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About This Book

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This monograph brings forth biomechanical research methods and outcomes on human tissue experiments such as those of the brain and the heart under a single umbrella. Different mechanical characterization techniques employed in human tissue property estimation are presented in detail. The contents also focus on a hyperelastic constitutive model (e.g., Mooney-Rivlin, Ogden) for both isotropic and anisotropic tissue characterization. It also discusses energy dissipation in soft tissues and associated viscoelasticity. Human tissues, including skin, muscles, connective tissues, and tissues in all functional organs are listed and their mechanical properties are presented in detail. These tissue properties are indispensable for computational modeling of biological systems, validation of biomechanical tissue testing, medical simulation through development of artificial phantoms and surrogates, and testing of medical devices and interventions. This book will serve as a key reference for research in tissue engineering & biomedical engineering, medical simulation, biomechanics, finite element modeling of biological systems, biomaterials, biotechnology, implant and medical device development, and healthcare wearables.

About This Book

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The book provides an overview of prospective material simulants for hard tissues, such as knee joints, hip joint, and bones, and soft tissues, such as skin, muscles, and functional organs. These materials can repair, replace the functionality, or mimic the mechanical, structural, and biological properties of the parent tissue. This book discusses hard and soft human tissue simulating biomaterials under a single umbrella, covering a broad area of design and development of biomaterials, implants, and multi-functional materials along with their characterization. The progress in emerging biomaterials has increased manifold in the recent decades with the unprecedented focus on healthcare technologies. This book is dedicated to ground-breaking research in biomaterials and highlights the current trends and future roadmap of different materials for simulation of hard and soft tissues. Authored by prominent researchers around the globe, the chapters of this book emphasize recent advances in biomedical material simulation. This book brings together novel contributions to different aspects of hard and soft human tissue-based biomaterials, including recent advances and emerging developments in designing and developing simulants for tissue replacement alternatives.

JOURNALS

60. Ayush Malviya, Shubham Gupta, Subhodip Chatterjee, Arnab Chanda (2023) "Development of A Novel Biomedical Device for Shoe Traction Safety Characterization", Journal of Engineering Research, DOI: 10.1016/j.jer.2023.08.018

59. Rohan Singla, Shubham Gupta, Arnab Chanda (2023) "A Computational Fluid Dynamics- Based Model for Assessing Rupture Risks in Cerebral Arteries with Varying Aneurysm Sizes", Mathematical and Computational Application, DOI:10.3390/mca28040090

58. Vivek Gupta, Arnab Chanda (2023) “Auxetic Incisions with Alternating Slit Shapes: A Promising Technique for Enhancing Synthetic Skin Grafts Expansion”, Materials Research Express, DOI: 10.1088/2053-1591/ace611

57. Vivek Gupta, Arnab Chanda (2023) “Expansion potential of novel skin grafts simulants with I-shaped auxetic incisions”, Biomedical Engineering Advances, 5:100071 DOI: 10.1016/j.bea.2023.100071

56. Shubham Gupta, and Arnab Chanda (2023) "Biomechanical Modeling of Footwear-Fluid-Floor Interaction During Slips", Journal of Biomechanics, 156: 111690. DOI: 10.1016/j.jbiomech.2023.111690

55. S. Shaikh, B. Jamdade and Arnab Chanda (2023) "Effects of Customised 3D-Printed Insoles in Patients with Foot-Related Musculoskeletal Ailments—A Survey-Based Study", Prosthesis, 5:550-561. DOI: 10.3390/prosthesis5020038

54. V Gupta , R Singla , G Singh and Arnab Chanda (2023) "Development of Soft Composite Based Anisotropic Synthetic Skin for Biomechanical Testing", Fibres, 11: 55. DOI: 10.3390/fib11060055

53. V Gupta , G Singh , and Arnab Chanda (2023) "Development of hierarchical auxetic skin graft simulants with high expansion potential", Biomedical Engineering Advances , 5: 100087. DOI: 10.1016/j.bea.2023.100087

