2025
F. Bonsignore, S. Pozzi, E. Aloi, D. Mazza, S. Zambrano. Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges. Frontiers in Cell and Developmental Biology, 13 (2025)
M. Milani, F. Starinieri, S. Beretta, M. Monti, C. Canepari, F. Marabotti, S. Zambrano, D. Mazza, A. Fabiano, C. Simoni, E. Cammarota, M. Volpin, G. Bortolussi, F. Russo, M. Biffi, M. Genua, S. Degl'Innocenti, F. Sanvito, R. Ostuni, A.F. Muro, E. Montini, F. Moalli, M. Iannacone, I. Merelli, A. Cantore. Spatiotemporal liver dynamics shape hepatocellular heterogeneity and impact in vivo gene engineering. Journal of Hepatology. In press (2025).
2024
F. Colombo, V. Guzzeloni, C. Kizilirmak, F. Brambilla, J. M. Garcia-Manteiga, A. S. Tascini, F. Moalli, F. Mercalli, M. Ponzoni, R. Mezzapelle, M. Ferrarini, E. Ferrero, R. Visone, M. Rasponi, M. Bianchi, S. Zambrano*, A. Agresti. In vitro models of the crosstalk between multiple myeloma and stromal cells recapitulate the mild NF-κB activation observed in vivo. Cell Death and Disease 5: 731 (2024).
G. Pietrogrande, M. R. Shaker, S. J. Stednitz, F. Soheilmoghaddam, J. Aguado, S. D. Morrison, S. Zambrano, T. Tabassum, I. Javed, J. Cooper-White, T. P. Davis, T. J. O’Brien, E. K. Scott and E. J. Wolvetang. Valproic Acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models. Molecular Psychiatry 30 (3), 986-998 (2024).
2023
C. Kizilirmak, E. Monteleone, J. García-Manteiga, F. Brambilla, A. Agresti, M.E. Bianchi, S. Zambrano. Small transcriptional differences among cell clones lead to distinct NF-κB dynamics. iScience 26(12):108573 (2023)
E. Cantoni, I. Merelli, D. Stefanoni, A. Tomelleri, C. Campochiaro, V. Giordano, M. Panigada, E. M. Baldissera, L. Merlo Pich, V. Natoli, A. Ziogas, J. Domínguez-Andrés, G. De Luca, D. Mazza, S. Zambrano, D. Gnani, M. Ferrarini, E. Ferrero, A. Agresti, B. Vergani, B. Leone, S. Cenci, A. Ravelli, M. Matucci-Cerinic, A. D'Alessandro, L. Joosten, L. Dagna, M. Netea, R. Molteni, G. Cavalli. Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production. Rheumatology 62 (10), 3469–3479, (2023)
2022
C. Kizilirmak, M. E. Bianchi and S. Zambrano. Insights on the NF-κB System Using Live Cell Imaging: Recent Developments and Future Perspectives. Front. Immunol. 13:886127 (2022),
2021
R. Meucci, S. Euzzor, M. Ciofini, A. Lapucci, S. Zambrano. Demonstrating Filtered Feedback Control Near a Boundary Crisis. IEEE Transactions on Circuits and Systems I, 68(7) (2021)
R. Biavasco; R. Molteni; D. Stefanoni; T. Nemkov; M.G. Netea; J. Domínguez-Andrés; R.J.W. Arts; I. Merelli; D. Mazza; S. Zambrano; M. Panigada; E. Cantoni; I. Tengesdal; P. Maksud; F. Piras; G. De Luca; L. Cassina; G. Distefano; A. Loffreda; D. Gnani; C. Doglioni; A. Tomelleri; C. Campochiaro; L. Joosten; C.A. Dinarello; A. Kajaste-Rudnitski; J. Haroche; S. Cardaci; S. Cenci; L. Dagna; M. Ferrarini; E. Ferrero; A. Boletta; A. D'Alessandro; E. Montini; G. Cavalli. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood, 138(17), 1554-1569 (2021).
R. Mezzapelle, F. De Marchis, C. Passera, M. Leo, F. Brambilla, F. Colombo, M. Casalgrandi, A. Preti, S. Zambrano, P. Castellani, R. Ertassi, M. Silingardi, F. Caprioglio, V. Basso, R. Boldorini, A. Carretta, F. Sanvito, O. Rena, A. Rubartelli, L. Sabatino, A. Mondino, M.P. Crippa, V. Colantuoni, M.E. Bianchi. CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma. EMBO Mol Med, e12344 (2021)
2020
A. Fasciani, S. D’Annunzio, V. Poli, L. Fagnocchi, S. Beyes, D. Michelatti, F. Corazza, L. Antonelli, F. Gregoretti, G. Oliva, R. Belli, D. Peroni, E. Domenici, S. Zambrano, D. Intartaglia, C. Settembre, I. Conte, C. Testi, P. Vergyris, G. Ruocco, A. Zippo. MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome. Nature Genetics, 52, 1397–1411 (2020).
S. Zambrano*, A. Loffreda, E. Carelli, G. Stefanelli, F. Colombo, E. Bertrand, A. Agresti, M.E. Bianchi, N. Molina, D. Mazza. First responders shape an NF-κB-mediated prompt and sharp transcriptional response to TNF-α. iScience, 23(9), 101529 (2020).
2019
G. Careccia, F. Colombo, M. Tirone, A. Agresti, M.E. Bianchi, S. Zambrano*, E. Vénéreau. Exploiting Live Imaging to Track Nuclei During Myoblast Differentiation and Fusion. Journal of Visualized Experiments, (146), e58888 (2019).
2018
F. Colombo, S. Zambrano*, A. Agresti. NF-κB, the importance of being dynamic: role and insights in cancer. Biomedicines, 6(2), 45 (2018).
2017
F.T. Arecchi, S. Euzzor, M.R. Gallas, J.A.C. Gallas, R. Meucci, E. Pugliese, S. Zambrano. Exploring phase control with square pulsed perturbations. European Physical Journal Special Topics, 226, 1785 (2017).
R. Meucci, S. Euzzor, S. Zambrano, E. Pugliese, F. Francini, F.T. Arecchi. Energy constraints in pulsed phase control of chaos. Physics Letters A, 381(2), 82–86 (2017).
E. Ramos-Marquès, S. Zambrano, A. Tiérrez, M.E. Bianchi, A. Agresti, F. García-del Portillo. Single-cell analyses reveal an attenuated NF-κB response in the Salmonella-infected fibroblast. Virulence, 8, 719–740 (2017).
Relevant previous publications
2016
S. Zambrano, I. De Toma, A. Piffer, M.E. Bianchi, A. Agresti. NF-κB oscillations translate into functionally related patterns of gene expression. eLife, 5, e09100 (2016).
2015
S. Zambrano*, M.E. Bianchi, A. Agresti, N. Molina. Interplay between stochasticity and negative feedback leads to pulsed dynamics and distinct gene activity patterns. Physical Review E, 92, 022711 (2015).
2014
S. Zambrano*, M.E. Bianchi, A. Agresti. A simple model of NF-κB dynamics reproduces experimental observations. Journal of Theoretical Biology, 347, 44–53 (2014).
S. Zambrano, M.E. Bianchi, A. Agresti. High-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillations. PLOS ONE, 9(3), e90104 (2014).