Dong Kun Lee, Ph.D.
Associate Professor
Department of Pysiology,
Convergence Medical Sciences,
Institute of Health Sciences
e-mail: dklee@gnu.ac.kr
office: +82-55-772-8045
Dong Kun Lee, Ph.D.
Associate Professor
Department of Pysiology,
Convergence Medical Sciences,
Institute of Health Sciences
e-mail: dklee@gnu.ac.kr
office: +82-55-772-8045
Professional Experiences
2019. 09. – present Associate Professor, Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University Medical School, South Korea
2015. 09. – 2019. 08. Assistant Professor, Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University Medical School, South Korea
2013. 01. – 2015. 08. Postdoctoral Research Associate, Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
Educational Background
2008. 03. - 2012. 08. Ph.D.: Department of Biological Sciences, Pusan National University, South Korea
2006. 03. - 2008. 02. M.S.: Department of Biology, Pusan National University, South Korea
1998. 03. - 2006. 02. B.S.: Department of Biological Sciences, Pusan National University, South Korea
Publications
SCI(E)-listed Journals
Kang JS, Baek JH, Jung S, Chung HJ, Lee DK, Kim HJ (2021) Ingestion of Bis(2-ethylhexyl) phthalate (DEHP) during adolescence causes depressive-like behaviors through hypoactive glutamatergic signaling in the medial prefrontal cortex. Environ Pollut. 289.
Kim EA, Yang JH, Byeon EH, Kim W, Kang D, Han J, Hong SG, Kim DR, Park SJ, Huh JW, Cheong H, Yun SP, Lee DK (2021) Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice. Plants (Basel). 10: 837.
Siregar AS, Nyiramana MM, Kim EJ, Shin EJ, Woo MS, Kim JM, Kim JH, Lee DK, Hahm JR, Kim HJ, Kim CW, Kim NG, Park SH, Choi YJ, Kang SS, Hong SG, Han J, Kang D (2020) Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models. Mar Drugs. 18: 512.
Son H, Yang JH, Kim HJ, Lee DK (2019) A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice. JoVE. 15.
Son H, Kim S, Jung DH, Baek JH, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Lee DK, Kim HJ (2019) Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice. Sci Rep. 9: 252.
Kim KE, Jeong EA, Shin HJ, Lee JY, Choi EB, An HS, Park KA, Jin Z, Lee DK, Horvath TL, Roh GS (2019) Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet. Biochem Biophys Res Commun. 508: 123-129.
Park H, Kim EJ, Ryu JH, Lee DK, Hong SG, Han J, Han J, Kang D (2018) Verapamil Inhibits TRESK (K2P18.1) Current in Trigeminal Ganglion Neurons Independently of the Blockade of Ca2+ Influx. Int J Mol Sci. 19(7). pii: E1961.
Son H, Baek JH, Go BS, Jung DH, Sontakke SB, Chung HJ, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Lee DK, Kim HJ (2018) Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. Neuropharmacology. Equal contribution.
Lee DK, Park JY, Yoo JC, Byun EH, Bae YJ, Lee YS, Park N, Kang D, Han J, Park JY, Hwang E, Hong SG (2018) PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells. Pflugers Arch.
Jeong JH, Lee DK, Liu SM, Chua SC Jr, Schwartz GJ, Jo YH (2018) Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol. 16:e2004399.
Yang JH, Seo SY, Oh JH, Ryu IS, Kim J, Lee DK, Ryu Y, Choe ES (2018) Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens. Front Mol Neurosci. 11:263.
Ryu IS, Kim J, Seo SY, Yang JH, Oh JH, Lee DK, Cho HW, Lee K, Yoon SS, Seo JW, Shim I, Choe ES (2018) Repeated Administration of Cigarette Smoke Condensate Increases Glutamate Levels and Behavioral Sensitization. Front Behav Neurosci. 12:47.
Kim EJ, Lee DK, Hong SG, Han J, Kang D (2017) Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers. Int J Mol Sci. 18(11). pii: E2460.
