Received Ph.D. (1990) and trained as a postdoctoral fellow (1992) in Rutgers University, Ann-Shyn Chiang joined Department of Life Science, National Tsing Hua University as an associate professor (1992), promoted as professor (1997), took sabbatical to study Drosophila memory at Cold Spring Harbor Laboratory (2001) and became the adjunct International Faculty of Kavli Institute for Brain and Mind (KIBM) at the University of California, San Diego (2011). For his contribution to our understanding of memory formation using a connectomics approach, Chiang was elected as an Academician of Academia Sinica (2014) and The World Academy of Science Fellow (2016).

Chiang reconstructed a brain-wide wiring diagram in Drosophila (the New York Times reported this discovery as the first step toward mapping human brain) and published the first Cell (2007) paper from Taiwanese scientists. Guiding by this connectomics map, he and his colleagues discovered that long-term memory formation requires new protein synthesis only in few brain neurons and published the first full article in Science (2012) from Taiwanese scientists. He received many awards, including: Outstanding Research Award, National Science Council (2004, 2009, 2012), Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship (2007), Academic Award of Ministry of Education (2007), Outstanding Contributions in Science and Technology of Executive Yuan (2008), TWAS Prize in Biology (2012), and National Chair Award of Ministry of Education (2015, 2020). Chiang is currently the Director of Brain Research Center, and the Distinguished Chair Professor of National Tsing Hua University.

江安世教授現職為國立清華大學的特聘講座教授，並擔任腦科學研究中心主任。其最高學歷為1990年於羅格斯大學 (Rutgers University) 取得的昆蟲學博士學位，畢業後於同一單位接受博士後研究訓練，1992年返臺，受聘於清華大學生命科學系擔任副教授，並於1997年升任教授職位。江教授在2001年於美國冷泉港實驗室休假進修期間開啟了以果蠅 (Drosophila) 作為學習記憶生物模型之研究歷程，後於2011年受邀成為加州大學聖地牙哥分校卡夫里腦科學研究所的國際研究學者。在他的研究生涯中，對於大腦圖譜解密以及記憶形成機制的研究有非常大的貢獻，也因此獲選為「中央研究院院士」(2014年) 以及「發展中世界科學院院士」(2016年)。

江教授是國際知名的神經科學權威，是我國第一位研究成果獲刊於《細胞》雜誌之學者，此篇論文發表了解析度到達單細胞層次之果蠅全腦網絡立體圖譜，廣受國內外媒體報導，紐約時報更盛讚此研究為人類全腦圖譜解碼之第一步。藉由此圖譜，江教授與跨領域研究團隊得以發現長期記憶的形成所需的新生蛋白質，僅發生於來自於腦中少數幾顆神經細胞內，並再次成為國內首位以長篇論文形式發表在《科學》雜誌之科學家。 江教授至今獲得的獎項肯定甚多，摘選如下：科技部（前國科會）傑出研究獎 (2004、2009、2012)，傑出人才基金會傑出人才講座 (2007)，教育部學術獎 (2007)，行政院傑出科技貢獻獎 (2007)，發展中世界科學院生物獎 (2012)，教育部國家講座(生物及醫農類科；2015、2020) 並晉身為終身榮譽國家講座主持人

EDUCATION

1990 Ph.D. in Entomology, Rutgers University, New Jersey , U.S.A.

1983 M.S. in Plant Pathology and Entomology, National Taiwan University, Taiwan, R.O.C.

1981 B.S. in Entomology, National Chung-Hsing University, Taiwan , R.O.C.

ACADEMIC POSITION

2021-present Adjunct Distinguished Chair Professor, Institute of Brain and Mind Sciences, National Taiwan University

2019-present Adjunct Chair Professor, Tunghai University, Taiwan

2017-present Adjunct Investigator, Institute of Molecular and Genomic Medicine, The National Health Research Institutes, Taiwan

2016-present Adjunct Investigator, Institute of Physics, Academia Sinica, Taiwan

2016-present Adjunct Distinguished Investigator, National Synchrotron Radiation Research Center, Taiwan

