infarction. Journal of Transplant​ation & Stem Cell Biology 2014:1(1):7. http://www.avensonline.org/wp-content/uploads/JTSCB-2374-9326-01-0004.pdf

• 25. Seung Pil Yun*, Sei-Jung Lee*, Sang Yub Oh, Young Hyun Jung, Jung Min Ryu, Han Na Suh, Mi Ok Kim, Ho Jae Han. Reactive oxygen species induce matrix metalloproteinase-12-dependent degradation of collagen 5 and fibronectin to promote motility of human umbilical cord derived mesenchymal stem cells. British Journal of Pharmacology 2014:171(13):3283-3297. *Equally contributed. https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.12681

• 24. Seung Pil Yun, Sei-Jung Lee, Young Hyun Jung, Ho Jae Han. Galectin-1 stimulates motility of human umbilical cord blood-derived mesenchymal stem cells by downregulation of smad2/3-dependent collagen 3/5 and upregulation of NF-κB-dependent fibronectin/laminin 5 expression. Cell death & Disease 2014:5:e1049. https://www.nature.com/articles/cddis20143

[2013]

• 23. Tae Woo Son*, Seung Pil Yun*, Min Sik Yong, Bit Na Seo, Jung Min Ryu, Hwa Young Youn, Yeon Mok Oh, Ho Jae Han. Netrin-1 protects hypoxia-induced mesenchymal stem cell apoptosis through HSP27-expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1. Cell death & Disease 2013:4:e563. *Equally contributed. https://www.nature.com/articles/cddis201394

• 22. Bit Na Seo, Jung Min Ryu, Seung Pil Yun, Ji Hoon Jeon, Su Shin Park, Ho Jae Han. Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK, Nf-kB, and Akt inhibition. Apoptosis 2013:18(7):811-824. https://link.springer.com/article/10.1007%2Fs10495-013-0838-2

• 21. Su Shin Park, Mi Ok Kim, Seung Pil Yun, Jung Min Ryu, Jae Hong Park, Bit Na Seo, Ji Hoon Jeon, Ho Jae Han. C₁₆-Ceramide-induced F-actin regulation stimulates mouse embryonic stem cell migration: Involvment of N-WASP/cdc42/arp2/3 complex and cofilin-1/α-actinin. Biochimica et Biophysica Acta. 2013:1831(2):350-360. https://www.sciencedirect.com/science/article/pii/S1388198112002028?via%3Dihub

[2012]

• 20. Seung Pil Yun, Jung Min Ryu, Jae Hong Park, Mi Ok Kim, Jang-Hern Lee, Ho Jae Han. Rapid actions of plasma membrane estrogen receptors regulate motility of mouse embryonic stem cells through a profilin-1/cofilin-1-directed kinase signaling pathway. Molecular Endocrinology 2012:26(8):1291-303. https://academic.oup.com/mend/article/26/8/1291/2615013

• 19. Seung Pil Yun, Su Shin Park, Jung Min Ryu, Jae Hong Park, Mi Ok Kim, Jang-Hern Lee, Ho Jae Han. Mechanism of PKA-dependent and lipid-raft independent stimulation of connexin43 expression by oxytoxin in mouse embryonic stem cells. Molecular Endocrinology 2012:26(7):1144-57. https://academic.oup.com/mend/article/26/7/1144/2614946

• 18. Seung Pil Yun, Jung Min Ryu, Jae Hong Park, Mi Ok Kim, Jang-Hern Lee, Ho Jae Han. Prostaglandin E₂ maintains mouse ESC undifferentiated state through regulation of connexin31, connexin43 and connexin45 expression: Involvement of glycogen synthase kinase 3β/β-catenin. Biology of the Cell 2012:104(7):378-96. https://onlinelibrary.wiley.com/doi/abs/10.1111/boc.201100032