52. G Singh and Arnab Chanda (2023) "Development and mechanical characterization of artificial surrogates for brain tissues", Biomedical Engineering Advances, 5: 100084. DOI: 10.1016/j.bea.2023.100084

51. Komal Chhikara, Shubham Gupta, Dhruv Bose, Chitra Kataria, and Arnab Chanda (2023) "Development and Trial of a Multipurpose Customised Orthosis for Activities of Daily Living in Patients with Spinal Cord Injury", Prosthesis, 2: 467-479. DOI: 10.3390/prosthesis5020032

50. Mohammad Afazal, Shubham Gupta, Abhishek Tevatia, Saba Afreen, and Arnab Chanda (2023) "Computational Investigation of Dental Implant Restoration Using Platform-Switched and -Matched Configurations", Computation, 4:79. DOI: 10.3390/computation11040079

49. Gurpreet Singh, Arnab Chanda (2023) “Development and Mechanical Characterisation of Artificial Surrogates for Brain Tissues”, Biomedical Engineering Advances, 5:100084. DOI: 10.1016/j.bea.2023.100084

48. Vivek Gupta, Arnab Chanda (2023) “Expansion potential of novel skin grafts simulants with I-shaped auxetic incisions”, Biomedical Engineering Advances, 5:100071. DOI: 10.1016/j.bea.2023.100071

47. Vivek Gupta, Gurpreet Singh, Arnab Chanda (2023) “Development of Novel Hierarchical Designs for Skin Graft Simulants with High Expansion Potential”, Biomedical Physics & Engineering Express. DOI: 10.1088/2057-1976/acc661

46. Vivek Gupta, Gurpreet Singh, Arnab Chanda (2023) “High Expansion Auxetic Skin Graft Simulants for Severe Burn Injury Mitigation”, European Burn Journal, 4(1):108-120. DOI: 10.3390/ebj4010011

45. Anshika Garg, Shubham Gupta, Nitesh Tewari, Sukeshana Srivastav, Arnab Chanda (2023) “Effect of Adhesive Materials in Re-Attachment of Crown and Crown–Root Fractures of Permanent Maxillary Anterior Tooth: A Computational Study”, Mathematical and Computational Applications, 28(2):41. DOI: 10.3390/mca28020041

44. Shubham Gupta, Subhodip Chatterjee, Ayush Malviya, Abhishek Kundu, Arnab Chanda (2023) “Effect of Shoe Outsole Wear on Friction during Dry and Wet Slips: A Multiscale Experimental and Computational Study”, Multiscale Science and Engineering. DOI: 10.1007/s42493-023-00089-0

43. Komal Chhikara, Sarabjeet Singh Sidhu, Shubham Gupta, Sakshi Saharawat, Chitra Kataria, Arnab Chanda (2023) “Development and Effectiveness Testing of a Novel 3D-Printed Multi-Material Orthosis in Nurses with Plantar Foot Pain”, Prosthesis, 5(1):73-87. DOI: 10.3390/prosthesis5010006

41. Shubham Gupta, Subhodip Chatterjee, Ayush Malviya, Arnab Chanda (2023) “Frictional Assessment of Low-Cost Shoes in Worn Conditions Across Workplaces”, Journal of Bio-and Tribo-Corrosion, 9(1):23. DOI: 10.1007/s40735-023-00741-0

40. Komal Chhikara, Shubham Gupta, Sakshi Saharawat, Shruti Sarkar, Arnab Chanda (2023) “Design, Manufacturing, and Trial of a 3D Printed Customized Finger Splint for Patients with Rheumatoid Arthritis”, Rheumato, 3(1):51-62. DOI: 10.3390/rheumato3010004

30. Shubham Gupta, Rajan Jayaraman, Sarabjeet Singh Sidhu, Ayush Malviya, Subhodip Chatterjee, Komal Chhikara, Gurpreet Singh, Arnab Chanda (2023) “Diabot: Development of a Diabetic Foot Pressure Tracking Device”, J, 6(1):32-47. DOI: 10.3390/j6010003

