Programma Scientifico
12:00 - 13:50
13:50 - 14:00
SESSIONE I
Chairpersons: Giovanni Capranico - Daniela Montesarchio
14:00 - 14:15
"Counteracting G-quadruplex-induced genome instability"
14:15 - 14:30
"The plastic epigenetic remodeling of R-loops favors the maintenance of genomic integrity"
14:30 - 14:45
"Ligands stimulating antitumour immunity as the next G-quadruplex challenge"
14:45 - 15:00
"Analyses of G-quadruplex binder effects on immune genes and specific gene alterations in cancers for a precision medicine approach in anticancer immunotherapy"
15:00 - 15:15
"Functional characterization of the biological role of G-quadruplex ligands"
15:15 - 15:30
"Drug repurposing on TERRA G4"
15:30 - 15:45
"Macrocyclic naphthalene diimides as G-quadruplex based HIV-1 inhibitors with a dual mode of action"
15:45 - 16:00
"HIV latency: the role of G-quadruplex structure in proviral transcription of latently infected cells"
16:00 - 16:30
SESSIONE II
Chairpersons: Concetta Giancola - Bruno Pagano
16:30 - 16:45
"New insights in multimeric telomeric G4s selective targeting"
16:45 - 17:00
"Research activities in G4 field at UMG"
17:00 - 17:15
"Structure-based virtual screening and lead optimization of DNA G-quadruplex binders"
17:15 - 17:30
"Design, synthesis and screening of small molecules targeting human telomeric G-quadruplex"
17:30 - 17:45
"Chromene-based heterocycles with multitarget activity for drug-resistant tumors"
17:45 - 18:00
"Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity"
18:00 - 18:15
"Chromene derivatives as selective TERRA G-quadruplex RNA binders with antiproliferative properties"
18:15 - 18:30
"Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders"
18:30 - 19:00
20:00
SESSIONE III
Chairpersons: Sara Richter - Luigi Xodo
09:00 - 09:15
"The DNA helicases FANCJ and DDX11 are recruited to the DNA replication machinery to alleviate replication stress due to DNA G-quadruplex formation"
09:15 - 09:30
"The role of BLM and FANCJ DNA-helicases in the response to G-quadruplex-stabilizing ligand RHPS4"
09:30 - 09:45
"Exploring the G-quadruplex binding and unwinding activity of the bacterial FeS helicase DinG"
09:45 - 10:00
"Contribution of non-canonical DNA G-quadruplex structures to premature ageing"
10:00 - 10:15
"Genomic landscape of Vimentin binding sites within metastatic cancer cells"
10:15 - 10:30
"DNA i-Motif, from structure and thermodynamic to genome location"
10:30 - 10:45
"A peptide-based molecular probe that preferentially binds the c-MYC G-quadruplex"
10:45 - 11:00
"Porphyrins as chiroptical probe for G4 conformations"
11:00 - 11:30
SESSIONE IV
Chairpersons: Stefano Alcaro - Jussara Amato
11:30 - 11:45
"A lipophilic guanosine/Ag(I) complex"
11:45 - 12:00
"Self-orienting anisotropic structure and diffusivity properties of guanosine hydrogels"
12:00 - 12:15
"Computation of electronic circular dichroism spectra of guanine-quadruplex via FrDEx model and molecular dynamics calculations"
12:15 - 12:30
"UV resonance Raman spectroscopy of G4: a tool to detect the sequence of molecular events upon external variable changes"
12:30 - 12:45
"G-quadruplex forming aptamers as inhibitors of HMGB1 pathological activity"
12:45 - 13:00
"G-quadruplex-forming aptamers targeting mutant huntingtin: physicochemical stability, in vitro and in vivo biological activity"
13:00 - 13:15
"Modulating the properties of G-quadruplexes by chemical modifications: the case of thrombin binding aptamers"
13:15