Publications
2024
Abubaker MB, Hsu FY, Feng KL, Chu LA, de Belle JS, Chiang AS* (2024, March). Asymmetric neurons are necessary for olfactory learning in the Drosophila brain. Current Biology 34, 1-12. (IF: 8.983) [DOI]
2023
Chun-Chao Chen, Hsuan-Wen Lin, Kuan-Lin Feng, Der-Wan Tseng, J. Steven de Belle, and Ann-Shyn Chiang (2023) A subset of cholinergic mushroom body neurons blocks long-term memory formation in Drosophila. Cell Reports , 42(8), 112974. (IF: 8.825.6) [DOI]
Sakamura S, Hsu FY, Tsujita A, Abubaker MB, Chiang AS, Matsuno K (2023, Apr). Ecdysone signaling determines lateral polarity and remodels neurites to form Drosophila's left-right brain asymmetry. Cell Reports, 42(4), 112337. (IF: 8.825.6) [DOI]9本人為通訊作者.7 4,
Stampfl APJ, Liu Z, Hu J, Sawada K, Takano H, Kohmura Y, Ishikawa T, Lim JH, Je JH, Low CM, Teo A, Tok ES, Tan TW, Ban K, Libedinsky C, Tan FCK, Chen KP, Yang AC, Chuang CC, Chen NY, Shih CT, Lee TK, Yang DN, Lai HC, Shuai HH, Cheng CC, Ching YT, Li CW, Charng CC, Lo CC, Chiang AS, Recur B, Petibois C, Cheng CL, Chen HH, Yang SM, Hwu Y, Rojviriya C, Rugmai S, Rujirawat S, Margaritondo G* (2023) SYNAPSE: An international roadmap to large brain imaging. Physics Reports 999, 1–60. (IF: 25.6) [DOI]
2022
Lin HW, Chen CC, Jhang RY, Chen L, de Belle JS, Tully T, Chiang AS* (2022) CREBB repression of protein synthesis in mushroom body gates long-term memory formation in Drosophila. Proc Natl Acad Sci USA 119, e2211308119. (IF: 12.779) News
2021
Lin HW#, Chen CC#, de Belle JS, Tully T*, Chiang AS*. (2021) CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila. Proc. Natl. Acad. Sci. USA. 118; e2100624118 https://doi.org/10.1073/pnas.2100624118 (IF: 11.205)
Fu Z, Geng Q, Chen J, Chu LA, Chiang AS, AND Chen SC*. (2021) Light field microscopy based on structured light illumination. Optics Letters 46; 3424-27 https://doi.org/10.1364/OL.428562 (IF: 3.776)
Shih CT*, Chen NY, Wang TY, He GW, Wang GT, Lin YJ, Lee TK*, Chiang AS*. (2021) NeuroRetriever: Automatic neuron segmentation for connectome assembly. Front. Syst. Neurosci. 15; 687182 https://doi.org/10.3389/fnsys.2021.687182 (IF: 3.289)
Huang SH#, Irawati N#, Chien YF, Lin JY, Tsai YH, Wang PY, Chu LA, Li ML, Chiang AS, Tsia KK and Chu SW*. (2021) Optical volumetric brain imaging: speed, depth, and resolution enhancement. J Phys D Appl Phys 54;323002 https://doi.org/10.1088/1361-6463/abff7b. (IF: 3.207 )
2020
Tai CY, Chin AL, Chiang AS* (2020) Comprehensive map of visual projection neurons for processing ultraviolet information in the Drosophila brain. J Comp Neurol 2020;1–26. https://doi.org/10.1002/cne.25068. (IF: 3.331)
Chin AL, Yang SM, Chen HH, Li MT, Lee TT, Chen YJ, Lee TK, Petibois C, Cai X, Low CM, Tan FCK, Teo A, Tok ES, Ong EBL, Lin YY, Lin IJ, Tseng YC, Chen NY, Shih CT, Lim JH, Lim J, Je JH, Kohmura Y, Ishikawa T, Margaritondo G*, Chiang AS*, Hwu YK* (2020) A synchrotron X-ray imaging strategy to map large animal brains. Chinese Journal of Physics 65; 24-32. (IF: 2.638)
2019
Huang C, Tai CY, Yang KP, Chang WK, Hsu KJ, Hsiao CC, Wu SC, Lin YY*, Chiang AS*, Chu SW* (2019) All-optical volumetric physiology for connectomics in dense neuronal structures. iScience 22, 133-146. (IF:5.458 )
Shih CT, Lin YJ, Wang CT, Wang TY, Chen CC, Su TS, Lo CC*, Chiang AS* (2019) Diverse community structures in the neuronal-level connectome of the Drosophila brain. Neuroinformatics 18, 267–281. (IF: 3.2)
Hsu KJ, Lin YY, Lin YY, Su K, Feng KL, Wu SC, Lin YC, Chiang AS*, Chu SW* (2019) Millisecond two-photon optical ribbon imaging for small-animal functional connectome study. Optics Letters 44, 3190–3193. (IF:3.589)
