Research

Research Overview

Our laboratory is focusing on understanding the epigenetic silencing mechanisms that control the activity of retrotransposons especially those that are lost in human cancers. We are also studying the role of aberrant expression of retrotransposons and how they contribute to tumorigenesis. We integrate various wet lab and computational approaches including CRISPR-Cas,  in vitro and in vivo functional assays, transcriptome, methylome profiling and epigenome profiling (ATAC-seq, ChIP-seq) to study retrotransposons.