Ryu IS, Kim J, Seo SY, Yang JH, Oh JH, Lee DK, Cho HW, Yoon SS, Seo JW, Chang S, Kim HY, Shim I, Choe ES (2017) Behavioral changes after nicotine challenge are associated with α7 nicotinic acetylcholine receptor-stimulated glutamate release in the rat dorsal striatum. Sci Rep. 7: 15009.
Jeong JH, Lee DK, Jo YH (2017) Cholinergic neurons in the dorsomedial hypothalamus regulate food intake. Mol Metab. 6: 306-312.
Jeong JH, Lee DK, Blouet C, Ruiz HH, Buettner C, Chua S Jr, Schwartz GJ, Jo YH (2015) Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism. Mol Metab. 4: 483-492.
Lee DK, Jeong JH, Chun SK, Chua SC Jr, Jo YH (2015) Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons. Nat Commun. 6: 6618.
Lee DK, Jeong JH, Oh SH, Jo YH (2015) Apelin-13 Enhances Arcuate POMC Neuron Activity via Inhibiting M-current. PLoS One. 10: e0119457.
Oh JH, Lee DK, Shim YB, Ryu IS, Seo SY, Kim J, Yang JH, Cho HW, Choe ES (2015) Dopamine D4 receptors linked to protein kinase G are required for changes in dopamine release followed by locomotor activity after repeated cocaine administration. Exp Brain Res. 233: 1511-1518. Equal contribution.
Lee DK, Oh JH, Shim YB, Choe ES (2013) Protein kinase G regulates dopamine release, ΔFosB expression, and locomotor activity after repeated cocaine administration: involvement of dopamine D2 receptors. Neurochem Res 38:1424-1433.
Lee DK, Oh JH, Yang JH, Youn B, Shim YB, Shim I, Wang JQ, Choe ES (2013) Protein kinase G linked to dopamine D3 receptors in the dorsal striatum controls dopamine release, ΔFosB expression and locomotor activity after repeated cocaine administration. Neurosci Lett 541:120-125.
Lee DK, Ahn SM, Shim YB, Koh WCA, Shim I, Choe ES (2011) Interactions of Dopamine D1 and N-methyl-D-Aspartate Receptors are Required for Acute Cocaine-Evoked Nitric Oxide Efflux in the Dorsal Striatum. Exp. Neurobiol. 20: 116-122.
Lee DK, Koh WCA, Shim YB, Shim I, Choe ES (2010) Repeated cocaine administration increases nitric oxide efflux in the rat dorsal striatum. Psychopharmacology (Berl) 208: 245-256.
Koh WCA, Choe ES, Lee DK, Chang SC, Shim YB (2009) Monitoring the activation of neuronal nitric oxide synthase in brain tissue and cells with a potentiometric immunosensor. Biosens. Bioelectron. 25: 211-217.
Lee DK, Bian S, Rahman MA, Shim YB, Shim I, Choe ES (2008) Repeated cocaine administration increases N-methyl-D-aspartate NR1 subunit, extracellular signal-regulated kinase and cyclic AMP response element-binding protein phosphorylation and glutamate release in the rat dorsal striatum. Eur. J. Pharmacol. 590: 157-162.
Koh WCA, Rahman MA, Choe ES, Lee DK, Shim YB (2008) A cytochrome c modified-conducting polymer microelectrode for in vivo monitoring of nitric oxide fluctuation. Biosens. Bioelectron. 23: 1374-1381.
Domestic journals
Siregar AS, Nyiramana MM, Kim EJ, Shin EJ, Kim CW, Lee DK, Hong SG, Han J, Kang DW (2019) TRPV1 Is Associated With Testicular Apoptosis in Mice. J Anim Reprod Biotechnol. 34: 311-317.
Kim SW, Kim SM, Lee DK, Moon HB, Choi HG, Kang CK, Choe ES (2007) Characterization of proteins in the muscle of Limanda yokohamae from the Masan Bay, Korea. Ocean Science Journal. 42: 129-134.