2016-present Adjunct Distinguished Chair Professor, Graduate Institute of Clinical Medical Science, China Medical University, Taiwan

2016-present Director, Industrial Biotechnology Ph.D. program, National Tsing Hua University, Taiwan

2014-present Adjunct Chair Professor, Kaohsiung Medical University, Taiwan

2014-present Tsing Hua Distinguished Chair Professor, National Tsing Hua University, Taiwan

2013-present Scientific Advisory Board member, Center for Brain Activity Mapping at UCSD

2013-present Scientific Advisory Board member, Cold Spring Harbor Conferences Asia, China

2011-present International Faculty, Kavli Institute for Brain and Mind (KIBM) at the University of California, San Diego, USA.

2010-present Adjunct Chair Professor, National Chiao Tung University, Taiwan

2014-2020 Dean, College of Life Science, National Tsing Hua University, Taiwan

2008-2018 Adjunct Investigator, Genomics Research Center, Academia Sinica

2007-2014 Tsing Hua Chair Professor, National Tsing Hua University, Taiwan

2006-2008 Adjunct Professor, Cold Spring Harbor Laboratory, USA

2005 Chair of Biological Science Panel, National Science Council, Taiwan

2005-2010 Adjunct Professor, Department of Life Science, National Central University, Taiwan

2004-present Director, Brain Research Center, National Tsing Hua University, Taiwan

2002-2008 Director, Institute of Biotechnology, National Tsing Hua University, Taiwan

2001-2002 Visiting Scientist, Cold Spring Harbor Laboratory, USA

1997 Visiting Professor, Neurobiology Laboratory, CNRS, France

1997-present Professor, Department of Life Science, National Tsing Hua University, Taiwan

1994-2005 Advisor of EM Center, National Tsing Hua University, Taiwan

1992-1997 Associate Professor, Department of Life Science, National Tsing Hua University

1990-1992 Postdoc, Rutgers University, New Jersey, USA

HONOR 

2022 榮譽博士 (高雄醫學大學)

2021 National Chair Professorship Award, Ministry of Education (教育部第24屆終身國家講座，生物及醫農類科)

2022,-21-20-18 科技部「2020未來科技獎」4次

2020 李亦園院士榮譽講座

2020 國立清華大學厚德榮譽講座

2018-2023 深耕計畫(教育部腦科學中心、科技部特色中心)

2017 「遠見」雜誌再度選為「新台灣之光100」

2016 TWAS Fellow (發展中世界科學會 院士)

2016 Presidential Special Lecturer, The Society for Neuroscience 2016 Annual Meeting (>35,000 participants)

2015 National Chair Professorship Award, Ministry of Education (教育部第19屆國家講座，生物及醫農類科)

2014 Academician, Academia Sinica (中央研究院 院士)

2013 有庠科技獎-科技論文獎

2013-2017 Free-style Outstanding Research Project, MOST (自由型卓越學研計畫, 科技部)

2012 Published Taiwan’s first "Science" full article.

2012 AEARU Distinghuished Lecture (東亞研究型大學協會傑出講座)

2012 TWAS Prize in Biologoy (發展中世界科學會 生物學類獎)

2012 Hou Jindui Distinguished Honor Award (侯金堆傑出榮譽獎—基礎科學生物類)

2011-2013 Academic Summit Project, NSC (國科會攻頂計畫)

2010 「遠見」雜誌-選為中華民國建國百年「新台灣之光100」

2009 The Fifty Scientific Achievements, NSC 50th anniversary (國科會50週年慶「50科學成就」)

2008 Teco Award of Teco Technology Foundation (東元科技獎化工/生物/醫工領域)

2008 HuiSun Chair of National Chung Hsing University (中興大學蕙蓀講座)

2007 Distinguished Alumnus of National Chung Hsing University (中興大學傑出校友)

2007 Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship (傑出人才基金會傑出人才講座)

2007 Sun Yat-sen Academic Award (中山學術獎)

2007 Outstanding Contributions in Science & Technology, Executive Yuan (行政院傑出科技貢獻獎)

2007 Academic Award of Ministry of Education (教育部學術獎)

2007 Published Taiwan’s first "Cell" paper

2006-2017 邁向頂尖大學腦科學中心計畫(教育部)

