Orthopedic Applications
Orthopedic Applications
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Bone cells alter their cellular functions upon interacting with nanofeatured implant surfaces. To enhance integration of orthopedic implants with juxtaposed bone tissue, one of the main research thrusts of the Ercan Research Group is to fabricate nanofeatured surfaces on currently-used biomaterial surfaces. Through controlling surface topography, chemistry, wettability, crystallinity and other biomaterial related surface parameters, we are aiming to enhance osteointegration, and thus improve longevity of orthopedic and dental implants.
Bone cells alter their cellular functions upon interacting with nanofeatured implant surfaces. To enhance integration of orthopedic implants with juxtaposed bone tissue, one of the main research thrusts of the Ercan Research Group is to fabricate nanofeatured surfaces on currently-used biomaterial surfaces. Through controlling surface topography, chemistry, wettability, crystallinity and other biomaterial related surface parameters, we are aiming to enhance osteointegration, and thus improve longevity of orthopedic and dental implants.
Antibacterial Applications
Antibacterial Applications
Infections associated with medical devices are the leading cause of preventable deaths in hospitals. To fight against infections, antibiotics are the only tool in our arsenal. However, antibiotic treatment is ineffective against eradicating biofilms. Besides, the efficacy of antibiotics towards killing bacteria is decreasing based on the rise of multiple antibiotic-resistant bacteria strains, i.e. Methicillin Resistant Staphylococcus aureus. Towards fighting with infection, Ercan Research Group is designing antibacterial biomaterials to prevent growth of both gram positive and negative bacteria. We are utilizing nanotechnology-based tools to prevent attachment of bacteria onto implant surfaces, while controlled release of antibacterial agents (i.e. silver) prevent formation of biofilms on biomaterials.
Infections associated with medical devices are the leading cause of preventable deaths in hospitals. To fight against infections, antibiotics are the only tool in our arsenal. However, antibiotic treatment is ineffective against eradicating biofilms. Besides, the efficacy of antibiotics towards killing bacteria is decreasing based on the rise of multiple antibiotic-resistant bacteria strains, i.e. Methicillin Resistant Staphylococcus aureus. Towards fighting with infection, Ercan Research Group is designing antibacterial biomaterials to prevent growth of both gram positive and negative bacteria. We are utilizing nanotechnology-based tools to prevent attachment of bacteria onto implant surfaces, while controlled release of antibacterial agents (i.e. silver) prevent formation of biofilms on biomaterials.
Cardiovascular Applications
Cardiovascular Applications
Coronary artery disease is among the leading causes of death in the world. Accumulation of fat, cholesterol, calcium minerals and blood cells inside coronary arteries can lead to plaque formation (atherosclerosis), which interrupts blood flow to the cardiac muscle and gradually leads to heart attack. Although stent application is an effective treatment to re-establish blood flow, reoccurrence of similar symptoms, as well as blood clot formation on stent surfaces are fundamental problems. Towards integration of stents to vascular tissue, we are modifying stent surfaces in the nanoscale to enhance endothelial cell proliferation, while limiting formation of blood clots. Having this said, corrosion, metal ion release, mechanical properties and degradation characteristics of stents are also among the research interests of Ercan Research Group.
Coronary artery disease is among the leading causes of death in the world. Accumulation of fat, cholesterol, calcium minerals and blood cells inside coronary arteries can lead to plaque formation (atherosclerosis), which interrupts blood flow to the cardiac muscle and gradually leads to heart attack. Although stent application is an effective treatment to re-establish blood flow, reoccurrence of similar symptoms, as well as blood clot formation on stent surfaces are fundamental problems. Towards integration of stents to vascular tissue, we are modifying stent surfaces in the nanoscale to enhance endothelial cell proliferation, while limiting formation of blood clots. Having this said, corrosion, metal ion release, mechanical properties and degradation characteristics of stents are also among the research interests of Ercan Research Group.
Soft Tissue Applications
Soft Tissue Applications
Soft tissue repair requires materials that can actively interact with cells and support dynamic healing processes. The Ercan Research Group focuses on developing advanced biomaterials for neural, cardiac, and skin tissue repair. These systems are designed to guide cellular behavior, promote extracellular matrix formation, and facilitate tissue regeneration, while also providing protective and functional support when needed. By integrating material design with biological functionality, we aim to enhance tissue repair, improve integration, and support long-term performance in soft tissue applications.Â
Soft tissue repair requires materials that can actively interact with cells and support dynamic healing processes. The Ercan Research Group focuses on developing advanced biomaterials for neural, cardiac, and skin tissue repair. These systems are designed to guide cellular behavior, promote extracellular matrix formation, and facilitate tissue regeneration, while also providing protective and functional support when needed. By integrating material design with biological functionality, we aim to enhance tissue repair, improve integration, and support long-term performance in soft tissue applications.Â
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