I helped to identify plasma IgG aggregates as biomarkers for multiple sclerosis (MS) through a simple ELISA-based blood test. Elevated levels of IgG1, IgG3, and total IgG in MS aggregates were highly accurate for diagnosis (AUC >90%) and could distinguish secondary progressive MS from relapsing-remitting MS (AUC = 91%). These biomarkers also correlate with IgG-induced neuronal cytotoxicity, providing biological validation. This non-invasive blood test offers a promising alternative to invasive diagnostic procedures, enabling easier MS diagnosis, subtype differentiation, and treatment monitoring. 

Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, Ledreux A, Zizzo Z, Lundt M, Alvarez E, Yu X. Plasma IgG aggregates as biomarkers for multiple sclerosis. Clin Immunol. 2023 Nov;256:109801. doi: 10.1016/j.clim.2023.109801. Epub 2023 Oct 8. PMID: 37816415.