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Understanding and Manipulating Biomolecular Dynamics and Chemical Reactions for Single-Molecule Analysis and Diagnostics
Understanding and Manipulating Biomolecular Dynamics and Chemical Reactions for Single-Molecule Analysis and Diagnostics
In Kawai lab,
We engage in chemical biology research employing photochemistry, with a particular focus on "molecules," "fluorescence," and "single-molecule measurements."
We pay special attention to the distinctive blinking (fluorescence blinking) characteristics of fluorescent molecules, which become apparent only through single-molecule observations. These fluorescent molecules are widely used across diverse research fields such as bioimaging, pathological clinical testing, and molecular biology.
By adopting an interdisciplinary approach, we strive to generate both social and academic value through the development of novel analytical methods, new fluorescent molecules, and innovative diagnostic technologies.
Single-Molecule Analysis of Biomolecular Structures and Sequences
Single-Molecule Analysis of Biomolecular Structures and Sequences
We are developing single-molecule analytical techniques targeting the structural conformations and sequences of biomolecules such as nucleic acids and peptides. Gaining detailed insights into these biomolecular structures and sequences is expected to enhance our understanding of fundamental biological processes and improve diagnostic techniques for diseases. Through precise control and analysis of fluorescence blinking, we aim to elucidate structural dynamics, sequence-specific reactions, and chemical reaction rate constants at the single-molecule level.
References：
Accounts Chem. Res., 54, 1001-1010 (2021).
Development of Fluorescent Molecules/Fluorescence Blinking Systems for Next-Generation Single-Molecule Analysis and Diagnostics
Development of Fluorescent Molecules/Fluorescence Blinking Systems for Next-Generation Single-Molecule Analysis and Diagnostics
We are developing innovative fluorescent molecules/fluorescence blinking systems designed for next-generation single-molecule analysis and diagnostics. Utilizing a unique photochemical perspective for molecular design, we aim to precisely control fluorescence blinking rates and responsiveness, thereby opening new avenues in single-molecule measurements and ultra-sensitive diagnostic technologies.
J. Phys. Chem. Lett., 16, 5202−5207 (2025).
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