Publications 

Link to all of Dr. Fleets Publications 

Link to Dr. Fleet’s Google Scholar Page  

Key Cancer Prevention papers Key Vitamin D and Calcium Metabolism papers Key Gene x Environment Interaction Papers Key Review Papers

Key Cancer Prevention papers:

a. Kovalenko, P.L., Zhang, Z., Cui, M., Clinton, S.K., Fleet, J.C. (2009) 1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1. BMC Genomics 11:26.  PMID:20070897

b. Fleet, J.C., Kovalenko, P., Li, Y., Smolinski, J., Spees, C.K., Yu, J., Thomas-Ahner, J.M., Cui, M., Neme, A., Carlberg, C., Clinton, S.K. (2019) Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT121 Mice. Cancer Prevention Research 12:343-356. PMID: 31028080

c. Wang, F, Johnson, R.L., DeSmet, M.L., Snyder, P.W., Fairfax, K. Fleet, J.C. (2017) Vitamin D Receptor-Dependent Signaling Protects Mice from Dextran Sulfate Sodium-Induced Colitis. Endocrinology 158:1951-63.

d. Fleet, J.C., Burcham, G.N., Calvert, R.D., Ratliff, T.L. (2019) 1a, 25 dihydroxyvitamin D (1,25(OH)2D) inhibits the T cell suppressive function of myeloid derived suppressor cells (MDSC). Journal of Steroid Biochemistry and Molecular Biology 198:105557 PMID: 31783150.

Key Vitamin D and Calcium Metabolism papers

a. Xue, Y. and Fleet, J.C. (2009) Complete recovery of the VDR knockout phenotype by villin-directed expression of VDR in the intestine.  Gastroenterology 136:317-327. PMID:19254681

b. Reyes-Fernandez, P., Fleet, J.C. (2016) Compensatory changes in calcium metabolism accompany the loss of vitamin D receptor (VDR) from the distal intestine and kidney of mice.  J. Bone Min. Res. 31:143-151. PMID: 26211511

c. Cui, M., Li, Q., Johnson, R., Fleet, J.C. (2012) Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice. 27:2097-107 https://pubmed.ncbi.nlm.nih.gov/22589201/ 

d. Fleet, J.C., Aldea, D., Chen, L., Christakos, S., Verzi, M. (2022) Regulatory domains controlling high intestinal vitamin D receptor (VDR) gene expression are conserved in mouse and human. J. Biol. Chem.  298:101616. PMID: 35065959

e. Aita, R., Aldea, D., Hassan, S., Hur, J., Pallon-Cardenas, O., Cohen, E., Chen, L., Shroyer, N., Christakos, S., Verzi, M., Fleet, J.C. (2022) Spatial differences in vitamin D mediated gene regulation across the mouse intestinal tract.   J. Biol. Chem.  298:102213 PMID: 35779631

Key Gene x Environment Interaction Papers

a. Replogle, R.A, Li, Q., Wang, L., Zhang, M., Fleet, J.C. (2014) Gene-by-diet interactions influence calcium absorption and bone density in mice. J. Bone Miner. Res. 29:657-665. PMID:23955923

b. Fleet, J.C., Replogle, R.A., Reyes-Fernandez, P., Wang, L., Zhang, M., Clinkenbeard, E.L., White, K.E. (2016) Gene-by-diet interactions affect serum 1,25 dihydroxyvitamin D levels in male BXD recombinant inbred mice.  Endocrinology 157:470-481. PMID:26587785 

c. Reyes-Fernandez, P.C., Replogle, R.A., Wang, L., Zhang, M., Fleet, J.C. (2016) Novel genetic loci control calcium absorption and femur bone mass as well as their response to low calcium intake in BXD recombinant inbred mice.  J. Bone Min. Res. 31:994-1002. PMID: 26636428

d. Chanpaisaeng, K., Reyes-Fernandez, P., Fleet, J.C. (2022) Diet x Gene Interactions Control Femoral Bone Adaptation to Low Dietary Calcium.  JBMR Plus 6:e10668 PMID: 36111202

e. Ucer-Ozgurel, S., Chanpaisaeng, K., Reyes Fernandez, P.C., and Fleet, J.C. (2024) Male Lrp5A214V Mutant Mice Maintain High Bone Mass During Dietary Calcium Restriction by Altering the Vitamin D Endocrine System. J Bone Min Res 39:315-325. PMID: 38477773  https://pubmed.ncbi.nlm.nih.gov/38477773/ 

Key Review Papers

a. Johnson, R.L., Fleet, J.C. (2013) Animal models of colorectal cancer. Cancer Metastasis Rev. 32:39-61. https://pubmed.ncbi.nlm.nih.gov/23076650/ 

b. Fleet, J.C., DeSmet, M., Johnson, R., Li, Y. (2012) Vitamin D and Cancer: A review of molecular mechanisms. Biochemical Journal 441:61-76 https://pubmed.ncbi.nlm.nih.gov/22168439/ 

c. Fleet, J.C. (2022) Vitamin D and Gut Health, In: Nuclear hormone receptors in human health and disease. Adv Exp Med Biol. 1390:155-167. PMID: 36107318 https://pubmed.ncbi.nlm.nih.gov/36107318/ 

d. Fleet, J.C. (2022) Vitamin D and Intestinal Calcium Absorption.   Nutrients 14:3351 PMID: 36014856 https://pubmed.ncbi.nlm.nih.gov/36014856/ 

e. Fleet, J.C., Christakos, S., Jiang, H. (2024) Regulation of calcium and phosphorus absorption by vitamin D.  In: Vitamin D, Fifth Edition, M. Hewison Ed. Chpt 20, Elsevier.