2004, 2010, 2013 Outstanding Research Award, MOST, Taiwan (科技部傑出獎三次)

1990 First place in the Student Paper Competition, Eastern Branch of Entomological Society of America 62nd Annual Meeting, Baltimore, MD, USA

1989 Radclyffe B. Roberts Scholarship, Department of Entomology, Rutgers Univ, USA

1987 Thomas J. Headlee Fellowship, Department of Entomology, Rutgers Univ, USA

SELECTED PROFESSIONAL ACTIVITIES

• The Society for Neuroscience member

• Editorial Board: GigaScience (2012-present), Journal of Neurogenetics (2009〜present), Chinese Journal of Entomology (1995-present).

• 媒體報導: The New York Times (2010); Nature (2009, 2017); Current Biology (2011);「遠見」雜誌選為中華民國建國百年「新台灣之光100」(2010, 2017)

• 指導委員: 教育部學審會生醫領域召集人(2014, 2015, 2016, 2017, 2018)、國家同步輻射中心諮議委員、國家高速網路與計算中心諮議委員、高雄醫學大學校務發展諮議委員(2017〜present)、中興大學講座特聘教授頂尖人才遴聘審議委員

• 遴選委員：中興大學校長(2010, 2015)、中興大學農學院院長(2015)、成功大學生命科學院院長(2017)、中研院生物多樣性中心主任(2015)、國家衛生院細胞及系統醫學研究所所長(2017)、中原大學特聘教授(2015)、中興大學講座教授(2016, 2017)

• 評審委員: 總統科學獎(2015, 2017, 2018, 2019)、教育部國家講座暨學術獎(2014, 2015, 2016, 2017, 2018)、科技部傑出獎(2015, 2017)、東元獎(2015, 2016, 2017)、王民寧獎(2016, 2017)、永信李天德醫藥科技獎(2015, 2016, 2017, 2019)、工研院傑出研究獎(2017, 2018, 2019)、杜聰明獎(2016)、臺法科技獎(2016)、中研院年輕學者研究著作獎(2014, 2016, 2017, 2018)、吳大猷科普獎(2018)、中研院前瞻計畫(2017, 2018)、中研院主題計畫(2016, 2017, 2018)、中研院生涯發展計畫(2015)、科技部曜星研究計畫(2017, 2018)、教育部臺灣人才躍昇計畫(2014, 2016, 2017, 2018)、教育部產研計畫(2018, 2019)、教育部產業博士計畫(2019)、傑出人才發展基金會年輕學者創新獎(2018, 2019)、有庠科技獎(2019)、李國鼎科技與人文講座(2018, 2019)、玉山學者(2018)

• 學會理監事: 中華民國細分學會理監事(2018, 2019)、清華教師會(2017, 2018, 2019)

• Reviewed manuscripts for Science, Current Biology, PNAS, Cell Reports, PLoS Biology, PLoS Genetics, eLife, Journal of Neuroscience, Nature Communications

• Reviewed International grants for: National Science Foundation, Science Foundation Ireland, Wellcome Trust (2014, 2015, 2016, 2017), AXA Research Fund (2015), European Research Council (2017)

• 國際課程講師: National Centre for Biological Sciences, Bangalore, India (2011); Marine Biological Laboratory at Woods Hole (2006); Cold Spring Harbor Laboratory (2002)

MAJOR SCIENTIFIC ACHIEVEMENTS

We aim to understand the genetic and neural basis of brain functions using Drosophila as a model system. We take two main approaches: (i) to construct a wiring diagram of information flows in the entire brain, and (ii) to manipulate target neurons for understanding the computation process in specific neural circuits orchestrating the studied behaviors. Major achievements in our attempts to reach these goals include: 

• Invent the world-first tissue clearing technology. We developed an optical tissue clearing solution, called FocusClear (J Comp Neurol 2001, 440:1-11; Methods 2003, 30:86-93), compatible to GFP for the visualization of gene expressions in an intact brain at single cell resolution. Making biological tissue transparent allows efficient excitation and detection of fluorescence signals at the depth hundreds of micron beneath the surface. Combining with confocal microscopy, our tissue clearing technology has revolutionized traditional anatomy by allowing high-resolution 3D imaging of large biological tissues without physical sectioning. The invention has received patents from Taiwan (Patent No: 206390), UAS (Patent No: US 6472216 B1), France (Patent No: 2830323) and United Kingdom (Patent No: GB237757).