Feng KL and Chiang AS* (2019) Forgetting memories through distinct actin remodeling mechanisms Proc. Natl. Acad. Sci. U.S.A. 116, 20807–20808. (IF: 9.809)
Chu LA#, Lu CH#, Yang SM, Liu YT, Feng KL, Tsai YCh, Chang WK, Wang WC, Chang SW, Chen P, Lee TK, Hwu YK, Chiang AS*, Chen BC* (2019) Rapid single-wavelength lightsheet localization microscopy for clarified tissue. Nature Communications 10, 4762. https://doi.org/10.1038/s41467-019-12715-3. (IF:11.878)
Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu Anthony YT, Ko John JS, Lai Charles PK, Lu TT*, Chen Y* (2019) Nanotechnology-enabled delivery of nitric oxide promotes tumor vessel normalization and potentiates anti-cancer therapies. Nature Nanotecnology 14, 1160-1169. (IF:33.407)
Zhang Y, Tsang TK, Bushong EA, Chu LA, Chiang AS, Ellisman MH, Reingruber J, Su CY* (2019) Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. Nature Communications 10: 1560. (IF:12.353) read more
Lin HY, Chu LA, Yang H, Hsu KJ, Lin YY, Lin KH *, Chu SW*, Chiang AS* (2019) Imaging through the whole brain of Drosophila at λ/20 super-resolution. iScience (in press) https://doi.org/10.1016/j.isci.2019.03.025 (IF:5.458 )
Hsu KJ, Lin YY*, Chiang AS*, Chu SW* (2019) Optical properties of adult Drosophila brains in one-, two-, and three-photon microscopy. Biomedical Optics Express 10, 1627-1637. https://doi.org/10.1364/BOE.10.001627
Huang YC, Wang CT, Su TS, Kao KW, Lin YJ, Chuang CC, Chiang AS*, Lo CC* (2019) A single-cell level and connectome-derived computational model of the Drosophila brain. Frontiers in Neuroinformatics DOI: 10.3389/fninf.2018.00099 doi.org/10.3389/fninf.2018.00099
2018
Wang TY, Chen NY, He GW, Wang GT, Shih CT*, Chiang AS* (2018) Kaleido: Visualizing big brain data with automatic color assignment for single-neuron images. Neuroinformatics doi.org/10.1007/s12021-018-9363-3. doi.org/10.1007/s12021-018-9363-3. (IF: 3.2)
2017
Hwu Y*, Margaritondo G* and Chiang AS* (2017) Q&A: Why use synchrotron x-ray tomography for multi-scale connectome mapping? BMC Biology 15:122, doi: 10.1186/s12915-017-0461-8 (IF: 6.779)
Wu JK, Tai CY, Feng KL, Chen SL, Chen CC, Chiang AS* (2017) Long-term memory requires sequential protein synthesis in three subsets of mushroom body output neurons in Drosophila. Scientific Reports 7: 7112 | DOI:10.1038/s41598-017-07600-2 (IF: 4.25)
2016
Lo CC*, Chiang AS* (2016) Toward whole-body connectomics. J Neurosci 36, 11375–11383. (IF: 5.924) (This review article is based on a Presidential Lecture at the Neuroscience 2016 Annual Meeting) https://www.jneurosci.org/content/36/45/11375
Yang CH, Shih MF, Chang CC, Chiang MH, Shih HW, Tsai YL, Chiang AS, Fu TF, Wu CL* (2016) Additive expression of consolidated memory through Drosophila mushroom body subsets. PLoS Genet 12, e1006061. doi: 10.1371. (IF: 6.661)
2015
Shih HW, Wu CL, Chang SW, Liu TH, Lai JSY, Fu TF, Fu CC, Chiang AS*(2015) Parallel circuits control temperature preference in Drosophila during aging. Nature Communications 6, 7775. doi: 10.1038/ncomms8775 (IF:11.329)
Shih CT*, Sporns O, Yuan SL, Su TS, Lin YJ, Chuang CC , Wang TY, Lo CC, Greenspan RJ, Chiang AS* (2015) Connectomics-based analysis of information flow in the Drosophila brain. Current Biology 25, 1249-1258. DOI:https://doi.org/10.1016/j.cub.2015.03.021 (IF: 8.983)
Lin CW, Lin HW, Chiu MT, Shih YH, Wang TY, Chang HM, Chiang AS* (2015) Automated in situ brain imaging for mapping the Drosophila connectome. J Neurogenet 26, 157-168. DOI: 10.3109/01677063.2015.1078801 (IF:1.854)
