Scientific Program

Stefano Masiero, invited speaker

University of Bologna

"Simple guanosine – amino acid hybrids as low molecular weight hydrogelatorsators"

Rodrigo Fernandes De Almeida

Polytechnic University of Marche

"In-situ formation of guanosine-based hydrogels for the molecular-level consolidation of cultural heritage paper"

Edoardo Spaccasassi

Polytechnic University of Marche

"Optimized Guanosine hydrogel bioscaffolds for 3D murine muscle cell culture"

Roberto Improta

Institute of Biostructures and Bioimaging (IBB-CNR)

"What are the effects determining the measured NMR parameters in I-motifs?"

Luca Bertini

University of Perugia

"SAXS and extremely coarse-grained simulations reveal distinct roles of compactness and stability in ligand-bound telomeric G-quadruplex dimers"

Giulia Teodori

Roma Tre University

"Unfolding and refolding mechanisms in telomeric G-quadruplexes: an experiment-calibrated coarse-grained model"

Coffee break

G4@Ancona 

Several colleagues will trace Prof. Paolo Mariani’s scientific path, focusing on his key contributions to the study of G-quadruplexes and other DNA-based systems

Sunset dinner on the terrace 

Dinner will be on the Department's terrace. A shuttle bus will depart at 9:30 PM for the return trip to Ancona city center.

Naoki Sugimoto, invited speaker

FIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, Kobe, Japan

"To B or not to B in nucleic acids chemistry"

Chiara Platella

University of Naples

"Unraveling the NMR structures of G-quadruplex-forming aptamers acting as inhibitors of High Mobility Group Box 1 pathological activity"

Erica Salvati

Institute of Molecular Biology and Pathology (IBPM-CNR)

"The telomeric protein TRF2 binds to ribosomal DNA and RNA putatively through GQ structures and fuels the ribosomal pathway"

Daniele Malpicci

University of Milan

"Cyclic triimidazoles for G-quadruplex stabilization: when less is better"

Coffee break

Roberta Rocca

University of Catanzaro

"Exploiting the multi-domain architecture of HIV-1 LTR-III for the discovery of novel transcription-modulating ligands"

Anna Di Porzio

University of Naples

"Phen-DC3 potentiates chemotherapeutic response in cervical cancer cells via mitochondrial disfunction"

Sara Iachettini

Regina Elena National Cancer Institute

"NDI-NIs: unveiling the role of G4 ligands in autophagy regulation"

Andrea Avati

University of Padua

"Roles of G-quadruplexes in Kaposi’s sarcoma herpesvirus latent replication"

Lunch on the Department's terrace

Giulia Poggianti

Sapienza University of Rome

"Highly cytotoxic NDI dyads impact nucleolar structural organization and protein synthesis rate in cancer cells"

Valeria Libera

University of Perugia

"Low-resolution investigation of G4-photosensitive ligand interactions"

Coffee break

Social event - Frasassi Caves

Dinner at the "Da Maria" restaurant in Pierosara, followed by return by coach to Ancona city center.

SESSION V

Luca Zecchinello

University of Milan

"Mono-, di- and trisubstituted derivatives of a flat nitrogen rich organic scaffold for G-quadruplex stabilization"

Greta Mucignat

University of Padua

"Exploring the nuclear role of vimentin and lamin B1 in epithelial-mesenchymal plasticity"

Emanuela Ruggiero

University of Padua

"HTLV-1 antisense transcription is promoted by increased SP1 binding at 3’-LTR G-quadruplexes"

Valentina Notarstefano

University of Teramo

"Guanosine hydrogels under the spotlight: An extensive analysis through vibrational spectroscopy"

Valentina Arciuolo

University of Naples

"Screening of G-quadruplex DNA ligands by fluorescence detection of peptide displacement"

Coffee break

Gian Piero Spada award

Introduction: Jeffery Davis

University of Maryland

Irene Zanin

University of Padua

"Ku70 directly binds G-quadruplex DNA at oncogenic loci, particularly at the amplified CDK4 oncogene in liposarcoma"

Round table

Open discussion and future perspectives