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Prevention and treatment of neurodegenerative diseases such as dementia and Alzheimer's disease using probiotic strains
Prevention and treatment of neurodegenerative diseases such as dementia and Alzheimer's disease using probiotic strains
supported by the Ottogi Foundation (2024.02~2027.01)
supported by the Ottogi Foundation (2024.02~2027.01)
This study aims to select probiotic strains that can reduce advanced glycation end-products (AGEs), a causative agent of degenerative neurological diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), and improve reactive gliosis, a typical indicator of dementia, by inhibiting the growth of Proteus mirabilis, and to identify the mechanism of action and develop probiotic products that can prevent or improve degenerative neurological diseases.
Development of prebiotics using functional oligosaccharides produced by bioconversion technology using lactic acid bacteria
Development of prebiotics using functional oligosaccharides produced by bioconversion technology using lactic acid bacteria
supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019.03~2022.02)
supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019.03~2022.02)
The ultimate goal is to build a library of various types of oligosaccharides using lactic acid bacteria, analyze the structure of isolated and purified new oligosaccharides, verify prebiotics activity and immune activity, and develop new prebiotics materials with immune activity.
Development of high-functional vegan probiotics and materialization of health-functional foods
Development of high-functional vegan probiotics and materialization of health-functional foods
supported by the Technology Development Program funded by the Ministry of SMEs and Startups (MSS, Republic of Korea). (2022.03~2023.12)
The goal of the project is
Discovery and development of plant lactic acid bacteria from domestic resources, development of immune and anti-obesity functional probiotics using them, DB construction, and materialization of Jeju's native plant lactic acid bacteria for the first time in Korea
Development and vegan certification of functional vegan yogurt using plant-based ingredients from Jeju's natural resources with plant-based lactic acid bacteria
Development of functional formulation and productization technology using plant-based lactic acid bacteria
Discovery of microbiome-targeted probiotics and development of materialization technology
Discovery of microbiome-targeted probiotics and development of materialization technology
supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) funded by the Korea government (Ministry of Agriculture, Food and Rural Affairs) (2020.11~2025.12)
The goal of the project is
for the discovering and developing new probiotic strains targeting the human microbiome derived from Korean people and domestic agricultural products.
for the various biochemical and molecular biological functions and safety verification based on the human microbiome (especially in the intestinal tract) for the new probiotic strains secured.
for the industrialization through materialization and mass production technology for new probiotic strains secured
Optimizing production of commercial probiotics based on the data – Preparation of the infrastructure for smart manufacturing system
Optimizing production of commercial probiotics based on the data – Preparation of the infrastructure for smart manufacturing system
supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) funded by the Korea government (Ministry of Agriculture, Food and Rural Affairs) (2020.11~2023.12)
The goal of the project is
for the establishment of production optimization development process for each strain for probiotics
for the process development for fermentation process improvement based on production parameter data
for the development of experimental method for cell surface property analysis
for the establishment of efficacy and ingredient methods for quality control
for the selection of major stress-related genes during the production process and establishment of analysis methods and the analysis of protein expression patterns of related genes
Development of lactic acid bacteria decomposing advanced glycation end product , biogenic amine-degrading lactic acid bacteria and nitric oxide producing strains
Development of lactic acid bacteria decomposing advanced glycation end product , biogenic amine-degrading lactic acid bacteria and nitric oxide producing strains
supported by Metacen Terapeutics (2020.11~2023.12)
Using the strains possessed by this research team, we intend to secure a lactic acid strain that decomposes the fadvanced glycation end product (AGEs), lactic acid strains that can reduce biogenic amine, and an excellent strains that produces nitric oxide.
<Schematic representation of non-enzymatic protein glycation>
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