29. Prem Nath Yadav, Gurpreet Singh, Shubham Gupta, Arnab Chanda (2023) “Biomechanical Modeling of Cerebral Aneurysm Progression to Estimate Rupture Risk”, Biomechanics, 3(1):13-28. DOI: 10.3390/biomechanics3010002

28. Shubham Gupta, Subhodip Chatterjee, Arnab Chanda (2023) “Influence of Vertically Treaded Outsoles on Interfacial Fluid Pressure, Mass Flow Rate, and Shoe–Floor Traction during Slips”, Fluids, 8(3):82. DOI: 10.3390/fluids8030082

27. Vivek Gupta, Shubham Gupta, Arnab Chanda (2023) “Development of an ultra-low-cost planar biaxial tester for soft tissue characterization”, Biomedical Physics & Engineering Express, 9(2):025011. DOI: 10.1088/2057-1976/acb940

26. Shubham Gupta, Subhodip Chatterjee, Ayush Malviya, Gurpreet Singh, Arnab Chanda (2023) “A Novel Computational Model for Traction Performance Characterization of Footwear Outsoles with Horizontal Tread Channels”, Computation, 11(2):23. DOI: 10.3390/computation11020023

25. Shubham Gupta, Mithil Kumar, Gurpreet Singh, Arnab Chanda (2023) “Development of a Novel Footwear Based Power Harvesting System”, e-Prime-Advances in Electrical Engineering, Electronics and Energy, 3:100115. DOI: 10.1016/j.prime.2023.100115

24. Shubham Gupta, Ayush Malviya, Subhodip Chatterjee, Arnab Chanda (2022) “Development of a Portable Device for Surface Traction Characterization at the Shoe–Floor Interface”, Surfaces 5(4):504-520. DOI: 10.3390/surfaces5040036

23. Gurpreet Singh, Arnab Chanda (2022) “Biomechanical modeling of progressive wound healing: A computational study”, Biomedical Engineering Advances 4:100055. DOI: 10.1016/j.bea.2022.100055

22. Shubham Gupta, Subhodip Chatterjee, Ayush Malviya, Arnab Chanda (2022) “Traction Performance of Common Formal Footwear on Slippery Surfaces”, Surfaces 5(4):489-503. DOI: 10.3390/surfaces5040035

21. Komal Chhikara, Gurpreet Singh, Shubham Gupta, Arnab Chanda (2022) “Progress of Additive Manufacturing in Fabrication of Foot Orthoses for Diabetic Patients: A Review”, Annals of 3D Printed Medicine 8):100085. DOI: 10.1016/j.stlm.2022.100085

20. Shubham Gupta, Sarabjeet Singh Sidhu, Subhodip Chatterjee, Ayush Malviya, Gurpreet Singh, Arnab Chanda (2022) “Effect of floor coatings on slip-resistance of safety shoes”, Coatings 12(10):1455. DOI: 10.3390/coatings12101455

19. Gurpreet Singh, Vivek Gupta, Arnab Chanda (2022) “Mechanical Characterization of Rotating Triangle Shaped Auxetic Skin Graft Simulants ”, Facta Universitatis, Series: Mechanical Engineering. DOI: 10.22190/FUME220226038S

18. Vivek Gupta, Shubham Gupta, Arnab Chanda (2022) “Expansion potential of skin grafts with novel rotating-triangle-shaped auxetic incisions”, Emerging Materials Research 11(4):406-414. DOI: 10.1680/jemmr.22.00026

17. Subhodip Chatterjee, Shubham Gupta, Arnab Chanda (2022) “Barefoot Slip Risk in Indian Bathrooms: A Pilot Study”, Tribology Transactions 65(6):977-990. DOI: 10.1080/10402004.2022.2103863

16.Vivek Gupta, Arnab Chanda (2022) “Finite element analysis of a hybrid corrugated hip implant for stability and loading during gait phases”, Biomedical Physics & Engineering Express 8(3):035028. DOI: 10.1088/2057-1976/ac669c