• 17. Min Woo Jang*, Seung Pil Yun*, Jae Hong Park, Jung Min Ryu, Jang-Hern Lee, Ho Jae Han. Cooperation of Epac1/Rap1/Akt and PKA in prostaglandin E₂-induced proliferation of human umbilical cord blood derived mesenchymal stem cells: Involvement of c-Myc and VEGF expression. Journal of Cellular Physiology 2012:227(12):3756-67. *Equally contributed. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.24084

• 16. Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Mi Ok Kim, Ho Jae Han. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: Involvement of RhoA, Ca²⁺/CaM, and ERK. Biochimica et Biophysica Acta-General Subjects 2012:1820(10):1618-27. https://www.sciencedirect.com/science/article/pii/S030441651200164X?via%3Dihub

• 15. Mi Ok Kim, Yu Jin Lee, Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Ho Jae Han. PKA and cAMP stimulate proliferation of mouse embryonic stem cells by elevating GLUT1 expression mediated by the NF-κB and CREB/CBP signaling pathways. Biochimica et Biophysica Acta-General Subjects 2012:1820(10):1636-46. https://www.sciencedirect.com/science/article/pii/S0304416512001560?via%3Dihub

[2011]

• 14. Seung Pil Yun, Dong Hyun Kim, Jung Min Ryu, Jae Hong Park, Su Shin Park, Ji Hoon Jeon, Bit Na Seo, Hyun-Jeong Kim, Jun-Gyu Park, Kyoung-Oh Cho, Ho Jae Han. Magnetic resonance imaging evaluation of Yukatan minipig brains for neurotherapy applications. Laboratory Animal Research 2011:27(4):309-16. http://submission.kalas.or.kr/search/viewJournal.htm?year=2011&vol=27&page=309

• 13. Seung Pil Yun, Jung Min Ryu, Min Woo Jang, Ho Jae Han. Interaction of profilin-1 and F-actin via a β-arrestin-1/JNK signaling pathway involved in prostaglandin E₂-induced human mesenchymal stem cells migration and proliferation. Journal of Cellular Physiology 2011:226(2):559-71. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.22366

• 12. Seung Pil Yun, Jung Min Ryu, Ho Jae Han. Involvement of β1-integrin via PIP complex and FAK/paxillin in dexamethasone-induced human mesenchymal stem cells migration. Journal of Cellular Physiology 2011:226(3):683-92. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.22383

• 11. Jung Min Ryu, Woong Yoon, Jae Hong Park, Seung Pil Yun, Min Woo Jang, Ho Jae Han. Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation. Journal of Veterinary Science 2011:12(3):209-14. http://www.vetsci.org/paper/journal_view.html?year=2011&vol=12&iss=3&page=209

[2010]

• 10. Woong Yoon, Jung Min Ryu, Min Young Lee, Yong Ju Moon, Sang Hun Lee, Jae Hong Park, Seung Pil Yun, Min Woo Jang, Sung Su Park, Ho Jae Han. 64-channel multi-detector row CT angiographic evaluation of the micropigs for potential living donor lung transplantation. Journal of Veterinary Science 2010:11(3):185-189. http://www.vetsci.org/journal/view.html?volume=11&number=3&spage=185

• 9. Jung Min Ryu, Min Young Lee, Seung Pil Yun, Ho Jae Han. High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-β1 expression via Ca²⁺/PKC/MAPKs and PI3K/Akt/mTOR signal pathways. Journal of Cellular Physiology 2010:224(1):59-70. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.22091

• 8. Woong Yoon, Min Young Lee, Jung Min Ryu, Yong Ju Moon, Sang Hun Lee, Jae Hong Park, Seung Pil Yun, Min Woo Jang, Sung Su Park, Ho Jae Han. Multidetector row computed tomography evaluation of the micropig kidney as a potential renal donor. Journal of Veterinary Science 2010:11(1):9-13. http://www.vetsci.org/journal/view.html?volume=11&number=1&spage=9

