We use human induced pluripotent stem cell (iPSC) models to study neural differentiation and neurological disorders. A key goal is to understand how disruption of gene regulation and non-coding variantion contribute to disorders.  

Regulatory elements such as enhancers are key to cell type-specific gene expression. They are often located a long way from their target gene in the linear genome and 3D genome structure plays an important role in bringing them into proximity. We develop and apply methods to identify and profile 3D genome interactions that function in neural development. Our core methods include ViCAR, CUT&Tag, and CRISPR-based genome editing. 

We aim to dissect the mechanism by which they regulatory elements control gene expression. To do this we use a combination of genetic and biochemical approaches.