15.Shubham Gupta, Vivek Gupta, Arnab Chanda (2022) “Biomechanical Modeling of Novel High Expansion Auxetic Skin Grafts ”, International Journal for Numerical Methods in Biomedical Engineering 38(5):e3586. DOI: 10.1002/cnm.3586

14.Vivek Gupta, Arnab Chanda (2022) “Expansion Potential of Skin Grafts with Alternating Slit Based Auxetic Incisions”, Forces in Mechanics 7:100092. DOI: 10.1016/j.finmec.2022.100092

13. Subhodip Chatterjee, Arnab Chanda (2022) “Development of a Tribofidelic Human Heel Surrogate for Barefoot Slip Testing”, Journal of Bionic Engineering 19(2):429-439. DOI: 10.1007/s42235-021-00138-0

12.Vivek Gupta, Arnab Chanda (2022) “Biomechanics of Skin Grafts: Effect of Pattern Size, Spacing and Orientation”, Engineering Research Express 4(1):015006. DOI: 10.1088/2631-8695/ac48cb

11. Komal Chhikara, Shubham Gupta, Arnab Chanda (2022) “Development of a novel foot orthosis for plantar pain reduction”, Materials Today: Proceedings 62(6):3532-3537. DOI: 10.1016/j.matpr.2022.04.361

10. Shubham Gupta, Subhodip Chatterjee, Arnab Chanda (2022) “Effect of footwear material wear on slips and falls”, Materials Today: Proceedings 62(6):3508-3515. DOI: 10.1016/j.matpr.2022.04.313

9. Vivek Gupta, Gurpreet Singh, Arnab Chanda (2022) “Development and testing of skin grafts models with varying slit orientations”, Materials Today: Proceedings 62(6):3462-3467. DOI: 10.1016/j.matpr.2022.04.282

8. Subhodip Chatterjee, Shubham Gupta, Arnab Chanda (2022) “Barefoot slip risk assessment of Indian manufactured ceramic flooring tiles”, Materials Today: Proceedings 62(6):3699-3706. DOI: 10.1016/j.matpr.2022.04.428

7.Prem Nath Yadav, Gurpreet Singh, Arnab Chanda (2022) “Biomechanical modeling of cerebral aneurysm”, Materials Today: Proceedings 62(6):3295-3300. DOI: 10.1016/j.matpr.2022.04.235

6.Gurpreet Singh, Vivek Gupta, Arnab Chanda (2022) “Artificial Skin with Varying Biomechanical Properties”, Materials Today: Proceedings 62(6):3162-3166. DOI: 10.1016/j.matpr.2022.03.433

5.Vivek Gupta, Arnab Chanda (2022) “Expansion Potential of Skin Grafts with Novel I-Shaped Auxetic Incisions”, Biomedical Physics and Engineering Express 8(1):015016. DOI: 10.1088/2057-1976/ac3b72

4.Shubham Gupta, Gurpreet Singh, Arnab Chanda (2021) “Prediction of Diabetic Foot Ulcer Progression: A Computational Study”, Biomedical Physics and Engineering Express, 7(6):065020. DOI: 10.1088/2057-1976/ac29f3

3.Shubham Makode, Gurpreet Singh, Arnab Chanda (2021) “Development of Novel Anisotropic Skin Simulants”, Physica Scripta, 96(12):125019. DOI: 10.1088/1402-4896/ac2efd

2.Gurpreet Singh, Shubham Gupta, Arnab Chanda (2021) “Biomechanical Modelling of Diabetic Foot Ulcers: A Computational Study”, Journal of Biomechanics 127(4):110699. DOI: 10.1016/j.jbiomech.2021.110699

1.Gurpreet Singh, Arnab Chanda (2021) “Mechanical Properties of Whole-Body Soft Human Tissues: A Review”, Biomedical Materials, 16(6):062004. DOI: 10.1088/1748-605X/ac2b7a

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