• 7. Min Woo Jang, Bu Kab Jin, Sang Hun Lee, Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Sung Won Park, Heyong Seok Kim, Chang Jong Moon, Guk Hyun Suh, and Ho Jae Han. Effect of PMMA and Cross-Linked Dextran Mixture on Bio-Safety and Volume in Rat. Tissue Engineering and Regenerative Medicine 2010:7(1):57-63. http://kiss.kstudy.com/thesis/thesis-view.asp?key=3130216

[2009]

• 6. Seung Pil Yun, Min Young Lee, Jung Min Ryu, Ho Jae Han. Interaction between PGE₂ and EGF receptor through MAPKs in mouse embryonic stem cell proliferation. Cellular and Molecular Life Sciences 2009:66(9):1603-1616. https://link.springer.com/article/10.1007%2Fs00018-009-9076-8

• 5. Seung Pil Yun, Min Young Lee, Jung Min Ryu, Chang Hoon Song, Ho Jae Han. Role of HIF-1α and VEGF in human mesenchymal stem cell proliferation by 17β-estradiol: involvement of PKC, PI3K/Akt, and MAPKs. American Journal of Physiology-Cell Physiology 2009:296(2):C317-326. https://www.physiology.org/doi/abs/10.1152/ajpcell.00415.2008?url_ver=Z39.88- 2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

• 4. Jung Min Ryu, Dong Hyun Kim, Min Young Lee, Sang Hun Lee, Jae Hong Park, Seung Pil Yun, Min Woo Jang, Seong Hwan Kim, Gyu Jin Rho, Ho Jae Han. Imaging evaluation of the liver using multi-detector row computed tomography in micropigs as potential living liver donors. Journal of Veterinary Science 2009:10(2):93-98. http://www.vetsci.org/journal/view.html?volume=10&number=2&spage=93

• 3. Jung Min Ryu, Min Young Lee, Seung Pil Yun, Ho Jae Han. Zinc chloride stimulates DNA synthesis of mouse embryonic stem cells: Involvement of PI3K/Akt, MAPKs, and mTOR. Journal of Cellular Physiology 2009:218(3):558-567. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.21628

[2008]

• 2. Mi Na Lee, Sang Hun Lee, Min Young Lee, Yun Hee Kim, Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Yu Jin Lee, Mi Ok Kim, Kwangsung Park, Ho Jae Han. Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H₂O₂-induced oxidative stress. Journal of Veterinary Science 2008:9(3):247-256. http://www.vetsci.org/paper/journal_view.html?year=2008&vol=9&iss=3&page=247

• 1. Young Keun Ahn, Jung Min Ryu, Hea Chang Jeong, Yun Hyeon Kim, Myung Ho Jeong, Min Young Lee, Sang Hun Lee, Jae Hong Park, Seung Pil Yun, Ho Jae Han. Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography. Journal of Veterinary Science 2008:9(2):121-126. http://www.vetsci.org/journal/view.html?volume=9&number=2&spage=121

[Review]

• 3. Seung Pil Yun, Yong-Seok Han, Jun Hee Lee, Yeo Min Yoon, Chul Won Yun, Peter Rhee, Sang Hun Lee. Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis. Molecular Medicine Reports 2017:16(5):5747-5751. https://www.spandidos-publications.com/mmr/16/5/5747

• 2. Min Young Lee, Yu Jin Lee, Yun Hee Kim, Sang Hun Lee, Jae Hong Park, Mi Ok Kim, Han Na Suh, Jung Min Ryu, Seung Pil Yun, Min Woo Jang, Ho Jae Han. Role of peroxisome proliferator-activated receptor (PPAR) d in embryonic stem cell proliferation. International journal of stem cells 2009:2(1):28-34 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021791/

• 1. Jung Sun Heo, Yun Hee Kim, Min Young Lee, Sang Hun Lee, Jae Hong Park, Mi Ok Kim, Sun Im Na, Min Hee Kim, Han Na Suh, Yu Jin lee, Jung Min Ryu, Seung Pil Yun, Ho Jae Han. Therapeutic applications of stem cells in regenerative medicine. Chonnam Medical Journal 2007:43(1):1-12.