Fish Pathology Laboratory, Tokyo University of Marine Science and Technology
Fish Pathology Laboratory, Tokyo University of Marine Science and Technology
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2025-9-11
Professor Sano, Ms. Chaw, Mr. Carlo, Ms. Saito, Mr. Baba, Ms. Goto, Mr. Numata from our laboratory gave presentations at the 22nd International Conference on Diseases of Fish and Shellfish (EAFP2025)
2025-9-1
High school students from Hyogo Prefectural Awaji Mihara High School visited our laboratory and took part in a mock lesson.
2025-4-1
Mr. Saito, Mr. Baba, and Ms. Goto from our laboratory gave presentations at the 2025 Spring Meeting of The Japanese Society of Fish Pathology. Ms. Saito and Mr. Numata also gave presentations at the Spring Meeting of the Japanese Society of Fisheries Science.
当研究室では、魚介類の感染症（ウイルス病・細菌病）に対し、病原体の特性の解明、ワクチンの開発、魚類の免疫機構や耐病性機構に関する研究を行っています。病原体と宿主の両面からアプローチすることにより新たな技術開発を行い、養殖魚介類の感染症被害の軽減を目指しています。
In our laboratory, we delve into research on the infectious diseases (viral and bacterial) affecting aquatic organisms. Our focus includes understanding pathogen characteristics, developing vaccines, and studying the immune and disease tolerance mechanisms in fish. By approaching both pathogens and hosts, we aim to pioneer new technologies to reduce the impact of infectious diseases on cultured fish.
研究 Research Theme
研究 Research Theme
キンギョヘルペスウイルスに対するワクチンの開発 Development of Vaccines for Cyprinid Herpesvirus
キンギョヘルペスウイルスに対するワクチンの開発 Development of Vaccines for Cyprinid Herpesvirus
キンギョの養殖で問題となっている「ヘルペスウイルス性造血器壊死症」。病原体となるキンギョヘルペスウイルスを継代培養したり、遺伝子工学的に改変したりすることで、日本初となる魚類用の「弱毒生ワクチン」の開発・実用化に取り組んでいます。
Addressing "Herpesvirus Hematopoietic Necrosis", a troubling disease in goldfish aquaculture, we are pioneering the development and practical application of Japan's first "attenuated live vaccine" for fish by continuously culturing and genetically altering the pathogen, Cyprinid Herpesvirus.
不明病の診断 Diagnosis of Unknown Diseases
不明病の診断 Diagnosis of Unknown Diseases
日本各地の水産試験場などから原因不明の病気にかかった魚が持ち込まれることも。病理解剖、病理組織検査、病原体の同定などを行い、その病気の原因や発症過程を解明することも、水族病理学研究室の大切な役割です。
Fish affected by unidentified diseases are brought in from fisheries experiment stations across Japan. By conducting pathological dissections, histopathological inspections, and pathogen identification, elucidating the causes and progression of these diseases is another crucial role of the Laboratory of Fish Pathology.
魚類独自の粘膜免疫機構に関する研究 Study of Fish-Unique Mucosal Immune Systems
魚類独自の粘膜免疫機構に関する研究 Study of Fish-Unique Mucosal Immune Systems
病原体などの微生物が非常に多い水中で生活するために、魚類は陸上動物とは異なった粘膜免疫システムを発達させてきました。このような魚類独自の粘膜免疫機構の解明を通して、新しいワクチンデリバリーシステムの開発に挑戦しています。
Because of the abundance of microorganisms, including pathogens, in aquatic environments, fish have evolved distinct mucosal immune systems from those of terrestrial animals. By unraveling these unique systems, we are challenging the development of a new vaccine delivery system.
教員 Faculty
教員 Faculty
佐野 元彦 教授
佐野 元彦 教授
Professor SANO Motohiko
加藤 豪司 准教授
加藤 豪司 准教授
Associate Professor KATO Goshi
松本 萌 助教授
松本 萌 助教授
Assistant Professor MATSUMOTO Megumi
業績 Publications
業績 Publications
Hiroaki Saito, Lik-Ming Lau, Shungo Minami, Manami Yuguchi, Megumi Matsumoto, Teruyuki Nakanishi, Hidehiro Kondo, Goshi Kato, Motohiko Sano, "Cell-mediated and humoral immune responses of cyprinids induced by a live attenuated vaccine against cyprinid herpesvirus 2 infection in comparison to the virus non-permissive high temperature water treatment", Fish & Shellfish Immunology Volume 154, November 2024, 109991
Megumi Matsumoto, Tang Belinda Chien Chien, Yuichiro Machida, Hisato Matoyama, Tatsuya Kishihara, Shoh Sato, Satoshi Kawato, Ikuo Hirono, Motohiko Sano, Goshi Kato, "Mycolicibacterium cyprinidarum sp. nov., a rapidly growing species isolated from diseased koi carp, Cyprinus carpio", 2024年05月 International Journal of Systematic and Evolutionary Microbiology, 74 (5)
Megumi Matsumoto, Yuichiro Machida, Motohisa Kanernaru, Masato Yamamoto, Motohiko Sano, Goshi Kato, "Infection with Mycobacterium pseudoshottsii in Cultured Yellowtail Seriola quinqueradiata in Owase Bay, Japan", FISH PATHOLOGY, 2022年6月1日, https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000889220100001&DestApp=WOS_CPL
Hiroaki Saito, Takumi Okamura, Tomoya Shibata, Goshi Kato, Motohiko Sano, "Development of a live attenuated vaccine candidate against herpesviral hematopoietic necrosis of goldfish", Aquaculture, 2022年4月1日, https://doi.org/10.1016/j.aquaculture.2022.737974
Megumi Matsumoto, Uwe Fischer, Motohiko Sano, Goshi Kato, "Cell-mediated immune response against mycolic acids of Mycobacteroides salmoniphilum in rainbow trout Oncorhynchus mykiss", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021年11月1日, https://doi.org/10.1016/j.dci. 2021.104195
Yuichiro Machida, Belinda Chien Chien Tang, Mitsuo Yamada, Shoh Sato, Kazue Nakajima, Hisato Matoyama, Tatsuya Kishihara, Makoto Endo, Motohiko Sano, Goshi Kato, "Mycobacteriosis in cultured koi carp Cyprinus carpio caused by Mycobacterium paragordonae and two Mycolicibacterium spp.", AQUACULTURE, 2021年6月1日, https://doi.org/10.1016/j.aquaculture.2021.736656
Nayu Kawashima, Shungo Minami, Kyuma Suzuki, Shun Watanabe, Chihaya Nakayasu, Motohiko Sano, Goshi Kato, "Changes in Resistance against Bacterial Cold-Water Disease and in Leukocyte Composition along with Sexual Maturation in Ayu Plecoglossus altivelis", FISH PATHOLOGY, 2021年1月1日, https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000644948200006&DestApp=WOS_CPL
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Building Number 2, 2nd floor, 4-5-7 Konan, Minato-ku, Tokyo 108-8477 JAPAN
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