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more than one tumour in the same lobe; it has not spread to nearby lymph nodes but may invade other parts of the lung, the airway or the surrounding areas just outside the lung, e.g. the diaphragm STAGE IIIA (T1/2-N2-M0 or T3-N1-M0 or T4-N0/1-M0) • The tumour is no larger than 5 cm, has spread to further lymph nodes but is not in any other part of the body; or • The tumour is 5–7 cm in size or there is more than one tumour in the same lobe; it has spread to nearby lymph nodes and may invade other parts of the lung, the airway or the surrounding areas just outside the lung, e.g. the diaphragm; or • The tumour is larger than 7 cm and invades tissues and structures further away from the lung, such as the heart, windpipe or oesophagus, but it has not spread to other parts of the body; or there is more than one tumour in different lobes of the same lung. The cancer may or may not have spread to nearby lymph nodes Locally advanced NSCLC STAGE IIIB (T1/2-N3-M0 or T3-N2-M0 or T4-N2-M0) • The tumour is no larger than 5 cm, has spread to more distant lymph nodes but is not in any other part of the body; or • The tumour is 5–7 cm in size or there is more than one tumour in the same lobe; it has spread to further lymph nodes and may invade other parts of the lung, the airway or the surrounding areas just outside the lung, e.g. the diaphragm; or • The tumour is larger than 7 cm and invades tissues and structures further away from the lung, such as the heart, windpipe or oesophagus, but it has not spread to other parts of the body; or there is more than one tumour in different lobes of the same lung. The cancer has spread to further lymph nodes STAGE IV (any T-any N-M1) • The tumour is of any size and may or may not have spread to the lymph nodes. The cancer is in both lungs, has spread to another part of the body (e.g. the liver, adrenal glands, brain or bones) or it has caused a collection of fluid around the lung or heart that contains cancer cells Metastatic NSCLC AJCC/UICC system 8th edition – abridged version (Planchard et al., 2018) AJCC, American Joint Committee on Cancer; NSCLC, non-small-cell lung cancer; UICC, Union for International Cancer Control 19 ESMO Patients Guide Type of NSCLC Biopsy results Your biopsy will be examined in the laboratory to determine: • The histological subtype (adenocarcinoma, SCCor large cell carcinoma). • Grade. • Tumour biology. Histological subtype
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