• Discover odor representation in the higher brain centers via a circuit shunting mechanism. We discovered neuronal temporal identity and stereotyped neural connections in the 3rd order olfactory center of the Drosophila brain (published in Cell 2006, 127:409-422; Cell 2007, 128:1205-1217) and a shunting mechanism for gating CO2 information flow in parallel neural circuits (Science 2013, 340:1338-1341). Our findings extend the understanding of olfactory representations to the 3rd order brain center and show that information routing is context dependent.

• Discover that long-term memory stores in only few brain neurons. Forming long-term memory requires new protein synthesis in all animals. We found that learning-induced new proteins occur in only few brain neurons for the formation of long-term memory (Science 2012, 335:678-685; Proc Natl Acad Sci USA 2013, 110:7898-7903). Previously, we have established fly models for studying long-term memory formation (Current Biology 2003, 13:286-296), intermediate-term memory consolidation (Current Biology 2011, 21:848-854; Proc Natl Acad Sci USA 2011, 108:13794-13799), aging dependent memory defect (Neuron 2003, 40:1003-1011), Alzheimer’s diseases (Proc Natl Acad Sci USA 2004, 101:6623-6628), Huntington’s diseases (Proc Natl Acad Sci USA 2005, 102:3777-3781), and IBMPFD disease model (PLoS Genetics 2011, 7:e1001288). Importantly, we discovered the first functional NMDA receptors in insects (Proc Natl Acad Sci USA 2002, 99:37-42; Current Biology 2005, 15:603-615; Nature Neuroscience 2007, 10:1578-1586). This series of studies suggest a unified cellular model for learning and memory and extend our understanding of memory formation from molecular to systems consolidation. (Curr Opin Neurobiol 2013, 23:84-91).

• Construct the world-first 3D fly brain database at single neuron resolution. We created the first brain-wide wiring map in Drosophila (Current Biology 21:1-11, 2011). The study managed to bar code 16,000 neurons in the fly brain, an advance that is comparable to the sequencing of the fly genome and considered as the first step toward decoding the human brain by The New York Times. The breakthrough paves the way for a comprehensive analysis of information processing within and between neurons and ultimately a deeper understanding of control and causality in fly behavior (Current Biology 2011, 21:R19-20; Proc Natl Acad Sci USA 2014, 111:5367-5372). Guided by this brain circuit map, we have mapped auditory circuit (Proc Natl Acad Sci USA 2012, 109:2607-2612; Neuron 2013, 77:115-128), temperature circuits (Nature Communications 2015, 6:7775) and established a comprehensive map of the central complex indicating the direction of information flow at single cell resolution (Cell Reports 3:1739-1753, 2013). For his contribution in connectomics, Chiang was invited as one of the Presidential Special Lecturers at the Neuroscience 2016 Annual Meeting where he demonstrated the first effort toward whole body connectomics (reviewed in J Neurosci 2016, 36:11375–11383).

PATENTS

1. 具高解析度之共軛焦顯微鏡影像拼接方法(江安世、陳永昌、蔡耀萱), 中華民國專利證書: I480833, 專利期間:2015/04/11-2029/06/04。

2. 三維影像資料處理方法- Method of three-dimensional image data processing (江安世、林志勇、莊朝均、張修明、謝昌煥) 中華民國專利證書:I460684, 專利期間:2014/11/11-2030/09/26；US patent No: 8593457, Effective period: 2013/11/26.