2014
Wu MC, Chu LA, Hsiao PY, Lin YY, Chi CC, Liu TH, Fu CC*, Chiang AS*(2014) Optogenetic control of selective neural activity in multiple freely moving Drosophila adults. Proc. Natl. Acad. Sci. U.S.A. 111, 5367-5372. doi: 10.1073/pnas.1400997111 (IF: 9.809)
2013
Wu CL, Shih MF M, Lee PT, Chiang AS* (2013) An octopamine–mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila. Current Biology 23, 1-9. (IF: 8.983)
Lin HH, Chu LA, Fu TF, Dickson BJ, Chiang AS*(2013) Parallel neural pathways mediate CO2 avoidance responses in Drosophila. Science 340, 1338-1341. (IF: 31.477; this article has been reviewed in the “PERSPECTIVES” of the same Science issue, p1295-1297) doi: 10.1126/science.1236693
Lin CY, Chuang CC, Hua TE, Chen CC, Dickson BJ, Greenspan RJ, Chiang AS* (2013) A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain. Cell Report 3, 1739-1753. https://doi.org/10.1016/j.celrep.2013.04.022 (IF: 7.207)
Pai TP, Chen CC, Lin HH, Chin AL, Lai JSY, Lee PT, Tully T, Chiang AS* (2013) Drosophila ORB protein in two mushroom body-output neurons is necessary for long-term memory formation. Proc. Natl. Acad. Sci. U.S.A. 110, 7898-7903. doi: 10.1073/pnas.1216336110 (IF: 9.809)
Dubnau J*, Chiang AS*(2013) Systems memory consolidation in Drosophila. Curr Opin Neurobiol 23, 84-91. https://doi.org/10.1016/j.conb.2012.09.006 (IF: 6.765)
Lehnert BP, Baker AE, Gaudry Q, Chiang AS, Wilson RI (2013) Distinct roles of TRP channels in auditory transduction and amplification in Drosophila. Neuron 77, 115-128. doi: 10.1016/j.neuron.2012.11.030 (IF: 15.982)
2012
Zhou C, Huang H, Kim S, Lin HW, Meng X, Chiang AS, Wang JW, Jiao R, Rao Y (2012) Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J Neurosci 32, 14281-14287. doi: 10.1523/JNEUROSCI.0517-12.2012 (IF: 6.747)
Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS* (2012) Visualizing long-term memory formation in two neurons of the Drosophila brain. Science 335, 678–685.[101年大學指考試題39-41] DOI: 10.1126/science.1212735 (IF: 31.477; this article has been reviewed in the “PERSPECTIVES” of the same Science issue, p664-665; this article has been introduced by the Science Editor in the “EDITOR’S CHOICE” of the Science Signaling 14, ec50)
Lai JSY, Lo SJ, Dickson BJ and Chiang AS*(2012) Auditory circuit in the Drosophila brain. Proc. Natl. Acad. Sci. U.S.A. 109, 2607-2612. doi: 10.1073/pnas.1117307109 (IF: 9.809, 5-Year IF: 10.727)
2011
Chiang AS* (2011) Q&A: Ann-Shyn Chiang. Curr Biol 21, R938-R939. (IF: 8.983)
Lee PT, Lin HW, Chang YH, Fu TF, Dubnau J, Hirsh J, Lee T and Chiang AS* (2011) Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 108, 13794–13799. doi: 10.1073/pnas.1019483108 (IF: 9.809)
Wu CL, Shih MF Lai SY, Yang HT, Turner GC, Chen L, Chiang AS* (2011) Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Curr Biol 21, 848-854. https://doi.org/10.1016/j.cub.2011.02.041 (IF: 8.983; this article has been reviewed in the “Dispatch” of the Current Biology21, R394-R395)
Chiang AS*, Lin CY, Chuang CC, Chang HM, Hsieh CH, Yeh CW, Shih CT, Wu JJ, Wang GT, Chen YC, Wu CC, Chen GY, Ching YT, Lee PC, Lin CY, Lin HH, Wu CC, Hsu HW, Huang YA, Chen JY, Chiang HJ, Lu CF, Ni RF, Yeh CY, Hwang JK (2011) Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution. Curr Biol 21,1-11. (Article, cover story) DOI:https://doi.org/10.1016/j.cub.2010.11.056 (IF: 8.983; this article has been reviewed in the “Dispatch” of the Current Biology21, R19-R20)「紐約時報」專欄報導