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biopsies. The data presented herein supports the empirically acquired knowledge of every dermatologist that although skin biopsy is performed for the diagnosis of a wide range of dermatoses, it is used predominantly for the determination of malignancies, mainly melanomas and epitheliomas, and also for inflammatory dermatoses such as dermatitis and psoriasis. Nevertheless, despite the high diagnostic usefulness of skin biopsy (97.2% in this study) with a diagnostic accuracy of 83.3%, there have been 11.2% of all instances lacking histological diagnosis. The possible reasons for this discrepancy have not been quantitatively assessed in the literature. Technically speaking, this could be attributed to several factors such as inadequate and inappropriate specimens, as previously analyzed. However, a number of 𝑛 = 25 (0.4%) of all skin biopsies were lacking both clinical diagnosis and usable histological data. Also there were 𝑛 = 232 (3.5%) without specific clinical diagnosis and 𝑛 = 158 (2.4%) without any clinical description or diagnosis. Although these cases were infrequent, they would probably cause therapeutic problems. Hence, a closer cooperation between the dermatologist and the dermatopathologist is advisable. 5. Conclusion Despite the fact that a plethora of modern techniques have been developed and utilized in the diagnosis of skin disease, dermatologists still rely vastly on biopsy for diagnostic purposes. As discussed in this study, there is a wide range of diseases that allow dermatologists to select skin biopsy in order to confirm their suspected diagnosis, and the histological perspective proves to be both helpful and reliable in the majority of cases. However, there are also limitations in this method and there are cases that the performance of a biopsy does not produce diagnostic results. As a consequence proper diagnosis is delayed and all imminent therapeutic decisions rely heavily upon the dermatologist’s comprehension of the situation.Therefore an optimal use of the process is suggested with comprehensive descriptions and relevant diagnoses by the dermatologist along with a closer cooperation with the dermatopathologist performing clinicopathological correlation whenever possible. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. References [1] I. Ahnlide and M. Bjellerup, “Accuracy of clinical skin tumour diagnosis in a dermatological setting,” Acta Dermato-Venereologica, vol. 93, no. 3, pp. 305–308, 2013. [2] F. B. Yap, “Dermatopathology of 400 skin biopsies from Sarawak,” Indian Journal of Dermatology, Venereology and Leprology, vol. 75, no. 5, pp. 518–519, 2009. [3] U. Khopkar and B. Doshi, “Improving diagnostic yield of punch biopsies of the skin,” Indian Journal of Dermatology, Venereology and Leprology, vol. 74, no. 5, pp. 527–531, 2008. [4] R. Sleiman, M. Kurban, and O. Abbas, “Maximizing diagnostic outcomes of skin biopsy specimens,” International Journal of Dermatology, vol. 52, no. 1, pp. 72–78, 2013. [5] E. McInnes, “Artefacts in histopathology,” Comparative Clinical Pathology, vol. 13, no. 3, pp. 100–108, 2005. [6] L. Bomm, M. D. Benez, J. M. Maceira, I. C. Succi, and M. F. Scotelaro, “Biopsy guided by dermoscopy in cutaneous pigmented lesion—case report,” Anais Brasileiros de Dermatologia, vol. 88.