3. 微小昆蟲自動分類系統(江安世、陳榮順、蔡宏營、賀陳弘、方維倫、吳嘉霖、林建宏、林育慶、楊智舜、吳鈺徵、朱麗安), 中華民國專利證書:I442884, 專利期間:2014/07/01-2031/09/28。

4. 一種提高三維影像資訊密度之方法-Image processing method for feature retention and the system of the same (江安世、張修明、陳永昌、陳冠宇), 中華民國專利證書:I435112, 專利期間:2014/04/21-2031/06/02；US patent No: 8665276, Effective period: 2014/03/04.

5. Sample carrying apparatus capable of revolving sample (江安世、傅建中、張修明), US patent No: 8659825 B2, Effective period: 2014/02/25.

6. 觀察厚組織三維結構之方法 (江安世、湯學成、劉原安), 中華民國專利證書: I425201, 專利權期間:2014/2/10-2030/9/30。

7. 提供三維立體影像之方法及系統(王國肇、江安世、張修明、莊朝鈞、葉昌偉、謝昌煥), 中華民國專利證書:I407773,專利權期間:2013/9/1-2030/4/12。

8. 一種建構和搜尋三維影像資料庫之方法- A Method for Searching and Constructing 3D Image Database(王聖川、江安世、李秉璋、林敬堯、荊宇泰、莊朝鈞、張修明、陳永昌、蔡坤龍、謝昌煥),中華民國專利證書: I406181, 專利權期間:2013/8/21-2029/05/10;US patent No:8520933, Effective period: 2013/08/27.

9. 一種三維影像補密重建方法(江安世、張修明、陳家和、傅建中、謝昌煥), 中華民國專利證書: I396142, 專利權期間:2013/05/11-2028/09/10。

10. 可保留影像特徵之影像處理方法及系統(江安世、張修明、陳永昌、陳冠宇), 中華民國專利證書: I393071, 專利權期間:2013/04/11-2030/02/11。

11. 具可翻轉樣本功能之樣本承載設備(江安世、張修明、傅建中),中華民國專利證書:I386679, 專利權期間:2013/02/21-2027/12/19。

12. 具有用以產生標準果蠅腦模型及其座標系統之模組之生物表現系統(江安世、陳永昌、張修明), 中華民國專利證書:I381283, 專利權期間:2013/01/01-2029/04/23。

13. 用於三維影像資料庫建構之影像預處理系統(江安世、李秉璋、荊宇泰、莊朝鈞、張修明、陳永昌、謝昌煥),中華民國專利證書:I378402, 專利權期間:2012/12/01-2029/06/11。

14. Bio-expression system with module for creating the standard Drosophila brain model and its coordinate system(江安世、陳永昌、張修明), UAS patent No: 8315809, Effective period: 2012/11/10.

15. Image preprocessing system for 3D image database construction (江安世、李秉璋、荊宇泰、莊朝鈞、張修明、陳永昌、謝昌煥), UAS patent No:8126247, Effective period:2012/02/28.

16. A method for searching and constructing 3D image database (王聖川、江安世、李秉璋、林敬堯、荊宇泰、莊朝鈞、張修明、陳永昌、蔡坤龍、謝昌煥), UAS patent No: 8520933, Effective period: 2010/06.

17. 生物表現系統及其方法- Bio-expression system and the method of the same (江安世、陳永昌、林强、荊宇泰、唐傳義、張修明), 中華民國專利證書: I291630, 專利權期間: 2007/12/21-2025/04/25 ; UAS patent No: 7742878, Effective period: 2010/06。

18. 橫臥式果繩訓練機(江安世), 中華民國專利證書:M291798, 專利權期間:2006/06/11- 2015/12/18。

19. 水溶性組織澄清溶液-Aqueous Tissue Clearing Solution (江安世), 中華民國專利證書: M291798, 專利權期間:2004/06/21-2021/06/28;USA patent No: US 6472216 B1, Effective period: 2002/10; United Kingdom patent No: GB237757, Effective period: 2004/11/17; France patent No: 2830323, Effective period: 2001/10/01。

20. 生物顯微鏡影像技術以正反掃描與3D影像套合達到增加景深及解析度之方法(江安世), 中華民國專利證書:594593, 專利權期間: 2004/06/21-2023/01/29。